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	Germ Cell Tumors: Encyclopedia of Cancer
		Germ cell tumors are tumors that begin in cells that, in a developing fetus, become sperm or egg cells.
		Germ cell tumors are a diverse group of tumors that all begin in germ cells, the cells in the developing fetus that become sperm or egg cells.
		Germ cell tumors are divided into two types: germinomas, which contain only immature germ cells; and embryonic tumors, which contain some cells that have started to develop into other tissues (as would happen in normal development of a fetus).
	health.enotes.com /cancer-encyclopedia/germ-cell-tumors (3782 words)

	Germ cell tumor - Wikipedia, the free encyclopedia
		Germ cell tumors are neoplasms derived from germ cells.
		In younger women germ cell lesions are more common, thus in patients under the age of 21, 60% of ovarian tumours are of the germ cell type, and up to one-third are malignant.
		In males, germ cell tumours occur typically after puberty and are malignant (testicular cancer).
	en.wikipedia.org /wiki/Germ_cell_tumor (256 words)

	Germ Cell Tumors Childhood Extracranial Germ Cell Tumor
		These germ cell tumors are usually located in the sacrum (a triangular-shaped section of fused bone located between the hip bones at the base of the spine) and the coccyx (the fused bones located on the end of the sacrum; also called the tailbone).
		Ovarian germ cell tumors Ovarian germ cell tumor, a rare type of cancer that affects teenage girls and young women, is a disease in which cancer (malignant) cells are found in egg-making cells in an ovary.
		Germ cell tumors form in developing cells and usually contain tissues that are foreign to the location of the tumor.
	www.medhelp.org /lib/cancernet/208723.htm (2530 words)

	OHSU Doernbecher - Oncology (Site not responding. Last check: 2007-09-29)
		Germ cells tumors are malignant (cancerous) or non-malignant (benign, non-cancerous) tumors that are comprised mostly of germ cells.
		Germ cells are the cells that develop in the embryo (fetus, or unborn baby) and become the cells that make up the reproductive system in males and females.
		Because these sacrococcygeal tumors are often visible from the outside of the body, diagnosis is made early and treatment and/or surgery are initiated early, making the prognosis for this type of germ cell tumor very favorable.
	www.ohsuhealth.com /dch/health/oncology/germ.asp (1303 words)

	HON Mother & Child Glossary, Childhood Cancers: Germ Cell Cancer
		Germ cell tumours of early childhood have biological characteristics which are different than those that occur in adolescents and young adults.
		These germ cell tumours are usually located in the sacrum (a triangular-shaped section of fused bone located between the hip bones at the base of the spine) and the coccyx (the fused bones located on the end of the sacrum; also called the tailbone).
		Ovarian germ cell tumour, a rare type of cancer that affects teenage girls and young women, is a disease in which cancer (malignant) cells are found in egg-making cells in an ovary.
	www.hon.ch /Dossier/MotherChild/child_cancer/cancer_germcell.html (441 words)

	Ovarian Germ Cell Tumor Treatment - National Cancer Institute
		Ovarian germ cell tumor is a disease in which malignant (cancer) cells form in the germ (egg) cells of the ovary.
		Germ cell tumors begin in the reproductive cells (egg or sperm) of the body.
		Ovarian germ cell tumor is a general name that is used to describe several different types of cancer.
	www.nci.nih.gov /cancertopics/pdq/treatment/ovarian-germ-cell/patient (787 words)

	Extragonadal Germ Cell Tumors Information on Healthline
		The cause, or causes, of extragonadal germ cell tumors are not known.The symptoms of an extragonadal germ cell tumor depend on the type and location of the tumor.Germ cell tumors of the mediastinum are primarily diagnosed in men between the ages of 20 and 30.
		Tumors detected in children over the age of six months are malignant in approximately 65% of cases.Almost all pineal germ cell tumors occur in people under the age of 40.
		In cases where a germ cell tumor of the pineal area is suspected, a complete neurological examination will be performed.The first test for a tumor of the mediastinum is a standard chest x ray.
	www.healthline.com /galecontent/extragonadal-germ-cell-tumors (932 words)

	Ovarian Germ Cell Tumor Treatment - Article (Site not responding. Last check: 2007-09-29)
		After ovarian germ cell tumor has been diagnosed, tests are done to find out if cancer cells have spread within the ovary or to other parts of the body.
		Cancer cells are found in the fluid of the peritoneal cavity or in washings of the peritoneum (tissue that lines the abdominal wall and covers most of the organs in the abdomen).
		Stem cells (immature blood cells) are removed from the bone marrow of the patient or a donor and are frozen for storage.
	goldbamboo.com /topic-a55077.html (3400 words)

	Germ Cell Tumors of the Testis - Tumors of the Testis
		Germ Cell Tumors of the Testis - Tumors of the Testis
		Of all primary testicular tumors, 90-95% are germ cell tumors (seminoma and nonseminoma), while the remainder are nongerminal neoplasms (Leydig cell, Sertoli cell, gonadoblastoma).
		Seminoma is the most common germ cell tumor in bilateral primary testicular tumors, while malignant lymphoma is the most common bilateral tumor of the testis.
	www.health.am /cr/testis-germ-cell-tumors (491 words)

	Ovarian Cancer - Treatment Options by Stage and Type - WomensHealthChannel
		Germ cell tumors, which arise from cells that normally form the eggs, usually are benign and tend to occur in women younger than age 30.
		If the germ cell tumor is a dysgerminoma (the most widespread germ cell tumor, representing nearly half of all cases), initial treatment begins with surgery to remove the tumorous ovary and the corresponding fallopian tube on the same side - known as unilateral salpingo-oophorectomy.
		If the germ cell tumor is a dysgerminoma (the most widespread germ cell tumor, representing nearly half of all cases), treatment may start with surgery, including total hysterectomy and bilateral salpingo-oophorectomy, followed by radiotherapy.
	www.womenshealthchannel.com /ovariancancer/treatmentoptions.shtml (873 words)

	Strong Health - Golisano Children's Hospital at Strong - Pediatric Conditions - Extracranial Germ Cell Tumor
		Germ cells are the reproductive cells that develop into testicles in boys and ovaries in girls.
		Cells that are designed to form the reproductive system break away and travel to other parts of the body.
		A treatment plan will be determined by the type of tumor that exists, the stage of the disease, whether or not it is malignant (cancerous), as well as your child's age and general health.
	www.stronghealth.com /services/childrens/conditions/germcell.cfm (346 words)

	Childhood Extracranial Germ Cell Tumor Treatment - Article (Site not responding. Last check: 2007-09-29)
		Germ cells are reproductive cells that develop into testicles in males and ovaries in females.
		Ovarian germ cell tumor, a rare type of cancer that affects teenage girls and young women, is a disease in which cancer (malignant) cells are found in egg-making cells in an ovary.
		Due to the small number of childhood extracranial germ cell tumors and the effectiveness of treatment, the number of patients who have tumors that return is small.
	goldbamboo.com /topic-a55109.html (2536 words)

	Germ Cell Tumors - symptoms, diagnosis and treatment information at Mayo Clinic.
		More than 90 percent of germ cell tumors develop in the reproductive cells of the testicles or ovaries (though less than 10 percent of ovarian cancers are germ cell tumors).
		Germ cell tumors that originate in the brain typically occur near the pineal gland in the central nervous system of children or adults.
		Retroperitoneal (originating behind the abdominal cavity) tumors probably occur as a result of germ cells left in this area during migration of the testes to the scrotum during embryonic development.
	www.mayoclinic.org /germ-cell-tumors/index.html (452 words)

	Ovarian Germ Cell Tumors at Fox Chase Cancer Center (Site not responding. Last check: 2007-09-29)
		Many of the tests used to diagnose ovarian germ cell tumor are also used to determine the stage of the disease.
		Stage IIIA: The tumor is found only in the pelvis, but cancer cells have spread to the surface of the peritoneum (tissue that lines the abdominal wall and covers most of the organs in the abdomen).
		Tumor debulking: A surgical procedure in which as much of the tumor as possible is removed.
	www.fccc.edu /pdq/English/Patients/OvarianGermCellTumors.html (3225 words)

	Syndromes Associated with Mediastinal Nonseminomatour Germ Cell Tumors -Malignant Germ Cell Tumors
		The average age of patients with Klinefelter syndrome who develop extragonadal germ cell tumors is approximately 18 years, 10 years younger than the median age of those developing this tumor in the absence of Klinefelter syndrome.
		In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed.
		The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass.
	www.health.am /cr/more/nonseminomatour-germ-cell-tumors (920 words)

	eMedicine - Germ Cell Tumors : Article by Mansoor Javeed, MD, FACP
		Recent studies of GCTs have suggested that cyclin D2 is overexpressed in malignant germ cells and is oncogenic.
		GCT differentiation may be influenced by several interacting pathways, such as regulators of germ-cell totipotentiality, embryonic development, and genomic imprinting.
		GCTs should be distinguished by seminoma versus nonseminoma subtypes because they are treated differently.
	www.emedicine.com /med/topic863.htm (5419 words)

	Ovarian Cancer Germ Cell
		Many of the tests used to diagnose ovarian germ cell cancer are also used to determine the stage of the disease.
		The peritoneal tumors are larger than 2 centimeters and/or cancer is found in lymph nodes in the pelvis.
		Treatment of other germ cell tumors may be either: - unilateral salpingo-oophorectomy followed by careful observation; or - unilateral salpingo-oophorectomy, sometimes followed by combination chemotherapy.
	www.medhelp.org /lib/cancernet/203125.htm (2949 words)

	Extragonadal Germ Cell Cancer
		That is, the tumors originate in the sperm forming cells in the testicles (the males gonads) or egg producing cells in the ovary (female gonads).
		During embryonic development (when you are but a clump of cells), germ cells are first seen outside of the embryo in the yolk sac.
		If these cells miss their destination, they are likely to come to rest in one of a number of midline sites in the body.
	tcrc.acor.org /egc.html (584 words)

	Retroperitoneal germ cell tumor treated by PVeBV chemotherapy: a case report -- Abe et al. 29 (5): 261 -- Japanese ...
		The extragonadal germ cell tumors (EGCTs) are uncommon neoplasms which account for only 1-5% of germ cell tumors (1), and most EGCTs arise from the mediastinum or retroperitoneum in young males (2).
		In this case, testicular biopsy was not performed according to the specific criterion of `probable germ cell tumors of extragonadal origin' (10).
		AFP and beta-hCG are invaluable tumor marker in the diagnosis and follow-up of non-seminomatous germ cell tumor, and LDH has also been reported to have prognostic significance (11).
	jjco.oxfordjournals.org /cgi/content/full/29/5/261 (1809 words)

	Germ Cell Tumors (Solid Tumor) (Site not responding. Last check: 2007-09-29)
		Germ cell tumors include a diverse group of tumors that arise from primitive germinal cells in either the gonads (ovaries, testicles) or non-gonadal sites (brain, chest, tailbone).
		Germ cell tumors are more common in patients with Klinefelter syndrome or with a history of an undescended testicle.
		The treatment of germ cell tumors is based on the stage, location, and the microscopic appearance of the tumor (histology).
	www.stjude.org /disease-summaries/0,2557,449_2167_7407,00.html (526 words)

	Intratubular Germ Cell Neoplasia
		Forty-five patients with testicular germ cell tumors and intratubular germ cell neoplasia (identified in 42/45 cases) were included in the study.
		Unexpectedly, Fhit expression was frequently (16/18) observed in the glandular tissue of mature teratomatous component of mixed germ cell tumors, despite the absence of Fhit in the intratubular germ cell neoplasia, the presumed precursor lesion.
		The loss of Fhit expression is a consistent characteristic of intratubular germ cell neoplasia, which suggests a potential role in a maturation/differentiation defect early in the development of testicular germ cell tumors.
	www.thedoctorsdoctor.com /diseases/igcnu.htm (1547 words)

	Extragonadal germ cell tumor: 103773 (Site not responding. Last check: 2007-09-29)
		Extragonadal germ cell tumors are rare and account for only a small percentage of all germ cell tumors.
		Patients with nonseminomatous extragonadal germ cell tumors who relapse after front-line chemotherapy generally have a poor prognosis with a poor response to salvage chemotherapy regimens, including autologous bone marrow transplantation, that have had success for recurrent testicular cancer.
		An international germ cell tumor prognostic classification has been developed based on a retrospective analysis of 5,202 patients with metastatic nonseminomatous and 660 patients with metastatic seminomatous germ cell tumors.
	www.acor.org /cnet/103773.html (950 words)

	Germ Cell Tumors (Brain) (Site not responding. Last check: 2007-09-29)
		Germ cell tumors can spread to other areas of the brain and spinal cord.
		These tumors are very rare, accounting for only one percent of all newly diagnosed brain tumors in children.
		Current efforts are focusing on the addition of chemotherapy for germinomas to reduce the volume and dose of irradiation and to increase the cure rate in patients with other types of germ cell tumors.
	www.stjude.org /disease-summaries/0,2557,449_2160_5037,00.html (425 words)

	Extragonadal germ cell tumor
		Germ cell tumors develop from testicular or ovarian cells.
		Sometimes these cells travel to the chest or abdomen and may turn into a rare type of cancer called extragonadal germ cell tumor.
		Patients who have large tumors, or tumors that are spreading, are treated with chemotherapy that consists of etoposide- and cisplatin-based anticancer drugs.
	cancerweb.ncl.ac.uk /cancernet/203773.html (1079 words)

	Germ cell tumors, childhood extracranial: Treatment - Patient Information [NCI PDQ]
		This type of germ cell tumor is found in a male fetus developing in the womb or in a newborn male infant.
		Many testicular germ cell tumors present at birth are not cancerous and are found in midline areas of the body, such as the tailbone.
		This type of germ cell tumor forms within the testis of young boys.
	www.peacehealth.org /kbase/nci/ncicdr0000062857.htm (2625 words)

	Germ Cell Tumor of the Testicle. (Site not responding. Last check: 2007-09-29)
		Testicular tumors in children (most commonly yolk sac tumor and teratoma) are uncommon representing only 1.5% of all childhood malignancies.
		Ninety to ninety-five percent of these neoplasms are of germ cell origin and for the most part are highly malignant.
		Only 60% of these germ cells tumors are of a single histologic type with the remainder comprised of two or more cell types.
	brighamrad.harvard.edu /Cases/mcr/hcache/320/full.html (224 words)

	Germ Cell Tumors
		Germ cell tumors are diagnosed in about 900 children each year.
		Germ cell tumors account for 16 percent of all cancers diagnosed in adolescents between the ages of 15 and 19 years old, and nearly 4 percent of cancers diagnosed in children younger than 15 years old.
		Long-term outlook of a child with a germ cell tumor:
	www.healthsystem.virginia.edu /uvahealth/hub_cancer/germcell.cfm (1335 words)

	Ovarian germ cell tumor
		After ovarian germ cell tumor has been diagnosed (found), tests are done to find out if cancer cells have spread within the ovary or to other parts of the body.
		Stage IC: Cancer has spread to the outside surface of one or both ovaries, or the tumor has ruptured the wall of the ovary, or cancer cells are found in fluid in the peritoneum (tissue that lines the abdominal wall and covers most of the organs in the abdomen).
		Stage IIIC: Cancer has spread to the peritoneum and tumors are larger than 2 centimeters and/or cancer is found in lymph nodes in the pelvis.
	cancerweb.ncl.ac.uk /cancernet/203125.html (2757 words)

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