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| | 938. Glucono-delta-lactone/calcium/magnesium/potassium/sodium salts/gluconic acid (WHO Food Additives Series 42) |
 | | C was excreted unchanged in the urine, 14% appeared in expired carbon dioxide, and a fraction (gluconate carbon) was recovered as urinary saccharate. |
 | | In two new four-week studies in rats, sodium gluconate was administered orally either by gavage at doses of 0, 500, 1000, or 2000 mg/kg bw per day or by feeding at doses of 0, 1, 1.25, 2.5, or 5% w/w (equal to 1000, 2000, and 4100 mg/kg bw per day). |
 | | EVALUATION On the basis of a re-evaluation of data previously considered by the Committee and new data on the short-term toxicity of sodium gluconate, the Committee extended the previous ADI 'not specified' for glucono-delta-lactone to a group ADI for glucono-delta-lactone and the calcium, magnesium, potassium, and sodium salts of gluconic acid. |
| www.inchem.org /documents/jecfa/jecmono/v042je12.htm (3775 words) |
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