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Topic: Gatifloxacin

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	Baylor Health Care System: Fluoroquinolone drug class update
		The FDA approved gatifloxacin, an advanced-generation fluoroquinolone, in December 1999 for the treatment of community-acquired pneumonia, acute sinusitis, acute bacterial exacerbation of chronic bronchitis, uncomplicated skin and skin structure infections, uncomplicated and complicated urinary tract infections, and pyelonephritis.
		Gatifloxacin is entering the market as an agent that is expected to be comparable to levofloxacin and is touted to have pharmacologic properties that may provide a more favorable side effect profile and improved activity against resistant organisms.
		Gatifloxacin appears to be similar to levofloxacin in its coverage of gram-positive and atypical pathogens and, therefore, may prove to be an alternative agent for the treatment of community-acquired pneumonia.
	www.baylorhealth.edu /proceedings/13_3/13_3_gurkturner.html (2671 words)

	Gatifloxacin (Site not responding. Last check: 2007-11-04)
		Gatifloxacin inhibits the activity of bacterial enzymes (DNA gyrase and a topoisomerase) that are necessary for proper DNA formation and replication.
		Gatifloxacin may pass into breast milk and cause serious side effects in the nursing infant; use of the drug is discouraged when nursing.
		Gatifloxacin should not be taken by people with prolongation of the QT interval on an electrocardiogram, known heart rhythm disturbances, uncorrected hypokalemia (low blood potassium levels), or those taking antiarrhythmic drugs such as amiodarone, quinidine, procainamide, or sotalol.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,891,00.html (700 words)

	Gatifloxacin
		Gatifloxacin is an 8-methoxyfluoroquinolone with in vitro activity against a wide range of gram-negative and gram-positive microorganisms.
		Gatifloxacin is used to treat bacterial infections of the lungs, sinuses, skin, and urinary tract and certain sexually transmitted diseases.
		Gatifloxacin pharmacokinetics are linear and time-independent at doses ranging from 200 to 800 mg administered over a period of up to 14 days.
	www.greatvistachemicals.com /pharmaceuticals-bulk-drugs/gatifloxacin.html (287 words)

	Topics in Drug Therapy (Site not responding. Last check: 2007-11-04)
		Concomitant administration of gatifloxacin and digoxin did not produce significant alteration of the pharmacokinetics of gatifloxacin; however, an increase in digoxin concentrations was observed for 3 of 11 subjects.
		Gatifloxacin should also be used with caution in those with uncorrected hypokalemia and in patients receiving class Ia (procainamide, quinidine) or class III (amiodarone, dofetilide, sotalol) antiarrhythmic agents.
		Gatifloxacin should be used with caution in patients with known or suspected CNS disorders, such as severe cerebral atherosclerosis, epilepsy, and other factors that predispose one to seizures.
	daccx.bsd.uchicago.edu /drug/Bulletins/SEP2002.html (1744 words)

	MedlinePlus Drug Information: Gatifloxacin Oral
		Gatifloxacin is in a class of drugs called quinolone antibiotics.
		Gatifloxacin is also used occasionally to eliminate bacteria that cause infections in the skin and prostate.
		Gatifloxacin may make your skin sensitive to sunlight.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601239.html (709 words)

	gatifloxacin ophthalmic - [Medication]
		Gatifloxacin ophthalmic is used to treat bacterial infections of the eyes.
		Gatifloxacin ophthalmic is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby.
		Gatifloxacin ophthalmic is available with a prescription under the brand name Zymar in a solution formulation.
	www.peacehealth.org /kbase/multum/d04857a1.htm (1033 words)

	Allergy & Asthma Disease Management Center: Ask the Expert: Sinusitis
		Gatifloxacin was as effective as clarithromycin or amoxicillin/clavulanic acid, and was significantly more effective (in terms of clinical response; p < 0.035) than 7 to 10 days' treatment with cefuroxime axetil in the treatment of acute exacerbations of chronic bronchitis.
		Gatifloxacin is a useful addition to the fluoroquinolones currently available for use in the clinical setting and has an important role in the management of adult patients with various bacterial infections.
		Gatifloxacin should be avoided in the same patient population, and the recommended dosage of 400 mg/day should not be exceeded.
	www.aaaai.org /AADMC/ate/sinusitis.html (6483 words)

	Treating acute, uncomplicated bacterial sinusitis with gatifloxacin (Site not responding. Last check: 2007-11-04)
		Gatifloxacin is an advanced-generation, expanded-spectrum, 8-methoxy fluoroquinolone that provides excellent coverage of typical and atypical respiratory pathogens.
		Of the enrolled patients, the primary inclusion criteria (sinus tenderness, sinus pain, and purulent discharge) were noted in 89%, 90%, and 94%, respectively, of patients in the gatifloxacin arm and in 87%, 94%, and 97%, respectively, of those in the clarithromycin arm.
		Gatifloxacin (400 mg once daily for 10 days) is as effective as clarithromycin (500 mg twice daily for 14 days) in the treatment of patients with acute sinusitis.
	www.bms.com.ph /tequin/S17.htm (2449 words)

	Clinical Trials: Treating community-acquired pneumonia in hospitalized patients: Gatifloxacin vs ... (Site not responding. Last check: 2007-11-04)
		Gatifloxacin is a new 8-methoxy fluoroquinolone with a broad spectrum of activity encompassing gram-positive, gram-negative, and atypical pathogens.
		Failure with gatifloxacin treatment was noted in 1 patient in whom S pneumoniae was identified and 1 patient in whom H influenzae was identified.
		In this study, treatment with gatifloxacin was associated with a shorter length of stay (LOS) in the hospital and I CU.Among clinically evaluable patients, mean LOS was 5.4 vs 5.6 days in the hospital and 2.7 vs 8.2 days in the ICU in the gatifloxacin and ceftriaxone arms, respectively.
	www.bms.com.ph /tequin/S60.htm (3497 words)

	Review of Ophthalmology
		Vitreous levels of gatifloxacin were 5.4 times the MIC, or minimum inhibitory concentration, a standard susceptibility grading for antibiotics to specific pathogens, for Staphylococcus epidermidis, a common conjunctivitis pathogen; 10.4 times the MIC for Staphylococcus aureus, and exceeded the MICs for P. acnes, Streptococcus species and Proteus mirabilis.
		Gatifloxacin was also superior to ciprofloxacin in preventing keratitis in a rabbit LASIK model.
		The study shows that moxifloxacin, gatifloxacin and ciprofloxacin were cytotoxic to the cells at relevant MIC levels after 15 or 30 minutes of incubation, while levofloxacin was cytotoxic to both cell types at one hour.
	www.revophth.com /index.asp?page=1_303.htm (2045 words)

	Gatifloxacin Health Web Links
		Gatifloxacin - Familydoctor.org - Information for patients in English and Spanish.
		Perhaps you will Gatifloxacin One of the greatest discoveries a man makes, one of his great surprises, is to find he can do what he was afraid he couldn't do.
		Half the tracks, in fact, were recorded in a dismal, cheap basement eight-track studio with puddles of water on the fl Gatifloxacin There are three kinds of lies: lies, damned lies, and statistics.
	www.internet-health-directory.com /Pharmacy_Drugs_and_Medications_G_Gatifloxacin.html (1594 words)

	Tequin Side Effects, and Drug Interactions - Gatifloxacin - RxList Monographs
		Gatifloxacin was discontinued for adverse events thought related to drug in 2.7% of patients.
		In patients who were treated with either intravenous gatifloxacin or with intravenous followed by oral therapy, the incidence of adverse events was similar to those who received oral therapy alone.
		Concomitant administration of TEQUIN and digoxin did not produce significant alteration of the pharmacokinetics of gatifloxacin; however, an increase in digoxin concentrations was observed for 3 of 11 subjects.
	www.rxlist.com /cgi/generic3/gatifloxacin_ad.htm (635 words)

	MYGAT (Site not responding. Last check: 2007-11-04)
		Gatifloxacin undergoes limited biotransformation in humans with less than 1% of the dose excreted in the urine as ethylenediamine and methylethylenediamine metabolites.
		Concomitant administration of Gatifloxacin and glyburide (steady-state once daily regimen) in patients with type 2 diabetes mellitus had no significant effects on the disposition of either drug, nor were the fasting glucose levels significantly changed.
		Gatifloxacin should be used with caution when given concurrently with these drugs, as well as in patients with ongoing proarrhythmic conditions, such as clinically significant bradycardia or acute myocardial ischemia.
	www.panacea-biotec.com /products/mygativ.htm (1305 words)

	Treating acute, uncomplicated bacterial sinusitis with gatifloxacin (Site not responding. Last check: 2007-11-04)
		Abstract : Gatifloxacin, an advanced-generation, 8-methoxy fluoroquinolone, is active against the gram-positive and grarn-negative pathogens commonly associated with acute, uncomplicated, bacterial sinusitis.
		Gatifloxacin exhibits a steady-state peak concentration of 4.2 µg/mL, which exceeds the MI required to kill most respiratory pathogens.
		Susceptibility to gatifloxacin was determined by the disk diffusion and standard broth dilution methods outlined by the National Committee for Clinical Laboratory Standards.
	www.bms.com.ph /tequin/S11.htm (2798 words)

	- GATIFLOXACIN
		Gatifloxacin is given to treat infections of the lower respiratory system, urinary tract, sinuses, the skin, bones and joints, and prostate.
		Gatifloxacin belongs to the family of Flouroquinolone, which are effective against many organisms that traditional antibiotics fail to resist.
		Gatifloxacin kills a variety of bacteria, and prevent them from reproducing and is often used to treat infections all over the body.
	www.themedicine.net /drugs/gatifloxacin.html (469 words)

	MedlinePlus Drug Information: Gatifloxacin Injection
		If you are receiving gatifloxacin intravenously (in your vein), you probably will be told to store it in the refrigerator or freezer.
		If you are told to store additional gatifloxacin in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
		If you are receiving gatifloxacin in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601238.html (898 words)

	ICAAC: Gatifloxacin Effective In Treatment Of Sinusitis (Site not responding. Last check: 2007-11-04)
		-- September 29, 1999 -- The results of a multicenter Phase III study comparing the efficacy and safety of gatifloxacin to clarithromycin in the treatment of patients with acute maxillary sinusitis showed gatifloxacin to be equivalent to clarithromycin - even though gatifloxacin was administered less often and for a shorter treatment period.
		Drug-related adverse reactions were 25 percent more common among clarithromycin patients than among gatifloxacin patients, leading to discontinuation in nine percent of clarithromycin patients, compared with five percent of gatifloxacin patients.
		Gatifloxacin is the first in a new chemical class of antibiotics, an advanced-generation broad-spectrum 8-methoxy fluoroquinolone.
	www.pslgroup.com /dg/133CA6.htm (422 words)

	Efficacy of Gatifloxacin in Experimental Escherichia coli Meningitis -- Lutsar et al. 43 (7): 1805 -- Antimicrobial ...
		Efficacy of Gatifloxacin in Experimental Escherichia coli Meningitis
		Gatifloxacin, a new fluoroquinolone, demonstrated rapid bacterial killing in this experimental model of E.
		Pharmacodynamics of gatifloxacin in cerebrospinal fluid in experimental cephalosporin-resistant pneumococcal meningitis.
	aac.asm.org /cgi/content/full/43/7/1805 (1522 words)

	gatifloxacin - [Medication]
		Do not take gatifloxacin without first talking to your doctor if you or any member of your family have a heart condition known as prolongation of the QT interval.
		You may not be able to take gatifloxacin or you may require a dosage adjustment or special monitoring during your treatment.
		Gatifloxacin is in the FDA pregnancy category C. This means that it is not known whether gatifloxacin will be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d04504a1.htm (1397 words)

	Pharmacokinetics of Gatifloxacin and Interaction with an Antacid Containing Aluminum and Magnesium -- Lober et al. 43 ...
		Gatifloxacin is a new fluoroquinolone with a 3-methylpiperazinyl side chain at position 7 and a methoxy group at position
		Gatifloxacin (400 mg) plasma concentration-time curves and urinary recovery levels for treatments A to C (group 1) determined by HPLC.
		Gatifloxacin was rapidly absorbed in 1.3 to 1.8
	aac.asm.org /cgi/content/full/43/5/1067 (2809 words)

	Gatifloxacin Efficacy in Treatment of Experimental Methicillin-Sensitive Staphylococcus aureus-Induced Osteomyelitis in ...
		The effectiveness of oral gatifloxacin was compared to that of standard parenteral antibiotic therapy (nafcillin) for the treatment of experimental methicillin-sensitive Staphylococcus aureus -induced osteomyelitis in a rabbit model.
		Gatifloxacin was as effective as nafcillin in clearing the infection.
		Therefore, oral gatifloxacin treatment of osteomyelitis may be an effective alternative to intravenous nafcillin treatment.
	www.erc.montana.edu /Res-Lib99-SW/pubs/Abstracts/2002/02-003.htm (119 words)

	Tequin Online, Description, Chemistry, Ingredients - Gatifloxacin - RxList Monographs
		To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEQUIN and other antibacterial drugs, TEQUIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
		Gatifloxacin is a sesquihydrate crystalline powder and is white to pale yellow in color.
		TEQUIN (gatifloxacin in 5% dextrose) Injection is also available in ready-to-use 100-mL (200-mg) and 200-mL (400-mg) flexible bags as a sterile, preservative-free aqueous solution of gatifloxacin with pH ranging from 3.5 to 5.5.
	www.rxlist.com /cgi/generic3/gatifloxacin.htm (391 words)

	Activity of Gatifloxacin against Haemophilus influenzae and Moraxella catarrhalis, Including Susceptibility Test ...
		In Table 1, the activity of gatifloxacin is compared to those of 12 other antimicrobial agents.
		of gatifloxacin in serum at 3.35 to 5.41 µg/ml (half-life, 7 to
		Gatifloxacin (AM-1155, CG5501) susceptibility testing interpretive criteria and quality control guidelines for dilution and disk (5-µg) diffusion methods.
	jcm.asm.org /cgi/content/full/37/6/1999 (1880 words)

	Tequin (gatifloxacin) for Oral Suspension : BuyPath.com (Site not responding. Last check: 2007-11-04)
		TEQUIN is available as TEQUIN (gatifloxacin) Tablets for oral administration and TEQUIN (gatifloxacin) Injection and TEQUIN (gatifloxacin in 5% dextrose) Injection for intravenous administration.
		Tequin® (gatifloxacin) is indicated for the treatment of patients 18 years and older for infections due to susceptible strains of the designated microorganisms in the conditions listed below.
		Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to gatifloxacin.
	www.buypath.com /t/tequin_gatifloxacin_for_oral_suspension/index.html (413 words)

	Gatifloxacin at Absolute Authority :: Gatifloxacin Information, Products, Services, Resources ...
		This is your central hub for exploring the world of Gatifloxacin.
		If you would like to contribute any articles or resources on Gatifloxacin just use the submission form.
		Gatifloxacin - This is your central hub for exploring the world of Gatifloxacin on the web.
	www.absoluteauthority.com /on/gatifloxacin.htm (276 words)

	ICAAC: Gatifloxacin Has Higher Cure Rate For Bronchitis Than Cefuroxime Axetil (Site not responding. Last check: 2007-11-04)
		Microbiologic eradication was 100 percent for gatifloxacin compared with 38 percent for cefuroxime axetil.
		Chronic bronchitis is a long-term inflammation in the bronchi of the lungs (the two main branches leading from the trachea to the lungs), characterized by symptoms of a cough with excessive phlegm production for more than three months of the year and more than two years in a row.
		The results of gatifloxacin in this AECB trial prove it to be a useful addition to the practitioner’s armamentarium," observed Dr. DeAbate.
	www.pslgroup.com /dg/133caa.htm (522 words)

	Gatifloxacin (Ophthalmic)
		Ophthalmic gatifloxacin ((ga-ti-FLOKS-a-sin)) is used in the eye to treat bacterial infections of the eye.
		However, studies in animals that were given very high doses of gatifloxacin by mouth have shown that gatifloxacin can cause problems in the fetus.
		Although there is no specific information comparing use of gatifloxacin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
	allnutritionals.com /drugs/g/gatifloxacin-ophthalmic.shtml (986 words)

	Braz J Infect Dis vol.8 no.1; Abstract: S1413-86702004000100006 (Site not responding. Last check: 2007-11-04)
		Gatifloxacin in the treatment of community-acquired pneumonias : a comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
		We made a multicenter, prospective and randomized trial to compare the "standard" treatment of ceftriaxone IV alone or in combination with erythromycin IV, followed by clarithromycin PO (ceftriaxone treatment arm), with gatifloxacin IV, followed by oral administration (gatifloxacin treatment arm).
		Of these, 51 were clinically evaluable, 26 in the gatifloxacin and 25 in the ceftriaxone arm, with comparable success rates, 92% and 88%, respectively, even when major prognostic factors were considered.
	www.scielo.br /scielo.php?script=sci_abstract&pid=S1413-86702004000100006&lng=en&nrm=iso&tlng=en (253 words)

	Tequin (gatifloxacin) Promising in Treatment of Recurrent Ear Infections
		CHICAGO, IL -- December 18, 2001 -- New research findings show that Tequin® (gatifloxacin), an advanced-generation, broad-spectrum fluoroquinolone antibiotic, is safe and effective in the treatment of recurrent/difficult-to-treat acute otitis media (RNR-AOM) in children.
		The study is the first-ever Phase II trial of an advanced-generation fluoroquinolone in children.
		Children were treated with Tequin (gatifloxacin) oral suspension given once daily as a 10 mg/kg dose for ten days.
	www.docguide.com /dg.nsf/PrintPrint/B5A68B1CAA6DE63185256B2600708AAC (567 words)

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