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Topic: Glycoprotein

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In the News (Mon 22 Jul 19)

  Glycoprotein definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
Glycoprotein: A molecule that consists of a carbohydrate plus a protein.
For instance, in the immune system almost all of the key molecules involved in the immune response are glycoproteins.
A glycopeptide is similar in structure to a glycoprotein but has a shorter chain of amino acids.
www.medterms.com /script/main/art.asp?articlekey=16842   (196 words)

  Glycoprotein - Wikipedia, the free encyclopedia
Glycoproteins are often used in proteins that are at least in part located in extracellular space (that is, outside the cell).
One example of glycoproteins found in the body are mucins, which are secreted in the mucus of the respiratory and digestive tracts.
Glycoproteins are important for immune cell recognition, especially in mammals.
en.wikipedia.org /wiki/Glycoprotein   (296 words)

 Glycoprotein Summary
Glycoproteins are most commonly found embedded in the plasma membranes of cells, with the carbohydrate exposed to the cell interior.
The carbohydrate portion of a glycoprotein is commonly a branched chain of fifteen or fewer monosaccharides.
Other glycoproteins are thought to act during development to aid cells as they migrate to their proper location in the body.
www.bookrags.com /Glycoprotein   (484 words)

 Post-Translational Modifications
Membrane associated carbohydrate is exclusively in the form of oliogsaccharides covalently attached to proteins forming glycoproteins, and to a lesser extent covalently attached to lipid forming the glycolipids.
Glycoproteins on cell surfaces are important for communication between cells, for maintaining cell structure and for self-recognition by the immune system.
Some glycoproteins are tethered to the membrane by a lipid linkage: the protein is attached to the carbohydrate through phosphatidylethanolamine (PE) linkage, and the carbohydrate is in turn attached to the membrane via linkage to phosphatidylinositol (PI), which anchors the structure within the membrane.
web.indstate.edu /thcme/mwking/protein-modifications.html   (3869 words)

 Patent 6,359,118
Glycoprotein activity--an activity selected from the group consisting of binding, catalysis, signalling, transport, or other activities which induce a functional response within the environment in which the glycoprotein is used, such as induction of immune response and immunogenicity, or combinations thereof.
Glycoprotein crystals may also be crosslinked in such a way that they dissolve or release their protein activity upon exposure to a trigger in their environment encountered under conditions of use.
Alternatively, carbohydrate crosslinked glycoprotein crystals are characterized by stability and integrity in the presence of a solvent contained in the sample to be separated, as compared with the soluble uncrosslinked form of the glycoprotein that is crystallized to form the glycoprotein crystals that are crosslinked.
www.pharmcast.com /Patents/Yr2002/Mar2002/031902/6359118_Glycoprotein031902.htm   (5360 words)

 HRG - histidine-rich glycoprotein
Histidine-rich glycoprotein complexed with thrombospondin was capable of binding heparin and neutralizing the anticoagulant activity of heparin in plasma.
On the significance of antithrombin-III, alpha 2-macroglobulin, alpha 2-antiplasmin, histidine-rich glycoprotein, and protein C in patients with acute myocardial infarction and deep vein thrombosis.
The plasma proteins alpha 2-plasmin inhibitor and histidine-rich glycoprotein were compared directly with respect to their effectiveness in inhibiting the binding of plasminogen to fibrin under the same experimental conditions.
www.ihop-net.org /UniPub/iHOP/gg/89176.html   (2351 words)

In nerve tissue glycoproteins are abundant in gray matter and appear to be associated with synaptosomes, axons, and microsomes.
Reproduction: Glycoproteins found on the surface of spermatozoa appear to increase a sperm cell's attraction for the egg by altering the electrophoretic mobility of the plasma membrane.
Freezing-point depression: Glycoproteins were found in the sera of antarctic fishes to decrease the freezing point due to their apparent interaction with water(Gottschalk).
www.cs.stedwards.edu /chem/Chemistry/CHEM43/CHEM43/Glycoproteins/Glycoproteins.HTML   (3046 words)

 Baylor Health Care System: Glycoprotein IIb/IIIa receptor antagonists
Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes.
Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction.
Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty.
www.baylorhealth.edu /proceedings/13_2/13_2_gurkturner.html   (1994 words)

 Definition of glycoprotein - Merriam-Webster Online Dictionary
Learn more about "glycoprotein" and related topics at Britannica.com
Find more about "glycoprotein" instantly with Live Search
See a map of "glycoprotein" in the Visual Thesaurus
www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=glycoprotein   (38 words)

 Carbohydrate deficient Glycoprotein Syndrome Type Ia
Carbohydrate-deficient Glycoprotein Syndrome Type Ia (CDG1A) is an extremely rare inherited metabolic disorder belonging to a group of diseases known as Carbohydrate-deficient Glycoprotein Syndromes (CDGS).** These disorders are characterized by the presence of abnormal oligosaccharides, or "sugar chains," on many glycoproteins (e.g., transferrin).
Carbohydrate-deficient Glycoprotein Syndrome Type II (CDG2) is an extremely rare inherited metabolic disorder belonging to the group of diseases known as Carbohydrate-deficient Glycoprotein Syndromes (CDGS).
Although many glycoproteins may exhibit carbohydrate abnormalities similar to those seen in transferrin (e.g., alpha-1-antitrypsin and thyroxine-binding globulin) in cases of CDG1A, none has been as thoroughly researched and studied as transferrin; therefore, in most cases, diagnostic methods for CDGS Type Ia are based upon transferrin analyses (e.g., isoelectric focusing).
hw.healthdialog.com /kbase/nord/nord1071.htm   (6929 words)

 Invitrogen - Molecular Probes - Proteomics and Protein Biochemistry Products - Detect Glycoproteins Directly in Gels or ...
Pro-Q Emerald stain detects glycoproteins more easily and reliably than mobility–shift assays, which only detect glycoproteins susceptible to specific deglycosylating enzymes and which can only be used in 1-D gels.
Glycoproteins and molecular weight markers stained with Pro-Q Emerald 300 glycoprotein stain (left) or SYPRO Ruby protein gel stain (right), shown before (lanes 2, 4 and 6, respectively) and after treatment with glycosidases (lanes 3, 5 and 7, respectively).
1-acidic glycoprotein (40% carbohydrate), glucose oxidase 12% carbohydrate) and avidin (7% carbohydrate).
probes.invitrogen.com /lit/catalog/1/sections/1143.html   (544 words)

 glycoprotein — Infoplease.com
Glycoproteins from the cuticle of the Atlantic shore crab Carcinus maenas: I. Electrophoresis and Western-blot analysis by use of......
Prehospital therapy with the platelet glycoprotein IIb/IIIa inhibitor eptifibatide in patients with suspected acute coronary syndromes......
Rapid, efficient separations of glycoprotein monosaccharides using a new anion-exchange separator column and electrochemical detection......
www.infoplease.com /ce6/sci/A0821065.html   (384 words)

 ISMRD - What Is Known?
The carbohydrate portion of glycoproteins is usually made of combinations of sugar molecules such as glucose, galactose, mannose and fucose, which are collectively known as oligosaccharides.
Normal functioning of the cell is characterized by the continual degradation of glycoproteins by enzymes within the lysosomes, which are membrane-bound compartments in the cell and essentially the cell’s recycling center.
Glycoprotein and Related Storage Diseases are autosomal recessive conditions, meaning that a defective trait or mutation passed on from both parents is required for the disease to be expressed.
www.mannosidosis.org /whatIsKnown.htm   (823 words)

 InterPro: IPR000936 Alphavirus E2 glycoprotein
Together the E1, E2, and sometimes E3 glycoprotein "spikes" form an E1/E2 dimer or an E1/E2/E3 trimer, where E2 extends from the centre to the vertices, E1 fills the space between the vertices, and E3, if present, is at the distal end of the spike [ 2, 3 ].
Upon exposure of the virus to the acidity of the endosome, E1 dissociates from E2 to form an E1 homotrimer, which is necessary for the fusion step to drive the cellular and viral membranes together [ 4 ].
The E2 glycoprotein functions to interact with the nucleocapsid through its cytoplasmic domain, while its ectodomain is responsible for binding a cellular receptor.
www.ebi.ac.uk /interpro/IEntry?ac=IPR000936   (3172 words)

 Glycoprotein IIb/IIIa Inhibitors
Glycoprotein IIb/IIIa inhibitors are medicines used in treating patients who have unstable angina, certain types of heart attacks, and in combination with angioplasty with or without stent placement.
Glycoprotein IIb/IIIa inhibitors are classified as potent platelet inhibitors.
Glycoprotein IIb/IIIa inhibitors are not available in prescription form.
www.clevelandclinic.org /health/health-info/docs/2700/2703.asp?index=9966   (415 words)

 Glycoprotein definition - Medical Dictionary definitions of popular medical terms
Glycoprotein: A molecule that consists of a carbohydrate plus a protein.
For instance, in the immune system almost all of the key molecules involved in the immune response are glycoproteins.
A glycopeptide is similar in structure to a glycoprotein but has a shorter chain of amino acids.
www.medicinenet.com /script/main/art.asp?ArticleKey=16842   (198 words)

 Comparative Analysis of Various Platelet Glycoprotein IIb/IIIa Antagonists on Shear-Induced Platelet Activation and ...
Lefkovits J, Plow EF and Topol EJ (1995) Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine.
Mousa SA, Khurana S and Forsythe MS (2000) Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists.
Shenkman B, Savion N, Dardik R, Tamarin I and Varon D (2000) Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer: role of platelet activation, fibrinogen and von Willebrand factor.
jpet.aspetjournals.org /cgi/content/full/303/3/1114   (4275 words)

 Platelet Glycoprotein IIb/IIIa Receptor Blockade Improves Vascular Nitric Oxide Bioavailability in Patients With ...   (Site not responding. Last check: 2007-10-11)
Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction.
Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets.
Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction.
circ.ahajournals.org /cgi/content/full/108/5/536   (2857 words)

 NEJM -- Platelet Glycoprotein IIb/IIIa Receptors in Cardiovascular Medicine
Glycoprotein IIb/IIIa inhibitors and acute coronary syndromes: summary report of the full submission to NICE, and beyond.
Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty.
Safety and preliminary efficacy of one month glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation A phase II study.
content.nejm.org /cgi/content/extract/332/23/1553   (2508 words)

 Glycoprotein Isolation Kit
Glycoprotein isolation from human serum and cell lysate – performance comparison of kits using WGA resin.
Eluted glycoprotein fractions were normalized by volume and resolved on 8-16% polyacrylamide gels.
Glycoprotein isolation from human serum and cell lysate – performance comparison of kits using ConA resin.
www.piercenet.com /Objects/View.cfm?type=ProductFamily&ID=C8873A87-8A85-4DDF-B246-5C1548917B10   (454 words)

 Myelin Oligodendrocyte Glycoprotein - multiple sclerosis encyclopaedia
Myelin Oligodendrocyte Glycoprotein (MOG) is one of the proteins in myelin, a fatty insulating substance found in the white matter of the central nervous system.
Myelin and myelin oligodendrocyte glycoprotein are produced by maintenance cells called oligodendrocytes.
MOG is confined to oligodendrocyte bodies and the outermost surface of the myelin sheath.
www.mult-sclerosis.org /myelinoligodendrocyteglycoprotein.html   (320 words)

 Classic diseases revisited: Carbohydrate-deficient glycoprotein syndromes -- Gordon 76 (893): 145 -- Postgraduate ...
Four types of carbohydrate-deficient glycoprotein syndrome have been described, and the cause of two of them has been found.
Linkage of a locus for carbohydrate-deficient glycoprotein syndrome type I (CDG1) to chromosome 16p, and linkage disequilibrium to microsatellite marker D16S406.
Phosphomannomutase deficiency is the main cause of carbohydrate-deficient glycoprotein syndrome with type I isoelectrofocusing pattern of serum sialotransferrins.
pmj.bmj.com /cgi/content/full/76/893/145   (2934 words)

 The Structure & Function Of Myelin Oligodendrocyte GlycoProtein
The structure of this key AutoAntigen suggests a relationship between the dimeric form of MOG within the Myelin sheath and a breakdown of Immunological Tolerance to MOG that is observed in Multiple Sclerosis.
Myelin Oligodendrocyte Glycoprotein (MOG) is an Ag present in the Myelin sheath of the CNS thought to be targeted by the AutoImmune T-Cell response in Multiple Sclerosis (MS).
Myelin Oligodendrocyte Glycoprotein (MOG) is a quantitatively minor component of CNS Myelin whose function remains relatively unknown.
members.tripod.com /ThJuland/mog.html   (1152 words)

 The G Glycoprotein of Respiratory Syncytial Virus Depresses Respiratory Rates through the CX3C Motif and Substance P -- ...
The G Glycoprotein of Respiratory Syncytial Virus Depresses Respiratory Rates through the CX3C Motif and Substance P -- Tripp et al.
Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection.
Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse.
jvi.asm.org /cgi/content/full/77/11/6580   (3197 words)

 The Human Cytomegalovirus UL74 Gene Encodes the Third Component of the Glycoprotein H-Glycoprotein L-Containing ...
The UL10 gene of herpes simplex virus 1 encodes a novel viral glycoprotein, gM, which is present in the virion and in the plasma membrane of infected cells.
Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus.
Glycoprotein H of pseudorabies virus is essential for entry and cell-to-cell spread of the virus.
jvi.asm.org /cgi/content/full/72/10/8191   (5633 words)

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