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	Germ cell tumour - Wikipedia, the free encyclopedia
		Germ cell tumours are neoplasms derived from germ cells.
		In younger women germ cell lesions are more common, thus in patients under the age of 21, 60% of ovarian tumours are of the germ cell type, and up to one-third are malignant.
		In males, germ cell tumours occur typically after puberty and are malignant (testicular cancer).
	en.wikipedia.org /wiki/Germ_cell_tumour (180 words)

	Germ cell tumour: Just the facts... (Site not responding. Last check: 2007-10-08)
		Germ cell tumours are neoplasm (An abnormal new mass of tissue that serves no purpose) s derived from germ cell (A spermatozoon or an ovum) s.
		In younger women germ cell lesions are more common, thus in patients under the age of 21, 60% of ovarian tumours are of the germ cell type, and up to one-third are malignant (additional info and facts about malignant).
		In males, germ cell tumours occur typically after puberty and are malignant (testicular cancer (Malignant tumor of the testis; usually occurring in older men)).
	www.absoluteastronomy.com /encyclopedia/g/ge/germ_cell_tumour.htm (256 words)

	Encyclopedia: Germ cell
		A germ cell is a kind of cell that is part of the germline, and is involved in the reproduction of organisms.
		Cells in culture, stained for keratin (red) and DNA (green) The cell is the structural and functional unit of all living organisms, and are sometimes called the building blocks of life.
		Germ cell tumours are (An abnormal new mass of tissue that serves no purpose) neoplasms derived from (A spermatozoon or an ovum) germ cells.
	www.nationmaster.com /encyclopedia/Germ-cell (519 words)

	Germ cell definition - Medical Dictionary definitions of popular medical terms
		Germ cell: The eggs and sperm are the germ cells: the reproductive cells.
		Each mature germ cell is haploid in that it has a single set of 23 chromosomes containing half the usual amount of DNA and half the usual number of genes.
		The germs cells -- the eggs and sperm -- are thus notable exceptions to the usual rules governing chromosomes, genes, and DNA.
	www.medterms.com /script/main/art.asp?articlekey=8591 (258 words)

	Germ Cell Tumors (Site not responding. Last check: 2007-10-08)
		Germ cells are the cells from which the future ova are developed in a woman.
		Unlike epithelial ovarian cancer, the germ cell tumors usually occurs in much younger age groups, usually in teenagers and women who are in their early twenties.
		The development of chemotherapy has revolutionized the treatment of germ cell tumors and now almost 90 percent of the germ cell ovarian cancers are curable.
	ccc.domaindlx.com /ovarian/germ-cell-tumors.html (116 words)

	National Cancer Institute - Ovarian Germ Cell Tumor Treatment
		Ovarian germ cell tumor is a disease in which malignant (cancer) cells form in the germ (egg) cells of the ovary.
		Germ cell tumors begin in the reproductive cells (egg or sperm) of the body.
		Ovarian germ cell tumor is a general name that is used to describe several different types of cancer.
	www.cancer.gov /cancer_information/doc_pdq.aspx?version=patient&viewid=48ee0975-4bb3-4351-86e1-86f2a3f6f7ea (771 words)

	Ovarian germ cell tumor: 103125 (Site not responding. Last check: 2007-10-08)
		Germ cell tumors of the ovary, uncommon but aggressive tumors seen most often in young women or adolescent girls, are frequently unilateral, and are generally curable if found and treated early.
		In the absence of obvious metastatic disease, accurate staging of germ cell tumors of the ovary requires laparotomy with careful examination of the entire diaphragm, both paracolic gutters, pelvic nodes on the side of the ovarian tumor, the para-aortic lymph nodes, and the omentum.
		Stage III ovarian germ cell tumor is growth involving 1 or both ovaries with peritoneal implants outside the pelvis and/or positive retroperitoneal or inguinal nodes.
	www.acor.org /cnet/103125.html (2856 words)

	Germ Cell Tumors - Lucile Packard Children's Hospital
		Germ cells tumors are malignant (cancerous) or non-malignant (benign, non-cancerous) tumors that are comprised mostly of germ cells.
		Germ cells are the cells that develop in the embryo (fetus, or unborn baby) and become the cells that make up the reproductive system in males and females.
		Germ cell tumors account for 16 percent of all cancers diagnosed in adolescents between the ages of 15 and 19 years old, and nearly 4 percent of cancers diagnosed in children younger than 15 years old.
	www.lpch.org /DiseaseHealthInfo/HealthLibrary/oncology/gct.html (1375 words)

	OVARIAN CANCER: Diagnosis and Treatment
		Germ cell neoplasms are thought to be derived from primitive germ cells of the embryonic gonad.
		In adults, the vast majority of germ cell tumors are benign (nearly all mature cystic teratomas).
		Yolk sac tumors (also known as Endodermal sinus tumors) are the second most common germ cell tumor, accounting for 20% of all cases, and are common in girls and young adults (average age: 19).
	ovariancancer.jhmi.edu /germcell.cfm (649 words)

	Germ Cell Tumors
		Germ cell tumors develop from cells, called germ cells, that normally mature into eggs in the female ovaries and sperm in the male testes.
		The germ cells normally move from the yolk sac into the embryo and grow within the developing testes, if the fetus is male, or the ovary, if the fetus is female.
		Malignant germ cell tumors in the pineal area, around the middle of the brain, put pressure on the brain or block the flow of cerebrospinal fluid (CSF), which normally circulates through the brain and spinal cord.
	www.hmc.psu.edu /childrens/healthinfo/g/germcell.htm (1169 words)

	National Cancer Institute - Childhood Extracranial Germ Cell Tumor Treatment
		Childhood extracranial germ cell tumors are rare in children younger than 15 years, accounting for approximately 3% of cancer cases in this age group.[2,3] Extracranial germ cell tumors (particularly testicular germ cell tumors) are much more common among adolescents aged 15 to 19 years, representing approximately 14% of cancer diagnoses in this age group.
		Germ cell tumors develop from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4] Childhood extracranial germ cell tumors most commonly arise in midline extragonadal sites (i.e., sacrococcygeal, mediastinal, retroperitoneal), and the midline location may represent aberrant embryonic migration of the primordial germ cells.
		While the majority of ovarian germ cell tumors are benign mature teratomas, a heterogeneous group of malignant germ cell tumors occur in females, including immature teratomas, dysgerminomas, yolk sac tumors and mixed germ cell tumors.
	www.cancer.gov /cancerinfo/pdq/treatment/extracranial-germ-cell/healthprofessional (1525 words)

	Ovarian Germ Cell Tumors
		Many of the tests used to diagnose ovarian germ cell tumor are also used to determine the stage of the disease.
		cancer cells are found in the fluid of the peritoneal cavity (the body cavity that contains most of the organs in the abdomen) or in washings of the peritoneum (tissue lining the peritoneal cavity).
		Stem cells (immature blood cells) are removed from the bone marrow of the patient or a donor and are frozen and stored.
	www.meb.uni-bonn.de /cancer.gov/CDR0000062967.html (3224 words)

	Extra-gonadal Germ Cell Tumors
		Bilateral synchronous or metachronous germ cell tumors (GCT) of the testis are recognized in 2-3% of patients.
		Fine-needle aspiration biopsy of nonteratomatous germ cell tumors of the mediastinum.
		We assessed the usefulness of fine-needle aspiration biopsy (FNAB) in the diagnosis of mediastinal germ cell tumors (GCTs).
	www.thedoctorsdoctor.com /diseases/gct_extragonadal.htm (9288 words)

	Mechanisms of germ cell specification across the metazoans: epigenesis and preformation -- Extavour and Akam 130 (24): ...
		in a subset of the proximal epiblast cells.
		PGCs in the germ cell zone (Z) are distinguishable from somatic cells of the ventral ectoderm (VE) as large cells with round nuclei and granular cytoplasm.
		Induction of germ cells at the anterior pole of the egg.
	dev.biologists.org /cgi/content/full/130/24/5869 (8289 words)

	Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development -- Cheng and ...
		by germ cells in transit from the basal to the adluminal compartment.
		Sertoli cell membranes at the basal compartment of the epithelium
		apposing membrane of adjacent cells with claudin-2 or -3 (459),
	physrev.physiology.org /cgi/content/full/82/4/825 (10185 words)

	Germ cell cancer - MayoClinic.com (Site not responding. Last check: 2007-10-08)
		Germ cell tumors typically begin in the reproductive (germ) cells of the body.
		Germ cell tumors are not associated with germs or infection.
		The prognosis for germ cell cancers is generally favorable.
	www.mayoclinic.com /health/germ-cell-cancer/AN00831 (240 words)

	Extragonadal Germ Cell Cancer
		That is, the tumors originate in the sperm forming cells in the testicles (the males gonads) or egg producing cells in the ovary (female gonads).
		During embryonic development (when you are but a clump of cells), germ cells are first seen outside of the embryo in the yolk sac.
		If these cells miss their destination, they are likely to come to rest in one of a number of midline sites in the body.
	tcrc.acor.org /egc.html (584 words)

	Ovarian Cancer Germ Cell
		Many of the tests used to diagnose ovarian germ cell cancer are also used to determine the stage of the disease.
		Recurrent ovarian germ cell tumor may come back in the other ovary or in other parts of the body.
		Treatment of other germ cell tumors may be either: - unilateral salpingo-oophorectomy followed by careful observation; or - unilateral salpingo-oophorectomy, sometimes followed by combination chemotherapy.
	www.medhelp.org /lib/cancernet/203125.htm (2949 words)

	Ovarian Germ Cell Tumors
		Patients with stage II germ cell tumors of the ovary are candidates for clinical trials.
		For patients with stage III germ cell tumors other than pure dysgerminoma, total abdominal hysterectomy and bilateral salpingo-oophorectomy is recommended with removal of as much tumor in the abdomen and pelvis as can be done safely without resection of portions of the urinary tract or large segments of small or large bowel.
		For patients with stage IV germ cell tumors other than pure dysgerminoma, total abdominal hysterectomy and bilateral salpingo-oophorectomy is recommended with removal of as much tumor from the abdomen and pelvis as can be done safely without resection of kidney or large segments of small or large bowel.
	www.meb.uni-bonn.de /cancer.gov/CDR0000062935.html (4032 words)

	Germ Cell Tumors (Site not responding. Last check: 2007-10-08)
		This group of tumors arise from sex cells and are related to various tumors of the sex organs.
		Other members of the germ cell tumor classification are embryonal carcinoma, yolk sac tumor, choriocarcinoma and teratoma.
		The symptoms of a germ cell tumor are related to its location, size and speed of growth.
	www.cinn.org /ibsc/braintumor/diagnoses/germcelltumors.html (330 words)

	Germ Cell Tumours in Children and Young Adults
		In the developing embryo germ cells migrate to the ovaries or testicles and form the ova (egg cells) or sperm cells.
		Germ cell tumours are most common in children and young adults, there are different sub-types including endodermal tumours (mostly found in children), dysgerminoma, teratoma, and seminoma (young men).
		Physician's PDQ statement for Childhood extracranial germ cell tumor (CancerNet) A referenced overview of the disease, cellular classification, staging, and current treatment overviews.
	www.cancerindex.org /ccw/guide2u.htm (355 words)

	Ovarian Cancer Germ Cell
		Kurman RJ, Norris HJ: Malignant germ cell tumors of the ovary.
		Gershenson DM, Morris M, Cangir A, et al.: Treatment of malignant germ cell tumors of the ovary with bleomycin, etoposide, and cisplatin.
		Treatment options under clinical evaluation: Patients with stage II germ cell tumors of the ovary are candidates for clinical trials.[4] Information about ongoing clinical trials is available from the NCI (http://cancer.gov/clinical_trials).
	www.medhelp.org /lib/cancernet/103125.htm (2758 words)

	eMedicine - Extragonadal Germ Cell Tumors : Article by Issam Makhoul, MD (Site not responding. Last check: 2007-10-08)
		According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal GCTs may be explained by differences in the cellular environment between the gonad and the anterior mediastinum.
		The cell carrying this abnormality is relatively protected against apoptotic death because of the oncogenic effect of CCND2, leading to re-initiation of cell cycle and genomic instability.
		The germ cell origin of these tumors is suggested by the typical abnormalities of chromosome 12 and the elevation of beta human chorionic gonadotropin (bhCG) and/or alpha-fetoprotein (AFP).
	www.emedicine.com /med/topic759.htm (6224 words)

	Germ Cell Tumors (Brain) (Site not responding. Last check: 2007-10-08)
		Different types of germ cells give rise to different types of tumors, including germinoma, embryonal carcinoma, endodermal sinus tumor and teratoma.
		Germ cell tumors can spread to other areas of the brain and spinal cord.
		Current efforts are focusing on the addition of chemotherapy for germinomas to reduce the volume and dose of irradiation and to increase the cure rate in patients with other types of germ cell tumors.
	www.stjude.org /disease-summaries/0,2557,449_2160_5037,00.html (425 words)

	Ovarian germ cell tumor
		After ovarian germ cell tumor has been diagnosed (found), tests are done to find out if cancer cells have spread within the ovary or to other parts of the body.
		Stage IC: Cancer has spread to the outside surface of one or both ovaries, or the tumor has ruptured the wall of the ovary, or cancer cells are found in fluid in the peritoneum (tissue that lines the abdominal wall and covers most of the organs in the abdomen).
		There are treatments for all patients with ovarian germ cell tumor.
	cancerweb.ncl.ac.uk /cancernet/203125.html (2757 words)

	Germ Cell Tumors
		Germ cell tumors of the ovary are uncommon but aggressive tumors seen most often in young women or preteen and adolescent girls, and are generally curable if found and treated early.
		Ovarian germ cell tumors can be difficult to diagnose early.
		Once ovarian germ cell tumor has been found, surgery and staging is the first course of action.
	www.acor.org /ped-onc/diseases/germcell.html (812 words)

	Germ Cell Migration
		The primordial germ cells multiply in the upper reaches of the yolk sac and migrate to the gonad, a mesodermal structure which forms near the embryonic kidneys.
		If the primordial germ cells are XX containing, they proliferate in the cortex or outer layer of the gonad.
		If the primordial germ cells are XY containing, they proliferate in the medulla or core of the gonad.
	www.people.virginia.edu /~rjh9u/gondev.html (87 words)

	eMedicine - Germ Cell Tumors : Article by Mansoor Javeed, MD, FACP (Site not responding. Last check: 2007-10-08)
		Background: Germ cell tumors (GCTs) are a morphologically distinct group of neoplasms with varied clinical presentation.
		Recent studies of GCTs have suggested that cyclin D2 is overexpressed in malignant germ cells and is oncogenic.
		Embryonal carcinoma is characterized by rapid and bulky growth and by spread via lymphatic and hematogenous routes to distant viscera (eg, lungs, liver).
	www.emedicine.com /med/topic863.htm (4289 words)

	The Germantown Cell Goup (Site not responding. Last check: 2007-10-08)
		Affliated with the Chinese Community Church of Washington, D.C.; the Germ-Cell is a weekly cell group that meets to study the Bible, worship and praise God along with having a community of fellowship between fellow Christian Brothers and Sisters.
		Formed in the early first quarter of 1998, a small band of members from the Chinese Community Church who all lived in the Germantown/Gaithersburg area were asked if they would like a cell group in that area.
		At that point in my life, April 1998, I was searching for a group of Christians that I could go and be apart of outside of just Sunday.
	www.glue.umd.edu /~shyeah/CELL (338 words)

	Germ Cell Tumours - Genetics
		Chromosome abnormalities of eighty-one pediatric germ cell tumors: sex-, age-, site-, and histopathology-related differences--a Children's Cancer Group study.
		DNA ploidy analysis of pediatric germ cell tumors.
		Ploidy of primary germ cell tumors of the testis.
	www.cancerindex.org /geneweb/X2207.htm (130 words)

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