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Topic: Gastrin

Related Topics

Zollinger Ellison syndrome

Gastric acid

Secretin

Digestive fluid

CCK receptor

Somatostatin

CCK

Parietal cell

Hormone

Peptide hormone

Digestion

Stomach

Glucagon

Hydrochloric acid

Histamine

	Gastrin - boo
		Gastrin is the major hormone that regulates acid secretion in the stomach.Â A gastrin testÂ measures the amount of gastrin in the blood.
		Gastrin is a hormone produced by specialized cells in the stomach.
		Small amounts of gastrin may also be produced by the pancreas and possibly the intestines.
	www.umm.edu /ency/article/003697.htm (655 words)

	Gastrin
		Gastrin is synthesized in G cells, which are located in gastric pits, primarily in the antrum region of the stomach and binds receptors found predominantly on parietal and enterochromaffin-like cells.
		Gastrin is a linear peptide that is synthesized as a preprohormone and is post-translationally cleaved to form a family of peptides with identical carboxytermini.
		Stimulation of ECL cells by gastrin leads to histamine release, and histamine binding to H2 receptors on parietal cells is necessary for full-blown acid secretion.
	arbl.cvmbs.colostate.edu /hbooks/pathphys/endocrine/gi/gastrin.html (0 words)

	Gastrin
		A gastrin test measures the level of the hormone gastrin in the blood.
		Gastrin is produced by cells called G cells in the stomach lining.
		Sometimes a test for gastrin is done after eating a high-protein diet or after receiving an injection of the digestive hormone secretin into a vein.
	www.webmd.com /digestive-disorders/Gastrin (0 words)

	THE MERCK MANUAL OF GERIATRICS, Ch. 106, Gastric Disorders
		A syndrome characterized by marked hypergastrinemia, gastric hypersecretion, and peptic ulceration caused by a gastrin-producing tumor (gastrinoma) of the pancreas or the duodenal wall.
		In the calcium test, calcium gluconate infusion at 5 mg/kg/hour is given for 3 hours; serum gastrin levels are measured 30 minutes before and immediately before infusion and at 30-minute intervals thereafter for 4 hours.
		Chemotherapy with streptozocin and 5-fluorouracil decreases serum gastrin levels in patients with metastatic disease but is usually reserved for patients with liver metastases to relieve symptoms.
	www.merck.com /mrkshared/mmg/sec13/ch106/ch106e.jsp (546 words)

	Anti-Gastrin Mab: XOMA
		Gastrin expression and the appearance of gastrin receptors have been associated with increasing malignant characteristics of GI tumors and with poorer prognostic outcomes.
		Specifically, gastrin is known to be involved in the progression of colorectal, stomach, liver and pancreatic cancers and inhibiting gastrin may inhibit such growth.
		In a homeostatic situation gastrin is produced by the G-cells of the antral mucosa of the stomach and its functions are to prepare the stomach for ingestion of food by stimulating the secretion of gastric acid (parietal cell-derived HCl) and pepsin.
	www.xoma.com /wt/page/anti_gastrin_mab (433 words)

	Gastrin - Definition, explanation
		Gastrin is a linear peptide hormone produced by G cells that are located mainly in the antrum of the stomach and the D cells of the pancreatic islets.
		Gastrin release is inhibited by the presence of acid (primarily the secreted HCl) in the stomach (a case of negative feedback).
		In the Zollinger-Ellison syndrome, gastrin is produced at excessive levels, often by a gastrinoma (gastrin-producing tumor, mostly benign) of the antrum or the pancreas.
	www.calsky.com /lexikon/en/txt/g/ga/gastrin.php (378 words)

	GAST - gastrin
		Thus, the gastrin receptors on the parietal cells and the brain appear to be encoded by the same gene as those on the ECL carcinoid tumor in Mastomys.
		Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis.
		The growth of the mammary gland is stimulated by growth hormone and prolactin, adrenocortical steroids, oestrogens and progesterone, and that of the gastrointestinal (GI) tract by gastrin, CCK and secretin.
	www.ihop-net.org /UniPub/iHOP/gg/88457.html (5474 words)

	Clinical Biochemistry-Gastrin: An analytical review
		The achlorhydria in auto-immune atrophic gastritis is attributable to parietal cell antibodies and the elevated plasma gastrin is a consequence of the lack of negative feedback of acid on the G-cell.
		The concentrations of plasma gastrin in these patients may be between 80 and 30 000 pmol/L, most commonly around 500-1500 pmol/L.60,61 When these patients present with gastric symptoms or abdominal pain, acid secretory studies or investigations for the presence of antibodies to parietal cells and to intrinsic factor are useful in the differential diagnosis.
		Gastrin biosynthesis in the antrum of patients with pernicious anemia.
	mpelembe.mappibiz.com /archives_02/Gastrin_Hormone.html (4980 words)

	Gastrin at AllExperts
		Gastrin is a linear peptide hormone produced by G cells that are located mainly in the antrum of the stomach.
		Gastrin release is inhibited by the presence of acid (primarily the secreted HCl) in the stomach (a case of negative feedback).
		In the Zollinger-Ellison syndrome, gastrin is produced at excessive levels, often by a gastrinoma (gastrin-producing tumor, mostly benign) of the antrum or the pancreas.
	en.allexperts.com /e/g/ga/gastrin.htm (528 words)

	Gastrin - Health Centers
		Gastrin is the major hormone that regulates acid secretion in the stomach.?A gastrin test?measures the amount of gastrin in the blood.
		Gastrin is a hormone produced by specialized cells in the stomach.
		Small amounts of gastrin may also be produced by the pancreas and possibly the intestines.
	www.wdsu.com /encyclopedia/6864764/detail.html (840 words)

	News & Views Online
		The measurement of circulating gastrin is integral to the diagnosis, treatment and monitoring of a variety of rare tumors and common gastric disorders.
		The degree of gastrin overproduction is disease dependent and usually results in an increased rate of gastric acid secretion with concomitant dyspepsia, gastric pain, and ulcerations of the stomach and duodenum.
		Antral G cells are stimulated to produce gastrin by increased gastric pH, vagus nerve stimulation (sight, smell, and initial taste of food) and the presence of protein.
	www.dpcweb.com /documents/news&views/issue2_2004/gastrin.html (1508 words)

	Definition: gastrin from Online Medical Dictionary
		Gastrin then stimulates the stomach parietal cells to produce hydrochloric acid.
		Gastrin blood levels can be determined to be elevated in conditions such as Zollinger-Ellison syndrome and pernicious anaemia.
		Several different gastrins have been identified, human gastrin I has 16 amino acids (2116 D).
	cancerweb.ncl.ac.uk /cgi-bin/omd?gastrin (0 words)

	The Individualist: Gastrin
		Gastrin is a linear peptide hormone produced by G cells that are located mainly in the antrum of the stomach and the D cells of the pancreatic islets.
		Gastrin release is inhibited by the presence of acid (primarily the secreted HCl) in the stomach (a case of negative feedback).
		In the Zollinger-Ellison syndrome, gastrin is produced at excessive levels, often by a gastrinoma (gastrin-producing tumor, mostly benign) of the antrum or the pancreas.
	www.dadamo.com /wiki/wiki.pl/Gastrin (580 words)

	[No title]
		Gastrin and cholecystokinin (CCK) [1] are structurally and functionally related peptide hormones that function as hormonal regulators of various digestive processes and feeding behaviors.
		The biological activity of gastrin and CCK is associated with the last five C-terminal residues.
		The amphibian caerulein skin peptide, the cockroach leukosulphakinin I and II (LSK) peptides, Drosophila melanogaster putative CCK-homologs Drosulphakinins I and II, cionin, a chicken gastrin/cholecystokinin-like peptide and cionin, a neuropeptide from the protochordate Ciona intestinalis belong to the same family.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR001651 (0 words)

	COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer
		Gastrin is a gastrointestinal peptide that possesses potent trophic properties on both normal and neoplastic cells of gastrointestinal origin.
		Here we demonstrate that gastrin leads to a dose-dependent increase in colon cancer cell proliferation and tumour growth in vitro and in vivo, and that this increment is progressively reversed by pretreatment with the cyclo-oxygenase-2 inhibitor NS-398.
		The results of these studies demonstrate that cyclo-oxygenase-2 appears to represent one of the downstream targets of gastrin and that selective cyclo-oxygenase-2 inhibition is capable of reversing the trophic properties of gastrin and presumably might prevent the growth of colorectal cancer induced by hypergastrinaemia.
	www.nature.com /bjc/journal/v87/n5/abs/6600495a.html (236 words)

	Carilion - Gastrin - [Medical Test]
		The gastrin test measures the level of the hormone gastrin in the blood.
		Gastrin is produced by special cells called G cells in the stomach lining.
		Sometimes a test for gastrin is done after eating a high-protein diet or after receiving an injection of the digestive hormone secretin into a vein.
	www.carilion.com /kbase/htm/hw81/94/hw8197.htm (186 words)

	UpToDate Physiology of gastrin
		The study of gastrin accelerated with the isolation and characterization of the peptide in 1964 after which it was found to promote growth of the gastric antrum and have a proliferative effect, which has implicated it as having a possible role in cancer [2,3].
		Like other hormones, gastrin is synthesized on rough endoplasmic reticulum, processed in the Golgi apparatus and packaged in secretory granules, where final modifications occur [5].
		In endocrine cells, the glycine residue at the carboxyl terminus is cleaved and the terminus is amidated to form the mature gastrin peptide.
	patients.uptodate.com /topic.asp?file=gi_dis/16036 (507 words)

	Carilion - Gastrin - [Medical Test] (Site not responding. Last check: )
		Gastrin levels can be increased in G-cell hyperplasia, peptic ulcers, hypercalcemia, hyperparathyroidism, sarcoidosis, and stomach cancer.
		Gastrin can also be markedly increased in pernicious anemia and conditions in which the stomach is unable to produce gastric acid, such as atrophic gastritis.
		Gastrin levels may be increased in people who have undergone surgery to remove a large portion of the intestines (small bowel resection).
	www.carilion.com /kbase/htm/hw81/94/hw8208.htm (163 words)

	Gastrin Linked to Body Weight, Insulin; Removal Raised Cancer Risk
		Removing gastrin not only made the mice obese, but also had the unexpected result of raising the mice's insulin levels.
		As is the case with humans, diabetes in mice stems from genetic predisposition to the disease and non-genetic factors such as obesity, bad diet and sedentary lifestyle.
		The article titled "Abdominal obesity, insulin resistance and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression," appeared in the June 15, 2005 issue of Cancer.
	www.medicalnewstoday.com /medicalnews.php?newsid=29116 (659 words)

	Dr. Koop - Gastrin
		Gastrin is the major hormone that regulates acid secretion in the stomach.Â A gastrin testÂ measures the amount of gastrin in the blood.
		Blood is drawn from a vein on the inside of the elbow or the back of the hand.
		Drugs that can increase gastrin measurements include antacids, H2-blocking agents (such as cimetidine), and proton pump inhibitors (such as omeprazole).
	www.drkoop.com /ency/93/003697.html (371 words)

	Gastrin, Serum
		Gastrin >1000 pg/mL with gastric acid hypersecretion (basal acid secretion >15 mmol/hour in a patient with peptic ulcer who has not had surgery) establishes unequivocally the diagnosis of the Zollinger-Ellison syndrome.
		At least half of patients with the Z-E syndrome lack diagnostic serum gastrin levels, although in nearly all, fasting serum gastrin levels are increased.
		Gastrin is secreted by antral G cells and stimulates gastric acid production, antral motility, and secretion of pepsin and intrinsic factor.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sr002100.htm (1010 words)

	Zollinger-Ellison Syndrome - causes, gastrin, peptic ulcer, malignant tumour, symptoms
		Zollinger-Ellison syndrome is the name that doctors use to describe a collection of symptoms arising from the stomach and part of the small bowel called the duodenum (the part of the small intestine leaving the stomach), which occur because the stomach makes too much acid all the time.
		Zollinger-Ellison syndrome is a rare disorder in which lumps (tumours) in the pancreas or, less often, in the wall of the duodenum secrete a chemical hormone (signal carried in the blood) substance (called gastrin) that causes the stomach to produce too much acid.
		The tumour in the pancreas that produces too much gastrin in this syndrome is usually malignant (in other words, it is a cancer and can spread to other parts of the body).
	www.patienthealthinternational.com /article/501579.aspx (426 words)

	BIOHIT - Human Gastrin Biomarkers -
		Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and “pyloric” in differentiation (so called pseudopyloric metaplasia).
		Amidated gastrin-17 is a biologically and physiologically important molecule among the family of the gastrin peptides.
		Amidated gastrin-17 is the most powerful gastrin peptide in the feedback control mechanism of the acid secretion and output from the parietal cells in the gastric corpus.
	www.biohit.com /view/products.asp?document_id=1290&cat_id=293 (305 words)

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