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Topic: Glycans

In the News (Mon 16 Nov 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	ARS \| Publication request: Cell Wall Biosynthesis: Glycan Containing Oligomers in Developing Cotton Fibers, Cotton ... (Site not responding. Last check: 2007-10-04)
		We hypothesize that the glycans are intermediates in the biological assembly of cellulose(s).
		Glycans that produce the similar profiles on high pH anion chromatography with pulsed amperometric detection (HPAEC-PAD) are also found in a protein complex extracted from developing fibers and in amorphous aggregates found in association with immature fibers in developing, but not in mature, cotton bolls.
		We hypothesize that the glycans are intermediates in the biological assembly of cellulose, and that their incorporation in cellulose is mediated by physicochemical and enzymatic mechanisms.
	www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=120401 (470 words)

	Facts about topic: (Polysaccharide) (Site not responding. Last check: 2007-10-04)
		Polysaccharides (sometimes called glycans) are relatively complex carbohydrate (An essential structural component of living cells and source of energy for animals; includes simple sugars with small molecules as well as macromolecular substances; are classified according to the number of monosaccharide groups they contain) s.
		They are polymer (A naturally occurring or synthetic compound consisting of large molecules made up of a linked series of repeated simple monomers) s made up of many monosaccharide (A sugar (like sucrose or fructose) that does not hydrolyse to give other sugars; the simplest group of carbohydrates) s joined together by glycosidic linkages.
		Acidic polysaccharides are a group of polysaccharides that contain carboxyl group (The univalent radical -COOH; present in and characteristic of organic acids) s and/or sulfuric ester groups.
	www.absoluteastronomy.com /encyclopedia/p/po/polysaccharide.htm (464 words)

	The Degree of Branching of the Glycans of alpha 1-Acid Glycoprotein in Asthma . A Correlation with Lung Function and ... (Site not responding. Last check: 2007-10-04)
		The Degree of Branching of the Glycans of alpha 1-Acid Glycoprotein in Asthma.
		The Degree of Branching of the Glycans of
		by an increase in the degree of glycan branching in AGP.
	ajrccm.atsjournals.org /cgi/content/full/161/6/1972 (4048 words)

	Phosphorylcholine-containing N-glycans of Trichinella spiralis: identification of multiantennary lacdiNAc structures -- ...
		The derivatized glycans were purified by Sep-Pak and the 35% (v/v) aq.
		Although the structures shown are predicted from the linkage data to be the major triantennary glycans present, it is probable that glycans branched on the 6-arm rather than the 3-arm are also present.
		The derivatized glycans were purified by Sep-Pak and the 50% (v/v) aq.
	glycob.oxfordjournals.org /cgi/content/full/10/9/941 (4695 words)

	GlycoTechnology (Site not responding. Last check: 2007-10-04)
		Glycans are incubated in the presence of sodium borohydride to reduce the reducing terminal.
		Glycans are resuspended in a slurry of NaOH in DMSO and methyl iodide is added to methylate all exposed hydroxyl groups.
		The starting material for this procedure is typically isolated glycan, although glycopeptides and intact proteins may also be deemed appropriate depending on the nature of the sample.
	glycotech.ucsd.edu /desc.shtml (1763 words)

	Ludger Ltd: Technical Info: A3 Family Glycans (Site not responding. Last check: 2007-10-04)
		The importance of the ligand clustering effect of multi-antennary oligosaccharides such as the A3 family glycans is seen in a study of the carbohydrate binding properties of mouse macrophage lectin which is expressed on the cell surfaces of inflammatory and tumoricidal macrophages [Yamomoto et al (1994)].
		However, the size and complexity of the glycan may reduce the efficiency of the reaction and, depending on the enzyme reaction conditions, some of the carbohydrate arms may be resistant to sialylation.
		A3 glycans are ligands for a number of lectins including rice lectin [Poola et al (1986)] and elderberry lectin [Shibuya et al (1987)], NA3 glycan binds to a variety of plant lectins with affinity for terminal Gal residues, and NGA3 binds to lectins specific for terminal GlcNAc residues.
	www.ludger.com /info-a3-glycans.htm (2478 words)

	[No title] (Site not responding. Last check: 2007-10-04)
		We conclude that the glycan of peak 4 is a
		Third, the amount of triantennary glycans (peak 3 and 4) was decreased (P= 0,0005) with respect to the biantennary glycans (peaks 0,1 and 2).
		Because glycan structure strongly influences the purification behavior of a glycoprotein, it is of definite advantage to have a technology that can give the glycan structural information without having to go through purification optimization.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=01/92890.011206&ELEMENT_SET=DECL (9232 words)

	Secretory IgA N- and O-Glycans Provide a Link between the Innate and Adaptive Immune Systems -- Royle et al. 278 (22): ... (Site not responding. Last check: 2007-10-04)
		the glycans (the larger the GU, the larger the glycan).
		glycans on residues 83, 186, and 499; an FcA2G2S2 glycan on
		This leaves the Fab regions clear for interaction with antigens (adaptive immunity), whereas the O-glycans on the hinge region of the H chains and the N-glycans on SC cloak the rest of the surface, free for interaction with bacterial adhesins (innate immunity).
	www.jbc.org /cgi/content/full/278/22/20140 (6531 words)

	Ludger Ltd: Technical Info: A2F Family Glycans (Site not responding. Last check: 2007-10-04)
		Core α (1-6) fucosylation of glycoprotein glycans is an important process in a number of normal and aberrant biological processes including cell adhesion, neurogenesis, the development and cancers, the natural suppression of cancer metastases, and liver diseases.
		The glycans can be conjugated to suitable carriers including proteins and resin particles to produce negoglycoconjugates for use in receptor studies (including locatisation and inhibition experiments), targeting, and purification methods, etc..
		A2F and A1F glycans are ligands for a number of lectins including rice lectin [Poola et al (1986)] and elderberry lectin [Shibuya et al (1987)], NA2F glycan binds to a variety of plant lectins with affinity for terminal Gal residues, and NGA2F binds to lectins specific for terminal GlcNAc residues.
	www.ludger.com /info-a2f-glycans.htm (1843 words)

	Deficiency of Reproductive Tract alpha (1,2)Fucosylated Glycans and Normal Fertility in Mice with Targeted Deletions of ... (Site not responding. Last check: 2007-10-04)
		In mammals, the large number of discrete cell surface glycan structures includes many that are decorated with fucose (42).
		Fucosylated glycans are also implicated in the maturation of sperm in the rodent (30, 34).
		Glycans as legislators of host-microbial interactions: spanning the spectrum from symbiosis to pathogenicity.
	mcb.asm.org /cgi/content/full/21/24/8336 (5383 words)

	Procognia — how different glycans occur in the same protein sample (Site not responding. Last check: 2007-10-04)
		The glycans attached to proteins are extremely diverse in structure.
		The residues occur in a variety of combinations, and the chains may be linear or may contain one or more branches as is the case with one of the glycans found on erythropoietin.
		Different glycans can be attached to the same glycosylation site on different glycoforms, although only a single glycan can be added to each site during glycoprotein synthesis.
	www.procognia.com /technology/overview/glycans.htm (208 words)

	Characterization of N-Glycans from Arabidopsis. Application to a Fucose-Deficient Mutant -- Rayon et al. 119 (2): 725 ... (Site not responding. Last check: 2007-10-04)
		Glycans a and e were identified as the PA derivatives
		Fitchette-Lainé A-C, Gomord V, Cabanes M, Michalski J-C, Saint Macary M, Foucher B, Cavelier B, Hawes C, Lerouge P, Faye L (1997) N-glycans harboring the Lewis a epitope are expressed at the surface of plant cells.
		von Schaewen A, Sturm A, O'Neill J, Chrispeels MJ (1993) Isolation of a mutant Arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesize Golgi-modified complex N-linked glycans.
	www.plantphysiol.org /cgi/content/full/119/2/725 (3790 words)

	Production of an Endo-beta -N-Acetylglucosaminidase Activity Mediates Growth of Enterococcus faecalis on a ...
		glycans and the subsequent degradation of the released glycans
		(a) Glycans from heat-inactivated culture supernatant after 2 h of incubation were resolved by HPAEC using a gradient of 10 to 60 mM sodium acetate (0 to 30 min) in 100 mM sodium hydroxide.
		Glycans were quantified by peak integration of detector response.
	jb.asm.org /cgi/content/full/182/4/882 (4790 words)

	AllRefer Health - Medical News > Scientists unveil malaria mechanism
		Interestingly, these glycans were discovered to be sandwiched between surfaces where the two RII molecules bind to each other when they form their handshake.
		An important idea stemming from this view is that blocking the RII interaction--with drugs or vaccines--should block glycophorin A receptor binding and forestall malaria infection.
		The result: All such altered versions of the RII protein failed to bind to red blood cells, confirming the idea that drugs or vaccines that block the RII interaction, glycan binding, or both might be effective therapies for malaria.
	health.allrefer.com /news/index.php?ID=7857 (477 words)

	Structural Analysis of Murine Zona Pellucida Glycans. EVIDENCE FOR THE EXPRESSION OF CORE 2-TYPE O-GLYCANS AND THE Sda ... (Site not responding. Last check: 2007-10-04)
		Permethylation of Released Glycans and Preparation of Partially Methylated Alditol Acetates-- Permethylation was performed using the sodium hydroxide/methyl iodide procedure exactly as established previously (15).
		The permethylated glycans were subjected to FAB-MS analysis using an established method (15).
		not be unreasonable for murine ZP glycans to undergo modification
	www.jbc.org /cgi/content/full/275/11/7731 (5295 words)

	Mathews/van Holde/Ahern 3rd Edition (Site not responding. Last check: 2007-10-04)
		In N-linked glycoproteins, the glycans are usually attached through N-acetylglucosamine or N-acetylgalactosamine to the side chain amino group in an asparagine residue.
		In O-linked glycoproteins, glycans are usually attached through an O-glycosidic bond between N-acetylgalactosamine and the hydroxyl group of a threonine or serine residue.
		Part of the recognition of immunoglobulins is due to the sequence of the oligosaccharide chains of the glycans.
	oregonstate.edu /instruct/bb451/winter2004/common451/ch09/c09gp.htm (271 words)

	John B. Lowe
		Interactions between fucosylated glycans on these cells, or on their precursors, and molecules that recognize these glycans may therefore contribute to control of blood leukocyte number.
		FX-null mice are deficient in all fucosylated glycans.
		We are also using this system to identify molecules and mechanisms that operate downstream of this conditional and reversible block and that direct differentiation of T lymphocyte progenitors in the marrow.
	www.hhmi.org /research/investigators/lowe.html (1245 words)

	Surface Glycans of Candida albicans and Other Pathogenic Fungi: Physiological Roles, Clinical Uses, and Experimental ... (Site not responding. Last check: 2007-10-04)
		in covalent linkage of the attached biotin to the glycan.
		glycan being on the bacterial, not the fungal, cell surface.
		Glycan binding to and activation of immune cells.
	cmr.asm.org /cgi/content/full/17/2/281 (7856 words)

	The Number and Location of Glycans on Influenza Hemagglutinin Determine Folding and Association with Calnexin and ...
		glycans were evidently needed for calreticulin but not for calnexin
		It is somewhat surprising that glycan N81 should prove to be so essential because it is not conserved among influenza strains.
		It is also clear that glycans have effects on HA folding that are independent of calnexin and calreticulin.
	www.jcb.org /cgi/content/full/139/3/613 (7065 words)

	In Vivo Synthesis of Mammalian-Like, Hybrid-Type N-Glycans in Pichia pastoris -- Vervecken et al. 70 (5): 2639 -- ... (Site not responding. Last check: 2007-10-04)
		they are further modified into complex glycans (18).
		Glycans were detected at the end of the gel with an
		In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides—evidence for N-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei.
	aem.asm.org /cgi/content/full/70/5/2639 (4442 words)

	Specific N-Glycans Direct Apical Delivery of Transmembrane, but Not Soluble or Glycosylphosphatidylinositol-anchored ...
		Duplicate filters of polarized MDCK cells stably expressing wild-type endolyn or the indicated mutant proteins were radiolabeled for 2 h and chased for 15 min before domain-selective biotinylation.
		glycans) was critical for generating the apical sorting determinant.
		Glycans have previously been implicated in the function of endolyn/CD164.
	www.molbiolcell.org /cgi/content/full/15/3/1407 (6304 words)

	N-Linked Glycans with Similar Location in the Fusion Protein Head Modulate Paramyxovirus Fusion -- von Messling and ...
		The positions of the CDV glycans are indicated at the top using the CDV numbering and the g1, g2, g3 code used for Fig.
		Numbers above glycan symbols indicate the asparagine position in the CDV sequence; n1 through 3 refer to the CDV glycan that is complemented by the respective mutant (as in Fig.
		Glycans essential for folding and transport are labeled with a T, glycans that modulate fusion activity are labeled with an F, and dispensable glycans are labeled with an N. The table shown in Fig.
	jvi.asm.org /cgi/content/full/77/19/10202 (6516 words)

	Mutational Analysis of the N-Linked Glycans on Autographa californica Nucleopolyhedrovirus gp64 -- Jarvis et al. 72 ...
		Mutational Analysis of the N-Linked Glycans on Autographa californica Nucleopolyhedrovirus gp64 -- Jarvis et al.
		The reactions were terminated by the addition of an equal volume of 2× Laemmli sample buffer, heated for 10 min at 65°C, and analyzed by SDS-PAGE and autoradiography.
		glycans had any direct effects on behavior of the protein.
	jvi.asm.org /cgi/content/full/72/12/9459 (7823 words)

	Lewis X-Containing Glycans are Specific and Potent Competitive Inhibitors of the Binding of ZP3 to Complementary Sites ... (Site not responding. Last check: 2007-10-04)
		of glycans with other nonreducing termini implicated in sperm-ZP binding were not inhibitors [12, 15].
		A list of the glycans and neoglycoproteins used in these studies, their structures, and the suppliers and catalog numbers of these reagents.
		glycans are structural mimics of sperm-binding glycans on ZP3.
	www.biolreprod.org /cgi/content/full/71/3/770 (4749 words)

	Biosynthesis and Immunolocalization of Lewis a-Containing N-Glycans in the Plant Cell -- Fitchette et al. 121 (2): 333 ... (Site not responding. Last check: 2007-10-04)
		We recently demonstrated the presence of a new asparagine-linked complex glycan on plant glycoproteins that harbors the Lewis
		Ogawa H, Hijikata A, Amano M, Kojima K, Fukushima H, Ishizuka I, Kuruhara Y, Matsumoto L (1996) Structures and contribution to the antigenicity of oligosacharides of Japanese cedar (Cryptomeria japonica) pollen allergen Cry j I: relationship between the structures and antigenic epitopes of plant N-linked complex-type glycans.
		Analysis of Asn-linked glycans from vegetable foodstuffs: widespread occurrence of Lewis a, core {{alpha}}1,3-linked fucose and xylose substitutions
	www.plantphysiol.org /cgi/content/full/121/2/333 (5591 words)

	O-glycans on human high endothelial CD34 putatively participating in L-selectin recognition -- Satomaa et al. 99 (7): ... (Site not responding. Last check: 2007-10-04)
		The L-selectin-binding glycans are synthesized by various glycosyltransferases.
		Enzyme-assisted synthesis of a tetravalent sialyl Lewis x glycan, derived from a linear polylactosamine.
		L-selectin ligands in rat high endothelium: multivalent sialyl Lewis x glycans are high affinity inhibitors of lymphocyte adhesion.
	www.bloodjournal.org /cgi/content/full/99/7/2609 (2075 words)

	Sulfated glycans and elevated temperature stimulate PrPSc-dependent cell-free formation of protease-resistant prion ... (Site not responding. Last check: 2007-10-04)
		Sulfated glycans and elevated temperature stimulate PrPSc-dependent cell-free formation of protease-resistant prion protein -- Wong et al.
		glycans or an intact GPI anchor (Rudd et al., 1999).
		Shyng,S.L., Lehmann,S., Moulder,K.L. and Harris,D.A. (1995) Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.
	embojournal.npgjournals.com /cgi/content/full/20/3/377 (6032 words)

	Burnham Institute - Faculty & Research - Faculty - Minoru Fukuda Report (Site not responding. Last check: 2007-10-04)
		Polysialic acid and HNK-1 glycan represent carbohydrates enriched in neural cells.
		Polysialic acid is mainly attached to NCAM in embryos, while the majority of NCAM in adults lack this carbohydrate.
		To understand the roles of these glycans in neural development, we have cloned cDNAs encoding human polysialyltransferase, PST, and HNK-1 sulfotransferase, HNK-1ST, that are responsible for the synthesis of polysialic acid and HNK-1 glycan, respectively.
	www.burnham.org /FacultyAndResearch/faculty/minoru_fukuda_report.asp (915 words)

	N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication -- Wagner et ...
		Thus, it appears that this glycan is indispensable for the generation
		glycans on the replication of intact influenza viruses.
		Structural elucidation of the individual glycans of the FPV hemagglutinin by two-dimensional 1H n.m.r.
	vir.sgmjournals.org /cgi/content/full/83/3/601 (4761 words)

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