
	Where results make sense

Topic: Glycogenin

In the News (Thu 24 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	[No title]
		Glycogenin activity, a measure of the glycosylating ability of the protein increased at 30min and remained elevated for the remainder of the study.
		Glycogenin, the self-glucosylating primer for glycogen synthesis, is expressed in wild-type E. coli as a recombinant protein in an already partly glucosylated form, owing to the presence of its substrate, UDP-glucose.
		Glycogenin in the glycogen/sarcovesicular fraction is therefore bound covalently to glycogen, and not associated (covalently or non-covalently) with the sarcoplasmic reticulum.
	www.pdg.cnb.uam.es /martink/LINKS/PRACTICS/glycogenin.xml (18510 words)

	glycogen
		Therefore, the production of active glycogenin primer in the cell has the potential to be the overall rate-limiting process in glycogen formation, capable of overriding the better understood hormonally controlled mechanisms of protein phosphorylation/dephosphorylation that regulate the activities of glycogen synthase and phosphorylase.
		Glycogenin has the ability to glucosylate molecules other than itself and to hydrolyze UDP glucose.
		This is proglycogen, a low molecular mass (similar to 400 kDa) form of glycogen that serves as a stable intermediate on the pathways to and from depot glycogen (macroglycogen, mass 10(7) Da, in muscle).
	www.msu.edu /~delgadoi/glycogen.html (809 words)

	APStracts 6:0222E, 1999.
		Glycogenin activity in human skeletal muscle is proportional to muscle glycogen concentration..
		The de novo biosynthesis of glycogen is catalyzed by glycogenin, a self-glucosylating protein primer.
		To date, the role of glycogenin in regulating glycogen metabolism and the attainment of maximal glycogen levels in skeletal muscle is unknown.
	www.uth.tmc.edu /apstracts/1999/endo/October/222e.html (273 words)

	APStracts 6:0256E, 1999. (Site not responding. Last check: 2007-11-03)
		We examined whether the protein level and/or activity of glycogenin, the protein core upon which glycogen is synthesized, is limiting for maximal attainable glycogen levels in rat skeletal muscle.
		Glycogenin activity was 27.5+/-1.4, 34.7+/-1.7 and 39.7+/-1.3 mU_mg-1 protein in white gastrocnemius, red gastrocnemius and soleus muscles respectively.
		Neither glycogenin protein level nor the activity of glycogenin correlated with previously determined maximal attainable glycogen levels, which were 69.3+/-5.8, 137.4+/-10.1 and 80.0+/-5.4 _mol_g-1 wet weight in white gastrocnemius, red gastrocnemius and soleus muscles respectively.
	www.uth.tmc.edu /apstracts/1999/endo/October/256e.html (250 words)

	GNIP, a Novel Protein That Binds and Activates Glycogenin, the Self-glucosylating Initiator of Glycogen Biosynthesis -- ...
		Glycogenin is a self-glucosylating protein involved in the initiation of glycogen biosynthesis.
		yeast glycogenin, Glg2p, and yeast glycogen synthase, Gsy2p (14).
		of GNIP on the self-glucosylation reaction catalyzed by glycogenin.
	www.jbc.org /cgi/content/full/277/22/19331 (5347 words)

	41MR3e.html
		In skeletal muscle, all of the glycogenin is incorporated into glycogen molecules (1) The glycogen molecules also are all presumed to be proteoglycans.
		In the TCA precipitable fractions of the retinal membranes, the glycogen to which glycogenin was attached had an average Mr of 470 kDa as determined on a sizing column.
		A similar enzyme is present but whether it is identical to skeletal muscle glycogenin is not known but it is likely to be the case (40, 62-64).
	www.gak.co.jp /TIGG/41MR3e.html (4113 words)

	Xtremebodyshop.com- Muscle Glycogen Resynthesis and Bodybuilding! (Site not responding. Last check: 2007-11-03)
		Glycogenin, a glycoprotein, serves as a guide for all glycogen synthesis.
		Thus the production of active glycogenin primer in the cell has the potential to be the overall rate limiting process in glycogen formation.
		The unique structural and metabolic properties of these compounds make it highly likely that in addition to priming glycogen synthesis on their own, they could act synergistically with other drugs to stimulate glucose disposal and glycogen synthesis.
	www.xtremebodyshop.com /articles/articles05/nutrition/muscleglyco.html (2550 words)

	Rabbit skeletal muscle glycogenin. Molecular cloning and production of fully functional protein in Escherichia coli -- ...
		Glycogenin is a self-glucosylating protein involved in the initiation
		isolate DNA fragments encoding a portion of glycogenin from rat and cow.
		indicating that the recombinant glycogenin was enzymatically active and
	www.jbc.org /cgi/content/abstract/267/36/25759 (506 words)

	Centro de Investigaciones en Química Biológica de Córdoba
		In 1985 we described that glycogen is bound to a tyrosine residue of the protein in a new type of glycosidic linkage.
		glycogen-bound protein, named glycogenin, is an autoglucosyltransferase that initiates the polymerization of glucose, synthesizing the primer for further polymerization by glycogen synthase.
		We have also described the isolation of the C-chain bound to glycogenin (c-glycogenin), the modulation of glycogenin expression during development and its thermal stabilization and inhibition of glucosyltransferase activity caused by linkage to the polysaccharide.
	www.ciquibic.gov.ar /Investcurtinoing.htm (195 words)

	Structure of glycogen
		In addition it is worth noting the molecule of glycogenin, a protein that acts as a primer, at the centre of the structure.
		In addition, of course, the glycogenin molecule at the core is omitted, as this was not suspected in 1940.
		If they mention glycogenin at all they do so in a different context from the one in which the structure is given.
	bip.cnrs-mrs.fr /bip10/glycogen0.htm (1029 words)

	Glycogenin activity in human skeletal muscle is proportional to muscle glycogen concentration -- Shearer et al. 278 ...
		Glycogenin activity in human skeletal muscle is proportional to muscle glycogen concentration -- Shearer et al.
		Glycogenin activity was measured as previously described (4, 6).
		which glucose is transferred to glycogenin have yet to be explored.
	ajpendo.physiology.org /cgi/content/full/278/1/E177 (2478 words)

	University of Miami Department of Biochemistry and Molecular Biology (Site not responding. Last check: 2007-11-03)
		We discovered a covalently bound protein in glycogen, which we have named glycogenin, and on which glycogen is synthesized via a unique carbohydrate-to-protein linkage involving the hydroxyl group of a tyrosine residue.
		Glycogenin is autocatalytic, and adds an average of eight glucose residues to itself to become the primer for the synthesis of a newly discovered, stable glycogen intermediate, proglycogen, the amount of which varies from trace proportions (liver) to as much as 50% by weight of the total glycogen (heart).
		With human volunteers we are investigating the effects on the glycemic index of the rate at which digestible carbohydrate is eaten or drunk.
	molbio.med.miami.edu /index.php?option=content&task=view&id=23&Itemid=26 (513 words)

	Poster Session Abstracts (Site not responding. Last check: 2007-11-03)
		Glycogenin (GN) is a self-glucosylation protein involved in the initiation of glycogen biosynthesis.
		A Tyr194Phe mutant glycogenin was found to be inactive for self-glucosylation.
		This raises the possibility that the intramolecular self-glucosylation of glycogenin is an intersubunit reaction.
	www.medlib.iupui.edu /faculty/scs/p42.html (183 words)

	Effect of flax supplementation and growth promotants on lipoprotein lipase and glycogenin messenger RNA concentrations ... (Site not responding. Last check: 2007-11-03)
		Biopsy samples of the LM were taken on alternating sides beginning on d 0 (before flaxseed was fed) and on d 14 and 28.
		The RNA was isolated from the muscle biopsy samples and used to produce complimentary DNA, which was quantified with real-time quantitative PCR, comparing the quantity of glycogenin relative to the quantity of 18S rRNA.
		Glycogenin steady-state messenger RNA concentration in cultures of satellite cells cultured with increasing levels of
	www.animal-science.org /cgi/content/full/82/6/1868 (4496 words)

	Yeast glycogenin (Glg2p) produced in Escherichia coli is simultaneously glucosylated at two vicinal tyrosine residues ... (Site not responding. Last check: 2007-11-03)
		Yeast glycogenin (Glg2p) produced in Escherichia coli is simultaneously glucosylated at two vicinal tyrosine residues but results in a reduced bacterial glycogen accumulation -- Albrecht et al.
		in the presence or the absence of the eukaryotic glycogenin
		Lomako, J., Lomako, W.M. and Whelan, W.J. (2004) Glycogenin: the primer for mammalian and yeast glycogen synthesis.
	content.febsjournal.org /cgi/content/full/271/20/3978 (5237 words)

	Welcome to The Supplement Research Foundation
		Glycogen synthase activation is considered to be an important regulatory step in glycogen synthesis (1).
		By the way, supercompensated muscle glycogen levels can maintained at least three days after carb loading on a moderate carbohydrate diet according to a study at the Naval Health Research Center in San Diego.
		The amount of glycogenin will influence how much glycogen a cell can store (15).
	www.tsrf.com /articles/article_muscle.htm (2562 words)

	Amazon.com: "rabbit muscle glycogenin": Key Phrase page (Site not responding. Last check: 2007-11-03)
		Rabbit muscle glycogenin is a 37 kDa self-glycosylating protein containing 332 amino acids (Campbell & Cohen, 1989) that glycosylates the hydroxyl group of...
		In vitro, yeast Csy2p works poorly to elongate rabbit muscle glycogenin, and mammalian glycogen synthase is less effective with the Glg proteins than with glycogenin (17).
		the sugar nucleotide to a protein, glycogenin, which is currently considered to participate in the initiation of glycogen synthesis.""' The rabbit muscle glycogenin is a 37 kDa self-glucosylating protein of 332 amino acids," that glycosylates the hydroxyl group of its tyrosine residue 194;"v-9t...
	www.amazon.com /phrase/rabbit-muscle-glycogenin (675 words)

	Glycogen
		Glycogenin remains bound to the reducing end of glycogen (the C1 hydroxyl group at the right side of the pictures).
		Glycogen synthase works efficiently only when it is bound to glycogenin.
		Thus the number of glycogen granules in a cell is determined by the number of glycogenin molecules available, and the size of the granules is limited by the need for physical association between glycogenin and glycogen synthase.
	cmgm.stanford.edu /biochem200/glycogen (1143 words)

	The size of the C-chain maltosaccharide of glycogen: evidence for the presence of only a single branch -- Bazán ...
		the fifth glucose from the tyrosine residue of glycogenin.
		Pitcher, J., Smythe, C., and Cohen, P. (1988) Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.
		Romero, J.M. and Curtino, J.A. (2003) C-chain-bound glycogenin is released from proteoglycogen by isoamylase and is able to autoglucosylate.
	glycob.oxfordjournals.org /cgi/content/full/15/10/14C (2784 words)

	BioMed Central \| Full text \| Structure of GlgS from Escherichia colisuggests a role in protein-protein interactions
		In eukaryotes, glycogenin plays this initiating role and is required for glycogen synthesis [2,3].
		Instead, glycogen synthase from Agrobacterium tumefaciens was shown to be sufficient for both glucan priming and elongation, and this appears to be generally true in eubacteria [6].
		A relevant example is the recent discovery of glycogenin interacting protein (GNIP) in the eukaryotic glycogen synthesis [18].
	www.biomedcentral.com /1741-7007/2/10 (2405 words)

	Glycogenin activity and mRNA expression in response to volitional exhaustion in human skeletal muscle -- Shearer et al. ...
		Glycogenin activity and mRNA expression in response to volitional exhaustion in human skeletal muscle -- Shearer et al.
		an increase in glycogenin gene expression as exercise and glycogenolysis
		Glycogenin mRNA and activity in human skeletal muscle during exercise to volitional exhaustion.
	jap.physiology.org /cgi/content/full/99/3/957 (3804 words)

	ISOT/ECRO (Site not responding. Last check: 2007-11-03)
		Glycogenin is a unique, autocatalytic protein that constitutes the primer for glycogen synthesis.
		Any underexpression of the glycogenin receptor could result in hyperglycemia because of the inability of muscle to act as the reservoir in which excess glucose is stored.
		It seems likely that proteins, perhaps autocatalytic, will be found to be the primers/receptors for the synthesis of storage polysaccharides and that their integrity will be found vital to proper cellular function.
	www.fst.rdg.ac.uk /research/tostq/brighton00.htm (2362 words)

	From maternal glucose to fetal glycogen: expression of key regulators in the human placenta -- Hahn et al. 7 (12): 1173 ...
		Representative Western blot of glycogenin (at 37 kDa), also showing glucosylated species at higher molecular weights in homogenates of first trimester and term placental villous tissue and in a homogenate of term villous tissue after enzymatic glycogen degradation (amylolysis).
		GLUT3 in endothelium, basal decidua and invading extravillous
		Smythe, C. and Cohen, P. (1991) The discovery of glycogenin and the priming mechanism for glycogen biogenesis.
	molehr.oxfordjournals.org /cgi/content/full/7/12/1173 (3423 words)

	Increases in glycogenin and glycogenin mRNA accompany glycogen resynthesis in human skeletal muscle -- Shearer et al. ...
		Increases in glycogenin and glycogenin mRNA accompany glycogen resynthesis in human skeletal muscle -- Shearer et al.
		Glycogenin is the self-glycosylating protein primer that initiates
		glycogenin was detected in muscle, indicating that all glycogenin
	ajpendo.physiology.org /cgi/content/abstract/289/3/E508 (325 words)

	Glycogenin at AllExperts
		Glycogenin is an enzyme involved in the initiation of glycogen biosynthesis.
		Because glycogen synthase (the main enzyme involved in glycogen synthesis) can only add to an existing chain, glycogenin acts as the "primer" to begin this mechanism.
		Glycogenin can catalyze the addition of glucose to itself by binding the first UDP-Glucose to a Tyr-194 residue in its active site.
	en.allexperts.com /e/g/gl/glycogenin.htm (154 words)

	Effects of exercise on GLUT-4 and glycogenin gene expression in human skeletal muscle -- Kraniou et al. 88 (2): 794 -- ...
		Effects of exercise on GLUT-4 and glycogenin gene expression in human skeletal muscle -- Kraniou et al.
		argued that glycosylated glycogenin is the primary substrate for
		Glycogen storage in L6 cells are increased by overexpression of glycogenin (Abstract).
	jap.physiology.org /cgi/content/full/88/2/794 (2568 words)

	Glycogenin 2, Homo sapiens - UniGene Hs.567381
		Homo sapiens glycogenin 2 (GYG2), transcript variant 2, mRNA
		Homo sapiens clone FG060304 glycogenin 2 mRNA, complete cds, alternatively spliced
		Homo sapiens glycogenin 2 (GYG2), transcript variant 1, mRNA
	www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=567381 (258 words)

	Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces ...
		approximately 33% identity to glycogenin, a mammalian protein postulated to
		Albrecht, T., Haebel, S., Koch, A., Krause, U., Eckermann, N., Steup, M. Yeast glycogenin (Glg2p) produced in Escherichia coli is simultaneously glucosylated at two vicinal tyrosine residues but results in a reduced bacterial glycogen accumulation.
		Wilson, W. A., Wang, Z., Roach, P. Systematic Identification of the Genes Affecting Glycogen Storage in the Yeast Saccharomyces cerevisiae: Implication of the Vacuole as a Determinant of Glycogen Level.
	mcb.asm.org /cgi/content/abstract/15/12/6632?vol=15&fp=6632&view=abstract (568 words)

Try your search on: Qwika (all wikis)