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| | L-Glutamine (Site not responding. Last check: 2007-11-06) |
 | | Glutamine is considered a non-essential amino acid, as human cells can readily synthesize it via activity of the enzyme glutamine synthetase (see Figure 1), which is found in high concentration in skeletal muscle, liver, brain, and stomach tissue. |
 | | Glutamine is converted in the mitochondria of intestinal cells to glutamate, then alpha ketoglutarate, which is utilized in the tricarboxylic acid (TCA, Krebs) cycle for ATP production (see Figure 2). |
 | | Glutamine supplementation is necessary in trauma and surgical patients, and in the critically ill to prevent gut mucosal atrophy, infection, and to reduce gut permeability, sepsis, and possibly multiple organ failure. |
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