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Topic: Gentamycin

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	gentamycin antibiotic - Oman - Horizon Medical and Veterinary Necessities LLC - Engormix.com
		Gentamycin is an antibiotic belonging to the group of aminoglycosides.
		Gentamycin is excreted mainly by the kidneys, resulting in high concentrations of the active compound in the urine.
		Gentamycin is an aminoglycoside broad-spectrum antibiotic, active against most gram +ve and gram -ve bacteria.It is used in animals (horses, dogs & cats) for control of uterine infections (metritis), urinary tract infections (cystitis), respiratory tract infections (pneumonia and tracheobronchitis), and soft tissue infections.
	www.engormix.com /e_products414-438.htm (334 words)

	Alpha Pharmaceuticals - (Site not responding. Last check: 2007-10-26)
		Gentamycin sulfate corresponding to gentamycin base 80 mg.
		Ototoxicity in the form of vestibular damage has been recorded after the use of gentamycin in high doses for long periods especially in patients with renal failure.
		It is advised not to share gentamycin with diuretics like furosemide because it may leads to hearing troubles.
	www.alpha-syria.com /modules.php?op=modload&name=My_eGallery&file=index&do=showpic&pid=137&orderby= (463 words)

	Medication Errors: Section 3f
		A physician's claim that he or she never had a problem with that particular medication, or never monitored its effects before is unacceptable to a judge or jury.
		A 55-year-old woman with renal insufficiency was admitted to the hospital for pyelonephritis and treated with gentamycin.
		The gentamycin level was not measured for four days and the trough level found upon measurement was 4.6 mg/L. Safe levels are less than 2 mg/L. The patient developed acute renal failure and is on dialysis three times a week.
	www.norcalmutual.com /cme/med_errors_rx_3f.html (401 words)

	Regeneration of Cochlear Efferent Nerve Terminals after Gentamycin Damage -- Hennig and Cotanche 18 (9): 3282 -- ...
		Cryostat sections of a 4 d AOI gentamycin cochlea immunolabeled with synapsin and counterstained with DAPI were examined to determine the distribution of the blobs within the BP.
		In contrast, after gentamycin damage, the terminal breaks apart with the presynaptic membrane containing syntaxin reactivity remaining attached to extruded hair cells, whereas other fragments of the terminal containing synapsin reactivity remain within the BP.
		E, Phalloidin reactivity at the inferior edge and 50% of the length from the proximal end of the same BP shown in C, distal to the region damaged by gentamycin, reveals stereocilia arrays and junctional complexes that were not damaged.
	www.jneurosci.org /cgi/content/full/18/9/3282 (9282 words)

	Intraocular Antibacterial Therapy in Persian Cats
		Analysis of the results revealed that the antibiotics gentamycin, erythromycin, and bacitracin/novobiocin/polymyxin B all had a substantial effect on the number of S. felis present in the Persian cats’ eyes and the amount of brown tearing.
		Chloramphenicol, the macrolides, and the aminoglycosides (streptomycin, gentamycin, neomycin) function in the same manner as tetracycline, by inhibiting protein synthesis (Allen 1998).
		Analysis of the results revealed that the gentamycin, erythromycin, and bacitracin/polymyxin B/neomycin combination all had a substantial effect on the amount of brown tearing (Figure 1) as well as the number of bacteria present in all ten Persian cats’ eyes (Figure 2).
	www.simbakui.com /thesis (2615 words)

	Synthetic resin-base, antibiotic compositions containing amino acids - Patent 4191740
		In a method aspect, the present invention also provides a method for improving the liberation characteristics of antibiotics from antibiotic-containing synthetic resin particles based on polymethacrylates and/or polyacrylates, wherein 0.3 to 5% by weight, based on the amount of polymers, of at least one amino acid is added to the synthetic resin.
		In the case of gentamycin, for example, additions of from 1 to 4% by weight, calculated as gentamycin base, have proven to be especially useful.
		According to the present invention, by the addition of amino acids, an improved liberation of gentamycin is achieved, particularly from synthetic resins based upon polymethacrylates and/or polyacrylates.
	www.freepatentsonline.com /4191740.html (3544 words)

	Ohio State Gentamicin Study
		Gentamycin is antibiotic that may be able to help boys with DMD due to a Stop Codon causing the problem with Dystrophin producton.
		Gentamycin will not be a cure, in that it will not repair muscles already damaged where fibrosis has set in.
		Matt was accepted into the Ohio State (OSU) Phase I Gentamicin Study in March 2000 after DNA testing indicated that he did indeed have a Stop Codon.
	www.geocities.com /CapeCanaveral/8676/gent.html (825 words)

	Common Drugs May Prevent Antibiotic-Induced Deafness (Site not responding. Last check: 2007-10-26)
		Because they are so effective and rarely produce allergic reactions, physicians continue to prescribe them, even though they are known to cause hearing loss and kidney damage in a significant percentage of individuals who take them.
		In 1995, Schacht and his colleagues discovered gentamycin is not toxic until it combines with iron in the bloodstream and becomes activated.
		The quantity and physical condition of hair cells in the cochlea or inner ear of all animals were examined in tests conducted at the experiment's conclusion.
	www.pslgroup.com /dg/3c296.htm (814 words)

	A New Topical Antibiotic Delivery System
		When bacterial organisms were determined to be resistant to gentamycin or the oral agent, then a change in antibiotics was made (Table 3).
		Of the 12 patients initially started on gentamycin in type I collagen, six remained with this form of topical therapy until all appearance of infection was resolved clinically and the wound areas were 100% re-epithelialized.
		Of the six patients to which culture biopsy revealed resistance to gentamycin, three of the patients were started onto Clindamycin impregnated into type I bovine collagen and three patients were started on Vancomycin impregnated into type I bovine collagen.
	www.worldwidewounds.com /1998/july/Topical-Antibiotic-Delivery-System/topical-antibiotic-delivery-system.html (4751 words)

	R - Rhinotracheitis
		It can still be useful to use an anti-bacterial ophthalmic drop but the best recommendation is to use one that will work well against gram positive bacteria, which is gentamycin's weak area.
		A triple antibiotic drop with polymyxin and bacitracin may work better than gentamycin in this case.
		This is especially likely in a cat that had pneumonia because of the high probability of rhinotracheitis being involved in that, too.
	www.vetinfo.com /cencyclopedia/cerhino.html (266 words)

	Journal of Orthopaedic Surgery: Use of antibiotic-loaded polymethyl methacrylate beads in the management of ...
		The infective organisms were sensitive to gentamycin in 26 cases and resistant in 19 cases; 14 cases were sensitive to cefuroxime, 11 to cloxacillin, 8 to ampicillin, and 5 to cotrimoxazole.
		As gentamycin in powder form was not available in India and liquid gentamycin does not mix uniformly with bone cement, cefuroxime was used in this study: 8 g of cefuroxime powder was mixed homogenously in a sterile bowl with 40 g of PMMA polymer.
		The organisms were found to be sensitive to gentamycin in 26 cases and resistant in 19 cases.
	www.findarticles.com /p/articles/mi_qa3794/is_200306/ai_n9297550 (1374 words)

	Oubari Pharmaceuticals :: A better way of life (Site not responding. Last check: 2007-10-26)
		If body weight is less than 80 kg, 1 mg/kg every 8 hours.In Children:- Up to 2 weeks of age: 3 mg/kg every 12 hours.- 2 weeks to 12 years: 1 mg/kg every 8 hours.in elderly:They can be more susceptible to aminoglycoside toxicity whether secondary to previous eighth nerve impairment or borderline renal - dysfunction.
		Therapy should be closely monitored by frequent determination of gentamycin serum levels, assessment of renal function and signs of ototoxicity.
		Gentamycin 80 mg 2 ml x 3 ampoules.Gentamycin 40 mg 2 ml x 3 ampoules.Gentamycin 20 mg 2 ml x 3 ampoules.
	www.oubari.com /new/modules.php?op=modload&name=My_eGallery&file=index&do=showpic&pid=44&orderby= (303 words)

	Common Drugs May Prevent Antibiotic-Induced Deafness
		Discovered in the 1940s, these antibiotics -- which include streptomycin, gentamycin, neomycin and others -- are the most widely-used antibiotics in the world.
		In an article published in the July 1997 issue of the Journal of Pharmacology and Experimental Therapeutics, Schacht published the results of experiments showing that iron chelators did protect guinea pigs from gentamycin's ototoxic effects.
		While the guinea pigs receiving gentamycin alone experienced significant hearing loss with complete loss of hair cells in certain areas of the cochlea, animals receiving some combination of iron chelators and antioxidant therapy did much better.
	www.docguide.com /dg.nsf/PrintPrint/B39B690DF032989685256528006B76A9 (842 words)

	:: Brazilian Journal of Urology ::
		This study compared the lubrication of urethral catheters with 0.1% gentamycin cream and 2% lidocaine jelly in relation to the quantitative results of the urine culture and incidence of symptomatic urinary tract infection and nonsymptomatic bacteriuria in patients who undergo clean intermittent catheterization.
		Group A patients were directed to lubricate the urethral catheter with 0.1% gentamycin cream, and group B with 2% lidocaine jelly.
		Conclusion: The results of this study showed that the lubrication of urethral catheters with 0.1% gentamycin cream is not an effective alternative to reduce significant bacteriuria and prevent urinary infection in patients who undergo clean intermittent catheterization.
	www.brazjurol.com.br /vis.asp?code=177 (292 words)

	FEBS Abstract (Site not responding. Last check: 2007-10-26)
		It has been demonstrated that high antimicrobial activity (towards bacteria contaminating the tissue) of the gentamycin was not dependent on temperature used (4, 22, and 37 °C).
		On the other hand, the increase in temperature caused significant decrease in the tissue susceptibility to extraction of proteins, which was demonstrated by lower concentration of liberated peptides in electrophoregrams.
		It may be stated that treatment with gentamycin of the collagen-rich pericardium tissue is the most favorable at the temperature 37 °C, taking into account both the sterilization effect as well as the satisfactory structural properties of the tissue.
	www.blackwellpublishing.com /febsabstracts2004/abstract.asp?id=17511 (299 words)

	Gemicin 100 (Site not responding. Last check: 2007-10-26)
		Broad spectrum antibiotic aimed at treating and controlling specific and not specific illnesses caused by Gentamycin sensitive germs.
		Indicated to treat and control specific and not specific diseases caused by Gentamycin sensitive germs.
		Gentamycin belongs to the group of aminoglucoside antibiotics with bactericidal action on negative Gram bacteria and also on some positive Gram ones.
	webs.satlink.com /usuarios/l/labover/i/i8309.htm (204 words)

	European Society of Clinical Microbiology and Infectious Diseases (Site not responding. Last check: 2007-10-26)
		The efficacy of this bactericidal treatmen is limited by the emergence of high level gentamycin, kanamycin and streptomycin resistance.
		High-level resistance to gentamycin and kanamycin were tested by diffusion agar screen method.
		Data on HLR to gentamycin are in according to that found in other countries of Europe, whereas high percentage of HLR was found for kanamycin.
	www.blackwellpublishing.com /eccmid15/abstract.asp?id=36630 (342 words)

	Title: font: times; size: 18 point; style: plain; justified: center; capitalization: first word and Names only
		Methods: Gentamycin, a highly toxic aminoglycoside antibiotic was injected to the right eyes of newborn rabbits, aged 10-30 days.
		When gentamycin was injected to rabbits close to 30 days old, b-wave ratio was severely reduced as has been previously found in adult rabbits.
		Therefore, in the developing retina during the process of outer segment elongation, the photoreceptors can recover from the insult of one dose of gentamicine.
	www.kenes.com /isopp3/abstracts/0168Loewenstein.htm (225 words)

	Editorials - A New Protocol for Treatment of Infected Wounds (Site not responding. Last check: 2007-10-26)
		Initially all six patients osteomyelitis lesions were impregnated with gentamycin 10 mg per cc of mature lyophilized type I bovine collagen particles, dressed with Ex-U-Dry and secondary dressing.
		Upon receipt of culture report, three cases remained with gentamycin, two were changed to clindamycin, mixed 60 mg of clindamycin per cc of mature Iyophilized type I bovine collagen particles.
		reported drawing serum gentamycin level attempts post implantation of collagen sponge impregnated with gentamycin and that there was 0.00 to 0.04 micrograms per cc, thus subtherapeutic gentamycin serum levels.
	www.woundcare.org /newsvol2n2/ed1.htm (849 words)

	[No title]
		From their data, they suggested the existence of a pathway that directly and rapidly shuttles portion of the internalized gentamycin to the Golgi complex, which affects protein synthesis in renal proximal epithelia after gentamycin administration.
		The small therapeutic doses that were used in the present investigation in albino rat were found to induce proliferation and interlacing of the microvilli of some cells.
		At the brush border membrane, gentamycin caused release of enzyme from the organelles at a higher level than when applied to basolateral membrane.
	www.uqu.edu.sa /majalat/EngSciMed/jan2000/magazine4/faisal.htm (2354 words)

	News - Gentamycin May Correct Some Genetic Mutations In Cystic Fibrosis (Site not responding. Last check: 2007-10-26)
		The aminoglycoside antibiotic gentamycin appears to restore the deficiency or absence of chloride channel activity caused by stop mutations in the cystic transmembrane conductance regulator (CTCR) seen in patients with cystic fibrosis (CF), report researchers in Israel.
		Michael Wilschanski and associates at the Cystic Fibrosis Center of Shaare Zedek Medical Center in Jerusalem, Israel, conducted a double-blind, placebo-controlled crossover trial of CF patients with stop mutations in the CFTR gene or patients carrying the deltaF508 mutation.
		The authors say the genetic correction of CFTR mutation through nasal inhalation of gentamycin should translate to a clinical response in symptoms in patients with CF, but more studies are needed.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256DBB004AC057 (364 words)

	gentamicin sulfate
		Gentamycin fries kidneys, especially if there is dehydration present.
		My heifer was on a round of gentamycin for navel ill. It worked when nothing else did.
		Has anyon eever heard that once they have been on gentamycin that they can't be sold for beef or their milk used?
	www.cattletoday.com /forum/about2982.html (363 words)

	Hearing impairment -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-26)
		Some medications cause irreversible damage to the ear, and are limited in their use for this reason.
		The most important group is the (additional info and facts about aminoglycoside) aminoglycosides (main member (additional info and facts about gentamycin) gentamycin).
		There can be damage either to the ear itself or to the brain centers that process the aural information conveyed by the ears.
	www.absoluteastronomy.com /encyclopedia/h/he/hearing_impairment.htm (2344 words)

	Friends of the Earth: Briefing: Antibiotic Resistance Genes in GM Foods
		gentamycin B - used for serious illnesses, such as for treating meningitis and infections of the central nervous system.
		The Government should refuse approval for any genetically modified organism containing such a gene and use the powers available to them under the EU Directive 90/220/EEC on the Deliberate Release of Genetically Modified Organisms to revoke the marketing consent for any such food and crops.
		GM plants contain genes which confer resistance to many antibiotics including neomycin, kanamycin, spectinomycin, amikacin, gentamycin B and ß-lactam antibiotics such as ampicillin.
	www.foe.co.uk /resource/briefings/antibiotic_resistant_genes.html (1154 words)

	Title: font: times; size: 18 point; style: plain; justified: center; capitalization: first word and Names only
		Purpose: To investigate retinal toxicity of gentamycin injected subconjunctivally in areas adjacent to thinned or ectatic sclera.
		Methods: Scleral scrapping to half thickness was performed in both eyes of 8 rabbits followed by subconjunctival gentamycin injection in the right eye and saline in the left.
		Discussion: Subconjunctival injection of antibiotics which are considered safe might diffuse throught thinned sclera and be toxic to the retina.
	www.kenes.com /isopp3/abstracts/0167Loewenstein.htm (127 words)

	To Hear Again
		Rubel and coworkers had set out to study not regeneration, but rather the onset, rate, and mechanism of hair cell degeneration in baby chicks after they were given the antibiotic gentamycin.
		They measured the hair cell counts in chicks treated with gentamycin compared to age-matched controls, from 1 day to 3 weeks after treatment.
		When gentamycin-treated chicks were allowed to live 2 weeks longer than that, the researchers found that hair cells were actually regenerating.
	www.washington.edu /research/pathbreakers/1987a.html (536 words)

	Department of Environmental Health - University of Washington (Site not responding. Last check: 2007-10-26)
		A total of 901 Escherichia coli O157 isolates collected from health departments and cattle feedlots were tested using the Kirby-Bauer disk diffusion method for the occurrence of resistance to 12 antimicrobial agents.
		Resistance within cows to all other antibiotics was very rare; less than 1% for ampicillin, ampicillin / sulbactam, gentamycin, kanamycin, nalidixic acid and trimethoprim / sulfamethoxazole.
		Ampicillin / sulbactam, gentamycin, kanamycin and trimethoprim / sulfamethoxazole and nalidixic acid resistance were all found to be higher in human isolates as well.
	depts.washington.edu /envhlth/news/abstract03/abstracts_wilkerson.html (403 words)

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