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Changes in the Lipid Turnover, Composition, and Organization, as Sphingolipid-enriched Membrane Domains, in Rat ... Data on the mass sphingolipid and glycerophospholipid contents at 8th DIC are from Refs. and it was not paralleled by the increase in glycerophospholipids The mass composition of the sphingolipid-enriched membrane fraction was calculated on the basis of the endogenous lipid content in the homogenate (reported in Tables I and II) and the distribution of radioactivity in each species within the gradient. www.jbc.org /cgi/content/full/276/24/21136   (7363 words)

Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic ... Positive-ion electrospray ionization mass spectra of choline glycerophospholipids in myocardial nuclei prepared from isolated perfused adult rat heart. Individual choline glycerophospholipid molecular species for each experimental condition are listed in Table 1. Total choline and ethanolamine glycerophospholipid mass in rat myocardial nuclei as determined by ESI mass spectrometry. www.jlr.org /cgi/content/full/41/10/1585   (4990 words)

Lipids & Membranes   (Site not responding. Last check: 2007-10-21) In most glycerophospholipids (phosphoglycerides), the phosphate is in turn esterified to an alcohol of one of the following polar head groups: Sphingomyelin, with a phosphocholine head group, is comparable in size and shape to the glycerophospholipid phosphatidyl choline. Glycerophospholipids often include at least one fatty acid that is kinked, due to having one or more double bonds. www.carleton.ca /biology/2200/notes/membranes.html   (1589 words)

Search Results   (Site not responding. Last check: 2007-10-21) Membrane glycerophospholipid biosynthesis in Neisseria meningitidis and Neisseria gonorrhoeae: identification, characterization, and mutagenesis of a lysophosphatidic acid acyltransferase, A Tn916-generated mutant of a serogroup B meningococcal strain was identified that exhibited increased amounts of capsular polysaccharide and a threefold increase in the number of assembled pili. Implementation of these secondary enzymes results in alterations of glycerophospholipid composition that lead to pleiotropic effects on the cell surface components, including effects on capsule and piliation. hpv-web.lanl.gov /cgi-bin/gene_id_search.cgi?dbname=ngon&gene_id=NG0611   (425 words)

NIHbioDang.htm   (Site not responding. Last check: 2007-10-21) Effects of streptozotocin-induced diabetes on glycerophospholipid metabolism of the rat liver. Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism. Regulation of rat liver glycerophospholipid fatty acid composition in hypo- and hyperthyroidism. www.med.unc.edu /physiolo/labs/arendshorst/NIHbiodang.htm   (570 words)

Learning Strategies: Lipids & Membranes   (Site not responding. Last check: 2007-10-21) Learn how to draw phosphatidic acid, the parent compound of glycerophospholipids, starting from structural formulas of any two fatty acids, glycerol, and phosphate. Then look closely at how the "head-group substituents" (alcohols) listed in the table are joined to phosphatidic acid to make a glycerophospholipid. Your learning goal is to be able to take the structures of the components and correctly link them into a drawing of a glycerphospholipid (see quiz below). www.usm.maine.edu /~rhodes/LearnStrats99/Text/LipStrat.html   (454 words)

Cross Talk between Sphingolipids and Glycerophospholipids in the Establishment of Plasma Membrane Asymmetry -- Kihara ... that altered glycerophospholipid asymmetry was the cause of Overproduction of Rsb1p affects the flip-flop of NBD-labeled glycerophospholipids. Glycerophospholipids in the plasma membrane are arranged asymmetrically www.molbiolcell.org /cgi/content/full/15/11/4949   (6173 words)

Antiretroviral effects of glycerophospholipid stereoisomers of AZT on HIV replication in HT4-6C cells. Antiretroviral effects of glycerophospholipid stereoisomers of AZT on HIV replication in HT4-6C cells. CONCLUSIONS: Contrary to expectations, the sn-1 and sn-3 derivatives of pAZT were equally effective in reducing HIV replication of HT4-6C cells. This is a surprising result since most cellular phospholipases are thought to be specific for the sn-3 glycerophospholipids. www.aegis.com /aidsline/1990/dec/M90C3532.html   (477 words)

biol 2315 chapt8notes In most glycerophospholipids, the phosphate group is esterified to both glycerol and another group Each type of glycerophospholipid is a family of molecules that have the same polar head group and many different fatty acyl groups. Different phospholipases are used to dissect glycerophospholipid structure. www.langara.bc.ca /biology/mario/Biol2315notes/biol2315chap8.html   (1391 words)

AfCS Research Reports A list of lipids having significant or highly significant changes is summarized in Table 3. A summary of observed changes for the entire array is shown in Table 4. Summary of glycerophospholipid changes following AIG stimulation of WEHI-231 cells (negative mode). www.signaling-gateway.org /reports/v1/DA0011/ResultsC.htm   (467 words)

Selective plasmalogen substrate utilization by thrombin-stimulated Ca2+-independent PLA2 in cardiomyocytes -- McHowat ... Individual choline and ethanolamine glycerophospholipid molecular species were isolated by reverse-phase HPLC with the use The majority of ethanolamine glycerophospholipid was found to be arachidonylated, with 62% of plasmenylethanolamine and 73% Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myocytes. ajpheart.physiology.org /cgi/content/full/278/6/H1933   (3919 words)

Selective hydrolysis of plasmalogen phospholipids by Ca2+-independent PLA2 in hypoxic ventricular myocytes -- McHowat ... Calculation of relative percent is based on integrated peak areas and use of relative response factors for each FAME and DMA component as described previously (5). Individual choline and ethanolamine glycerophospholipid molecular species were isolated by reverse-phase HPLC using an Ultrasphere Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myoctes. ajpcell.physiology.org /cgi/content/full/274/6/C1727   (5448 words)

Lipids and glycosphingolipids in caveolae and surrounding plasma membrane of primary rat adipocytes -- Örtegren et ...   (Site not responding. Last check: 2007-10-21) occupied by sphingomyelin and glycerophospholipids in a membrane This is in sharp contrast to the detergent-insoluble fatty acid composition and polar head-groups of glycerophospholipids content.febsjournal.org /cgi/content/full/271/10/2028   (4901 words)

Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions.   (Site not responding. Last check: 2007-10-21) Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions. The metabolism of phospholipids in separated glial and neuronal cells has been reviewed in this paper. Therefore the results of in vitro and in vivo experiments indicate that neurons are more active than astroglia in metabolizing glycerophospholipids. www.arclab.org /medlineupdates/abstract_7301041.html   (134 words)

Synthesis, Isolation, and Characterization of the Adduct Formed in the Reaction of p-Hydroxyphenyl- acetaldehyde with ... CN, reduced Schiff base adducts of pHA with ethanolamine glycerophospholipid and serine glycerophospholipid (pHA-PE and pHA-PS, respectively) were produced. Collectively, these results demonstrate that an aldehyde generated by the myeloperoxidase system of phagocytes can covalently modify the amino groups of phosphatidylethanolamine and phosphatidylserine. Because amino glycerophospholipids are critical components of cell membranes and circulating lipoproteins such as LDL, similar reactions may play important roles in the initiation or progression of disease at sites of inflammation. pubs.acs.org /cgi-bin/abstract.cgi/crtoec/1999/12/i01/abs/tx980147s.html   (331 words)

Transcription Factor C/EBP{delta} in Fetal Lung: Developmental Regulation and Effects of Cyclic Adenosine ... initiated during the third trimester, in concert with augmented glycerophospholipid (27) subsequent to the appearance of differentiated type II cells and the initiation of synthesis of surfactant glycerophospholipids expression of enzymes involved in surfactant glycerophospholipid synthesis. endo.endojournals.org /cgi/content/full/138/12/5527   (5386 words)

AEGiS-06IAC: Antiretroviral effects of glycerophospholipid stereoisomers of AZT on HIV replication in HT4-6C cells. AEGiS-06IAC: Antiretroviral effects of glycerophospholipid stereoisomers of AZT on HIV replication in HT4-6C cells. Intact pAZTs have no intrinsic activity against HIV reverse transcriptase (RT). Therefore, the sn-1 pAZT must be degraded in the cell by enzymatic processes which are still uncharacterized before being converted to AZT-triphosphate, the inhibitor of RT. www.aegis.com /conferences/iac/1990/ThA265.html   (395 words)

EC 2.3.1.148   (Site not responding. Last check: 2007-10-21) Comments: catalyses the transfer of fatty acids from intact choline- or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent) in requiring CoA and not favouring the transfer of polyunsaturated acyl groups. www.chem.qmw.ac.uk /iubmb/enzyme/EC2/3/1/148.html   (134 words)

EC 2.3.1.147   (Site not responding. Last check: 2007-10-21) Comments: catalyses the transfer of arachidonate and other polyenoic fatty acids from intact choline or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. Differs from EC 2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent) in not requiring CoA and in its specificity for poly-unsaturated acyl groups. www.chem.qmw.ac.uk /iubmb/enzyme/EC2/3/1/147.html   (124 words)

New perspectives on the regulation of intermembrane glycerophospholipid traffic -- Voelker 44 (3): 441 -- Journal of ... New perspectives on the regulation of intermembrane glycerophospholipid traffic -- Voelker 44 (3): 441 -- Journal of Lipid Research New perspectives on the regulation of intermembrane glycerophospholipid traffic Summary of mutations/genes involved in interorganelle transport of glycerophospholipids www.jlr.org /cgi/content/full/44/3/441   (5823 words)

Oligo Annotation AGmmA010416   (Site not responding. Last check: 2007-10-21) physiological process -> cellular physiological process -> cellular metabolism -> cellular lipid metabolism -> membrane lipid metabolism -> phospholipid metabolism -> glycerophospholipid metabolism physiological process -> metabolism -> cellular metabolism -> cellular lipid metabolism -> membrane lipid metabolism -> phospholipid metabolism -> glycerophospholipid metabolism physiological process -> metabolism -> primary metabolism -> lipid metabolism -> cellular lipid metabolism -> membrane lipid metabolism -> phospholipid metabolism -> glycerophospholipid metabolism bio.hitachi-sk.co.jp /acegene/mouse30k/search_30k/mouse30k_oligo_annotation/agmma/010416.html   (544 words)

Active Complete in vitro Replication of Nodavirus RNA Requires Glycerophospholipid -- Wu et al. 89 (23): 11136 -- ... Flockhouse virus (FHV) is a member of the nodavirus group of positive-strand RNA viruses. Upon addition of glycerophospholipid (GPL), this system reproducibly carries out complete highly active replication of added FHV RNA, producing newly synthesized (+)-strand RNA in predominantly single-stranded RNA form. This accounts for previously observed effects of Lipofectin (a mixture of GPL and cationic lipid) in the system. www.pnas.org /cgi/content/abstract/89/23/11136   (996 words)

Clostridium perfringens {alpha}-Toxin Activates the Sphingomyelin Metabolism System in Sheep Erythrocytes -- Ochi et ... to the glycerophospholipid cycles, has been recognized as a hemolysis of rabbit erythrocytes is due to glycerophospholipid which stimulates the glycerophospholipid system in the membrane, www.jbc.org /cgi/content/full/279/13/12181   (5480 words)

[No title]   (Site not responding. Last check: 2007-10-21) The membrane additionally contains protein structures to carry ions, molecules, or signals across the membrane. Chemical Composition: Lipids and proteins are the major components Intracellular membranes have high % of protein for their functional roles May also contain polysaccharides No free carbohydrates Lipids: glycerophospholipids, shingolipids, and cholesterol are major components of eukaryotic cell membranes.  palmitate - saturated oleate - unsaturated Two most common glycerophospholipids:  Phosphatidylglycerol phosphoglyceride, found nearly exclusively in mitochondrial and bacterial membranes. www.brown.edu /Courses/BI0028_Yeh/BI28/lecture7.doc   (1331 words)

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