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Topic: Glyceryl trinitrate

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	Data Sheet
		Glyceryl trinitrate is a smooth muscle relaxant with vascular effects manifested predominantly by venous dilation with pooling.
		The major beneficial effect of glyceryl trinitrate in angina pectoris is a reduction in myocardial oxygen consumption secondary to vascular dilation with resultant reduction in cardiac preload and afterload.
		Continuous glyceryl trinitrate infusion at 3.1 to 4.0 mg/hr for 2-4 weeks in 36 patients resulted in an average methaemoglobin level of 0.2%, which was comparable to the level observed in patients receiving placebo.
	www.medsafe.govt.nz /Profs/Datasheet/m/Minitranpatch.htm (1678 words)

	American Family Physician: Comparing Glyceryl Trinitrate and Ritodrine in Tocolysis (Site not responding. Last check: 2007-10-09)
		Glyceryl trinitrate treatment consisted of an initial 10-mg patch, followed by a second 10-mg patch one hour later if there was no reduction in the frequency or strength of contractions.
		Headache occurred in 30 percent of women in the glyceryl trinitrate group, while tachycardia (58 percent), palpitations (13 percent) and nausea (10 percent) were common in the ritodrine group.
		Glyceryl trinitrate was also easier to administer and had a more benign side effect profile than ritodrine.
	www.findarticles.com /p/articles/mi_m3225/is_2_61/ai_59486888 (671 words)

	Excite UK Channels - Health
		Glyceryl trinitrate is also available as sublingual tablets and sprays, which are administered under the tongue to give rapid relief from angina attacks.
		Glyceryl trinitrate patches should be applied to a clean, dry, non-hairy, non-irritated area of skin on the chest or upper arm.
		Glyceryl trinitrate ointment should be measured onto the paper 'Applirule' provided with the medicine and applied to the skin on the chest, upper arm or thigh.
	www.netdoctor.co.uk /excite/medicines/show_main.asp?id=1696 (1014 words)

	Glyceryl trinitrate (PIM 247)
		When glyceryl trinitrate was given sublingually peak plasma concentrations appeared within 4 minutes and at least half of the intact glyceryl trinitrate was cleared from the blood in 1 to 3 minutes (Reynolds, 1982).
		Glyceryl trinitrate is metabolized by hydrolysis to dinitrates and the mononitrate (Reynolds, 1982).
		The effect of glyceryl trinitrate in relaxing coronary vessels is not considered to increase appreciably coronary blood flow (Reynolds, 1982).
	www.inchem.org /documents/pims/pharm/glyceryl.htm (3865 words)

	Excite UK Channels - Health
		Glyceryl trinitrate is taken as a tablet that is dissolved under the tongue, or as a spray that is sprayed under the tongue.
		Glyceryl trinitrate taken in this way is used to give rapid relief from an angina attack, and can also be used to prevent an anticipated attack, for example before exercise.
		Glyceryl trinitrate is also available as long acting tablets, skin patches and ointment that are used regularly each day to help prevent angina attacks.
	www.netdoctor.co.uk /excite/medicines/show_main.asp?id=1197 (1064 words)

	Deponit 5 , SPC from the eMC
		During glyceryl trinitrate biotransformation nitrite ions are released, which may induce methaemoglobinaemia and cyanosis with subsequent tachypnoea, anxiety, loss of consciousness and cardiac arrest.
		Glyceryl trinitrate is metabolized to 1,2- and 1,3-dinitroglycerols.
		Glyceryl trinitrate is a well-known active substance, established for more than a hundred years.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?documentid=6080 (1517 words)

	JNNP -- eLetters published in the past 30 days
		Glyceryl trinitrate and migraine: nitric oxide donor precipitating and aborting migrainous aura
		Re: Glyceryl trinitrate and migraine: nitric oxide donor precipitating and aborting migrainous aura
		Since glyceryl trinitrate is commonly used as a therapy for migraine aura[4,5], it does not appear that visual cortex activation induced by it[1] is pathogenetic.
	jnnp.bmjjournals.com /cgi/eletters?lookup=by_date&days=30 (7849 words)

	Data Sheet
		Glyceryl trinitrate acts on vascular smooth muscles to produce arterial and venous vasodilation.
		Glyceryl trinitrate is rapidly absorbed through the buccal and sublingual mucosa, and in man peak concentrations in plasma are observed within four minutes of sublingual administration.
		Glyceryl trinitrate may potentiate the hypotensive and anticholinergic effects of tricyclic antidepressants.
	www.medsafe.govt.nz /Profs/Datasheet/g/Glytrinspr.htm (1134 words)

	Nitro-Dur 0.2mg/h; 0.4mg/h and 0.6mg/h Transdermal Patch, SPC from the eMC
		Glyceryl trinitrate, (as other organic nitrates), is a potent dilator of vascular smooth muscle.
		Glyceryl trinitrate is rapidly hydrolysed by liver enzymes which are a major factor in bioavailability.
		Orally administered glyceryl trinitrate is ineffective as a therapeutic agent due to first-pass metabolism and administration has therefore routinely been via the sub-lingual route thus bypassing the hepatic circulation initially.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?documentid=1873 (1286 words)

	Glyceryl trinitrate treatment of chronic fissure in ano
		Glyceryl trinitrate treatment of chronic fissure in ano: One year's experience with 0.5% GTN paste
		F.F. STEWARD and P.T. Department of Surgery, Queen Elizabeth Hospital, King's Lynn, UK Objective: Assessment of the efficacy of topical 0.5% glyceryl trinitrate (GTN) paste in the treatment of chronic fissures in ano.
		Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate.
	www.rcsed.ac.uk /journal/vol45_3/4530008.htm (1715 words)

	The every coloproctologist site (Site not responding. Last check: 2007-10-09)
		Reversible chemical sphincterotomy may be achieved by anal application of glyceryl trinitrate ointment (nitric oxide donor), which has been reported to heal the majority of patients with anal fissure by inducing sphincter relaxation and improving anodermal blood flow.
		This trial aimed to further clarify the role of glyceryl trinitrate in the treatment of chronic anal fissure.
		RESULTS: The study was completed by 119 patients (59 glyceryl trinitrate and 60 placebo), matched for gender, age, duration of symptoms, duration of treatment, site of fissure, previous attempts to treat, pain score, and maximum anal resting pressure.
	www.procto.com /fissure.htm (1098 words)

	Le Magazine, October 2002 - Abstracts: Anti-Inflammatory, Gamma Tocopherol, Cellular Aging
		There was a significant reduction in pain scores in the glyceryl trinitrate group (mean decrease 0.59, p< 0.05, 95% confidence limits 0.04-1.14), 0.025% capsaicin group (mean decrease 0.5, p< 0.05, 95% confidence limits 0.05-1.05) and the glyceryl trinitrate capsaicin group (mean decrease 1.1, p<0.05, 95% confidence limits 0.22-1.98).
		The odds ratio in favor of continuing treatment was 2.1 (95% confidence limits 1.0-4.4) for glyceryl trinitrate and 2.4 (95% confidence limits 1.2-5.1) for capsaicin and 5.0 (95% confidence limits 3.8-6.4) for capsaicin GTN combination.
		Analgesic consumption is decreased by capsaicin, glyceryl trinitrate and to a greater extent by both combined.
	www.lef.org /magazine/mag2002/oct2002_abs_01.html (1838 words)

	A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures -- ...
		Glyceryl trinitrate heals anal fissures, high doses do it quicker, but there is a high recurrence rate.
		Glyceryl trinitrate is an effective treatment for anal fissure.
		Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo controlled trial and long term follow up.
	gut.bmjjournals.com /cgi/content/full/52/2/264 (3650 words)

	PakMediNet - View Abstract
		To evaluate the efficacy and safety of glyceryl trinitrate this observational study was done at Jinnah Hospital Lahore.
		Seventy women with preterm labour were treated with glyceryl trinitrate dermal patches and labour was arrested in 63 (90%).
		Glyceryl trinitrate patches are effective and safe for treatment of preterm labour.
	www.pakmedinet.com /view.php?id=21 (183 words)

	Mahidol University Abstracts of International Publications 2000
		Randomized comparison of glyceryl trinitrate and prostaglandin E2 for cervical ripening at term.
		OBJECTIVE: To estimate the adverse effects of glyceryl trinitrate compared with prostaglandin (PG) E2 vaginal tablet for cervical ripening in term pregnancy.
		trinitrate was associated with fewer episodes of uterine tachysystole (0% versus 9%; P =.02).
	www.mahidol.ac.th /abstracts/Pub2000/0022.htm (741 words)

	Effect of the nitric oxide donor, glyceryl trinitrate, on human gall bladder motility -- Greaves et al. 42 (3): 410 -- ...
		Effect of the nitric oxide donor, glyceryl trinitrate, on human gall bladder motility -- Greaves et al.
		Effect of the nitric oxide donor, glyceryl trinitrate, on human gall bladder motility
		To study the effect of glyceryl trinitrate, a nitric oxide donor, on gall bladder emptying in healthy subjects using
	gut.bmjjournals.com /cgi/content/full/42/3/410 (1834 words)

	Glyceryl trinitrate -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-09)
		Glyceryl trinitrate -- Facts, Info, and Encyclopedia article
		Glyceryl trinitrate (GTN) is the (Drug or medicine that is prepared or dispensed in pharmacies and used in medical treatment) pharmaceutical name for (A heavy yellow poisonous oily explosive liquid obtained by nitrating glycerol; used in making explosives and medically as a vasodilator (trade names Nitrospan and Nitrostat)) nitroglycerin.
		GTN is a (A drug that causes dilation of blood vessels) vasodilator which is used in the treatment and (The prevention of disease) prophylaxis of (Any disease of the throat or fauces marked by spasmodic attacks of intense suffocative pain) angina.
	www.absoluteastronomy.com /encyclopedia/g/gl/glyceryl_trinitrate.htm (121 words)

	Transdermal glyceryl trinitrate for dysmenorrhoea -- Po and Stones 313 (7053): 364 -- BMJ
		Transdermal glyceryl trinitrate for dysmenorrhoea -- Po and Stones 313 (7053): 364 -- BMJ
		of the efficacy of glyceryl trinitrate is unduly optimistic.
		Pittrof R, Lees C, Thompson C, Pickles A, Martin JF, Campbell S. Crossover study of glyceryl trinitrate patches for controlling pain in women with severe dysmenorrhoea.
	bmj.bmjjournals.com /cgi/content/full/313/7053/364/a (292 words)

	Abnormal Rheologic Effects of Glyceryl Trinitrate in Patients with Non-Insulin-Dependent Diabetes Mellitus and Reversal ...
		Abnormal Rheologic Effects of Glyceryl Trinitrate in Patients with Non-Insulin-Dependent Diabetes Mellitus and Reversal by Antioxidants -- Giugliano et al.
		Blood filterability and viscosity and platelet aggregation at baseline and 15 and 60 minutes after administration of sublingual glyceryl trinitrate (0.3 mg) in 20 controls and 20 patients with non-insulin-dependent diabetes.
		Blood filterability and viscosity and platelet aggregation at baseline and 1 and 12 hours after transdermal glyceryl trinitrate patches (10 mg) in 20 controls and 20 patients with diabetes.
	www.annals.org /cgi/content/full/123/5/338 (3512 words)

	Nitrate patches (Site not responding. Last check: 2007-10-09)
		RESULTS: Patients in the glyceryl trinitrate group had significantly reduced elbow pain with activity at 2 weeks, reduced epicondylar tenderness at 6 and 12 weeks, and an increase in wrist extensor mean peak force and total work at 24 weeks.
		The goal of the present study was to determine if topical glyceryl trinitrate improves clinical outcome measures in patients with Achilles tendinopathy.
		Twenty-eight (78%) of thirty-six tendons in the glyceryl trinitrate group were asymptomatic with activities of daily living at six months, compared with twenty (49%) of forty-one tendons in the placebo group (p = 0.001, chi-square analysis).
	users.bigpond.net.au /johnorchard/scuba_medicals.htm (539 words)

	GLYCERYL TRINITRATE [GTN] (Site not responding. Last check: 2007-10-09)
		Glycerol Trinitrate produces, in a dose related manner, dilation of both arterial and venous beds.
		Myocardial oxygen consumption is decreased by both the arterial and venous effects of Gylceryl Trinitrate.
		Gylceryl Trinitrate concentration should not exceed 400 micrograms / ml and should not be mixed with other drugs.
	www.cs.nsw.gov.au /rpa/neonatal/html/meds/gtn.htm (449 words)

	Comparing two different protocols for tilt table testing: sublingual glyceryl trinitrate versus isoprenaline infusion ...
		Glyceryl trinitrate and isoprenaline tilt tests were performed in two successive days on a random basis in cases and
		respectively, for glyceryl trinitrate v 58% and 89.4% for isoprenaline.
		Sublingual glyceryl trinitrate tilt testing is an effective and safe alternative to the isoprenaline infusion test and can
	heart.bmjjournals.com /cgi/content/abstract/81/6/603 (391 words)

	Glyceryl Trinitrate - Patient UK
		Glyceryl Trinitrate can be used to treat an angina attack or can be taken before exercise or exertion to help prevent an attack.
		Glyceryl Trinitrate is available in sublingual (under the tongue) tablets, aerosol spray, buccal tablets (dissolve next to the cheek), patches, ointment and injection form.
		Glyceryl Trinitrate is also sometimes known as: GTN; Coro-Nitro; Glytrin; Nitrolingual; Nitromin; Suscard; Sustac; Nitrocine; Nitronal; Deponit; Minitran; Nitrodur; Transiderm Nitro; Trintek; Percutol.
	www.patient.co.uk /showdoc/30003883 (974 words)

	Your questions to the PBAC (Site not responding. Last check: 2007-10-09)
		The figure of nearly $28 million quoted as the cost to government for glyceryl trinitrate during 1992 refers to all the drug's forms and strengths that are listed on the Pharmaceutical Benefits Scheme.
		The Committee recognised that there may be instances where patients do not require as many as 100 tablets, but it was considered that the minimal cost savings achieved by reducing the maximum quantity does not warrant the inconvenience or potential danger to patients who use the drug more frequently.
		Thus, there would be minimal savings if glyceryl trinitrate tablets were packaged in smaller quantities and the availability of a smaller pack in addition to the 100 would mean unnecessary additional space in pharmacy dispensaries and wholesalers' shelves.
	www.australianprescriber.com /magazines/vol18no1/pbac.htm (438 words)

	DG DISPATCH - ASCRS: Topical Glyceryl Trinitrate Has Short-Lived Effect On Anal Pressure (Site not responding. Last check: 2007-10-09)
		Jonas, from the Section of Surgery at the University Hospital, in Nottingham, UK, and colleagues conducted a study to determine the duration of glyceryl trinitrate 0.2% ointment on resting anal pressure.
		Nine men and six women, all healthy, who had a median age of 30 years, underwent continuous anal manometry for ten minutes before and after application of glyceryl trinitrate to the skin of the anus.
		The researchers concluded that glyceryl trinitrate 0.2% ointment effectively lowers anal resting pressure for at least 90 minutes post-treatment.
	www.pslgroup.com /dg/1d84a2.htm (308 words)

	Progress in the understanding and treatment of chronic anal fissure -- McCallion and Gardiner 77 (914): 753 -- ...
		It has been suggested that tachyphylaxis may occur when glyceryl trinitrate is used to treat anal fissure,
		A potential problem with using glyceryl trinitrate ointment outside of a trial setting may be poor compliance.
		As topical glyceryl trinitrate is simple to apply, achieves satisfactory healing rates and is cheap, the authors recommend
	pmj.bmjjournals.com /cgi/content/full/77/914/753 (3885 words)

	WHO Guide to Good Prescribing: Example: Angina Pectoris (Site not responding. Last check: 2007-10-09)
		In general, three active substances are available for the treatment of an acute attack: glyceryl trinitrate (nitroglycerin), isosorbide mononitrate and isosorbide dinitrate (Table 4).
		In this case the active substance for your P-drug of choice for an attack of angina pectoris would be: sublingual tablets of glyceryl trinitrate 1 mg.
		In general only a small supply of glyceryl trinitrate tablets should be prescribed as the active substance is rather volatile and the tablet may become ineffective after some time.
	www.timl.se /sfam.lakemedel/guide/ggp-text/chapter3/page04.htm (393 words)

	OrigynRx.com
		Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure.
		Double-blind manometric assessment of two topical glyceryl trinitrate formulations in patients with chronic anal fissures.
		Systemic levels of glyceryl trinitrate following topical application to the anoderm do not correlate with the measured reduction in anal pressure.
	www.origynrx.com /physician_ref_list.asp (873 words)

	SINOPREN 5 Tablets; SINOPREN 10 Tablets; SINOPREN 20 Tablets
		The systematic administration of transdermal glyceryl trinitrate did not show any independent effect on the same outcome measures (OR 0,94; 95% CI 0,84 to 1,05 and OR 0,94; 95% CI 0,87 to 1,02).
		Systematic combined administration of lisinopril and glyceryl trinitrate also produced significant reductions in overall mortality (OR 0,83; 95% CI 0.70 to 0,97) and in the combined end-point (OR 0,85; 95% CI 0,76 to 0,94).
		Although the systematic administration of glyceryl trinitrate started early and continued for 6 weeks after acute myocardial infarction does not yield evidence of benefit, early treatment with lisinopril appears to improve prognosis.
	home.intekom.com /pharm/ranbaxy/sinopren.html (3352 words)

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