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Topic: Glioblastoma

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	Glioblastoma Multiforme - My Child Has - Children's Hospital Boston
		Glioblastoma multiforme is a high-grade, or malignant, glioma, a tumor of the glial (supportive) tissue of the brain.
		Glioblastoma multiforme of the cerebral hemispheres and the diencephalon, so called supratentorial glioblastoma multiforme, produce non-specific symptoms as a result of increased pressure within the head, as well as more localizing symptoms as a function of their specific location, rate of growth and associated inflammation.
		Glioblastoma multiformes are aggressive tumors that infiltrate adjacent normal brain tissue.
	www.childrenshospital.org /az/Site962/mainpageS962P0.html (1673 words)

	Glioblastoma multiforme - Wikipedia, the free encyclopedia
		Glioblastoma multiforme, (GBM) also known as grade 4 astrocytoma is the most common and aggressive type of primary brain tumor, accounting for 52 percent of all primary brain tumors cases.
		Glioblastoma multiformes are characterized by the presence of small areas of necrotizing tissue that is surrounded by highly anaplastic cells.
		Although glioblastoma multiforme can be formed from lower grade astrocytomas, post-mortem autopsies have revealed that most glioblastoma multiforme are not caused by previous lesions in the brain.
	en.wikipedia.org /wiki/Glioblastoma_multiforme (1290 words)

	Glioblastoma Multiforme Tumors (Site not responding. Last check: 2007-10-31)
		Glioblastoma accounts for 30 percent of all brain tumors, and is the most common primary brain tumor of adults.
		A glioblastoma is a malignant tumor that originates from the supportive tissue of the brain, and grows from star-shaped, astrocyte cells.
		While there are low-grade astrocytomas, the grade IV glioblastomas are more common, completely malignant, and can grow very rapidly in the brain, growing over three to six months.
	www.health-alliance.com /learnabout/learn_Glioblastoma.htm (221 words)

	ACR Learning File Web
		Glioblastoma accounts for approximately half of the glial tumors and is thought to be a manifestation of rapidly progressive anaplasia in an astrocytoma.
		Multifocal CNS involvement and true multiplicity of glioblastoma occur rarely, as seen in the axial contrast-enhanced CT scans (Image.4) and coronal T2-weighted MR scans (Image.5) of a different patient with gliomatosis cerebri.
		Malignant astrocytoma and glioblastoma often microscopically infiltrate beyond the enhancing margin on CT and MR.
	www.learningfile.com /learning_file/viewcase.php?section=nu&case_num=404 (558 words)

	Glioblastoma \| Comprehensive Cancer Center of Wake Forest University
		Glioblastoma are any growth of abnormal cells or uncontrolled proliferation of cells in the brain.
		Glioblastoma involves any such growth that originates in the brain, rather than spreading to the brain from another part of the body.
		Glioblastoma that is deep or infiltrates brain tissue may be debulked (removal of much of the mass of the tumor to reduce its size) rather than removed.
	www1.wfubmc.edu /cancer/glioblastoma.html (254 words)

	Temodar® Approved by FDA for Newly Diagnosed Glioblastoma Patients
		Glioblastoma is one of the most common, and aggressive, types of primary brain cancer.
		When glioblastoma is present, glial cells become malignant and grow out of control.
		One obstacle in the treatment of brain cancer is the inability of the majority of chemotherapy agents to penetrate the blood-brain barrier.
	patient.cancerconsultants.com /news.aspx?id=33672 (620 words)

	Glioblastoma / Stereotactic Radiosurgery
		Glioblastoma multiforme is the most common grade IV tumor.
		Glioblastoma multiforme, a grade IV tumor, is a malignant astrocytoma that contains areas of dead tumor cells.
		Glioblastomas comprise 23% of primary brain tumors in the U.S., and are the most commonly diagnosed brain tumor in adults aged 45-74.
	www.irsa.org /glioblastoma.html (2318 words)

	Glioblastoma Multiforme Brain Tumors
		Glioblastoma multiforme is the highest grade glioma (grade 4) tumor and is the most malignant form of astrocytomas.
		General symptoms of this type of tumor are the same as for brain tumors.
		A neurologic evaluation should be done if a patient has slowly increasing signs of mental dysfunction, new seizures, persistent headaches or evidence that there is pressure inside the skull, such as vomiting or swelling or protrusion of the blind spot at the back of the eye.
	www.csmc.edu /5305.html (284 words)

	eMedicine - Glioblastoma Multiforme : Article by Jeffrey N Bruce, MD
		Macroscopically, glioblastomas are poorly delineated, with peripheral grayish tumor cells, central yellowish necrosis from myelin breakdown, and multiple areas of old and recent hemorrhages.
		The simultaneous presence in glioblastoma cells of mutant EGFR (EGFRviii) and PTEN was associated with responsiveness to tyrosine kinase inhibitors.
		Hochberg FH, Pruitt A: Assumptions in the radiotherapy of glioblastoma.
	www.emedicine.com /med/topic2692.htm (6713 words)

	glioblastoma
		Glioblastomas are fast growing astrocytomas that contain areas of dead (necrotic) tumor cells.
		Glioblastoma are difficult to treat although surgery, radiation therapy, steroids, and chemotherapy have shown the ability to prolong survival.
		Glioblastoma multiforme is characterized as highly invasive and rapidly growing astrocytomas, and scientists have sought for efficient treatment against malignant gliomas for a long time.
	www.denvernaturopathic.com /news/glioblastoma.html (5125 words)

	p53, mdm2, EGFR, and msh2 expression in paired initial and recurrent glioblastoma multiforme -- Stark et al. 74 (6): ...
		Analysis of mdm2 and p53 gene alterations in glioblastomas and its correlation with clinical factors.
		Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes.
		Distinct radiochemotherapy protocols differentially influence cellular proliferation and expression of p53 and bcl-2 in glioblastoma multiforme relapses in vivo.
	jnnp.bmjjournals.com /cgi/content/full/74/6/779 (2193 words)

	Glioblastoma Review - Temodar partnering pipeline drugs: Table of Contents
		According to Datamonitor’s estimate, nearly 30,000 new cases of glioblastoma are expected to be diagnosed in the 7 major pharmaceutical markets in 2003.
		Incidence of glioblastoma is set to increase significantly as the proportion of elderly population increases
		Because glioblastoma predominantly affects the elderly patients, incidence is likely to increase significantly in the long term due to the ageing population.
	www.market-research-report.com /datamonitor/BFHC0611.htm (451 words)

	Science@Berkeley Lab: New Hope for Brain Cancer Therapy
		Glioblastoma multiforme, the most common of malignant brain tumors in adults, is one of the deadliest of all forms of cancer.
		Glioblastoma multiforme is a cancer of the glial cells; it's also known as "octopus tumors" because of the manner in which tendrils of malignant cells can extend into surrounding healthy brain tissue.
		Using seven lines of human glioblastoma multiforme cells, Forte and Blakeley and their collaborators found them to harbor anywhere from 125,000 to 950,000 LDL receptors (LDLRs) per cell.
	www.lbl.gov /Science-Articles/Archive/sabl/2006/Oct/1.html (1494 words)

	malignant brain tumors, glioblastoma, brain tumor symptoms
		CED allows potent drugs that would otherwise be too toxic to the body, or those that are not capable of passing through the blood-brain barrier, to be slowly and continuously infused into certain brain tumors.
		The most common signs and symptoms for Glioblastoma multiformes are seizures, progressive headaches, or progressive loss of brain function (such as speech, strength, memory, etc.).
		Glioblastoma multiformes represent a heterogeneous cell population, which means that certain cells may be more resistant to treatment than others.
	clevelandclinic.org /neuroscience/treat/brain/treatments/primary.htm (2065 words)

	Boron Neutron Capture Therapy (BNCT) For Glioblastoma Multiforme (Site not responding. Last check: 2007-10-31)
		Glioblastoma multiforme (GBM) accounts for approximately 80% of all adult malignant gliomas and continues to be one of the most intractable brain tumors.
		Tumor destruction during BNCT also depends on the use of nuclear reactors with the capability of delivering high fluxes of thermal neutrons at depths sufficient to reach all parts of the tumor.
		Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory.
	www.bcbst.com /MPManual/Boron_Neutron_Capture_Therapy_(BNCT)_For_Glioblastoma_Multiforme.htm (954 words)

	Glioblastoma of the Brain
		•The glioblastoma multiforme has a multiform or variable appearance with evidence of old and recent hemorrhage (yellowish-brown to red), necrosis and areas of firm tissue.
		•Usually the glioblastoma is seen as a mass lesion involving a focal area although it may cross the corpus callosum to the other hemisphere or be multifocal.
		•The clinical appearance of the glioblastoma is typical for brain tumors in general with a slowly progressive neurological deficit of a focal nature, that is, a slowly progressive hemiparesis of one side of the body.
	pathweb.uchc.edu /eAtlas/CNS/237.htm (299 words)

	FindArticles search for "Glioblastoma" (Site not responding. Last check: 2007-10-31)
		Glioblastoma is one of the most malignant tumors in humans.
		Context.-Giant cell glioblastoma multiforme (GCGBM) and pleomorphic xanthoastrocytoma (PXA) are clinically, radiographically, and histologically distinct...
		INTRODUCTION * Glioblastoma is the most common primary tumor of the CNS, making up 40% to 50% of all gliomas and 11% to 13% of all brain tumors.
	www.findarticles.com /p/search?tb=art&qt=Glioblastoma (829 words)

	Protein stops growth of brain tumor, OHSU study shows
		Herstatin inhibits the activation of a family of enzymes responsible for signaling inside tumor cells that tells the cells to proliferate and display other malignant properties, said Gail Clinton, Ph.D., professor of biochemistry and molecular biology in the OHSU School of Medicine who co-authored the study appearing this month in the journal Clinical Cancer Research.
		According to the nonprofit Central Brain Tumor Registry of the United States, glioblastomas account for the majority - 52 percent - of all gliomas, which are tumors that arise from glial cells and include astrocytomas, oligodendrocytomas, ependymomas, mixed gliomas, malignant gliomas NOS (nitric oxide synthase), and neuroepithelial tumors.
		She added, "This inhibitor we have is a naturally occurring one, and it's possible that the mutant EGF receptor may have developed to confer resistance to the class of inhibitors that blocks the extracellular domain" on the glioblastoma cells.
	www.eurekalert.org /pub_releases/2005-01/ohs-psg012705.php (818 words)

	Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma -- Galli et al. 64 ...
		Differently from normal human fetal neural stem cells (22), glioblastoma multiforme–derived tumor neural stem cells displayed different rates of amplification at low- and high-subculturing stages, as shown for cell line 0627.
		The exposure of cell line 0627 to EGF or FGF2 influenced the proliferation rate, which was higher in the presence of both mitogens and lower when using only one factor, as shown previously for normal human fetal neural stem cells (22).
		The table shows a quantitative analysis of the differentiation capacity of the various glioblastoma multiforme–derived tumor neural stem cell lines, normal human fetal neural stem cells, and U87 cells with respect to their ability to generate cells of the three major neural lineages and to cells that display aberrant, promiscuous neuronal/astroglial colabeling.
	cancerres.aacrjournals.org /cgi/content/full/64/19/7011 (6662 words)

	Medifocus: Glioblastoma Guidebook
		Malignant brain tumors, such as glioblastomas and anaplastic astrocytomas, among others, tend to grow rapidly spreading into the surrounding brain tissue and often cannot be entirely removed surgically.
		Glioblastomas are fast growing astrocytomas that contain areas of dead (necrotic) tumor cells.
		Glioblastoma can be difficult to treat although surgery, radiation therapy, steroids, and chemotherapy have shown the ability to prolong survival.
	www.medifocus.com /guide_detail.asp?gid=OC009&a=a&assoc=Google&keyword=glioblastoma (506 words)

	Glioblastoma (Site not responding. Last check: 2007-10-31)
		Less than 10 percent of childhood brain tumors are glioblastomas.
		Glioblastoma tumors have tentacle-like cells that grow into the surrounding tissue.
		As the tumor grows, loss of certain bodily functions may also occur, depending on the location of the tumor.
	www.nsiofdelaware.org /glioblastomacon.htm (205 words)

	EU Approves Temodal For Recurrent Glioblastoma Multiforme (Site not responding. Last check: 2007-10-31)
		Temodal, an oral cytotoxic, alkylating agent, is the lead compound in a new class of compounds known as imidazotetrazines.
		Glioblastoma multiforme is a rapidly growing cancer of the central nervous system, most often located in the cerebrum.
		It is the most common and deadliest type of malignant glioma (brain tumour), with median patient survival times ranging from nine to 12 months from initial diagnosis.
	www.pslgroup.com /dg/df952.htm (277 words)

	Glioblastoma Lawsuit Overview - Find Trial Lawyers and Attorneys with Experience in Glioblastoma Personal Injury Law
		Glioblastoma multiforme is the most common type of glioma.
		Glioblastoma develops in the cerebral hemisphere (most commonly in the frontal lobe).
		Symptoms of glioblastoma include, but may not be limited to, headaches, slowed thinking, and in advanced stages, fatigue, seizures, and coma.
	www.injuryboard.com /view.cfm/Topic=357 (321 words)

	Naturopath's Suggestions for Glioblastoma/Gliomas
		From the point of view of naturopathic medicine there are a number of agents which should be used to augment the effects of chemotherapy and radiation treatments for glioblastoma.
		In a clinical trial in which melatonin was administered to patients being treated with radiation therapy for glioblastoma a very significant increase in one year survival was seen.
		They are useful in decreasing the brain swelling associated with glioblastoma allowing a decrease in the use of prednisone and the resulting side effects.
	www.annieappleseedproject.org /natsugforgli.html (550 words)

	Genetics of glioma progression, definition of primary and secondary glioblastoma (Site not responding. Last check: 2007-10-31)
		Genetic studies of glioma progression and of distinctions between primary and secondary glioblastomas may point the way toward better diagnosis and staging of these lethal brain cancers, leading eventually to gene therapy or treatment with novel small molecules.
		In contrast, many patients with secondary glioblastoma are initially diagnosed with low-grade astrocytoma, which evolves over 4-5 years into anaplastic astrocytoma, then eventually becomes glioblastoma.
		The main age at diagnosis is 55 for patients with primary lesions and 39 for those with secondary glioblastoma.
	www.hms.harvard.edu /armenise/old_site/kleihues.html (639 words)

	Astrocytoma - Diagnosis and Treatment Options at Mayo Clinic
		Glioblastoma multiforme usually spread quickly to other parts of the brain.
		PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.
		Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR.
	www.mayoclinic.org /glioma/astrocytomas.html (1122 words)

	CancerWise - December 2002 - Glioblastoma Brain Tumors Puzzle Doctors
		Although her disease began as a low-grade tumor, it eventually progressed to glioblastoma multiforme, which took her life in August 2002.
		Cells in a glioblastoma, although of the same type, can behave in various ways, a characteristic that earned it the "multiforme" name and makes it very difficult to treat.
		The average survival rate of a glioblastoma patient is one to one and a half years.
	www.cancerwise.org /december_2002/display.cfm?id=dbb59002-1a31-48c6-b6823d1c45bff4b8&method=displayfull&color=green (1025 words)

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