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Topic: Gastrointestinal stromal tumor

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	eMedicine - Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma : Article by Vu Nguyen, MD
		Previously, these tumors were classified as GI leiomyomas, leiomyosarcomas, leiomyoblastomas, or schwannomas as a result of their histologic findings and apparent origin in the muscularis propria layer of the intestinal wall.
		The tumors appear as hypoechoic masses that are contiguous with the fourth hypoechoic layer of the GI wall, which corresponds to the muscularis propria.
		Gastrointestinal stromal tumor with central bull's eye appearance, which is compatible with contrast material collection in an ulceration.
	www.emedicine.com /radio/topic388.htm (3781 words)

	Gastrointestinal stromal tumor - Wikipedia, the free encyclopedia
		In medical oncology, gastrointestinal stromal tumors (GIST) are a rare tumor of the gastrointestinal tract (1-3% of all gastrointestinal malignancies).
		Small tumors are generally benign, especially when cell division rate is slow, but large tumors disseminate to the liver, omentum and peritoneal cavity.
		Some tumors of the stomach and small bowel referred to as leiomyosarcomas (malignant tumor of smooth muscle) would most likely be reclassified as GISTs today on the basis of immunohistochemical staining.
	en.wikipedia.org /wiki/Gastrointestinal_stromal_tumor (1200 words)

	Gastrointestinal Stromal Tumors
		Cyclooxygenase-2 expression in stromal tumors of the gastrointestinal tract.
		Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases.
		One of the lesions arose in the stomach, one in the ileum, and 2 in the colon.
	www.thedoctorsdoctor.com /diseases/stromal_tumors_gi.htm (12856 words)

	Extragastrointestinal Stromal Tumors
		Gastrointestinal stromal tumor or smooth muscle tumor (GIST) is the designation for a major subset of gastrointestinal mesenchymal tumors that histologically, immunohistochemically, and genetically differ from typical leiomyomas, leiomyosarcomas, and schwannomas.
		The clinicopathologic features of 48 tumors that were histologically similar to gastrointestinal stromal tumors but occurred in the soft tissues of the abdomen were analyzed to determine their overall similarity to their gastrointestinal counterpart, their biologic behavior, and the parameters that predict risk for adverse outcome.
		Forty tumors arose from the soft tissue of the abdominal cavity, and the remainder arose from the retroperitoneum.
	www.thedoctorsdoctor.com /diseases/stromal_tumors_extragastrointestinal.htm (1320 words)

	Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice Filippou ...
		Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms of the gastrointestinal tract, which are usually located in the small intestine and the stomach.
		Gastrointestinal stromal tumors constitute the largest group of the stomach and small intestine's primary non-epithelial neoplasms, although they represent only a small percentage (0.1-3%) of the gastrointestinal malignancies.
		Immuno-histochemical studies are essential for the tumor classification into four subtypes: (a) smooth muscle type, (b) neural type, (c) dual differentiation type (with characteristics from both smooth muscle and neural types) and (d) uncommitted types (lack of differentiation towards a specific cell type).
	www.jpgmonline.com /article.asp?issn=0022-3859;year=2006;volume=52;issue=3;spage=204;epage=206;aulast=Filippou (1873 words)

	Gastrointestinal stromal tumor (Site not responding. Last check: 2007-10-27)
		or discomfort, and the tumor has become rather large by time the diagnosis is made.
		Tumors of the stomach and small bowel referred to in older texts as
		Both are able to make the diagnosis of GIST, although small tumors may be missed, expecially in cases of a suboptimal examination.
	www.cancerbible.com /Gastrointestinal_stromal.shtml (579 words)

	Bioline International Official Site (site up-dated regularly)
		Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, but they are rare in occurrence.
		Most patients with malignant stromal tumors are symptomatic, the most common being abdominal mass closely followed by GI bleeding as a result of overlying mucosal ulceration and pain.
		The malignant potential of these tumors are best estimated by the simultaneous evaluation of several clinical parameters such as size, location in the gut, invasion of the adjacent organ, mucosal invasion, degree of cellularity, cellular architecture, mitotic count, nuclear polymorphism, necrosis and proliferation rate.
	www.bioline.org.br /request?is04027 (1482 words)

	RedOrbit - Health - A Gastrointestinal Stromal Tumor Discovered in a Resected Hemorrhoidal Donut After Stapled ... (Site not responding. Last check: 2007-10-27)
		The gastrointestinal stromal tumor was seen to measure 0.7 cm in greatest diameter and was completely contained within the fibers of the muscularis propria.
		Gastrointestinal stromal tumors and leimyosarcomas of the abdomen and retroperitoneum: a clinical comparison.
		Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathological, immunohistochemical, and molecular genetic study of 144 cases.
	www.redorbit.com /news/display/?id=140239&source=r_health (1698 words)

	eMedicine - Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma : Article by Vu Nguyen, MD (Site not responding. Last check: 2007-10-27)
		Previously, these tumors were classified as GI leiomyomas, leiomyosarcomas, leiomyoblastomas, or schwannomas as a result of their histologic findings and apparent origin in the muscularis propria layer of the intestinal wall.
		The tumors appear as hypoechoic masses that are contiguous with the fourth hypoechoic layer of the GI wall, which corresponds to the muscularis propria.
		Gastrointestinal stromal tumor with central bull's eye appearance, which is compatible with contrast material collection in an ulceration.
	emedicine.com /RADIO/topic388.htm (3781 words)

	Jejunal Gastrointestinal Stromal Tumor: A Cause of Obscure Gastrointestinal Bleeding Archives of Pathology & ...
		Jejunal Gastrointestinal Stromal Tumor: A Cause of Obscure Gastrointestinal Bleeding
		The tumor was excised (Figure 1) and identified histologically as a gastrointestinal stromal tumor (GIST).
		In patients between 30 and 50 years of age, tumors are the most common abnormalities, whereas in patients less than 25 years of age, Meckel diverticula are the most common source of small bowel bleeding.6 Vascular ectasias predominate in older patients.
	www.findarticles.com /p/articles/mi_qa3725/is_200402/ai_n9403024 (873 words)

	MIR Teaching file case pt076
		A gastrointestinal stromal tumor (GIST) was diagnosed by endoscopic biopsy of a gastric mass.
		The remaining tumors occur elsewhere in the gastrointestinal tract, or in the omentum or retroperitoneum.
		A gastrointestinal stromal tumor was diagnosed by biopsy of a gastric tumor.
	gamma.wustl.edu /pt076te173.html (625 words)

	World J Gastroenterol (Site not responding. Last check: 2007-10-27)
		Tumors were located in the stomach in 12 (70%) patients and 5 (30%) patients had tumor located in the jejunal mesentery.
		The distribution of 725 malignant smooth muscle tumors of the gastrointestinal tract was 47.3% in the stomach, 35.4% in the small intestine, 4.6% in the colon and 7.4% in the rectum, according to Skandalak and Gray
		The mean tumor diameter of the heterogeneous tumors was 11.6±2.1 cm and that of the homogenous tumors was 3.8±1.3 cm.
	www.wjgnet.com /1007-9327/10/2417.asp (1565 words)

	World Journal of Surgical Oncology \| Full text \| A gastrointestinal stromal tumor (GIST) masquerading as an ovarian mass
		Malignant gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating in the wall of the gastrointestinal tract.
		Gastrointestinal stromal tumors (GIST) are rare tumors that may arise anywhere in the tubular gastrointestinal tract, but stomach is the most common site of localization.
		In light of the tendency of these tumors to pursue an indolent clinical course with a significant risk of late relapse, a brisk follow-up is advocated for all patients [5].
	www.wjso.com /content/2/1/15 (1163 words)

	eSynopsis of Gastrointestinal Stromal Tumor of the Small Intestine
		•Malignant GIST tumors showing leiomyomatous differentiation most commonly present in the muscular wall of the jejeunum and ileum, and much less commonly in the large intestine.
		•Many tumors are exophytic and bulge from the serosal surface into the peritoneal cavity or adjoining tissue.
		•Tumors over 4cm in diameter should be considered to have malignant potential although this is a less reliable guide than mitotic activity.
	esynopsis.uchc.edu /S167.htm (465 words)

	Medical Dictionary: Gastrointestinal stromal tumor - WrongDiagnosis.com
		A type of tumor that usually begins in cells in the wall of the gastrointestinal tract.
		Gastrointestinal stromal tumor is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Gastrointestinal stromal tumor, or a subtype of Gastrointestinal stromal tumor, affects less than 200,000 people in the US population.
	www.wrongdiagnosis.com /medical/gastrointestinal_stromal_tumor.htm (230 words)

	High-grade Gastrointestinal Stromal Tumor (GIST)
		A heterogeneous mass in the small bowel could be a tumor (such as lymphoma or GIST) or a hematoma in the bowel wall; the lack of obstruction does not favor adenocarcinoma.
		Gastrointestinal stromal tumor (GIST) is a mesenchymal spindle cell (70-80%) or epithelioid (20-30%) neoplasm.
		An exoenteric pattern is much slower, and the tumor is typically not found until a palpable mass (or bleeding from excavation into bowel lumen) is noted.
	brighamrad.harvard.edu /Cases/bwh/hcache/348/full.html (632 words)

	vgn-ext-hidden_Cancer_Type_Home (Site not responding. Last check: 2007-10-27)
		Gastrointestinal stromal tumors (GISTs) are tumors that occur in the gastrointestinal (digestive) tract (GI), including the esophagus, stomach, gallbladder, liver, small intestine, colon, and rectum.
		These are rare tumors that differ from other types of gastrointestinal tumors because of the type of tissues in which they start and their prognosis (chance of recovery).
		The most common features of NF1 are multiple neurofibromas (tumors on the nerves), freckling under the arms and in the groin area, multiple café-au-lait spots (areas of light brown pigmentation) on the skin, and a symptom affecting the iris of the eye, called Lisch nodules.
	www.plwc.org /portal/site/PLWC/menuitem.6067beb2271039bcfd748f68ee37a01d/?vgnextoid=c607ea7105daa010VgnVCM100000ed730ad1RCRD&vgnextfmt=cancer (3897 words)

	World J Gastroenterol
		We report a patient with an inflammatory tumor of the liver who was found to have a malignant gastrointestinal stromal tumor (GIST) of the small bowel at the same time, with special emphasis on their possible etiological association and the diagnostic dilemma.
		The tumor and a segment of the small bowel were resected and frozen section examination showed a spindle cell tumor.
		Microscopic examination of the paraffin section of the liver "tumor" showed that it was composed of fascicles of spindle fibroblasts and myofibroblasts admixed with chronic inflammatory cells, which were mainly lymphocytes and plasma cells.
	www.wjgnet.com /1007-9327/10/1841.asp (1804 words)

	Synchronous Primary Gastric Adenocarcinoma and Gastrointestinal Stromal Tumor
		We report a case of synchronous gastric adenocarcinoma and three stromal tumors, incidentally detected in the stomach and in the esophagus.
		Microscopically, the gastric tumor was a poorly differentiated adenocarcinoma.
		Microscopic examination also showed one stromal nodule in the stomach and two nodules in the esophagus at the proximal resection margin which were composed of spindle cells with no pleomorphism and mitotic activitiy.
	content.karger.com /produktedb/produkte.asp?doi=99610 (203 words)

	Clinical Trial: Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST)
		Gastrointestinal stromal tumor (GIST) is a specific, immunohistochemically KIT+ mesenchymal neoplasm of the gastrointestinal tract.
		The GIST of targeted cancer therapy: a tumor (gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571).
		STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.
	www.clinicaltrials.gov /ct/show/NCT00290485?order=16 (1096 words)

	Gastrointestinal stromal tumor (Site not responding. Last check: 2007-10-27)
		This 6.5-cm tumor was removed from the stomach of a 68-year-old man who presented with gastric bleeding.
		At laparatomy, examination of the external surface of the stomach showed this oblong tumor that extended from the gastric wall superiorly to the surface of the liver, to which the tumor was stuck.
		The diagnosis of gastrointestinal stromal tumor was made intraoperatively by frozen section.
	web2.airmail.net /uthman/specimens/images/gist.html (403 words)

	Gastrointestinal Stromal Tumor (GIST)
		He found no ulcers, but he found a tumor ~2cm in diameter which he labeled a GIST in the stomach wall (into the lumen).
		Larger tumors should be surgically resected, because of the increased frequency of complications and the difficulty in excluding malignancy preoperatively.
		I hope they dont push for a biopsy, because my fear of cancer and the relatively poor prognosis (with this type of tumor) I may be facing is enough to want it OUT without risking spillage/seeding of any malignant cells (assuming it hasn't already).
	www.medhelp.org /forums/gastro/messages/36002.html (1016 words)

	Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation -- Antonescu ...
		Gastrointestinal Stromal Tumors in Children and Young Adults: A Clinicopathologic, Molecular, and Genomic Study of 15 Cases and Review of the Literature.
		Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.
		Clonal evolution of resistance to imatinib in patients with gastrointestinal stromal tumor: molecular and radiologic evaluation of new lesions.
	clincancerres.aacrjournals.org /cgi/content/full/11/11/4182 (5376 words)

	BioMed Central \| Full text \| Cerebral relapse of metastatic gastrointestinal stromal tumor during treatment with ...
		The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation.
		Gastrointestinal stromal tumors (GISTs) are rare mesenchymal gastrointestinal tumors which can have an aggressive course.
		Management of these tumors apart from surgical resection has been difficult in the past because they are resistant to conventional chemotherapy [1] and radiation.
	www.biomedcentral.com /1471-2407/4/74 (2420 words)

	Gastrointestinal Carcinoid Cancer Treatment at Fox Chase Cancer Center (Site not responding. Last check: 2007-10-27)
		A gastrointestinal carcinoid tumor is cancer that forms in the lining of the gastrointestinal tract.
		Gastrointestinal carcinoid tumors grow slowly and generally appear in the appendix, small intestine, and rectum.
		A diagnosis of a gastrointestinal carcinoid tumor increases your risk of developing another cancer in the digestive system.
	www.fccc.edu /cancer/types/gastrointestinal/carcinoid.html (200 words)

	Gastrointestinal Stromal Tumor of the Small Intestine
		•While it is difficult to distinguish between some benign mesenchymal tumors and low grade sarcomas, there is no convincing evidence that intestinal sarcomas arise from their beniogn counterparts.
		•Many tumors are exophytic and bulge from the serosal surface into the peritoneal cavity or adjoining tissue.
		•Tumors over 4cm in diameter should be considered to have malignant potential although this is a less reliable guide than mitotic activity.
	pathweb.uchc.edu /eAtlas/GI/497.htm (524 words)

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