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Topic: Glioblastoma multiforme

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	Glioblastoma multiforme - Wikipedia, the free encyclopedia
		Glioblastoma multiforme, (GBM) also known as grade 4 astrocytoma is the most common and aggressive type of primary brain tumor, accounting for 52 percent of all primary brain tumor cases.
		Glioblastoma multiformes are characterized by the presence of small areas of necrotizing tissue that is surrounded by highly anaplastic cells.
		Although glioblastoma multiforme can be formed from lower grade astrocytomas, post-mortem autopsies have revealed that most glioblastoma multiforme are not caused by previous lesions in the brain.
	en.wikipedia.org /wiki/Glioblastoma_multiforme (1558 words)

	eMedicine - Glioblastoma Multiforme : Article by Jeffrey Bruce, MD
		Genetic pathways elucidated in the evolution of primary and secondary glioblastoma.
		T1-weighted sagittal MRI with intravenous contrast in a patient with glioblastoma multiforme (GBM).
		Hochberg FH, Pruitt A: Assumptions in the radiotherapy of glioblastoma.
	www.emedicine.com /med/topic2692.htm (5604 words)

	Glioblastoma Multiforme
		Glioblastoma multiforme is a highly malignant, rapidly infiltrating, primary brain tumor, with tentacles that may invade surrounding tissue.
		Glioblastoma Multiforme may occur in any area of the cerebral hemispheres, but is most common in the frontal, temporal and parietal lobes, causing symptoms specific to each location.
		Uncommon metastasis of a glioblastoma multiforme in liver and spleen.
	hw.healthdialog.com /kbase/nord/nord281.htm (2230 words)

	ACR Learning File Web
		Glioblastoma accounts for approximately half of the glial tumors and is thought to be a manifestation of rapidly progressive anaplasia in an astrocytoma.
		Multifocal CNS involvement and true multiplicity of glioblastoma occur rarely, as seen in the axial contrast-enhanced CT scans (Image.4) and coronal T2-weighted MR scans (Image.5) of a different patient with gliomatosis cerebri.
		Angiographically, afferent vessels supplying malignant astrocytoma/glioblastoma multiforme may be increased in size with intratumoral bizarre, irregular, or widely spaced pathological vessels and early venous shunting.
	www.learningfile.com /learning_file/viewcase.php?section=nu&case_num=404 (558 words)

	Glioblastoma Multiforme - My Child Has - Children's Hospital Boston
		Glioblastoma multiforme is a high-grade, or malignant, glioma, a tumor of the glial (supportive) tissue of the brain.
		Glioblastoma multiforme of the cerebral hemispheres and the diencephalon, so called supratentorial glioblastoma multiforme, produce non-specific symptoms as a result of increased pressure within the head, as well as more localizing symptoms as a function of their specific location, rate of growth and associated inflammation.
		Near complete resection of glioblastoma multiforme in combination with radiation therapy has been reported to produce a 5-year survival rate as high as 25 percent, whereas incompletely removed tumors were associated with a less than 5 percent 5-year survival.
	www.childrenshospital.org /az/Site962/mainpageS962P0.html (1673 words)

	Glioblastoma Multiforme Tumors (Site not responding. Last check: 2007-10-20)
		Glioblastoma accounts for 30 percent of all brain tumors, and is the most common primary brain tumor of adults.
		A glioblastoma is a malignant tumor that originates from the supportive tissue of the brain, and grows from star-shaped, astrocyte cells.
		While there are low-grade astrocytomas, the grade IV glioblastomas are more common, completely malignant, and can grow very rapidly in the brain, growing over three to six months.
	www.health-alliance.com /learnabout/learn_Glioblastoma.htm (221 words)

	FDA Expedites Approval for Novel Treatment of Glioblastoma Multiforme
		Glioblastoma multiforme is an aggressive form of brain cancer that develops in certain cells found in the nervous system, called glial cells.
		One reason that glioblastoma multiforme is a difficult cancer to treat is that the cancer cells tend to be hypoxic.
		This is very important, as glioblastoma multiforme is considered an aggressive and deadly form of brain cancer that does not respond well to standard treatments.
	patient.cancerconsultants.com /brain_cancer_news.aspx?id=17064 (730 words)

	421.html (Site not responding. Last check: 2007-10-20)
		Forty to fifty percent of primary brain tumors are gliomas of which 50% are glioblastomas.
		Glioblastomas occur most commonly in the fifth through seventh decades.
		Glioblastomas grow as an irregular mass in the white matter and is frequently seen to cross the corpus callosum to the opposite side yielding a "butterfly" appearance.
	www.mritutor.org /mriteach/421.html (161 words)

	FDA approves Temodar as treatment for glioblastoma multiforme
		Glioblastoma multiforme is a rapidly growing neuroglia cell tumor of the central nervous system, most often located in the cerebrum.
		Glioblastoma multiforme is more common among males and occurs more frequently in Caucasians.
		The new approval of Temozolomide for glioblastoma multiforme was based on efficacy and safety data from a large randomized controlled study conducted by the European Organization for Research and Treatment of Cancer (EORTC) in patients with newly diagnosed glioblastoma multiforme.
	www.xagena.it /news/medicinenews_net_news/4042483f5c2c4015e2a6abd47aa76b6f.html (474 words)

	Gene Therapy \| Mayfield Clinic
		This therapy is being used for glioblastoma multiforme, a malignant, rapidly growing tumor of the brain that is difficult to treat.
		Gene therapy is being used in clinical trials for adults and children with glioblastoma multiforme.
		Glioblastoma multiforme: a rapidly growing tumor that arises from the supporting cells of the brain.
	www.mayfieldclinic.com /PE-GENE.HTM (1349 words)

	New treatment for recurrent glioblastoma multiforme
		NCCTG researchers used an investigational drug that is known as CCI-779, or Temsirolimus, it is a "smart" drug in the sense that it has been designed to target specific changes in the glioblastoma multiforme tumor cells that previous studies have identified as key factors in the tumor's aggressive behavior.
		In adults, glioblastoma multiforme is the most common form of brain tumor.
		Glioblastoma multiforme accounts for more than 50 percent of the estimated 18,000 primary malignant brain tumors diagnosed each year in the United States.
	www.xagena.it /news/medicinenews_net_news/e8ad3f3f04296aa9be9de71a674e3769.html (327 words)

	Glioblastoma multiforme hub (Site not responding. Last check: 2007-10-20)
		Glioblastoma Multiforme (GBM) - by the Chicago Institute of Neurosurgery and Neuroresearch.
		Interstitial chemotherapy of newly diagnosed glioblastoma multiforme with cisplatin polymer implants - by Sergey Sheleg, Edvard Zhavrid, Eugene Korotkevich, Arnold Smeyanovich, Yuri Shanko.
		A case of spinal glioblastoma multiforme immunohistochemical study and review of the literature - by Strik H, Schäfer C, Wienecke W, Wickboldt J, Meyermann R. and HC gp-39 are overexpressed in glioblastoma multiforme - by Oleg Garifulin, Andrew Marusyk, Yuriy Zozulya, Nina Gridina, Alexey Homenko, Guenter Zehetner, Vadym.
	www.genomelink.org /glioblastoma (765 words)

	My Allergies - Asthma, Allergy Genes May Ward Off Brain Tumors
		A recent study found that asthmatics and people with allergies are at lower risk of developing the most common type of brain tumor, glioblastoma multiforme.
		Glioblastomas tend to be more common in men than in women, and are much more common in older vs. young people.
		The average incidence is three cases of glioblastoma per 100,000 Americans, but after age 65 that number jumps to almost 14 per 100,000 people, according to the study authors.
	www.myallergies.org /ms/news/526881/main.html (838 words)

	Glioblastoma of the Brain
		•The glioblastoma multiforme has a multiform or variable appearance with evidence of old and recent hemorrhage (yellowish-brown to red), necrosis and areas of firm tissue.
		•Usually the glioblastoma is seen as a mass lesion involving a focal area although it may cross the corpus callosum to the other hemisphere or be multifocal.
		•The clinical appearance of the glioblastoma is typical for brain tumors in general with a slowly progressive neurological deficit of a focal nature, that is, a slowly progressive hemiparesis of one side of the body.
	pathweb.uchc.edu /eAtlas/CNS/237.htm (299 words)

	p53, mdm2, EGFR, and msh2 expression in paired initial and recurrent glioblastoma multiforme -- Stark et al. 74 (6): ...
		Analysis of mdm2 and p53 gene alterations in glioblastomas and its correlation with clinical factors.
		Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes.
		Distinct radiochemotherapy protocols differentially influence cellular proliferation and expression of p53 and bcl-2 in glioblastoma multiforme relapses in vivo.
	jnnp.bmjjournals.com /cgi/content/full/74/6/779 (2193 words)

	CancerWise - December 2002 - Glioblastoma Brain Tumors Puzzle Doctors
		Glioblastoma multiforme continues to challenge doctors who treat this fast-growing brain tumor.
		Although her disease began as a low-grade tumor, it eventually progressed to glioblastoma multiforme, which took her life in August 2002.
		The average survival rate of a glioblastoma patient is one to one and a half years.
	www.cancerwise.org /december_2002/display.cfm?id=dbb59002-1a31-48c6-b6823d1c45bff4b8&method=displayfull&color=green (1025 words)

	Glioblastoma Multiforme
		Glioblastoma multiforme is the most likely diagnosis given the irregular shape of the mass, the central necrosis, and the extensive surrounding edema and mass effect.
		Glioblastoma multiforme refers to a malignant neoplasm with abundant glial pleomorphism, numerous mitotic figures and giant cells, vascular hyperplasia, and focal areas of necrosis.
		Occurring most commonly in the fifth through seventh decades, glioblastoma multiforme usually develops in the cerebral hemispheres (more often in the frontal lobes than the temporal lobes or basal ganglia) but almost never in the cerebellum.
	brighamrad.harvard.edu /Cases/bwh/hcache/14/full.html (573 words)

	EU Approves Temodal For Recurrent Glioblastoma Multiforme (Site not responding. Last check: 2007-10-20)
		Temodal, an oral cytotoxic, alkylating agent, is the lead compound in a new class of compounds known as imidazotetrazines.
		Glioblastoma multiforme is a rapidly growing cancer of the central nervous system, most often located in the cerebrum.
		It is the most common and deadliest type of malignant glioma (brain tumour), with median patient survival times ranging from nine to 12 months from initial diagnosis.
	www.pslgroup.com /dg/df952.htm (277 words)

	Glioblastoma
		lioblastoma multiforme (GBM) is the most aggressive form of the primary brain tumors known collectively as gliomas.
		These tumors arise from the supporting, glial cells of the brain during childhood and in adults.
		Chemotherapy is the most controversial of treatments as many studies have failed to show prolonged median survival in treated patients, although the proportion of long term survivors may be somewhat greater.
	www.sd-neurosurgeon.com /diseases/glioblastoma.html (730 words)

	Glioblastoma Multiforme Brain Tumors
		Glioblastoma multiforme is the highest grade glioma (grade 4) tumor and is the most malignant form of astrocytomas.
		Although glioblastoma multiforme brain tumors can occur at almost any age, they're most common after 50 years of age.
		A neurologic evaluation should be done if a patient has slowly increasing signs of mental dysfunction, new seizures, persistent headaches or evidence that there is pressure inside the skull, such as vomiting or swelling or protrusion of the blind spot at the back of the eye.
	www.csmc.edu /5305.html (296 words)

	Glioblastoma Multiforme (Site not responding. Last check: 2007-10-20)
		Glioblastomas are the most common malignant brain tumors in adults, and they are notoriously difficult to treat successfully.
		"The survival with glioblastoma is usually a year on average, and that hasn't improved in a while, so this is a very serious and challenging disease," says Paul Mischel, M.D., of the David Geffen School of Medicine and Jonsson Comprehensive Cancer Center at the University of California, Los Angeles (UCLA), who led the study.
		While drugs are available to help treat glioblastoma, they often have minimal effect, and doctors usually have time to try only one or two treatments before the disease causes severe impairment.
	www.rxpgnews.com /glioblastomamultiforme.shtml (1636 words)

	Cancer Issues - New Treatment Target for Deadly Brain Tumors
		However, the EphA2 found in the glioblastoma cells is inactive and the researchers believe it's this inactive form of the protein that helps these cancer cells survive and spread.
		New therapies are clearly needed because, despite the standard treatment of surgically removing the tumor and treating the patient with chemotherapy and radiation, survival has increased only slightly over the past 30 years," Debinski said.
		People with glioblastoma multiforme have a median post-diagnosis survival time of nine to 12 months, and a five-year survival rate of just 1 to 5 percent.
	www.cancerissues.com /ms/news/528811/main.html (442 words)

	Glioma - Astrocytoma, Glioblastoma Multiforme, Oligodendroglioma- CyberKnife Stereotactic Radiosurgery System (Site not responding. Last check: 2007-10-20)
		Grade IV gliomas, often referred to as Glioblastoma Multiforme or “GBM”, possess multiple genetic and chromosomal abnormalities which cause these tumors to grow rapidly.
		Among patients with anaplastic astrocytoma and glioblastoma, there appears to be a definite increase in survival in those patients who have had at least a 97% or greater resection of their tumor, and in those patients whose tumor is located in the frontal lobe of the brain, as opposed to the temporal or parietal lobes.
		Although not curative, aggressive removal of malignant glioma can immediately alleviate symptoms caused by the mass of a tumor and improve the effectiveness of other therapies; if not removed, the hypoxic/necrotic central portions of a tumor tend to be particularly resistant to radiation and chemotherapy.
	www.cksociety.org /PatientInfo/MedicalConditions/glioma.asp (2281 words)

	ScienceDaily: Novel Treatment Target For Deadly Brain Tumors Identified (Site not responding. Last check: 2007-10-20)
		Debinski and colleagues demonstrated that glioblastoma cells have significantly increased levels of the protein EphA2 compared to normal cells -- but it is in an inactive form.
		The researchers believe that developing medication to change levels of EphA2 and ephrinA1 offers new promise for successfully treating glioblastoma multiforme, which is the most common form of brain tumor and the least curable of all human cancers.
		Debinski has already developed one treatment for glioblastoma, based on his discovery that the tumor's cells have a particular type of receptor for interleukin 13 (IL 13), a naturally occurring protein that regulates the immune system in the body.
	www.sciencedaily.com /releases/2005/10/051031075514.htm (1262 words)

	AR Online » Current Issue » Glioblastoma multiforme (GBM)
		The patient had a subtotal resection due to the proximity of the lesion to the Sylvian ﬁssure and to the motor cortex.
		Glioblastoma multiforme (GBM) with inﬁltration along the optic tract.
		Glioblastoma multiforme and other inﬁltrative astrocytomas account for the majority of adult primary CNS malignancies.
	www.appliedradiology.com /case/case.asp?Id=33&IssueID=16 (845 words)

	Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients -- Heimberger et ...
		Glioblastoma multiforme is the most common primary malignant
		A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival.
		PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.
	clincancerres.aacrjournals.org /cgi/content/full/11/4/1462 (2880 words)

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