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Topic: Gingerol

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	Interactions of 6-Gingerol and Ellagic Acid with the Cardiac Sarcoplasmic Reticulum Ca2+-ATPase -- Antipenko et al. ...
		In the present study, we investigated the effects of gingerol and ellagic acid on the Ca pump using purified (light) cardiac SR vesicles.
		Microsomes were incubated for 2 min (A) in the presence of either the indicated concentrations of gingerol or ellagic acid or the vehicle alone or (B) in the presence of 50 µM gingerol or the vehicle alone for the indicated times before the addition of 9 µM Ca to start the Ca uptake reaction.
		To determine whether the effect of gingerol was the result of stimulation of the Ca pump or of an inhibition of a parallel efflux pathway, Ca -ATPase activity was assayed in the presence and absence of 50
	jpet.aspetjournals.org /cgi/content/full/290/1/227 (4675 words)

	Ginger Constituents
		Sedative: 1,8-cineole ; 6-gingerol ; 6-shogaol ; alpha-pinene ; alpha-terpineol ; benzaldehyde ; borneol ; bornyl-acetate ; caffeic-acid ; citral ; citronellal ; citronellol ; eugenol ; farnesol ; geraniol ; geranyl-acetate ; gingerol ; isoborneol ; isoeugenol ; limonene ; linalool ; perillaldehyde ; shogaol
		Sedative: 1,8-cineole ; 6-gingerol ; 6-shogaol ; alpha-pinene ; alpha-terpineol ; benzaldehyde ; borneol; bornyl-acetate ; caffeic-acid ; citral ; citronellal ; citronellol ; cumene ; eugenol ; farnesol; geraniol; geranyl-acetate ; gingerol ; isoborneol ; isoeugenol ; limonene ; linalool; erillaldehyde; shogaol
		Sedative: 1,8-cineole ; 6-gingerol ; 6-shogaol ; alpha-pinene ; alpha-terpineol ; benzaldehyde ; borneol ; bornyl-acetate ; caffeic-acid ; citral ; citronellal ; citronellol ; cumene ; eugenol ; farnesol ; geraniol; eranyl-acetate; gingerol ; isoborneol ; isoeugenol ; limonene ; linalool; perillaldehyde ; shogaol
	www.riverhillwellness.com /ginger.htm (849 words)

	Gingerol - Wikipedia, the free encyclopedia
		Gingerol, or sometimes [6]-gingerol, is the active constituent of fresh ginger.
		Chemically, gingerol is a relative of capsaicin, the compound that gives chile peppers their spiciness.
		Cooking ginger transforms gingerol into zingerone, which is less pungent and has a spicy-sweet aroma.
	en.wikipedia.org /wiki/Gingerol (99 words)

	GINGEROL
		Gingerol is the principal flavor and odor constituent of ginger, structurally similar to vanilloid.
		Various chain length gingerol exist such as 6-gingerol, 8-gingerol and 10-gingerol.
		Gingerol is used as a flavor and in perfumery to be responsible for spicy aroma.
	www.chemicalland21.com /lifescience/UH/GINGEROL.htm (55 words)

	SuperCool Health
		SuperCool™Gingerol™ is an enhanced ginger product, which is standardized by the bioactive constituents, gingerols and shogaols.
		Ginger is on the FDA’s GRAS (generally regarded as safe) list as a food.
		Aphios' scientists and engineers utilized its patented polarity-guided SuperFluids™ fractionation and manufacturing technologies to develop its enhanced ginger product with a standardized concentration of gingerol and shogaol.
	www.supercoolhealth.com /Products/supercoolgingerol.htm (179 words)

	African Ginger
		Gingerol is an acrid constituent, responsible for much of the herb's hot taste and stimulating properties.
		The pungency of gingerol, in contrast to that of capsicum, is destroyed by heating with alkaline hydroxides.
		The gingerols alone are thought to be responsible for ginger's action as a liver protective.
	www.herbalafrica.co.za /HerbsAGinger.htm (980 words)

	Ciatra The Solution - Love Life Again (Site not responding. Last check: 2007-10-27)
		Gingerol, the active compound in Ginger is valued for its cardio-tonic properties.
		In a potent 4:1 ratio extract form, concentrated levels of Gingerol stimulate peripheral circulation to the extremities resulting in a warming effect on the testicles and improved functioning of penile muscles.
		Elevated quantities of Gingerol serve as an effective stress neutralizer by helping to reduce high blood pressure and cholesterol while improving appetite and digestion and relieving nausea.
	www.gociatra.com /ProductInfo.htm (1494 words)

	Gingerol Content of Diploid and Tetraploid Clones of Ginger (Zingiber officinale Roscoe)
		The gingerols are thermally unstable and can be converted to their corresponding shogaols, which are present in dried ginger.
		One cultivar known as "Jamaican" contained the highest concentrations of all three gingerols and was the most pungent of the clones analyzed.
		In contrast to previous findings, this study did not find significant differences in gingerol concentrations between the tetraploid clones and their parent diploid cultivar.
	pubs.acs.org /cgi-bin/abstract.cgi/jafcau/2005/53/i14/abs/jf050435b.html (231 words)

	1: article in Ginger / Materia Medica / Herbs / Alternative Medicine - UltimateHealthGuide.com (Site not responding. Last check: 2007-10-27)
		The active constituent of fresh ginger is gingerol, a relative of capsaicin.
		The chacteristic odor and flavor of ginger root is caused by a mixture of zingerone, shoagoles and gingerols, volatile oils that compose about 1%â“3% by weight of fresh ginger.
		The gingerols have analgesic, sedative, antipyretic, antibacterial, and GI tract motility effects.
	www.ultimatehealthguide.com /guide/alternative_medicine/herbs/materia_medica/ginger/articles (1010 words)

	Buderim Ginger
		Researchers from the University of Minnesota's Hormel Institute in Austin, fed half a milligram of [6]-gingerol to mice genetically engineered not to have an immune system three times a week before and after they were injected with human bowel tumour cells.
		Tumours were allowed to grow until they reached a size of one cubic centimetre (0.06 cubic inch), after which the mice were put to sleep.
		By day 49, all the control mice had been killed because they had developed tumours of one cubic centimetre or more, but 12 of the gingerol mice were still alive and their average tumour size was about half the maximum allowable size.
	www.buderimginger.com /commercial_info/news_events/news_article.asp?intCode=19 (602 words)

	The Hidden Power in Produce: - UMass Medical School (Site not responding. Last check: 2007-10-27)
		Gingerol is anti leukemic by inducing apoptosis in leukemia cells
		Based upon these clinical and biologic observations, we propose to explore the efficacy of the natural compounds curcumin and gingerol in MDS because these two agents possess many of the effects that are desirable in MDS as described below.
		I would like to suggest therapy with these natural compounds including Gingerol 350mg tablets, 1 tablet twice a day and Curcumin 500mg tablets, 2 tablets twice a day may increase to 4 tablets twice a day as tolerated.
	www.umassmed.edu /hema_oncology/MDSInfo/produce.cfm (1138 words)

	Curcumin and Gingerol protocol for MDS - UMass Medical School (Site not responding. Last check: 2007-10-27)
		To test the efficacy of the natural compounds curcumin and gingerol in improving the cytopenias of patients with myelodysplastic syndromes.
		As the name implies, MDS is not a single disease but a collection of heterogeneous syndromes that share in common, a dysplastic morphology and the clinical presentation of variable cytopenias despite a generally cellular bone marrow (BM).
		Both curcumin and gingerol will be increased as tolerated to a maximum dose of 12 Gm/day for curcumin and 2.8 Gm/day for gingerol.
	www.umassmed.edu /hema_oncology/MDSInfo/curcuminandgingerol.cfm (3675 words)

	AICR: The Science of Sweets
		Laboratory studies have found gingerol may help destroy cancer cells and block the action of compounds that lead to inflammation, which might lead to higher cancer risk.
		Gingerol is also used for treating nausea and other digestive troubles.
		When ginger is dried, the gingerol breaks down and the compounds shogaols and zingerone form.
	www.aicr.org /site/News2?JServSessionIdr001=nbr1irygj1.app14b&abbr=pub_&page=NewsArticle&id=10949 (737 words)

	Method for treatment of inflammation and pain in mammals - Patent 6949260
		Effective amounts of a boswellic acid, a curcuminoid, a gingerol, a capsaicinoid, a bioflavonoid, and a vitamin C source, in various combinations, all preferably from a botanical source, are blended to form a dose for oral administration.
		Gingerols are compounds that also inhibit 5-lipoxygenase in humans, and therefore reduce biosynthesis of certain inflammatory thromboxanes.
		It is believed that the mechanism responsible for the beneficial effects of some of the ingredients described herein is the reduction of pain and inflammation by interference with the development of an exaggerated inflammatory response mediated by the activity of several enzymes catalyzing the synthesis of prostaglandins and leukotrienes and the inhibition of platelet aggregation.
	www.freepatentsonline.com /6949260.html (7071 words)

	WHFoods: Ginger
		In this research, ginger was shown to suppress the pro-inflammatory compounds (cytokines and chemokines) produced by synoviocytes (cells comprising the synovial lining of the joints), chrondrocytes (cells comprising joint cartilage) and leukocytes (immune cells).
		Gingerols, the main active components in ginger and the ones responsible for its distinctive flavor, may also inhibit the growth of human colorectal cancer cells, suggests research presented at the Frontiers in Cancer Prevention Research, a major meeting of cancer experts that took place in Phoenix, AZ, October 26-30, 2003.
		Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids.
	www.whfoods.com /genpage.php?tname=foodspice&dbid=72 (2925 words)

	BBC NEWS \| Health \| Ginger 'could halt bowel cancer'
		Researchers from the University of Minnesota's Hormel Institute in Austin, fed half a milligram of [6]-gingerol to mice genetically engineered not to have an immune system three times a week before and after they were injected with human bowel tumour cells.
		Tumours were allowed to grow until they reached a size of one cubic centimetre (0.06 cubic inch), after which the mice were put to sleep.
		By day 49, all the control mice had been killed because they had developed tumours of one cubic centimetre or more, but 12 of the gingerol mice were still alive and their average tumour size was about half the maximum allowable size.
	news.bbc.co.uk /1/hi/health/3221547.stm (652 words)

	Ginger Root For Motion & Morning Sickness Nausea
		Those fed 500 micrograms of gingerol (the source of ginger's spiciness) three times a week for two weeks developed fewer tumors after being injected with human colorectal carcinoma cells.
		Mice fed gingerol also survived longer, implying that the tumors grew slower, said Ann Bode, at the Hormel Institute at the University of Minnesota.
		But fed gingerol, the mice developed a "marked suppression" of cancer cells, leading researchers to conclude the extract fueled apoptosis, or cell death, or interfered with a cellular transcription process.
	www.femhealth.com /ginger.html (1002 words)

	OmniActives.com - Products - Ginger (Site not responding. Last check: 2007-10-27)
		Gingerol was reported to possess substantial antioxidant properties.
		Gingerol and structurally related pungent principles including shogaol exert inhibitory effects on biosynthesis of prostaglandins and leukotrienes which are associated with inflammation.
		Ginger is already well known for its benefits as a digestive aid and its ability to relieve cough/cold related discomfort.
	www.omniactives.com /ginger.htm (200 words)

	East West Herbs Lda (Site not responding. Last check: 2007-10-27)
		Convincing evidence that the gingerols, particularly 6-gingerol, do produce the anti-emetic action of ginger was provided by further animal studies also carried out by Yamahara and co-workers (10).
		Thus the efficacy of the ginger extract and the gingerol was found to be comparable to the established anti-emetic drug metoclopramide which was employed as a control in the experiment.
		The activity is probably associated with the pungent principles, particularly gingerol, and lack of standardisation on these activities may explain the lack of efficacy observed in earlier trials.
	www.ewh.pt /mrl/ginger.html (919 words)

	Gentle Ginger :: Nutrition facts - Herbal nutrition guide
		The antioxidant effect of ginger, from its constituents gingerol and zingerone, is comparable to synthetic antioxidants.
		Both gingerol and zingerone have been shown to be strong antioxidants, inhibiting oils from going rancid in the body.
		The pungent (hot) factor is due to gingerol, shogaols, and related phenolic ketones.
	www.alive.com /4159a6a2.php?current_topic=35 (715 words)

	HealthScout - Ginger Snaps Colon Cancer Growth in Mice (Site not responding. Last check: 2007-10-27)
		Control mice were treated the same but their food had no gingerol.
		Thirteen tumors of a size that could be measured were found in the control mice, but only four were found in the gingerol-treated mice.
		By the 28th day after injection, all mice in the control group had tumors of measurable size, but it took the gingerol-treated group until the 38th day to have tumors of measurable size, and even then one mouse had no measurable tumors.
	www.heartinfo.org /printerFriendly.asp?id=515765 (608 words)

	Green Tea Beneficial vs. Cancer
		Those fed 500 micrograms of gingerol (the source of ginger's spiciness) three times a week for two weeks developed fewer tumors after being injected with human colorectal carcinoma cells.
		Mice fed gingerol also survived longer, implying that the tumors grew slower, said Ann Bode, at the Hormel Institute at the University of Minnesota.
		But fed gingerol, the mice developed a "marked suppression" of cancer cells, leading researchers to conclude the extract fueled apoptosis, or cell death, or interfered with a cellular transcription process.
	www.holymtn.com /tea/GreenTeaBeneficial.htm (795 words)

	I don't ~~ there is SO MUCH I'd like to know! (zinc, ginger) (Site not responding. Last check: 2007-10-27)
		The gingerols have been found to exert a dose-dependent positive inotropic action at doses as low as 10-4 g/ml when applied to isolated atrial tissue.
		Ginger contains gingerol, a Ginger oleoresin (combination of volatile oils and resin) that accounts for the characteristic aroma of Ginger, and explain its therapeutic properties.
		Components of gingerol (zingiberone, bisabolene, camphene, geranial, linalool and borneol) have recently been studied and found to possess beneficial properties for the treatment of poor digestion, heartburn, vomiting and preventing motion sickness.
	www.dadamo.com /forum/archivea/config.pl?read=76262 (1579 words)

	About Ginger Root - Facts and Information (Site not responding. Last check: 2007-10-27)
		Gingerols, the main compound in ginger is valued for its therapeutic properties.
		It is an aromatic stimulant that improves digestion and appetite, aids absorption and distribution of nutrients and medicines into the body, powerful natural anti-emetic for morning, motion and postanesthesia sickness and reduces the side effects of drugs.
		Another study showed that a moderate amount of ginger is a safe remedy for morning sickness during pregnancy; it helps about 2 out of 3 sufferers.
	www.herbalfields.com /ginger.html (426 words)

	Research on gimger
		The gingerols are a group of structurally related polyphenolic compounds isolated from ginger and known to be the active constituents.
		Since Helicobacter pylori (HP) is the primary etiological agent associated with dyspepsia, peptic ulcer disease and the development of gastric and colon cancer, the anti-HP effects of ginger and its constituents were tested in vitro.
		One fraction of the crude extract, containing the gingerols, was active and inhibited the growth of all HP strains with an MIC range of 0.78 to 12.5 micrograms/ml and with significant activity against the CagA+ strains.
	www.eattheapple.com /ginger.htm (3701 words)

	Jamu Iboe: Produk:: Gingerine
		Ginger contains atsiri oil and oleoresin (gingerol) that has antiinflamation and analgesic effect, which helps to reduce muscle pains, inflamation caused by rheumatism.
		Antiinflamation effect from ginger work is useful to block the activity of siklooksigenase and lipooksigenase, therefore it helps reducing prostaglandin and leukotriens, the agents that caused inflamation.
		Gingerol and Atsiri Oil from ginger also functioned as a gastritis, therefore long term use won’t cause maag gastritis iritation.
	www.jamuiboe.com /eng/prod_gingerine.php (111 words)

	Health 24 - News, Cancer
		Bode and her colleagues fed 20 mice a half milligram of [6]-gingerol, the main component in ginger, three times a week, then injected human colorectal tumour cells into the mice.
		By the 28th day after injection, all mice in the control group had tumours of measurable size, but it took the gingerol-treated group until the 38th day to have tumours of measurable size, and even then one mouse had no measurable tumours.
		Depending on how the spice is processed, the amount of gingerol in ginger root varies, she adds, noting, We really don't know how much ginger root you would have to eat to get the same effect.
	www.health24.com /news/Cancer/1-898,25208.asp (658 words)

	Ginger - Zingiber officinale.
		Gingerols have been shown to be inhibitors of prostaglandin biosynthesis.
		Other scientific studies show that gingerol, one of the primary pungent principles of ginger, helps counter liver toxicity by increasing bile secretion.
		The dried roots have a synergistic action between compounds in the essential oil and pungent principles such as gingerol.
	www.herbphoto.com /education/monograph/ginger.html (2309 words)

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