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Topic: Gestrinone

	Gestrinone - Drug information from Medic8.com
		Gestrinone is a synthetic steroid hormone that acts as an anti-progestin and also has some androgenic activity.
		The inhibition is the result of gestrinone's interaction with the androgen receptor; this is also the reason for androgenic side effects.
		Gestrinone has been shown to interact with the oestrogen receptor, the androgen receptor, and the progesterone receptor.
	www.medic8.com /medicines/Gestrinone.html (408 words)

	Dimetriose
		Gestrinone is a synthetic hormone which acts on a part of the brain called the pituitary gland.
		Gestrinone is used to treat a condition called endometriosis, in which the tissue (endometrium) normally lining the womb grows on different organs outside the womb.
		Gestrinone is also thought to act directly on the endometrial tissues to prevent their growth.
	www.netdoctor.co.uk /medicines/100000782.html (671 words)

	Gestrinone - Patient UK
		Gestrinone opposes the effects of oestrogen and progesterone.
		Gestrinone is used in the treatment of endometriosis.
		Gestrinone is usually taken twice a week starting on the first day of your menstrual cycle with the second dose three days later.
	www.patient.co.uk /showdoc/30002548 (683 words)

	Scheda Pubblicazione (Site not responding. Last check: 2007-11-01)
		If amenorrhea was not obtained after 1 month of treatment, the gestrinone dose was increased to 2.5 mg three times a week (7 patients) and the danazol dose to 800 mg/day (2 patients).
		Pain symptoms recurred during the follow-up in 57% of the gestrinone and 53% of the danazol group.
		The results of this study suggest that gestrinone is as effective as danazol in the treatment of infertility associated with endometriosis and is better tolerated.
	centri.univr.it /ricerca/pubblica.asp?Azione=VediScheda&IDPubblicazione=9766&Tipo=Rivista (259 words)

	Data Sheet
		An absolute bioavailability study in a healthy adult showed that gestrinone is completely absorbed after oral administration, and that there is a negligible first pass effect.
		The use of gestrinone in the elderly or in children is not envisaged.
		Gestrinone at the recommended dose inhibits ovulation in many women but pregnancies do occur with this regimen and gestrinone must not be relied on for contraception.
	www.medsafe.govt.nz /Profs/Datasheet/d/Dimetriosecap.htm (778 words)

	New Drugs (Site not responding. Last check: 2007-11-01)
		Gestrinone is a synthetic steroid hormone which inhibits the release of pituitary gonadotrophins.
		Gestrinone is structurally related to norgestrel and has some androgenic and progestogenic activity.
		Although gestrinone is effective in relieving the symptoms of endometriosis, its effect on infertility is not clear.
	www.australianprescriber.com /magazines/vol19no1/new_drugs.htm (2039 words)

	TRIDOMOSE Capsules
		Gestrinone, a synthetic trienic 19-norsteroid, inhibits the pituitary gland.
		Apart from its anti-pituitary activity, gestrinone exhibits anti-progesterone and anti-estrogenic properties at the cellular receptor level of the endometrium as well as the extra-uterine ectopic implants as well as other estrogen and progesterone dependent tissue.
		Gestrinone is contra-indicated in pregnancy and during breast-feeding, epilepsy and severe cardiac, renal or hepatic dysfunction.
	home.intekom.com /pharm/hmr/tridomse.html (466 words)

	CSIRO PUBLISHING - Reproduction, Fertility and Development (Site not responding. Last check: 2007-11-01)
		An open comparative study of gestrinone and danazol in the treatment of endometriosis demonstrated a similar decrease in the extent of active endometriotic deposits, assessed visually following therapy.
		Biochemical endocrinological changes during therapy with gestrinone showed that basal concentrations of gonadotrophin remained unchanged, oestradiol concentrations varied and the free fraction of testosterone increased.
		A similar range of side effects was reported in both treatment groups, consisting predominantly of 'androgenic' effects in 10 of 15 women treated with gestrinone and 5 of 12 treated with danazol.
	www.publish.csiro.au /nid/44/paper/RD9930103.htm (138 words)

	Gestrinone (Generic) - No Prescription, Lowest Price - Buy Online Gestrinone Pharmacy - Order Discount Gestrinone Drug ... (Site not responding. Last check: 2007-11-01)
		Gestrinone (Generic) is a synthetic hormone which acts on a part of the brain called the pituitary gland.
		Gestrinone (Generic) is used to treat a condition called endometriosis, in which the tissue (endometrium) normally lining the womb grows on different organs outside the womb.
		Gestrinone (Generic) may also be used to treat other conditions as determined by your doctor.
	www.mynetmeds.com /Gestrinone.htm (370 words)

	ESPN.com: GEN - A look inside the feds' THG probe
		Gestrinone itself is not very anabolic (or muscle producing).
		But since Gestrinone is primarily used to treat female infertility, the inventor needed to alter it a bit.
		Terry Madden, head of the U.S. Anti Doping Agency, calls THG "a very sophisticated designer steroid created by a very sophisticated chemist." But it may also be what William Llewellyn, a supplement maker and author of the book Anabolics 2004, calls a steroid of opportunity.
	espn.go.com /gen/news/2003/1112/1659917.html (1782 words)

	Scheda Pubblicazione (Site not responding. Last check: 2007-11-01)
		Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy.
		The ultrastructural investigation demonstrated complete involution of the cytoplasmic organelles with cytoplasmic collapse in glandular cells of patients treated with danazol, whereas in the gestrinone group degeneration phenomena were observed in both nucleus and cytoplasm.
		Long-term treatment with danazol caused endometrial atrophy similar to that induced by gestrinone, but it appeared earlier; thus, the former drug seems preferable in short-term treatment.
	centri.univr.it /ricerca/pubblica.asp?Azione=VediScheda&IDPubblicazione=9716&Tipo=Rivista (203 words)

	New Page 168
		Gestrinone (Dimetriose, Florizel) is used for treating endometriosis.
		The modifications made the drug undetectable in steroid tests, which is the reason for all the current hype on "THG".
		Gestrinone was modified at the 17a-position which then made THG an oral steroid.
	www.trenmarcnews.com /new_page_168.htm (916 words)

	Women's Health: Q 23 (Site not responding. Last check: 2007-11-01)
		Elimination or reduction of visible endometriosis was seen at laparoscopy after treatment in 42 (77 per cent) of gestrinone and 39 (82 per cent) of danazol treated patients.
		Side effects were reported by 91 per cent of gestrinone and 89 per cent of danazol patients, but only 19 per cent of the gestrinone group and 21 per cent in the danazol group withdrew.
		In conclusion, gestrinone is as safe and effective as danazol in treating and in preventing recurrence of the symptoms of endometriosis.
	2womenshealth.co.uk /23-21-656.htm (248 words)

	ELIZABETH ANNE HANLEY
		More recently, spectroscopy has been used clinically to diagnose equivocal brain lesions and research is still being undertaken using spectroscopy to monitor the response to certain treatments, e.g.
		In the Royal Preston Hospital, inoperable meningiomas are treated with the antiprogesterone drug Gestrinone.
		This treatment is usually monitored conventionally by contrasted CT or MRI Monitoring this treatment by spectroscopy would determine if there were any significant alteration in the brain metabolites because of this drug.
	web.apu.ac.uk /appsci/radiography/abstracts/ehdiss.htm (301 words)

	Cayman Chemical \| Gestrinone \| Description
		Gestrinone is a synthetic steroid used occasionally to treat endometriosis.
		Gestrinone binds to AR and PR with EC50 values of approximately 20 nM and 30 nM, respectively.
		Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol.
	www.caymanchem.com /app/template/Product.vm/catalog/10006488/tab/description/a/z (231 words)

	SuperiorMuscle - Tetrahydrogestrinone (THG) & Erythropoietin (EPO)
		Using a yeast-based in vitro bioassay, the investigators examined the biologic interactions of THG with the human androgen receptor (AR), progesterone receptor (PR), and estrogen receptor (ER).
		THG agonist activity in the AR bioassay was compared with that of gestrinone, its parent compound, the structurally similar steroid trenbolone, and nandrolone, used as a positive androgen control.THG strongly activated AR transactivation when compared with the other steroids.
		THG was synthesized by hydrogenation of gestrinone and characterized by mass spectrometry and NMR spectroscopy.
	www.superiormuscle.com /vbulletin/printthread.php?t=21640 (1433 words)

	C&EN: SCIENCE & TECHNOLOGY - DESIGNER STEROID ROCKS SPORTS WORLD
		THG is thought to be derived from gestrinone, a synthetic steroid used to treat gynecological disorders.
		Both gestrinone and trenbolone are listed as anabolic steroids in the IOC/ WADA Olympic Movement Anti-Doping Code, which is also generally adhered to by professional sports leagues.
		Tetrahydrogestrinone is a new synthetic steroid similar to the synthetic steroids gestrinone and trenbolone.
	pubs.acs.org /cen/science/8146/8146sci2.html (2632 words)

	CBC Sports Online: Drugs and Sport: Frequently Asked Questions on THG (Site not responding. Last check: 2007-11-01)
		Designer steroids such as THG are not naturally produced by the body and cannot be taken unintentionally.
		THG is a slightly altered form of steroid related to gestrinone and grenbolone.
		Gestrinone is used legally in Europe to treat endometriosis, a painful condition caused by uterine tissue growing in the pelvic area of some women.
	www.cbc.ca /sports/indepth/drugs/stories/thg_faq.html (477 words)

	Testosterone Nation - Cy-BORG
		As far as its half-life, simply judging from the fact that gestrinone's is around 24 hours, yet THG has an ethyl group instead of an ethinyl at the C-17, its half-life is likely to be shorter than that of gestrinone probably due to a decrease in electron-pair domain size, but probably not by too much.
		Gestrinone is reported in the literature as being slightly androgenic, strongly anti-estrogenic and possessing anti-progestogenic properties.
		You'd expect the substitution of the ethinyl in gestrinone for ethyl in THG to reduce progestogenic activity, but it increases it according to the assay as THG is nearly seven times more progestogenic than progesterone itself.
	www.t-nation.com /findArticle.do;jsessionid=9BEDDF95869058233D28AA372C5DDE9B.ba11?article=04-010-diet (2661 words)

	RemedyFind: patient ratings of Dimetriose for Endometriosis
		The basic approach in hormonal treatments for Endometriosis is to block production of female hormones (estrogen and progesterone) or to prevent ovulation with other hormonal effects.
		Dimetriose etc. (Gestrinone) is an antiprogestin hormone, a synthetic form of the male hormone testosterone which suppresses the output of pituitary gonadotrophins resulting in lowering of ovarian sex hormone production.
		Unfortunately, as Gestrinone causes estrogen defiency, adverse side effects are common and include: headaches; flushing; sweating; acne; edema; deepening of the voice and weight gain.
	www.remedyfind.com /rem.asp?id=5751 (376 words)

	Chin Med J (Taipei) 1996;58:89-96. (Site not responding. Last check: 2007-11-01)
		An oral synthetic 19 norsteroid (gestrinone) characterized by antigonadotropic activity and antioestrogenic properties provides its use in the treatment of oestrogen depending pathologic conditions.
		The purpose of this open study is to evaluate the efficacy and tolerance of gestrinone in the treatment of endometriosis.
		Gestrinone 2.5 mg given twice a week for six months provides an effective and safe treatment for those women suffering from endometriosis.
	www.vghtpe.gov.tw /~cmj/5802/580204.htm (266 words)

	Tetrahydrogestrinone Is a Potent Androgen and Progestin -- Death et al. 89 (5): 2498 -- Journal of Clinical ...
		gestrinone by reduction of the 17-ethynyl group to an ethyl
		Kim Y, Lee Y, Kim M, Yim YH, Lee W 2000 Determination of the metabolites of gestrinone in human urine by high performance liquid chromatography, liquid chromatography/mass spectrometry and gas chromatography/mass spectrometry.
		Kim Y, Lee Y, Kim M, Yim YH, Lee W 2000 Determination and excretion study of gestrinone in human urine by high performance liquid chromatography and gas chromatography/mass spectrometry.
	jcem.endojournals.org /cgi/content/full/89/5/2498 (1661 words)

	CBC News Indepth: Steroids (Site not responding. Last check: 2007-11-01)
		THG is a slightly altered form related to steroids Gestrinone and Trenbolone.
		Gestrinone is used legally in Europe to treat endometriosis, a painful condition caused by uterine tissue growing in the abdomen.
		The main reason was the similarity in its chemical structure to the steroid Gestrinone, already on the banned list.
	www.cbc.ca /news/background/steroids (2349 words)

	Endometriosis
		Progestins may also be used alone, since they have specific effects that can cause the endometrial tissue itself to atrophy.
		Inducing Pseudomenopause: Gonadotropin-releasing hormone (GnRH) agonists or gestrinone, an anti-progesterone that mimic menopause.
		Gestrinone is the most studied antiprogestin and may be comparable to GnRH agonists in reducing pain and have fewer menopausal symptoms.
	www.lifespan.org /ADAM/English/WellConnected/000074_8.htm (1882 words)

	Uterine Fibroids and Hysterectomy --- HealthandAge (Site not responding. Last check: 2007-11-01)
		Gestrinone has been shown to reduce uterine volume and stop bleeding.
		In one study, 89% of the women maintained a smaller uterine for at least 18 months after stopping the treatment.
		Adverse effects of gestrinone include male hormone symptoms, such as acne, and possibly the development of unhealthy cholesterol levels.
	www.healthandage.com /PHome/gid6=7308 (1156 words)

	PJ Online \| News feature: Hot on the heels of new drugs in sport: undetectable or just not yet detected?
		Tetrahydrogestrinone (THG) is a derivative of an existing steroid gestrinone.
		A licensed version of gestrinone (Dimetriose, Florizel) is available for treating endometriosis.
		Modification of gestrinone at the 17a-position confers oral activity, like ethinylestradiol, and THG has been reported to be administered under the tongue.
	www.pharmj.com /Editorial/20031101/news/news_drugsinsport.html (1005 words)

	Gestrinonum (Gestrinone) - Buy Gestrinonum online, no prescription slips (Site not responding. Last check: 2007-11-01)
		Description: Gestrinonum (Gestrinone) is a synthetic hormone which acts on a part of the brain called the pituitary gland.
		Gestrinonum (Gestrinone) is used to treat a condition called endometriosis, in which the tissue (endometrium) normally lining the womb grows on different organs outside the womb.
		The local name is listed when you order discount Gestrinonum (Gestrinone) if it differs from the US name.
	www.buy-online-prescription.com /Gestrinonum.htm (294 words)

	Untitled Document
		Enlargement of the clitoris occurs in about one percent of women taking the drug; noticeable change should mean stopping the danazol, because an increase in size can be permanent.
		Most people won’t notice a semitone loss in vocal range, but the loss may be critical for a singer, who needs not just her best vocal range but also confidence in the power of her voice over that range.
		Gestrinone has also been reported to deepen the voice.
	www.jansen.com.au /silver/16_B.htm (237 words)

	SuperiorMuscle - View Single Post - New steroid: THG
		gestrinone is very similar to trenbolone in structure with the same pattern of double bonds and lack of a 19-methyl group.
		The differences are that the 13-methyl group in trenbolone is replaced with a 13-ethyl group in gestrinone and it is 17-alkylated with an acetylene function.
		If the acetylene function was fully hydrogenated (adding 4 hydrogens), that could be tetrahydrogestrinone.
	www.superiormuscle.com /vbulletin/showpost.php?p=82592&postcount=9 (178 words)

	Gestrinon (Gestrinone) UK - No Prescription, Lowest Price. Buy Gestrinon Online Pharmacy Chemist- Order Discount ... (Site not responding. Last check: 2007-11-01)
		Therapeutic Indications: Gestrinon (Gestrinone) is a synthetic hormone which acts on a part of the brain called the pituitary gland.
		Gestrinon (Gestrinone) is used to treat a condition called endometriosis, in which the tissue (endometrium) normally lining the womb grows on different organs outside the womb.
		The study found that between 1977 and 2001 the amount of energy that Americans get from soft drinks has tripled from 50 to 144 calories a day, while energy intake from milk declined from 143 calories to 99 calories a day.
	www.prescription-mexico.co.uk /Gestrinon.htm (346 words)

	F.M. PRIMIERO, G. COZZA, S. BIANCHI, L. FEDELE, Endocrinologia 2001 - bibliografia (Site not responding. Last check: 2007-11-01)
		Endocrine, metabolic and clinical effects of gestrinone in women with endometriosis.
		Interaction of gestrinone with human plasma steroid-binding proteins.
		48 Donnez J, Nisolle M, Clerckx F, Casanas F. Evaluation of preoperative use of danazol, gestrinone, lynestrenol, buserelin spray and buserelin implant in the treatment of endometriosis associated infertility.
	www.apog.it /Endo/endo01/pri_bib.htm (2045 words)

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