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Topic: Genetic association

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	Genetic Association Database (Site not responding. Last check: 2007-10-03)
		The Genetic Association Database is an archive of human genetic association studies of complex diseases and disorders.
		The goal of this database is to allow the user to rapidly identify medically relevant polymorphisms from the large volume of polymorphism and mutational data, in the context of standardized nomenclature.
		The Genetic Association database is open to the public.
	hpcio.cit.nih.gov /gad.html (286 words)

	All View Search for 'IL1RN' Record found: 44
		Lack of association of genetic polymorphisms in the interleukin-1beta interleukin-1 receptor antagonist interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese.
		Association of interleukin-1 receptor antagonist gene polymorphism with IgA nephropathy.
		Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha IL-1beta and IL-1Ra genes.
	geneticassociationdb.nih.gov /cgi-bin/tableview.cgi?table=allview&cond=GENE='IL1RN' (328 words)

	American Genetic Association (Site not responding. Last check: 2007-10-03)
		On December 29-31, 1903, in St. Louis Missouri, a committee organized by the American Association of Agricultural Colleges and Experiment Stations held the first meeting to establish the constitution and by-laws of the new American Breeders Association.
		It was in 1914 that the ABA became the American Genetic Association and implemented a business-model organization and strove for financial stability in order to minimize it's dependence on donations and the influence these donations might carry.
		Today the American Genetic Association is publishing primary Genetics research in such fields as genomic diversity, comparative genetics, species conservation, polygenic and multi-factorial gene hunts, genetic epidemiology, bioinformatics, molecular evolution, plant and animal domestication, phylogenetics and phylogeography.
	www.theaga.org /overview.html (185 words)

	ADHD Genetic Research -- Neurotransmitter.net
		Association between ADHD and the 10-repeat allele of a 40-bp VNTR polymorphism that lies within the 3'-UTR of DAT1 was first reported in 1995, a finding that has been replicated in at least six independent samples from Caucasian populations.
		Molecular genetic investigations of ADHD have found positive associations with the 480-bp allele of a VNTR situated in the 3' untranslated region of DAT1 and allele 7 of a VNTR in exon 3 of DRD4.
		Associations of polymorphisms with ADHD and its subtypes were examined by: (i) comparing cases and controls; and (ii) using family-based association study in an extension of exact transmission-disequilibrium test (ETDT) and haplotype-based haplotype relative risk (HHRR).
	www.neurotransmitter.net /adhdgenetic.html (17885 words)

	Obsessive-Compulsive Disorder Genetic Research -- Neurotransmitter.net
		Association study of a null mutation in the dopamine D4 receptor gene in Italian patients with obsessive-compulsive disorder, bipolar mood disorder and schizophrenia.
		The association of identified clusters with demographic variables (age, gender), clinical variables (age of onset, obsessive-compulsive symptom severity and dimensions, level of insight, temperament/character, treatment response), and monoaminergic genotypes was examined.
		An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients.
	www.neurotransmitter.net /ocdgenetic.html (17342 words)

	Genetic association studies/LD mapping
		Association between phenotypes and marker loci is not only caused by marker loci being in LD with a disease locus but can also be due to population structure.
		In general, LINKAGE is considered to be the association between alleles and disease WITHIN families, whilst genetic ASSOCIATION is thought of as the association between alleles and disease at the population level, ie beyond that which exists within families.
		Testing/estimating phenotype-gene association using haplotypes is dealt with in estimation of haplotypes/testing and estimating phenotype-gene association.
	www.mep.ki.se /genestat/tl/genass_ldmap/index_alltext.htm (8629 words)

	OJHAS: 2005-1-4; Menik HL et al. Genetic Association between Insulin Resistance and Total Cholesterol in Type 2 ...
		We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients.
		We planned to identify the genetic association of IR with DM and the dyslipidemia because the data related to the prevalence and quantitative analysis of IR and prevalence of dyslipidemia among Sri Lankan diabetic population are not available.
		Therefore, the association between elevated total cholesterol and IR could be due to the effects of IR on cholesterol metabolism or vice versa.
	www.ojhas.org /issue13/2005-1-4.htm (1973 words)

	[No title]
		On the basis of observations of the deficits associated with sex chromosome aneuploidies there is a substantial case that the relevant gene is in the class that is present in homologous form on the X and Y chromosomes.
		With genetically informative data, latent growth curve analyses permit one to investigate the extent to which variations in (1) the intercept, or mean level of drinking, and (2) the slope, representing change in the trait over time, are due to genetic and environmental influences.
		Genetic and environmental sources of individual variation were assessed for masculine and feminine sex-typed behavior at 3 and again at 4 years of age as measured by parent reports on the Pre-school Activities Inventory (Golombok, S. & Rust, J. The pre-school activities inventory: A standardized assessment of gender role in children.
	www.bga.org /meetings/2001/bga01prabs4.html (15575 words)

	Nonreplication in Genetic Association Studies of Obesity and Diabetes Research -- Redden and Allison 133 (11): 3323 -- ... (Site not responding. Last check: 2007-10-03)
		association studies of 71 markers with obesity-related phenotypes.
		In an association study confounded by population stratification, an association between marker and phenotype is observed (broken line).
		However, the association is attributable to the unobserved admixture or subpopulations by which marker prevalence and phenotypic values vary together (solid lines).
	www.nutrition.org /cgi/content/full/133/11/3323 (2823 words)

	Genetic Professional Societies
		Association of Professors of Human or Medical Genetics
		Mexican Association of Human Genetics (Asociación Mexicana de Génetica Humana)
		National Laboratory for the Genetics of Israeli Populations
	www.kumc.edu /gec/prof/soclist.html (153 words)

	Case-Control Association Studies for the Genetics of Complex Respiratory Diseases -- Silverman and Palmer 22 (6): 645 ...
		A second criterion in evaluation of case-control association studies is the careful selection of cases and control subjects.
		Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.
		Use of unlinked genetic markers to detect population stratification in association studies.
	ajrcmb.atsjournals.org /cgi/content/full/22/6/645 (2654 words)

	Who We Are and Genetic Toxicology Association Membership Application
		The Genetic Toxicology Association (GTA) is a tax-exempt educational and scientific organization that was founded in 1975 and incorporated in 1981 under the laws of the state of Delaware.
		Its primary purpose is to promote the development of the science of genetic toxicology and to foster the exchange and dissemination of information concerning the field.
		Officers of the Association are elected from the Board membership and include a Chairperson, a Secretary and a Treasurer.
	www.ems-us.org /gta/memberapp.html (556 words)

	Bibliography: Association Studies (2001)
		GR Abecasis, SS Cherny, LR Cardon (2000), "The impact of genotyping error on linkage and association analysis of quantitative traits", European Journal of Human Genetics, 9:130-134.
		NJ Cox (2001), "Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene", Human Molecular Genetics, 10(20):2301-2305.
		GA Satten, D Flanders, Q Yang (2001), "Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model", American Journal of Human Genetics, 68:466-477.
	www.nslij-genetics.org /ld/2001.html (2953 words)

	Overview
		A paper describing the GAD database can be found here.
		Note: GAD is intended for use primarily by medical scientists and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.
		While GAD database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
	geneticassociationdb.nih.gov (221 words)

	Tennessee Genetic Counselors Association (Site not responding. Last check: 2007-10-03)
		TGCA Code of Ethics: As genetic counselors and members of the National Society of Genetic Counselor (NSGC), members of the TGCA uphold the NSGC Code of Ethics.
		TGCA was founded in October 2004 to create a forum for Tennessee genetic counselors and to be a resource for patients and patient advocates.
		A need for the TGCA was recognized as Tennessee genetic counselors discussed genetic counselor licensure in the State of Tennessee.
	tngca.org (140 words)

	Genetic association studies: Genes in search of diseases -- Bird et al. 57 (7): 1153 -- Neurology
		Genetic association studies: Genes in search of diseases -- Bird et al.
		Genet., August 1, 2005; 14(15): 2099 - 2111.
		A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache
	www.neurology.org /cgi/content/full/57/7/1153 (1380 words)

	linkage software list (page 1)
		Computer software on the following topics are included here: genetic linkage analysis for human pedigree data, QTL analysis for animal/plant breeding data, genetic marker ordering, genetic association analysis, haplotype construction, pedigree drawing, and population genetics.
		Given a set of marker haplotypes or genotypes from affected individuals, haplotypes or genotypes from appropriately selected controls, and a genetic map of the markers at which both sets of individuals are typed, DHSMAP estimates the location of the trait-associated variant by maximum likelihood or maximum quasi-likelihood.
		Laird, Horvath, Xu (2000), Implementing a unified approach to family based tests of association, Genetic Epi, supp 1, 19:36-42; Rabinowitz, Laird (2000), A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information, Human Heredity, 50:211-223.
	www.nslij-genetics.org /soft (4476 words)

	Genetic association studies in complex diseases (Site not responding. Last check: 2007-10-03)
		Genetic association studies are the most frequent type of study performed in the investigation of the genetic basis of complex cardiovascular conditions.
		While relatively easy to perform, and having previously correctly identified genetic effects subsequently proven to be due to genetic linkage, interpretation of the results of these studies is not always straightforward.
		Issues such as population stratification, data-driven subgroup analysis, possible absence of linkage disequilibrium between marker and disease locus, and testing of multiple hypotheses are discussed and the likely place for association studies in a strategy involving studies of a variety of designs geared to finding genetic determinants of disease susceptibility is addressed.
	www.nature.com /cgi-taf/DynaPage.taf?file=/jhh/journal/v14/n6/abs/1001020a.html (163 words)

	Medical College of Wisconsin - Genetic Association with Obstructive Sleep Apnea
		A genetic contribution to the sleep apnea is likely.
		The risk of sleep disordered breathing is much higher in family groups than unrelated individuals.
		More commonly, bone abnormalities are associated with less development of facial bones.
	www.mcw.edu /display/router.asp?docid=2485 (167 words)

	GSBS Course: Genetic Epidemiology: Association Studies (Site not responding. Last check: 2007-10-03)
		This introductory level course in genetic epidemiology focuses on the design of studies to identify disease-gene associations.
		The lectures concentrate on the two most common study designs for genetic association studies: case-control studies and case-parent trios, and addresses disease-gene associations, gene-environment interactions and maternal genetic effects.
		Students will learn about study design and data analysis through class lectures, independent readings, completion of problem sets and class discussions.
	gsbs.gs.uth.tmc.edu /courses/gs110112.html (67 words)

	AGSA - Association of Genetic Support of Australasia
		AGSA - Association of Genetic Support of Australasia
		AGSA facilitates support for those affected directly or indirectly by genetic conditions throughout Australasia
		[Home][About AGSA] [Genetic Conditions] [Get Support] [News] [Resources] [Membership]
	www.agsa-geneticsupport.org.au (61 words)

	National Society of Genetic Counselors, Inc.
		Perspectives in Genetic Counseling: Summer 2005 now available!
		© 1995 - 2005 National Society of Genetic Counselors, Inc. All Rights Reserved SM Disclaimer
		If you have comments about this web site, or if you have found an error, please contact webmaster@nsgc.org
	www.nsgc.org (71 words)

	AN INTRODUCTION TO GENETIC ASSOCIATION AND LINKAGE ANALYSIS (Site not responding. Last check: 2007-10-03)
		AN INTRODUCTION TO GENETIC ASSOCIATION AND LINKAGE ANALYSIS
		Early chapters from general genetics text books eg:
		Terwilliger JD, Ott J. Handbook of human genetic linkage.
	www.qimr.edu.au /davidD/Course (33 words)

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