| | Method for the preparation of an immune globulin solution suitable for intravenous use - Patent 4322403 |
 | | An immune globulin solution suitable for intravenous use is produced by purifying a salt-containing solution of an immune globulin in a number of adsorptive purification steps using an aqueous, humid, amorphous, chemically pure silicic acid of sub-microscopically fine distribution as the adsorption agent. |
 | | Both the immune globulin intramuscular (i.m.) preparations and also the immune globulin intraveneous (i.v.) preparations can vary considerably according to the method of production and suffer from the disadvantages that are to be found in their differing compatability and therapeutic effect. |
 | | Thus, for example, it is known that in order to produce an immune globulin preparation, the gamma globulin fraction of the serum, obtained in the usual way by ammonium sulphate precipitation or alcohol precipitation, may be treated at a pH value of 1.5 to 5.5 at a temperature between 0.degree. |
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