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Topic: Gestational trophoblastic disease


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In the News (Tue 21 May 19)

  
  Gestational Trophoblastic Disease
a group of several diseases, derived from the trophoblast, the cells that surround the embryo during gestation.
The trophoblasts - of which there are three, cytotrophoblast, synctitiotrophoblast, and intermediate trophoblast - contribute to the substance of the placenta.
Unlike other forms of GTD, villi formation is absent and the cells are markedly pleomorphic, with little resemblance to trophoblasts in some cases.
www.oncodx.com /onco/gestatinal.htm   (572 words)

  
  Malaysia Medical Association   (Site not responding. Last check: )
Gestational trophoblastic disease is a heterogenous group of neoplastic disorders, which originate from the placental trophoblastic epithelium.
Gestational trophoblastic disease comprises a wide spectrum of conditions, which may vary in their clinical presentations, malignant potential and outcomes.
Ultrasonography is a sensitive non-invasive investigation for the diagnosis of gestational trophoblastic disease.
www.mma.org.my /mjm/5_gestational_04.htm   (2106 words)

  
  Gestational trophoblastic disease - Wikipedia, the free encyclopedia
CCA, PSTT and ETT are frank malignant tumors of trophoblast.
GTD - usually referred to as a mole — is a very rare abnormality of pregnancy in the reproductive female that involves abnormal trophoblast proliferation.
It is the result of a (purely chance) genetic error during the fertilization process that in turn causes the growth of abnormal tissue (which is not an embryo) within the uterus.
en.wikipedia.org /wiki/Gestational_trophoblastic_disease   (398 words)

  
 Gestational Trophoblastic Disease - New Treatments, May 2, 2006
Gestational trophoblastic disease encompasses four types of growth disturbances of the placenta: 1) hydatidiform mole (complete and partial), 2) invasive mole, 3) choriocarcinoma, and 4) placental-site trophoblastic tumor.
Gestational trophoblastic tumor is most often diagnosed by a rise or plateau in hCG levels after evacuation of a molar pregnancy.
Gestational trophoblastic tumors should be distinguished from retained products of conception or endometritis as causes of postpartum uterine bleeding and subinvolution, primary or metastatic tumors of other organ systems, and another pregnancy occurring shortly after the first.
ccspublishing.com /journals3a/gestational_trophoblastic_neoplasia.htm   (1452 words)

  
 Molar Pregnancy and Gestational Trophoblastic Disease - New Treatments, May 2, 2007
Gestational trophoblastic disease encompasses four clinicopathologic forms of growth disturbances of the human placenta: 1) hydatidiform mole (complete and partial), 2) invasive mole, 3) choriocarcinoma, and 4) placental-site molar pregnancy.
Gestational trophoblastic tumor extends outside uterus but is limited to genital structures with one risk factor.
Gestational trophoblastic tumor extends to lungs with or without genital tract involvement and with one risk factor.
www.ccspublishing.com /journals4a/gestational_trophoblastic.htm   (1005 words)

  
 Gestational Trophoblastic Disease - New Treatments, May 2, 2007
Gestational trophoblastic disease encompasses four types of growth disturbances of the placenta: 1) hydatidiform mole (complete and partial), 2) invasive mole, 3) choriocarcinoma, and 4) placental-site trophoblastic tumor.
Gestational trophoblastic tumor is most often diagnosed by a rise or plateau in hCG levels after evacuation of a molar pregnancy.
Gestational trophoblastic tumors should be distinguished from retained products of conception or endometritis as causes of postpartum uterine bleeding and subinvolution, primary or metastatic tumors of other organ systems, and another pregnancy occurring shortly after the first.
www.ccspublishing.com /journals3a/gestational_trophoblastic_neoplasia.htm   (1452 words)

  
 ACS :: What Is Gestational Trophoblastic Disease?
Gestational trophoblastic disease (GTD) is actually a group of several diseases -- all involve abnormal growth of cells inside a woman's uterus.
This category refers to GTD that has not been cured by local surgery (see the section, "How Is Gestational Trophoblastic Disease Treated?").
Placental-site trophoblastic tumor (PSTT) is a rare form of GTD that develops where the placenta attaches to the uterus.
www.cancer.org /docroot/cri/content/cri_2_4_1x_what_are_gestational_trophoblastic_disease_49.asp?sitearea=cri   (882 words)

  
 Gestational Trophoblastic Disease -Gynocologic Malignancies
Human chorionic gonadotrophin (hCG) is produced by the proliferated trophoblastic tissue, and high serum levels of the β subunit of hCG (β-hCG) aid in the diagnosis of a gestational trophoblastic disease.
If persistent gestational trophoblastic disease is diagnosed and the patient requires chemotherapy, she should take oral contraceptives for 12 mo after successful treatment.
Gestational trophoblastic disease does not compromise fertility and does not increase the incidence of congenital anomalies, pregnancy wastage, or prenatal or perinatal complications.
www.health.am /cr/more/gestational-trophoblastic-disease   (825 words)

  
 Women's Health & Education Center - Obstetrics - Gestational Trophoblastic Disease: A Comprehensive Review
The incidence of various forms of gestational trophoblastic disease in the United States is approximately 1 in 600 therapeutic abortions and 1 in 1,500 pregnancies.
The term invasive mole is used to describe disease confined to the uterus and is characterized by the presence of edematous chorionic villi with trophoblastic proliferation that invade directly into the myometrium.
Patients with metastatic disease are further sub-divided depending on the presence or absence of factors that correlate with response to initial single-agent chemotherapy.
www.womenshealthsection.com /content/obs/obs015.php3   (3652 words)

  
 Cancer Information, Research, and Treatment for all Types of Cancer | OncoLink
Gestational trophoblastic tumor, a rare cancer in women, is a disease in which cancer (malignant) cells grow in the tissues that are formed following conception (the joining of sperm and egg).
Once gestational trophoblastic tumor has been found, more tests will be done to find out if the cancer has spread from inside the uterus to other parts of the body (staging).
Treatment of gestational trophoblastic tumor depends on the stage of the disease, and the patient's age and overall condition.
www.oncolink.com /types/article.cfm?c=6&s=22&ss=176&id=9061   (2123 words)

  
 Gestational Trophoblastic Disease: Gynecologic Tumors: Merck Manual Professional
Gestational trophoblastic disease is proliferation of trophoblastic tissue in pregnant or recently pregnant women.
Gestational trophoblastic disease is a tumor originating from the trophoblast, which surrounds the blastocyst and develops into the chorion and amnion (see Conception and Prenatal Development).
Gestational trophoblastic disease does not impair fertility or predispose to prenatal or perinatal complications (eg, congenital malformations, spontaneous abortions).
www.merck.com /mmpe/sec18/ch254/ch254f.html   (709 words)

  
 Channel3000.com - Health Encyclopedia - Gestational Trophoblastic Disease
A possible symptom is continued vaginal bleeding in a woman with a recent history of hydatidiform mole, abortion, or term pregnancy.
Nearly all women with malignant, nonmetastatic disease are cured, with more than 90% preserving reproductive function.
Disease has spread to the liver or brain.
www.channel3000.com /encyclopedia/6862101/detail.html   (748 words)

  
 Article
In estimating prognosis and adequate therapy of disease, the most significant are clinical factors: serum hCG level, duration of the disease from termination of antecedent pregnancy, prior chemotherapy, brain or liver metastases.
In the Institute of Oncology in Sremska Kamenica 32 patients with gestational trophoblastic disease were treated in the period from 1987 to 2001.
Treatment failures occurred in advanced disease with brain and liver metastasis Specificity and low incidence of this disease ask for the treatment to be carried out in specialized centers, as it is in developed countries (Trophoblastic Disease Centers).
dx.doi.org /10.2298/AOO0202071Z   (241 words)

  
 Gestational Trophoblastic Tumors
A diagnosis of nonmetastatic trophoblastic disease is made when there are persistently elevated HCG titers or a tissue diagnosis of uterine choriocarcinoma in the absence of detectable metastatic disease.
Of utmost importance in treating patients with gestational trophoblastic tumors is instituting therapy as quickly as possible and continuing chemotherapy at very close intervals until normal BHCG titers are obtained.
For resistant high-risk gestational trophoblastic tumors (GTT), combinations of etoposide, cisplatin, and either dactinomycin or bleomycin have shown promising results.[2] [3] A patient who has failed primary surgical therapy is generally treated with single-agent chemotherapy unless one of the poor-prognosis factors that requires combination chemotherapy supervenes.
www.cancersource.com /Oncology/NCI/48,CDR0000062901   (2790 words)

  
 Gestational Trophoblastic - Cancer Overview - GCC
Gestational trophoblastic disease is a group of diseases in which abnormal cells grow inside a woman's uterus in the tissues that are formed following conception (the joining of sperm and egg).
The disease can take several different forms, and not all of them are cancerous.
Unlike other forms of gestational trophoblastic disease, placental-site tumors are not responsive to chemotherapy drugs and must be treated with surgery.
www.umgcc.org /overview/gesta.html   (349 words)

  
 CancerLink - Gestational Trophoblastic Disease
The conditions are molar pregnancy, invasive mole, metastatic mole and gestational choriocarcinoma.
In the beginning, a single egg produced by the mother is fertilized by a single sperm from the father.
Gestational trophoblastic disease is characterized as either metastatic or nonmetastatic.
www.njh.u-net.com /cgest.html   (1388 words)

  
 Lifespan's A - Z Health Information Library - Gestational trophoblastic disease
Gestational trophoblastic disease is a quick growing form of cancer that occurs in a woman's uterus after a pregnancy, miscarriage, or abortion.
Gestational trophoblastic disease is also called a choriocarcinoma.
Chorioblastoma; Choriocarcinoma; Trophoblastic tumor; Chorioepithelioma; Invasive/malignant mole; Gestational trophoblastic neoplasia
www.lifespan.org /adam/healthillustratedencyclopedia/1/001496.html   (548 words)

  
 Dr. Schilling's Net Health Book - What's New With Gestational Trophoblastic Disease
This is achieved by uterine resection of local disease and subsequent reconstruction of the uterus.
It is a progessively invasive disease, which starts with retained placenta that gradually experiences a metamorphosis from a hydatidiform mole to an invasive mole and finally to a choriocarcinoma.
The best results, particularly in the later stages of this disease, appear to be achieved in the large Cancer Centers who constantly update their treatment protocols according to the latest data base.
www.nethealthbook.com /whatsnewregardinggestationaltrophoblasticdisease.html   (567 words)

  
 Gestational trophoblastic disease - Washington, DC
Gestational trophoblastic disease - Washington, DC Contact
Gestational trophoblastic disease, or choriocarcinoma, is an aggressive, malignant, often metastatic (spreading) cancer in the uterus that begins following a pregnancy, a miscarriage, or an abortion.
A possible symptom is continued vaginal bleeding in a woman with a recent history of hydatidiform mole, abortion, or term pregnancy.
www.georgetownuniversityhospital.org /body.cfm?id=555563&action=articleDetail&AEProductID=Adam2004_1&AEArticleID=001496   (662 words)

  
 Gestational Trophoblastic Disease (Hydatidiform Mole & Choriocarcinoma) -Gynecology And Obstetrics Articles
Gestational trophoblastic disease is a spectrum of disorders that includes hydatidiform mole, invasive mole, and choriocarcinoma.
Partial moles generally show evidence of an embryo or gestational sac; are polyploid, slower-growing, and less symptomatic; and often present clinically as a missed abortion.
The highest rates of gestational trophoblastic disease occur in some developing countries, with rates of 1:125 pregnancies in certain areas of Asia.
www.health.am /gyneco/more/gestational_trophoblastic_disease_hydatidiform_mole   (870 words)

  
 Gestational Trophoblastic Disease, GTD, Information, Seattle, Washington, gynecologic cancers, support, appointment at ...
Gestational trophoblastic disease includes several conditions that occur during pregnancy or shortly thereafter.
The pregnancy that triggers GTD may be a miscarriage, a tubal pregnancy or a full-term pregnancy in which a normal baby is delivered.
No one at SCCA will tell you that a diagnosis of metastatic GTD is not serious, but there is hope, especially if the cancer has not spread to the liver or brain, you have not received prior chemotherapy, your last pregnancy was less than four months ago and your blood levels of HCG are low.
www.seattlecca.org /patientsandfamilies/adultCare/clinicalProgs/GestationalTrophoblasticDisease/PatientEducation   (498 words)

  
 Gestational Trophoblastic Disease
Gestational trophoblastic disease (GTD) encompasses a large group of neoplastic diseases arising from trophoblastic tissue.
Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviors.
Human trophoblast is composed of a heterogeneous population of cells, which give rise to a variety of trophoblastic tumors and tumor-like lesions.
www.thedoctorsdoctor.com /diseases/gestationaltrophoblasticdisease.htm   (4886 words)

  
 Gestational Trophoblastic - Cancer Overview - GCC
Gestational trophoblastic disease is a group of diseases in which abnormal cells grow inside a woman's uterus in the tissues that are formed following conception (the joining of sperm and egg).
The disease can take several different forms, and not all of them are cancerous.
Unlike other forms of gestational trophoblastic disease, placental-site tumors are not responsive to chemotherapy drugs and must be treated with surgery.
www.umm.edu /cancer/gyn_program/gesta.htm   (349 words)

  
 Gestational Trophoblastic Tumors Treatment - National Cancer Institute
The hCG, produced normally during pregnancy, is abnormally elevated in the blood and urine of patients with this group of diseases and is a sensitive marker to indicate the presence or absence of disease before, during, and after treatment.
A study found recurrence of disease in 2.5% of patients with nonmetastatic disease, 3.7% of patients with good-prognosis metastatic disease, and 13% of patients with poor-prognosis metastatic disease.[1] All recurrences were within 36 months of remission (85% before 18 months).
For resistant high-risk gestational trophoblastic tumors (GTTs), combinations of etoposide, cisplatin, and either dactinomycin or bleomycin have shown promising results.[2,3] A patient who has failed primary surgical therapy is generally treated with single-agent chemotherapy unless one of the poor-prognosis factors that requires combination chemotherapy supervenes.
www.cancer.gov /cancertopics/pdq/treatment/gestationaltrophoblastic/healthprofessional/allpages/print   (3070 words)

  
 Gestational Trophoblastic Disease (GTD) - Female and Gynecologic Cancers - Stanford Cancer Center
Gestational trophoblastic disease (GTD) is actually a set of diseases that arise from cells related to pregnancy that become cancerous.
GTD occurs following fertilization when placenta forms in the absence of a fetus, or with a partial and abnormal fetus.
Detection, treatment, and especially follow-up care are critical for a women with GTD because treatment almost always results in a cure, but the disease can reoccur and needs to be addressed promptly.
cancer.stanford.edu /female/gestational.html   (278 words)

  
 eMedicine - Hydatidiform Mole : Article by Lisa E Moore
Gestational trophoblastic disease encompasses several disease processes that originate in the placenta.
Predicting who will develop gestational trophoblastic disease remains difficult, and treatment decisions should not be based on the presence of any or all of these risk factors.
The risk for malignant disease with metastasis is high, as is the risk of maternal morbidity from bleeding, eclampsia, or other complications of the molar gestation.
www.emedicine.com /MED/topic1047.htm   (2633 words)

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