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| | Hamartoma of the hypothalamus and tuber cinereum : a brief review of the literature. Sharma RR J Postgrad Med |
 | | The characteristic presenting clinical features, [11],[12],[13],[14],[19],[23],[24],[26],[28],[29],[31],[36],[39],[42],[43],[44],[47],[49],[64],[66],[70],[71],[72],[74] both endocrinological and neurological, are as follows: (1) iso-sexual precocious puberty of central origin (this is the commonest presentation), (2) seizure disorders, gelastic epilepsy and partial complex seizures; (3) mental changes, intellectual and behavioural disorders. |
| | Gelastic epilepsy is common with large tumours; and compression of mamillary region by these may initiate specific seizures. |
| | Although the attacks of laughter might be confused with behavioural or emotional disorders, the diagnosis of gelastic epilepsy can be based on their stereotyped recurrences, the absence of any precipitating factor and other manifestations of epilepsy (generalized, myoclonic, temporal lobe and psychomotor seizures), and no other obvious cause for the pathological laughter. |
| www.jpgmonline.com /article.asp?issn=0022-3859;year=1987;volume=33;issue=1;spage=1;epage=13;aulast=Sharma (5185 words) |
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