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Topic: Gestational choriocarcinoma

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 Gestational choriocarcinoma Definition / Gestational choriocarcinoma Research   (Site not responding. Last check: 2007-11-05)
Gestational choriocarcinoma is a malignant In medicine, malignant is a clinical term that is used to describe a clinical course that progresses rapidly to death.
Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the trophoblast (part of the placenta).
Gestational choriocarcinoma is a rare tumour in the West, but its incidence is reported to be frequent in south east Asia.
www.elresearch.com /Gestational_choriocarcinoma   (293 words)

 Archives of the AFIP -- RadioGraphics 1996; 16: 131-148
Atlas of tumor pathology: tumors of the uterine corpus and gestational trophoblastic disease, fasc 3, ser 3.
Gestational trophoblastic neoplasia: surgical pathologic considerations with clinical emphasis.
Gestational trophoblastic neoplasm of the uterus: MR assessment.
rsna.org /REG/publications/rg/afip/privateM/1996/0016/0001/0131/13.htm   (341 words)

 Gestational Trophoblastic Tumors:   (Site not responding. Last check: 2007-11-05)
Gestational trophoblastic tumor, a rare cancer in women, is a disease in which cancer ( malignant) cells grow in the tissues that are formed following conception (the joining of sperm and egg).
Once gestational trophoblastic tumor has been found, more tests will be done to find out if the cancer has spread from inside the uterus to other parts of the body ( staging).
Treatment of gestational trophoblastic tumor depends on the stage of the disease, and the patient's age and overall condition.
www.acor.org /cnet/62699.html   (1980 words)

 Metastatic choriocarcinoma presenting as multiple intracerebral haemorrhages: the role of imaging in the elucidation of ...
Metastatic choriocarcinoma presenting as multiple intracerebral haemorrhages: the role of imaging in the elucidation of the pathology -- Kidd et al.
Metastatic choriocarcinoma presenting as multiple intracerebral haemorrhages: the role of imaging in the elucidation of the pathology
Choriocarcinoma is a rare germ cell tumour in males, accounting for only 4% of testicular tumours.
www.jnnp.com /cgi/content/full/65/6/939   (1208 words)

 CHEST: Use of urine pregnancy test for rapid diagnosis of primary pulmonary choriocarcinoma in a man - selected reports   (Site not responding. Last check: 2007-11-05)
Due to its rarity, primary choriocarcinoma of the lung in men is often incorrectly diagnosed as more common diseases, such as primary or metastatic lung cancer, and therefore potentially curative chemotherapy or surgery may be withheld from the patient.
Choriocarcinoma, a representative neoplasm producing human chorionic gonadotropin (HCG), is an extremely malignant tumor originating from anaplastic trophoblastic tissue.
In contrast to gestational choriocarcinoma, the natural course of primary pulmonary choriocarcinoma is rapidly fatal in the great majority of cases.
findarticles.com /cf_dls/m0984/3_121/84666762/p1/article.jhtml   (1178 words)

 Choriocarcinoma -- eCureMe.com
Choriocarcinoma is a cancer that originates in trophoblastic cells of the placenta (afterbirth).
Gestational trophoblastic neoplasia is classified into three types (1) hydatiform mole, that stays in the uterus, (2) invasive hydatiform mole, that invades locally, and the gravest (3) choriocarcinoma, that may spread throughout the body.
Gestational trophoblastic neoplasia usually begins early in pregnancy when the embryo or fetus does not develop but the placental tissue continues to grow.
www.ecureme.com /especial/obgyn/Choriocarcinoma.asp   (279 words)

 Gestational trophoblastic tumors: Treatment - Health Professional Information [Cancer.gov]
Choriocarcinoma most commonly follows a molar pregnancy but can follow a normal pregnancy, ectopic pregnancy, or abortion, and should always be considered when a patient has continued vaginal bleeding in the postdelivery period.
Of utmost importance in treating patients with gestational trophoblastic tumors is instituting therapy as quickly as possible and continuing chemotherapy at very close intervals until normal BHCG titers are obtained.
For resistant high-risk gestational trophoblastic tumors (GTT), combinations of etoposide, cisplatin, and either dactinomycin or bleomycin have shown promising results.[ 2, 3 ] A patient who has failed primary surgical therapy is generally treated with single-agent chemotherapy unless one of the poor-prognosis factors that requires combination chemotherapy supervenes.
www.peacehealth.org /kbase/nci/ncicdr0000062901.htm   (2911 words)

 Gestational Trophoblastic Tumor   (Site not responding. Last check: 2007-11-05)
Gestational trophoblastic tumor, a rare cancer in women, is a disease in which cancer (malignant) cells grow in the tissues that are formed following conception (the joining of sperm and egg).
The chance of recovery (prognosis) and choice of treatment depend on the type of gestational trophoblastic tumor, whether it has spread to other places, and the patient's general state of health.
Once gestational trophoblastic tumor has been found, more tests will be done to find out if the cancer has spread from inside the uterus to other parts of the body (staging).
cchs.net /health/health-info/docs/1300/1397.asp?index=6130&...   (1335 words)

 ► Gestational trophoblastic disease
Gestational trophoblastic disease is an aggressive, malignant, often metastatic (spreading to other organs) cancer in the womb which begins following a pregnancy (particularly one with hydatidiform mole), a miscarriage, or an abortion.
In approximately one-half of cases of choriocarcinoma, the preceding factor is hydatidiform mole.
Nearly one-fourth of choriocarcinomas follow a term pregnancy, from which a normal child has been delivered.
www.umm.edu /ency/article/001496.htm   (293 words)

 Women's Cancer Center: Ovarian Cancer   (Site not responding. Last check: 2007-11-05)
Gestational trophoblastic diseases (GTD) are disorders of abnormal growth of the placenta.
Metastatic choriocarcinoma is considered low-risk when it is diagnosed less than four months after the onset of the pregnancy, when the HCG titer is less than 40,000 mIU/mL, when there are no liver or brain metastases and when there has been no previous treatment with chemotherapy.
Metastatic choriocarcinoma is considered high-risk when it is diagnosed more than four months after the onset of pregnancy, associated with a serum HCG titer greater than 40,000 mIU/mL, liver or brain metastases, a history of chemotherapy or if it occurs after a full-term pregnancy, or if the WHO score is greater than 8.
www.womenscancercenter.com /info/types/mole.html   (2612 words)

 Dr. Schilling's Net Health Book - Choriocarcinoma, Hydatidiform Mole And Gestational Trophoblastic Disease
This is the fleshy tissue,rich in blood vessels and located between the uterine wall and the fetus in a pregnant woman.
So we can think of the choriocarcinoma being a cancer that is derived from placental tissue.
The reason I included this type of cancer is that it is extremely important that both the mother of the new baby and the doctor have a suspicious mind about the possibility of a mole or choriocarcinoma.
www.nethealthbook.com /cancer_choriocarcinoma.html   (591 words)

 Gestational Choriocarcinoma Whose Responsible Pregnancy was a Complete Hydatidiform Mole Identified by PCR Analysis ...   (Site not responding. Last check: 2007-11-05)
The allele patterns of choriocarcinoma on D3S1744 and D12S1090 were not observed with DNA from the patient.
In this paper, we report a case of gestational choriocarcinoma in which the responsible pregnancy was not the antecedent pregnancy or normal term delivery, but clinically invasive mole ( 12) originating from a hydatidiform mole as identified by PCR analysis using five new STS primers: D1S225, D3S1744, D12S1090, D18S849 and D18S877.
The pregnancy responsible for choriocarcinoma was previously thought to be the antecedent pregnancy or a hydatidiform mole.
www.oup.co.uk /jjco/Volume_29/Issue_10/html/hyc133_gml.html   (2042 words)

 Gestational trophoblastic disease (Disease) - Southwest Washington Medical Center
Gestational trophoblastic disease, or choriocarcinoma, is an aggressive, malignant, often metastatic (spreading to other organs) cancer in the uterus that begins following a pregnancy, a miscarriage, or an abortion.
A possible symptom is continued vaginal bleeding in a woman with a recent history of hydatidiform mole, abortion, or term pregnancy.
Choriocarcinoma may recur, usually within several months but possibly as late as 3 years after treatment ends.
www.swmedicalcenter.com /13435.cfm   (680 words)

Methods: This study was done on patients with gestational choriocarcinoma presenting to Gynae-B unit of Khyber Teaching Hospital Peshawar, between May, 1996 to December, 1997, diagnosed on the basis of clinical course and elevated level of HCG.
Prognosis of gestational choriocarcinoma largely depends upon early diagnosis of the disease, comprehensive metastatic workup, selection of appropriate regimen of chemotherapy from outset and carefully planned follow up.
Diagnosis of choriocarcinoma was mainly based on clinical course of the disease (history, abnormal vaginal bleeding, adnexal masses) and elevated levels of serum b-HCG.
www.ayubmed.edu.pk /JAMC/PAST/15-2/Raisa%20Choriocarcinoma.htm   (1790 words)

 Practice Guidelines: Gestational Trophoblastic Disease
Gestational choriocarcinoma is the highly malignant form of gestational trophoblastic disease that, unfortunately, can arise in any form of pregnancy.
Because most deaths of patients with gestational trophoblastic disease occur either from the progression of advanced disease before any treatment is given or the development of drug resistance when inadequate treatment is given, a simple answer to the question is that a patient should be referred when she is in a high-risk category.
Choriocarcinoma: The Clinical Biology of the Trophoblast and its Tumors.
www.cancernetwork.com /journals/oncology/o9803g.htm   (3217 words)

 HerbChina2000.com - Herbal Remedies - Gestational trophoblastic neoplasia   (Site not responding. Last check: 2007-11-05)
A rare cancer in women of child-bearing age in which cancer cells grow in the tissues that are formed in the uterus after conception.
Choriocarcinoma tumors, may have started from a hydatidiform mole or from tissue in the uterus following an abortion or the delivery of a baby.
All forms of gestational trophoblastic disease (GTD) begin after an egg is fertilized with sperm.
www.herbchina2000.com /therapies/CGT.shtml   (712 words)

 Gestational trophoblastic tumor
Gestational trophoblastic tumors may be classified as follows: hydatidiform mole, chorioadenoma destruens (invasive mole), choriocarcinoma, and placental-site trophoblastic tumor.[1]
Choriocarcinoma is a malignant tumor of the trophoblastic epithelium.
Chemotherapy is necessary when there is: (1) a rising BHCG titer for 2 weeks, (3 titers), (2) a tissue diagnosis of choriocarcinoma (3) a plateau of the BHCG for 3 weeks (4) metastatic disease (good prognosis) (5) an elevation in BHCG after a normal value or (6) postevacuation hemorrhage not caused by retained tissues.
cancerweb.ncl.ac.uk /cancernet/101163.html   (2748 words)

 Choriocarcinoma of the kidney -- Mack et al. 92 (6): 799 -- Journal of the American Osteopathic Association
Choriocarcinoma of the kidney -- Mack et al.
Choriocarcinoma is a malignant germ cell tumor that usually arises from a previous gestation, but may also arise from germ cells anywhere along their known migratory pathway during fetal development.
The authors report the case of a patient with choriocarcinoma who was seen with pulmonary metastases and a single large lesion in the kidney 5 years posthysterectomy.
www.jaoa.org /cgi/content/abstract/92/6/799   (152 words)

 World Journal of Surgical Oncology | Full text | Unusual presentation of choriocarcinoma
Choriocarcinoma is an aggressive neoplasm arising in the body of the uterus.
On the other hand choriocarcinoma is rare but one of the most malignant neoplasms arising in the body of uterus.
There are reports describing metastasis to large intestine from choriocarcinoma presenting as pesudoobstruction [ 5 ] and metastasis to stomach [ 6 ].
www.wjso.com /content/1/1/4   (1423 words)

 eMedicine - Gestational Trophoblastic Neoplasia : Article by Enrique Hernandez, MD, FACOG, FACS
Choriocarcinomas are aneuploid and can be heterozygous, depending on the type of pregnancy from which the choriocarcinoma arose.
Of choriocarcinomas, 50% are preceded by a hydatidiform mole, 25% by an abortion, and the other 25% by a full-term pregnancy.
Rarely is a histopathologic diagnosis of an invasive mole made on a dilation and curettage (D&C) specimen because this requires the identification of destructive invasion of the myometrium by the trophoblasts.
www.emedicine.com /med/topic866.htm   (4716 words)

 [No title]
Gestational Trophoblastic Disease is a term that includes several conditions that are the consequences of an abnormal pregnancy.
This may be either persistent mole, invasive mole (mole growing into the wall of the uterus), metastatic mole, usually to the lungs, or choriocarcinoma, which is a very serious cancer.
Gestational Trophoblastic Disease is characterized as either metastatic or nonmetastatic.
www.gyncancer.com /gest.html   (1873 words)

 Gestational Trophoblastic Disease
Gestational trophoblastic disease (GTD) encompasses a large group of neoplastic diseases arising from trophoblastic tissue.
Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviors.
In all gestations p57 KIP2 was strongly expressed in decidua and in intervillous trophoblast islands, which served as internal positive controls for p57 KIP2 immunostaining.
www.thedoctorsdoctor.com /diseases/gestationaltrophoblasticdisease.htm   (4642 words)

 CancerLIT: 708200
Paraffin sections of 16 cases of partial mole, 25 cases of complete mole, 10 cases of gestational choriocarcinoma and 11 cases of therapeutic abortion were studied immunohistochemically for EGFR, c-erbB-2, c-erbB-3 and c-erbB-4 proteins.
JEG-3 human choriocarcinoma cells were incubated with varying concentrations of interleukin 1-alpha, interleukin 1-beta, interleukin 2, gamma-interferon, granulocyte-macrophage colony stimulating factor and tumor necrosis factor-alpha, and the expression of EGFR was measured by radioimmunoassay using a murine monoclonal antibody with specificity for EGFR.
Staining for EGFR was detected immunohistochemically in all cell type in gestational trophoblastic diseases and normal placenta.
cancerweb.ncl.ac.uk /cancernet/cancerlit/708200.html   (239 words)

 GTN   (Site not responding. Last check: 2007-11-05)
Gestational trophoblastic tumors (GTTs) are rare but highly curable tumors arising from the products of conception in the uterus.
Gestational trophoblastic tumors may be classified as follows: [ 1 ]
Nonmetastatic gestational trophoblastic tumor is defined as no disease outside the uterus.
www.gyn-oncology.com /gtn.htm   (2821 words)

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