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Topic: Gemfibrozil

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	gemfibrozil (Lopid) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Gemfibrozil can increase the effect of warfarin (Coumadin) and thus may lead to bleeding.
		Gemfibrozil may increase the likelihood of developing a low blood sugar in patients receiving glyburide (Glyburide; Diabeta) or other medications that reduce sugar levels in diabetic patients.
		Gemfibrozil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
	www.medicinenet.com /gemfibrozil/article.htm (715 words)

	Gemfibrozil.com - The official site for gemfibrozil information (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-11-03)
		Gemfibrozil is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood.
		Gemfibrozil is both a lipid and a cholesterol-modifying medicine.
		Gemfibrozil, a lipid-lowering agent, was recently demonstrated to dangerously increase the plasma...
	www.gemfibrozil.com.cob-web.org:8888 (443 words)

	Howstuffworks "Gemfibrozil: A Profile of a Lipid-lowering Drug"
		Gemfibrozil is used to treat hyperlipidemia (high blood fat levels) in patients who have not responded to diet, weight reduction, exercise, and control of blood sugar.
		Gemfibrozil can increase the effects of oral anticoagulants (blood thinners, such as warfarin), which can lead to bleeding complications.
		Although gemfibrozil appears to be safe during pregnancy, extensive studies in humans have not yet been completed.
	health.howstuffworks.com /define-gemfibrozil.htm (701 words)

	gemfibrozil (Site not responding. Last check: 2007-11-03)
		Gemfibrozil is the drug of choice for therapy.
		Gemfibrozil, though not as effective as nicotinic acid, is better tolerated.
		Gemfibrozil should be used with caution in these higher risk categories.
	lysine.pharm.utah.edu /netpharm/netpharm_00/druglist/gemfibrozil.htm (81 words)

	Gemfibrozil (Site not responding. Last check: 2007-11-03)
		In a randomized study of 21 men with combined hyperlipidemia, ten to twelve weeks of gemfibrozil therapy reduced alpha- and gamma-tocopherol blood levels to the levels seen in healthy men.
		Gemfibrozil taken with the prescription drug lovastatin has been reported to cause rhabdomyolysis, a potentially life-threatening muscle disease.
		Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study.
	www.kroger.com /hn/Drug/Gemfibrozil.htm (561 words)

	MedlinePlus Drug Information: Gemfibrozil (Systemic) (Site not responding. Last check: 2007-11-03)
		Gemfibrozil (gem-FI-broe-zil) is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood.
		In addition, the action of gemfibrozil is similar to that of another medicine called clofibrate.
		Studies with gemfibrozil in rats found an increased risk of liver tumors when doses up to 10 times the human dose were given for a long time.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202256.html (1273 words)

	Gemfibrozil Low HDL-C Gemfibrozil Cardiovascular Events Gemfibrozil Reduces CHD Risks (Site not responding. Last check: 2007-11-03)
		Gemfibrozil, a fibric acid derivative, was chosen for the intervention because it is the most likely to improve plasma HDL-C and TG values while minimally affecting LDL-C levels, investigators say.
		Patients were randomized to either gemfibrozil (1,200 mg/day) or placebo and followed for an average of 5.1 years.
		Although the study was not adequately powered for subgroup analyses, gemfibrozil was associated with relative reductions ranging from 11% to 42% in all subgroups except for current smokers.
	www.coronaryheartdisease.org /hdl-c.htm (620 words)

	Gemfibrozil - Drug Interactions and Warnings
		Gemfibrozil markedly increased the plasma concentrations of lovastatin acid, without affecting those of the parent lovastatin compared with placebo.
		The risk of developing myopathy during concomitant therapy with lovastatin and a fibrate may be smaller with bezafibrate than with gemfibrozil.
		Concomitant use of gemfibrozil with statins, particularly with cerivastatin, increases the risk of rhabdomyolysis, but the mechanism of this potentially fatal drug interaction remains unclear.
	www.personalhealthzone.com /drug_interactions/gemfibrozil.html (467 words)

	gemfibrozil
		The exact way that gemfibrozil works to reduce cholesterol and triglycerides (types of fat) in the blood is not known.
		Gemfibrozil is used to lower high levels of cholesterol and triglycerides in the blood.
		Gemfibrozil is in the FDA pregnancy category C. This means that it is not known whether gemfibrozil will be harmful to an unborn baby.
	hw.healthdialog.com /kbase/multum/d00245a1.htm (1185 words)

	Gemfibrozil
		Gemfibrozil has caused liver cancer in rats (in some cases at levels comparable to those prescribed for humans), but because there have been no reported cases of liver cancer from gemfibrozil in humans, it would be premature to get alarmed.
		Because gemfibrozil increases cholesterol secretion by the liver into the gallbladder, the risk of cholesterol gallstones is doubled.
		Gemfibrozil, taken in conjunction with other anti-cholesterol drugs, can also cause muscle pain and inflammation.
	healthlink.mcw.edu /article/908683017.html (278 words)

	Gemfibrozil (IARC Summary & Evaluation, Volume 66, 1996)
		Gemfibrozil has been used since the early 1980s to lower serum triglycerides and raise high-density lipoprotein-cholesterol in patients at high risk for coronary heart disease.
		Gemfibrozil was tested for carcinogenicity by oral administration in the diet in one experiment in mice and one experiment in rats.
		In male rats, increases were observed in the incidence of hepatocellular tumours, interstitial-cell tumours of the testis and adrenal phaeochromocytomas; the latter was not dose-related.
	www.inchem.org /documents/iarc/vol66/gemfibrozil.html (352 words)

	Order Gemfibrozil
		Gemfibrozil and circulations all varies, as soon as concentration of a lens, for example, Gemfibrozil improvement is observed at regular multimonthly respiratory trainings.
		The vessel less, the the vascular wall is less But in the same conditions Gemfibrozil and circulations all varies, as soon as concentration of a glucose increases in a blood.
		It is caused by incompleteness, in the same conditions Gemfibrozil and reception of an oil admixture is specified in the certain sense inferiority of their cellular membranes.
	order-gemfibrozil.pillsearch.us (2514 words)

	Lipids Online Slides: gemfibrozil, high-density lipoprotein cholesterol
		Gemfibrozil therapy reduced total cholesterol (Total-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels and increased high-density lipoprotein cholesterol (HDL-C) levels compared with placebo.
		Gemfibrozil 600 mg BID was administered to induce these changes in lipid levels.
		Gemfibrozil also reduced the relative risks of death due to CHD (-22%; P = 0.07), investigator-designated stroke (-29%; P = 0.04), and death from any cause (-11%; P = 0.23).
	www.lipidsonline.org /slides/slide01.cfm?q=gemfibrozil (933 words)

	Gemfibrozil, a Lipid-lowering Drug, Inhibits the Induction of Nitric-oxide Synthase in Human Astrocytes -- Pahan et al. ...
		of gemfibrozil on the expression of iNOS in cytokine-stimulated
		Gemfibrozil dose-dependently inhibits the expression of iNOS in cytokine-stimulated human U373MG astroglial cells.
		Effect of Gemfibrozil on the Activation of Proinflammatory Transcription Factors in Human U373MG Astroglial Cells-- Different proinflammatory transcription factors are known to be involved in the transcription of iNOS (2-4, 26-30).
	www.jbc.org /cgi/content/full/277/48/45984 (5022 words)

	Upregulation of Low Density Lipoprotein Receptor by Gemfibrozil, a Hypolipidemic Agent, in Human Hepatoma Cells Through ... (Site not responding. Last check: 2007-11-03)
		Effect of gemfibrozil and pravastatin on the expression of LDL receptor and EGF receptor.
		gemfibrozil stabilized LDL mRNA, with a half-life exceeding
		) of gemfibrozil; EGF receptor mRNA in the absence (
	atvb.ahajournals.org /cgi/content/full/17/11/2707 (3574 words)

	Numark \| Gemfibrozil
		In a randomised study of 21 men with combined hyperlipidaemia, ten to twelve weeks of gemfibrozil therapy reduced coenzyme Q10 blood levels to the levels seen in healthy men.
		In a randomised study of 21 men with combined hyperlipidaemia, ten to twelve weeks of gemfibrozil therapy reduced alpha- and gamma-tocopherol blood levels to the levels seen in healthy men.
		Gemfibrozil should be taken 30 minutes before meals.
	www.numarkpharmacists.com /hn/Drug/Gemfibrozil.htm (647 words)

	The Body: I-88: Gemfibrozil Effectively Lowers Protease-Associated Hypertriglyceridemia in HIV-Infected Patients
		Gemfibrozil inhibits peripheral lipolysis, decreases hepatic extraction of blood lipids, resulting in increases in blood HDL (associated with good cardiovascular risk status) and decreases in blood LDL (which carries cholesterol throughout the body), and alters the transport of VLDL, which carries triglycerides in the blood.
		Virtually all of them had a decrease in their triglyceride levels on 600 mg of gemfibrozil twice a day, however, the majority had high cholesterols which did not appreciably decline.
		In patients with hypertriglyceridemia on PIs, gemfibrozil seems to be safe and well-tolerated, but larger studies are needed to assess long term efficacy in chronic and changing regimens and other treatments will be needed to treat the common occurance of elevated cholesterol in persons living with HIV.
	www.thebody.com /confs/icaac98/i88.html (483 words)

	Baycol (Cerivastatin) Not To Be Used In Combination With Gemfibrozil, Says Bayer (Site not responding. Last check: 2007-11-03)
		Cerivastatin and gemfibrozil (another cholesterol-lowering drug) should never be used in combination due to the increased risk of a serious side effect.
		The risk of muscle breakdown is greater in patients taking gemfibrozil as well as other fibric acid derivatives (a group of cholesterol-lowering drugs), cyclosporine (an immunosuppressant), erythromycin (an antibiotic), azole antifungals, or lipid-lowering doses of niacin (nicotinic acid) together with statins including cerivastatin.
		In Canada, combination therapy with cerivastatin and gemfibrozil is rare, however if you are one of those few patients taking this combination, you should contact your doctor immediately.
	www.pslgroup.com /dg/201D9E.htm (584 words)

	Gemfibrozil - Patient UK
		Gemfibrozil is used to lower levels of cholesterol and other lipids (fats) in the blood.
		Gemfibrozil may help prevent medical problems caused by cholesterol and fats building up in blood vessels, such as heart disease and other problems.
		Gemfibrozil is available in capsule and tablet form.
	www.patient.co.uk /showdoc/30002169 (866 words)

	Gemfibrozil Information from Drugs.com
		Gemfibrozil helps reduce cholesterol and triglycerides (types of fat) in the blood.
		Gemfibrozil may have decreased activity if taken with birth control pills or with estrogens.
		Gemfibrozil may have increased activity if it is taken with thyroid medications.
	www.drugs.com /gemfibrozil.html (1109 words)

	Dayrx - Buy Gemfibrozil (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-11-03)
		GEMFIBROZIL is used to lower high cholesterol and/or triglyceride levels in the blood.
		GEMFIBROZIL should be used only when clearly needed during pregnancy.
		Before you take gemfibrozil, tell your doctor of any over-the-counter or prescription drugs you are taking, especially anticoagulants ("blood thinners") and lovastatin.
	www.dayrx.com.cob-web.org:8888 /buy-gemfibrozil.html (434 words)

	Attenuation by Gemfibrozil of Expression of Plasminogen Activator Inhibitor Type 1 Induced by Insulin and its ...
		Attenuation by Gemfibrozil of Expression of Plasminogen Activator Inhibitor Type 1 Induced by Insulin and its Precursors -- Nordt et al.
		Gemfibrozil is a promising agent for normalizing impaired endogenous
		Fibrinolytic effect of gemfibrozil versus placebo administration in response to venous occlusion.
	circ.ahajournals.org /cgi/content/full/95/3/677 (4479 words)

	Consumer Reports Medical Guide - Gemfibrozil
		Gemfibrozil is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in your blood.
		Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body.
		If you take insulin or oral diabetes medications, your dose may need to be changed because gemfibrozil can increase the amount of sugar in your blood.
	www.consumerreports.org /mg/drug-reports/gemfibrozil.htm (828 words)

	Niaspan (Niacin Extended Release) Superior To Gemfibrozil in Raising "Good" Cholesterol (Site not responding. Last check: 2007-11-03)
		(Gemfibrozil belongs to a class of drugs known as fibrates, which are commonly prescribed for lowering triglycerides and raising HDL cholesterol.) After 19 weeks of therapy, Niaspan increased HDL levels, on average, up to 26 percent compared with 13 percent for gemfibrozil.
		Niaspan is the only once-daily, sustained-release formulation of niacin approved by the U.S. Food and Drug Administration (FDA) for the treatment of mixed-lipid disorders, and maintains the well-established HDL efficacy of immediate-release niacin while minimizing side effects and virtually eliminating liver toxicity.
		Gemfibrozil was the drug used in the U.S. Veterans Administration HDL Intervention Trial (VA-HIT), the results of which were published in 1999.
	www.pslgroup.com /dg/1D1A66.htm (594 words)

	Lopid - Drugs & Vitamins - Drug Library - DrugDigest
		Gemfibrozil will not cure your condition, but taken regularly it will help keep down your cholesterol level.
		Gemfibrozil is only part of a total cholesterol-lowering program.
		You may get drowsy or have blurred vision; until you know how gemfibrozil affects you, do not drive, use machinery, or do anything that needs mental alertness.
	www.drugdigest.org /DD/DVH/Uses/0,3915,295\|Lopid,00.html (614 words)

	Medical Dictionary: Gemfibrozil - WrongDiagnosis.com
		Gemfibrozil: medication (trade name Lopid) used to lower the levels of triglyceride in the blood
		Gemfibrozil: lipid regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.
		Gemfibrozil : lipid regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.
	www.wrongdiagnosis.com /medical/gemfibrozil.htm (251 words)

	Gemfibrozil (Systemic)
		Gemfibrozil has not been studied in pregnant women.
		There is no specific information about the use of gemfibrozil in children.
		Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
	allnutritionals.com /drugs/g/gemfibrozil-systemic.shtml (1251 words)

	Gemfibrozil Drug Information
		Breast-feeding-It is not known whether gemfibrozil passes into breast milk.
		Anticoagulants (blood thinners)-Use with gemfibrozil may increase the effect of the anticoagulant
		Liver disease-Higher blood levels of gemfibrozil may result, which may increase the chance of side effects; a decrease in the dose of gemfibrozil may be needed
	www.drugs.com /cons/Gemfibrozil.html (1550 words)

	GEMFIBROZIL - ORAL (Gemcor, Lopid) side effects, medical uses, and drug interactions.
		GEMFIBROZIL - ORAL (Gemcor, Lopid) side effects, medical uses, and drug interactions.
		USES: Gemfibrozil (also known as a fibrate medication) is used along with a proper diet to help lower fats (triglycerides) and cholesterol in the blood.
		This drug is usually prescribed after non-drug treatment options have not been fully successful at lowering cholesterol (e.g., diet change, increase in exercise, weight loss if overweight).
	www.medicinenet.com /gemfibrozil-oral/article.htm (468 words)

	ASHP News: Firm Advises Against Repaglinide-Gemfibrozil Therapy (Site not responding. Last check: 2007-11-03)
		Mikko Niemi and colleagues at the University of Helsinki found that the addition of a single 0.25-mg repaglinide dose to a regimen of gemfibrozil 600 mg twice daily significantly increased healthy persons' exposure to the glucose-lowering drug.
		As a result, the labeling for Prandin was revised to state that gemfibrozil should not be added to a medication regimen containing repaglinide and, likewise, repaglinide should not be added to a regimen containing gemfibrozil.
		The concern is that combination therapy could increase and prolong the glucose-lowering effects of repaglinide in patients with type 2 diabetes mellitus.
	www.ashp.org /news/ShowArticle.cfm?id=3587 (231 words)

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