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Topic: Glomerular filtration rate

Related Topics

Creatinine clearance

Renal function

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	RENAL BLOOD FLOW-GLOMERULAR FILTRATION RATE
		Since the glomerular capillary pressure (Pgc) i.e., filtration pressure is one important determinant of the amount of fluid that filters across the glomerular membrane into the proximal tubules, the phenomenon of renal autoregulation also serves to regulate the glomerular filtration rate by supporting the Pgc.
		The principle function of the JGA is adapting the GFR to early distal tubule fluid characteristics by modulating renin synthesis and release: this is known as the tubuloglomerular feedback (TGF) loop.
		The glomerular filtrate is defined as an ultrafiltrate of plasma, that is, a protein-free filtrate of plasma.
	www.uhmc.sunysb.edu /internalmed/nephro/webpages/Part_A.htm (4603 words)

	Glomerular filtration rate - Wikipedia, the free encyclopedia
		Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal glomerular capillaries into the Bowman's capsule per unit time.
		Since inulin is not reabsorbed by the kidney after glomerular filtration, its rate of excretion is directly proportional to the rate of filtration of water and solutes across the glomerular filter.
		The GFR is calculated as M/P (where M is the mass of creatinine excreted per unit time and P is the plasma concentration of creatinine).
	en.wikipedia.org /wiki/Glomerular_filtration_rate (464 words)

	Glomerular filtration rate (GFR)
		Glomerular filtration is the process by which the kidneys filter the blood, removing excess wastes and fluids.
		Glomerular filtration rate (GFR) is a calculation that determines how well the blood is filtered by the kidneys, which is one way to measure remaining kidney function.
		Glomerular filtration rate is usually calculated using a mathematical formula that compares a person's age, sex, and race to serum creatinine, albumin, and blood urea nitrogen (BUN) levels.
	www.webmd.com /hw/health_guide_atoz/aa154102.asp (129 words)

	Glomerular Filtration Rate The glomerular filtration rate (
		The glomerular filtration rate (GFR) is the rate at which an ultrafiltrate of plasma is produced by glomeruli per unit of time.
		To measure GFR accurately, a marker is required that is filtered but not secreted, reabsorbed, or metabolized, such that the GFR is equal to the urinary clearance of the marker after its intravenous infusion.
		GFR may be determined by single-sample iohexol clearance 3 to 4 hours after the injection of 3 to 5 mL of iohexol.
	www.unict.it /medint/clearance.htm (1516 words)

	Postgraduate Medicine: Estimating the glomerular filtration rate
		Glomerular filtration rate (GFR) remains the most accurate index of kidney function--and is thus key to early management of the disease.
		GFR is a direct measurement of kidney function (2) and is reduced before the onset of symptoms of kidney failure (3).
		Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment.
	www.postgradmed.com /issues/2001/12_01/manjunath.htm (3308 words)

	glomerular filtration rate - General Practice Notebook (Site not responding. Last check: 2007-11-04)
		The rate of ultrafiltration is called the glomerular filtration rate which is about 120 ml/min or 170 litres per day.
		This is written 120 ml/min/1.73m2, to emphasise the fact that the rate is closely related to the body surface area.
		The glomerular filtration rate increases from birth - in the neonate it is about one millilitre per minute.
	www.gpnotebook.co.uk /cache/671481904.htm (157 words)

	Control of GFR
		With minor changes in APR (situation b, left) and flow rates around the turning point of the TGF response curve (which is close to the operating point of the TGF mechanism) the afferent arteriolar resistance change is the major factor determining GFR.
		Since the rate of proximal reabsorption (APR) amounts to 70-75% of GFR, changes in APR is a major factor determining changes in GFR ("regulation" of GFR).
		Pathophysiological changes in inulin clearance may be due to either a change in the glomerular filtration process, or to a change in the tubular reabsorptive capacity, or to a decrease in the number of functioning nephrons.
	www.mfi.ku.dk /undervisning/lecture-notes/gfr-en (1896 words)

	Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys -- Lund et al. 284 ...
		For a GFR of 3 ml/min, with the assumption of
		with increases in GFR in the GFR interval of 2.0-4.5 ml/min.
		Porous substructure of the glomerular slit diaphragm in the rat and mouse.
	ajprenal.physiology.org /cgi/content/full/284/6/F1226 (4759 words)

	Effects of Low-Carb Diet on the Kidneys
		The glomerular filtration rate of the rats with a single damaged kidney initially recovered to 75 to 80% of that of rats with an intact single kidney on the same diet.
		Nitrogen excretion rate was used as a measure for the daily protein intake, since it is known to correlate linearly with the daily protein intake.
		In 585 patients with moderate renal disease (baseline GFR, 25 to 55 mL/min per 1.73 m2; Study A), the primary analysis of the effect of the low-protein diet was inconclusive because of a nonlinear GFR decline and limited duration of follow-up.
	www.lowcarb.org /josh_yelon/topic4.html (5018 words)

	Clinical Practice Guidelines for Chronic Kidney Disease in Adults: Part II. Glomerular Filtration Rate, Proteinuria, ...
		The glomerular filtration rate can be estimated using prediction equations that take into account the serum creatinine level and some or all of specific variables (age, sex, race, body size).
		In clinical practice, GFR usually is estimated from the creatinine clearance or the serum creatinine concentration.
		GFR should be estimated using prediction equations that take into account the serum creatinine concentration and some or all of these variables: age, sex, race, and body size.
	www.aafp.org /afp/20040915/1091.html (3663 words)

	Glomerular Physiology
		GFR is defined as the volume of glomerular urine filtered per unit time.
		An ideal GFR indicator is a substance that is freely filtered by the glomerulus but not secreted or reabsorbed by the renal tubules.
		(c) The rate of filtration of a substance that is freely filtered and not reabsorbed or secreted by the renal tubules, is equal to its rate of urinary excretion.
	umed.med.utah.edu /MS2/renal/phys.html (1608 words)

	Regulation of Glomerular Function by Podocytes
		The recent advances in the isolation, characterisation and identification of human and animal visceral glomerular epithelial cells (podocytes) has led to the elucidation of how these cells, so tightly wrapped around the endothelial cells, use their molecular expression phenotype to control fluid and solute transport across the glomerular filtration barrier.
		However, the integration between the molecular regulation of podocyte function, and that impact on glomerular filtration rate is still being elucidated.
		This symposium will address the role of the podocyte in the control of glomerular filtration, using molecular studies in podocytes in vitro, examination of control of filtration by podocytes on endothelial cells and basement membrane, and the changes seen in intact glomeruli in response to podocyte stimulation in health and disease.
	www.the-aps.org /meetings/eb06/abs/renal-bates.htm (252 words)

	Creatinine clearance
		Because creatinine is found in stable plasma concentrations, is freely filtered and not reabsorbed, and is minimally secreted by the kidneys, creatinine clearance is used to estimate the glomerular filtration rate (GFR) -- the standard by which kidney function is assessed.
		The creatinine clearance is an estimate of the glomerular filtration rate, that is, the volume of filtrate made by the kidneys per minute.
		The amount of filtrate made in the kidney depends on the amount of blood that passes through the glomeruli and the ability of the glomeruli to act as filters.
	www.geocities.com /medipedia/003611.htm (874 words)

	Pathogenesis of Progressive Nephropathies
		One possible explanation is that the high glomerular capillary pressure enlarges the radius of the pores in the glomerular membrane by a mechanism that is mediated at least in part by angiotensin II.
		In patients with various renal diseases, reducing urinary protein excretion slows the rate of decline in the glomerular filtration rate, (86) and reducing blood pressure slows the decline in the glomerular filtration rate more in patients with a high rate of urinary protein excretion at base line than in those with a low rate.
		In addition, the decline in the glomerular filtration rate during the study was more effectively slowed by tight blood-pressure control in patients with higher rates of urinary protein excretion at base line than in those with lower rates.
	people.bu.edu /sobieraj/pdf/nephropathy.html (1717 words)

	Glomerular filtration rate
		Measurement of the GFR is necessary to define the exact level of renal function.
		Creatinine excretion is, however, by both glomerular filtration and tubular secretion, although at normal serum levels the latter is relatively small.
		The GFR may then be calculated from the slope of the exponential fall in blood level of the compound.
	www.total-health-care.com /illness/glomerular-filtration-rate.htm (567 words)

	Measuring Single-Kidney Glomerular Filtration Rate on Single-Detector Helical CT Using a Two-Point Patlak Plot ...
		Glomerular filtration rate (GFR) as measured with CT was considerably overestimated in both kidneys.
		Glomerular filtration rate (GFR) measured by plasma clearance was 113 mL/min.
		GFR calculated with Patlak plot is much higher than true GFR in patient with increased interstitial space.
	www.ajronline.org /cgi/content/figsonly/181/1/147 (1370 words)

	Estimated Glomerular Filtration Rate (eGFR) (Site not responding. Last check: 2007-11-04)
		Among patients with chronic kidney disease (CKD) the eGFR is instrumental in determining the stage of disease according to the K/DOQI CKD classification.
		Filtration Rate (GFR) and Staging of Kidney Disease.
		A simplified equation to predict glomerular filtration rate from serum creatinine.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/nf10004540.htm (397 words)

	Glomerular filtration rate (GFR) is the most widely used indicator... (Site not responding. Last check: 2007-11-04)
		Glomerular filtration rate (GFR) is the most widely used indicator...
		Glomerular filtration rate (GFR) is the most widely used indicator of kidney function in patients with renal disease.
		Filtration capacity: which is the GFR attained by the stimulated organ.
	www.indegene.com /Nep/FeatArt/indNepFeatArt14.html (1776 words)

	eMedicine - Renal Failure, Acute : Article Excerpt by: Richard Sinert, DO
		Since baseline serum creatinine level and GFRs are not readily available, the consensus committee recommends the use of the Modification of Diet in Renal Disease (MDRD) equation (see Lab Studies) to estimate the patients GFR/1.73 mm based upon: serum creatinine level, age, gender, and race.
		Pathophysiology: The driving force for glomerular filtration is the pressure gradient from the glomerulus to the Bowman space.
		Glomerular pressure is primarily dependent on renal blood flow (RBF) and is controlled by combined resistances of renal afferent and efferent arterioles.
	www.emedicine.com /emerg/byname/renal-failure-acute.htm (603 words)

	Glomerular filtration rate (GFR)
		The most accurate method to measure glomerular filtration rate (GFR) is to track the renal clearance of an ideal filtration marker (1).
		An ideal filtration marker is freely cleared through the glomerulus, is not reabsorbed and does not bind to serum proteins.
		The true measurement of GFR offers a superior end-point in renal drug development studies, as compared to estimating renal function by evaluating biomarkers, such as serum creatinine, cystatin-C, microalbumin, etc., that are influenced by non-renal factors.
	www.biopal.com /RenalRate.htm (431 words)

	IngentaConnect Susceptibility of glomerular filtration rate estimations to varia... (Site not responding. Last check: 2007-11-04)
		IngentaConnect Susceptibility of glomerular filtration rate estimations to varia...
		Susceptibility of glomerular filtration rate estimations to variations in creatinine methodology: a study in older patients
		Use of the differing creatinine methods to estimate GFR produced predictable biases of the estimate, with mean GFR estimates varying by 14% across the creatinine methods.
	www.ingentaconnect.com /content/rsm/acb/2005/00000042/00000001/art00004 (394 words)

	What To Do for the Patient with Minimally Elevated Creatinine Level?
		Calculation of the glomerular filtration rate is very important to more accurately measure and assess kidney function.
		Accuracy of the MDRD formula is validated, and use of this formula is currently the preferred method for estimating glomerular filtration rate.
		Therefore, calculated glomerular filtration rate, instead of absolute serum creatinine level, should be used to evaluate kidney function.
	xnet.kp.org /permanentejournal/winter04/cc.html (1414 words)

	Creatinine Clearance
		Where GFR is Glomerular Filtration Rate in ml/min
		Underestimates GFR in the absence of kidney disease
		GFR decreases by 1 ml/min/year over age 30 years
	www.fpnotebook.com /REN70.htm (247 words)

	Recent Developments in the Evaluation of Glomerular Filtration Rate: Is There a Place for {beta}-Trace? -- Huber and ... (Site not responding. Last check: 2007-11-04)
		Assessing glomerular filtration rate in renal transplant recipients by estimates derived from serum measurements of creatinine and cystatin C. Clin Chim Acta 2005;356:204-211.
		Diagnostic value of cystatin C as a glomerular filtration rate marker in decompensated liver cirrhosis.
		Calculation of glomerular filtration rate expressed in ml/min from plasma cystatin C values in mg/L. Scand J Clin Lab Invest 2004;64:25-30.
	www.clinchem.org /cgi/content/full/51/8/1329 (1592 words)

	Cross sectional longitudinal study of spot morning urine protein:creatinine ratio, 24 hour urine protein excretion ...
		ratios and rate of decline of the glomerular filtration rate
		As for the rate of decline of the glomerular filtration rate,
		Plasma clearance of non-radioactive iohexol as a measure of glomerular filtration rate in patients with normal or impaired renal function.
	www.bmj.com /cgi/content/full/316/7130/504 (3147 words)

	Estimated Glomerular Filtration Rate - Patient UK
		The estimated glomerular filtration rate (eGFR) does not diagnose any kidney disease but is a test to assess how well your kidneys are working.
		The estimated glomerular filtration rate (eGFR) is a test that is used to assess how well your kidneys are working.
		The test is called the estimated glomerular filtration rate because the glomeruli are the tiny filters in the kidneys.
	www.patient.co.uk /showdoc/27001111 (432 words)

	Tubuloglomerular Feedback and the Control of Glomerular Filtration Rate -- Vallon 18 (4): 169 -- Physiology (Site not responding. Last check: 2007-11-04)
		in reabsorption is not the consequence of glomerular hyperfiltration
		The resulting glomerular hyperfiltration serves to partly restore the fluid and electrolyte load to the distal nephron, but at the same time it initiates and/or maintains development of diabetic nephropathy.
		Glomerular hyperfiltration and the salt paradox in early diabetes mellitus: a tubulo-centric view.
	physiologyonline.physiology.org /cgi/content/full/18/4/169 (4066 words)

	Effect of Antihypertensive Therapy on the Kidney in Patients with Diabetes: A Meta-Regression Analysis -- Kasiske et ...
		Glomerular filtration rate was measured by creatinine clearance
		a decrease in the rate of decline in renal function [84].
		Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat.
	www.annals.org /cgi/content/full/118/2/129 (7115 words)

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