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Topic: Gene silencing

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	Imprinting (genetics) -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-07)
		If a gene is suppressed through imprinting from one parent, and the allele from the other parent is not expressed because of ((genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism) mutation, neither can act and the child will be deficient.
		Several (A disease or disorder that is inherited genetically) genetic diseases that map to 15q13 (locus 3 of section 1 of the long arm of chromosome 15) in humans are due to abnormal imprinting.
		This gene is expressed only if it is on chromosome 18 inherited from the father and is not on the chromosome from the mother.
	www.absoluteastronomy.com /encyclopedia/i/im/imprinting_(genetics).htm (448 words)

	Gene Silencing Technique Offers New Strategy For Treating, Curing Disease (Site not responding. Last check: 2007-10-07)
		Emory Researchers Report Abnormal Gene Silencing May Lead To Breast Cancer Progression (November 21, 2000) -- Emory University scientists have discovered that a mistake in the way DNA is labeled and packaged could lead to the abnormal silencing of a gene that plays an important role in keeping breast cancer...
		Genes are segments of DNA housed in the chromosomes in the nucleus of every cell.
		The information in a gene is not directly converted into proteins, but first is copied by special enzymes into many copies of messenger RNA, which then move out of the nucleus and into the body of the cell, where they go on to create a protein.
	www.sciencedaily.com /releases/2005/07/050731231517.htm (905 words)

	Kassel University \| Genetics Dept. \|\| Projects \|\|\| Mechanisms of antisense mediated gene silencing
		The aim of our investigations is to dissect the molecular machinery which mediates gene silencing by antisense RNA and RNAi and to see how this is related to the regulation by endogenous antisense RNA.
		It has been suggested that antisense effects are either caused by minor amounts of contaminating dsRNA in injection experiments or by dsRNA formed by hybridization of antisense RNA and mRNA in vivo.
		Coexpression of RNAi and antisense RNA had synergistic effects while coexpression of RNAi with sense RNA abolished gene silencing.
	www.uni-kassel.de /fb19/genetics/projects/prj_as.html (761 words)

	Publications (Site not responding. Last check: 2007-10-07)
		(2004) Virus induced gene silencing of a DEFICIENS ortholog in Nicotiana benthamiana.
		Permanent fixation of a transposable element insert in the A2 gene of maize (Zea mays L.) Journal of Heredity, 86:167-71.
		Genes and cis-acting sequences involved in replication of barley yellow dwarf virus-PAV RNA.
	plantfunctionalgenomics.yale.edu /Dinesh/research/paper.html (1104 words)

	Cancer Issues - Scientists Find Key to Gene Therapy
		The chief job of all genes is to produce proteins necessary to the function of healthy cells.
		But sometimes this process goes awry, with genes failing to produce the proper protein, or producing it in inadequate or excessive amounts, resulting in cellular dysfunction and disease.
		Between the activity of the gene, which is comprised of DNA, and the end-product protein, lies an intermediary step, known as transcription.
	www.cancerissues.com /ms/news/522296/main.html (974 words)

	AllRefer Health - Medical News > Gene silencing may be panacea for all ills (Site not responding. Last check: 2007-10-07)
		Gene silencing may be panacea for all ills
		In the study published in the journal Nature Chemical Biology, the researchers describe how they efficiently shut down gene expression in cultured cells by blocking the ability of chromosomal DNA to be copied into RNA and made into proteins.
		But blocking all the copies of messenger RNA before they can make a protein within a cell is akin to using a bucket to catch all the streams of water coming out of a yard sprinkler before they can hit the ground.
	health.allrefer.com /news/index.php?ID=7867 (611 words)

	Colon Cancer Today - Silencing a Key Cancer Gene
		However, mutant versions of Ras are cancer-causing genes (oncogenes) known to promote the growth of pancreatic, colon, lung and thyroid cancers, as well as leukemias.
		In this study, conducted in mice, researchers at the Huntsman Cancer Institute at the University of Utah report that deleting an enzyme called "DGK iota" appears to lower the incidence of Ras-related tumors in mice.
		"When we tested mice with an activated Ras gene, but an absent DGK iota gene, the number of tumors was significantly reduced," study lead author Dr. Matthew Topham, assistant professor of internal medicine at the University of Utah School of Medicine, Salt Lake City, said in a prepared statement.
	www.coloncancertoday.com /ms/news/525614/main.html (379 words)

	Plant Biology Research Profile: Dr. Richard S. Nelson
		We are also interested in the route viruses use to escape from the vascular tissue to initiate an infection in the upper uninoculated leaves and virus replication in this tissue.
		In order to identify the viral proteins or nucleic acid sequences necessary for viral passage from cell-to-cell and leaf-to-leaf and its subsequent accumulation we have assembled a battery of site-directed or truncated cDNA mutants of tobacco mosaic virus strains from which infectious transcripts can be produced.
		In addition, we are utilizing our knowledge in this area to study the function of host genes in monocotyledonous and dicotyledonous plants through virus-induced gene silencing.
	www.noble.org /PlantBio/Nelson/Index.htm (598 words)

	Heriberto D. Cerutti \| Faculty \| Plant Science Initiative
		Epigenetic processes, which result in heritable changes in gene expression without modifications in DNA sequence, play important roles in the control of development as well as in the cellular responses to viruses, viroids, and transposable elements.
		We have recently isolated two genes required for transcriptional gene silencing that encode, respectively, a WD-40 repeat containing protein (with partial homology to the yeast transcriptional repressor TUP1) and a novel serine/threonine protein kinase that appears to be specific to the plant kingdom.
		In Arabidopsis the genes are encoded by multigene families and some members appear to be involved in controlling developmental programs.
	psiweb.unl.edu /faculty.php?id=faculty3 (542 words)

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