| | Hypertension Online Slides - glomerulus, macrophage, glomerular hypertension |
 | | The nephron, comprised of the glomerulus (shown in the scanning electron photomicrograph on the top left and in the center of the light micrograph on the bottom left) and the tubules (surrounding the glomerulus in the light micrograph on the bottom left), is the primary functional unit of the kidney. |
 | | Both glomerular hypertension and proteinuria are associated with oxidative stress that can cause activation of circulating leukocytes and their diapedesis into the vessel wall and interstitium, can stimulate the release of cytokines and growth factors that leads to extracellular matrix formation, progressive sclerosis of both the glomerulus and tubules, and ultimately loss of nephron units. |
 | | Attempts by the proximal tubules to reabsorb this filtered protein causes injury to the tubular cells, activates an inflammatory response, and is associated with the development of lipid metabolic abnormalities that create further oxidative stress on the already compromised glomerulus. |
| www.hypertensiononline.org /slides2/slide01.cfm?q=glomerulus (783 words) |