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The comparative effectiveness of ondansetron and granisetron in a once daily dosage in the prevention of nausea and ... Ondansetron and granisetron are both claimed to be highly effective in the prevention of acute nausea and vomiting caused by chemotherapy. Granisetron has a longer half-life than ondansetron and is claimed to be more effective in the prevention of delayed nausea and vomiting associated with chemotherapy, but this is usually in combination with dexamethasone. Granisetron is more effective than ondansetron when used in combination with dexamethasone in the prevention of acute and delayed vomiting caused by highly emetogenic chemotherapy. www.pharmj.com /Editorial/20000708/papers/ondansetrontrial.html   (3839 words)

Kytril - Kytril Side Effects - Kytril Information - Canada Pharmacy - Canada Drugs Excretion: In normal volunteers, the urinary excretion of unchanged granisetron averages 12% of the administered dose over a period of 48 hours, while the remainder of the dose is excreted as metabolites, 47% in the urine and 34% in the feces. granisetron and of 325 patients 65 years of age or older who received oral granisetron, 298 were 65 to 74 years of age and 27 were 75 years of age or older. granisetron (2 to 160 µg/kg) and 2600 patients receiving oral granisetron (0.25 to 20 mg) in single-day and multiple-day clinical trials with emetogenic cancer therapies. www.rxcarecanada.com /Kytril.asp   (2112 words)

MedlinePlus Drug Information: Granisetron Granisetron is used to prevent nausea and vomiting caused by cancer chemotherapy and radiation therapy. Granisetron is in a class of medications called 5-HT antagonists. Granisetron should only be taken before chemotherapy or radiation therapy, as instructed by your doctor. www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601211.html   (549 words)

Granisetron - Patient UK Granisetron is used to treat sickness caused by chemotherapy and radiotherapy. Granisetron is also used to prevent and treat sickness that can sometimes occur after an operation. If Granisetron is taken to stop nausea caused by cancer chemotherapy or radiotherapy, a dose should be taken one to two hours before treatment and followed by another dose twelve hours later. www.patient.co.uk /showdoc/30003134   (614 words)

Granisetron - Wikipedia, the free encyclopedia   (Site not responding. Last check: 2007-11-05) Granisetron is a serotonin 5-HT receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main affect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. Granisetron was developed by chemists working at the British drug company Beecham around 1988 and is expected to go generic in 2007/2008. en.wikipedia.org /wiki/Granisetron   (320 words)

Granisetron Large randomized double-blind studies have shown that granisetron is very effective for the control of acute emesis but not entirely satisfactory against delayed emesis. Granisetron is safe provided maximum allowed dose is not exceeded. iv granisetron (3mg) once or twice at the onset of chemotherapy is as effective as ondansetron which has to be given iv (8mg) before treatment and then orally (again 8mg) twice daily for 3 days. www.themedicaldirectory.org /drugs/granisetron.shtml   (194 words)

Granisetron (Systemic) Granisetron is to be given only by or under the immediate supervision of your doctor. However, granisetron has not been shown to cause birth defects or other problems in animal studies. Although this use is not included in product labeling, granisetron injection is used in certain patients to prevent the nausea and vomiting that may occur after cancer radiation treatment in patients undergoing bone marrow transplantation. allnutritionals.com /drugs/g/granisetron-systemic.shtml   (777 words)

Randomized comparison of granisetron vs ondansetron in patients with HIV-related malignant tumors receiving moderately ... Randomized comparison of granisetron vs ondansetron in patients with HIV-related malignant tumors receiving moderately emetogenic chemotherapy regimens. There are no data published in the literature regarding the evaluation of both granisetron and ondansetron in pts with HIV infection and under CT for malignant tumors. Granisetron may be preferred both for the single dose administration and the less expense, especially in pts with HIV infection with related socio-economic problems. www.aegis.com /aidsline/1994/dec/M94C3590.html   (494 words)

Texas Medicaid Vendor Drug Program, Dolasetron (Anzemet®),Granisetron (Kytril®), Ondansetron(Zofran®) - ... Granisetron is utilized in preventing cancer chemotherapy-induced nausea and vomiting as well as radiation-induced nausea and vomiting. Ondansetron is indicated for use in preventing cancer chemotherapy-induced nausea and vomiting, postoperative nausea and vomiting, and radiotherapy-induced nausea and vomiting. Dolasetron, granisetron, and ondansetron are NOT indicated for use in controlling general nausea and vomiting. www.hhsc.state.tx.us /HCF/vdp/Criteria/hydrx5ht.html   (934 words)

Granisetron (Systemic) - MayoClinic.com   (Site not responding. Last check: 2007-11-05) Granisetron (gra-NI-se-tron) is used to prevent the nausea and vomiting that may occur after treatment with anticancer medicines (chemotherapy) or with radiation therapy. Nausea and vomiting from the chemotherapy—If granisetron is taken when these medical problems exist, it may mask very serious stomach problems. The dose of granisetron will be different for different patients. www.mayoclinic.com /health/drug-information/DR202724   (932 words)

TransPharma Medical - Potential Product Applications - Granisetron HCl Granisetron HCl falls within a class of small, very hydrophilic drug-molecules that cannot be delivered efficiently using existing passive transdermal delivery methods. Using Granisetron, TransPharma was able to demonstrate excellent results related to the three primary parameters: sustained release, constant blood drug levels and ease-of-use. Granisetron HCl is an antiemetic drug, given for prevention of chemotherapy-induced nausea and for pre- and post-surgical nausea and vomiting. www.transpharma-medical.com /product_apps_granisetron_hcl.html   (138 words)

Granisetron   (Site not responding. Last check: 2007-11-05) Granisetron decreases nausea and vomiting caused by chemotherapy drugs. Granisetron may also be taken by mouth with or without food. Granisetron should be kept at room at temperature, away from heat and light. www.hci.utah.edu /patientdocs/hci/drugs/granisetron.htm   (250 words)

JournalClub Review - IV dolasetron mesylate as effective as IV granisetron in controlling emesis after high-dose ...   (Site not responding. Last check: 2007-11-05) A total of 474 patients in 29 centres were randomised to receive dolasetron at a dose of 1.8 or 2.4 mg/kg, or a single 3-mg IV dose of granisetron, 30 minutes before the start of chemotherapy. The rates of headache were 28% and 22% in the 1.8 and 2.4 mg/kg dolasetron groups, respectively, and 23% in the granisetron group. Diarrhea occurred in 13% and 11% of patients in the 1.8 and 2.4 mg/kg dolasetron groups, respectively, and in 6% of patients in the granisetron group. www.pslgroup.com /jclub10.HTM   (662 words)

Newly Approved Drug Therapies (713): Kytril (granisetron) Solution, Roche Granisetron is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist with little or no affinity for other serotonin receptors, including 5-HT1; 5-HT1A; 5-HT1B/C; 5-HT2; for alpha1-, alpha2-, or beta-adrenoreceptors; for dopamine-D2; or for histamine-H1; benzodiazepine; picrotoxin or opioid receptors. Serotonin receptors of the 5-HT3 type are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. Animal studies demonstrate that, in binding to 5-HT3 receptors, granisetron blocks serotonin stimulation and subsequent vomiting after emetogenic stimuli such as cisplatin. www.centerwatch.com /patient/drugs/dru713.html   (395 words)

Ramosetron compared with granisetron for the prevention of vomiting following strabismus surgery in children -- Fujii ... Prophylactic antiemetic therapy with ramosetron is comparable with granisetron for the prevention of vomiting during 0-24 Granisetron is effective for the treatment of emesis induced by cancer chemotherapy. that granisetron is relatively free of adverse effects and is bjo.bmjjournals.com /cgi/content/full/85/6/670   (1991 words)

Unbound MEDLINE | Granisetron journal articles Granisetron reduces clinical and histological response to intra-arterial neoadjuvant chemotherapy in oral squamous cell carcinoma. The use of oral granisetron versus intravenous ondansetron for antiemetic prophylaxis in patients undergoing laparoscopic surgery: the effect on emetic symptoms and quality of recovery. The influence of granisetron on the pharmacokinetics and pharmacodynamics of docetaxel in Asian lung cancer patients. www.unboundmedicine.com /medline/ebm/mesh/Granisetron   (284 words)

Cancerquest: Granisetron   (Site not responding. Last check: 2007-11-05) Kytril (granisetron hydrochloride) is used to the prevent nausea and vomiting associated with cytotoxic effects of chemotherapy. Granisetron is administered in pill form or as in injection. The most common side effects associated with the use of Kytril during chemotherapy regimens are headache, constipation and weakness. www.cancerquest.org /printfriendly.cfm?printpage=1315   (58 words)

Pharmacy Choice - Pharmaceutical News - Granisetron delivery by iontophoretic patches characterized - October 29, 2006 "In vitro iontophoretic delivery of granisetron hydrochloride was evaluated at 5, 10, or 20 mg/mL concentrations of donor using Franz diffusion cells and hairless rat skin as a membrane," explained A. Chaturvedula and coauthors at Mercer University. "Similar concentrations of granisetron hydrochloride in dermal and subcutaneous tissue were observed," according to the report. "The patches successfully delivered granisetron hydrochloride by iontophoresis and depot formation was observed in the dermal and subcutaneous structures in the skin," the investigators concluded. www.pharmacychoice.com /News/article.cfm?Article_ID=13058   (396 words)

Optimal anti-emetic dose of granisetron for preventing postoperative nausea and vomiting -- Fujii et al. 41 (9): 794 -- ... Optimal anti-emetic dose of granisetron for preventing postoperative nausea and vomiting -- Fujii et al. Optimal anti-emetic dose of granisetron for preventing postoperative nausea and vomiting In conclusion, granisetron 40 micrograms.kg-1 is considered to be www.cja-jca.org /cgi/content/abstract/41/9/794   (331 words)

GRANISETRON FOR EMESIS FROM EPIDURAL ANESTHESIA FOR CAESAREAN SECTION -- Yoon et al. 50 (Supplement 1): 83 -- Canadian ... GRANISETRON FOR EMESIS FROM EPIDURAL ANESTHESIA FOR CAESAREAN SECTION -- Yoon et al. granisetron on nausea and vomiting of patients undergoing a The emetic score was statistically lower in the granisetron www.cja-jca.org /cgi/content/full/50/suppl_1/A83   (331 words)

MedlinePlus Drug Information: Granisetron Hydrochloride Injection Your doctor has ordered granisetron to prevent nausea and vomiting caused by cancer chemotherapy. The drug will be added to an intravenous fluid that will drip through a needle or catheter placed in your vein for at least 5 minutes, about a half-hour before chemotherapy administration. If you are receiving granisetron in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). www.nlm.nih.gov /medlineplus/druginfo/medmaster/a694011.html   (590 words)

Comparative clinical trial of granisetron and ondansetron in the prophylaxis of cisplatin-induced emesis. The ... Comparative clinical trial of granisetron and ondansetron in the prophylaxis of cisplatin-induced emesis. Granisetron was administered as a single dose of 10 or 40 of granisetron 10 or 40 micrograms/kg is as effective as three doses of www.jco.org /cgi/content/abstract/13/5/1242   (588 words)

Arch Surg -- Abstract: Prophylaxis With Oral Granisetron for the Prevention of Nausea and Vomiting After Laparoscopic ... Arch Surg -- Abstract: Prophylaxis With Oral Granisetron for the Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy: A Prospective Randomized Study, January 2001, Fujii et al. or granisetron at 3 different doses (1 mg, 2 mg, and 4 mg; n Granisetron: An Update on its Clinical Use in the Management of Nausea and Vomiting archsurg.ama-assn.org /cgi/content/abstract/136/1/101   (249 words)

Granisetron Hydrochloride Injection - Drugs & Vitamins - Drug Library - DrugDigest   (Site not responding. Last check: 2007-11-05) It is given by a health-care professional in a hospital or clinic setting 30 minutes before chemotherapy. Contact your pediatrician or health care professional regarding the use of this medicine in children. Injection of granisetron is only given on the day(s) chemotherapy is given. www.drugdigest.org /DD/PrintablePages/Monograph/0,7765,302|0,00.html   (325 words)

Granisetron (Generic) UK - No Prescription, Lowest Price. Buy Granisetron Online Pharmacy Chemist- Order Discount ... Indications: Granisetron (Generic) is an anti-emetic agent used to prevent nausea and vomiting caused by cancer chemotherapy and radiation. This saves you the time and cost of mailing or faxing your Granisetron prescription, or paying to have it re-written. Medical evaluations and prescriptions for Granisetron are free. www.prescription-mexico.co.uk /Granisetron.htm   (317 words)

MedlinePlus Drug Information: Granisetron (Systemic)   (Site not responding. Last check: 2007-11-05) Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to granisetron, dolasetron, or ondansetron. Breast-feeding—It is not known whether granisetron passes into breast milk. Other medical problems—The presence of other medical problems may affect the use of granisetron. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202724.html   (921 words)

Carilion - GRANISETRON (Injection) (Injectable) - [Medication]   (Site not responding. Last check: 2007-11-05) There may be other brand names for this medicine. You should not use this medicine if you have had an allergic reaction to granisetron. Your doctor will prescribe your exact dose and tell you how often it should be given. www.carilion.com /kbase/htm/mdx-/qudr/590/mdx-qudr590.htm   (238 words)

Healthopedia.com Drugs Information - Granisetron : Proper Use (Kytril) You are here : Healthopedia.com > Drugs and Medications > Detailed Drug Information (USP DI) > Granisetron : Proper Use Dosing—The dose of granisetron will be different for different patients. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. www.healthopedia.com /drugs/detailed/granisetron/proper-use.html   (362 words)

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