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Topic: Granulosa cell

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Granulosa cell tumour

	Granulosa Cell Tumor (Site not responding. Last check: 2007-11-03)
		"Granulosa-thecal cell" or "granulosa cell" tumors (GCT's) are one of the most common ovarian tumors to be found in equines.
		Granulosa cell tumors are usually benign steroid-producing tumors that may grow very large.
		Treatment of granulosa-thecal cell tumors is achieved by removal of the affected ovary and the tumor.
	www.equine-reproduction.com /articles/GCT.htm (336 words)

	Basal lamina of ovarian follicle regulates an inward Cl- current in differentiated granulosa cells -- Qin et al. 282 ...
		Granulosa cells isolated from the largest preovulatory follicle of hen ovary were incubated on plastic or intact basal lamina in serum-free medium 199 for 24 h.
		Granulosa cells isolated from the largest preovulatory follicle of hen ovary were incubated on plastic or intact basal lamina in serum-free medium 199 for 1, 6, 9, or 24 h.
		Granulosa cells isolated from the largest preovulatory follicle of hen ovary were incubated on glass coverslips precoated with solubilized basal lamina in serum-free medium 199 for 24 h.
	ajpcell.physiology.org /cgi/content/full/282/1/C34 (7190 words)

	Reproductive Biology and Endocrinology \| Full text \| Paracrine effects of oocyte secreted factors and stem cell factor ...
		Since oocyte granulosa cell communication is bi-directional [2] and there is bi-directional communication between the granulosa and theca cell compartments of the follicle [18], this raises the possibility that there is bi-directional communication between the oocyte and theca cells.
		SCF is essential for the colonisation of the gonad by germ cells and the continued survival and growth of germ cells in the ovine foetus [20].
		SCF mRNA is localised to granulosa cells at all stages of follicle growth in foetal and adult ovine ovaries [22].
	www.rbej.com /content/1/1/55 (6726 words)

	UCLA Department of Medicine - wfsection-Granulosa Cell Tumors
		The occurrence of postmenopausal bleeding is a characteristic complication in patients whose granulosa cell tumors occur in middle age.
		Granulosa cell tumor of the ovary: a study of 18 cases.
		Granulosa cell tumors of the ovary: prognostic factors and outcome.
	www.med.ucla.edu /modules/wfsection/article.php?articleid=177 (2304 words)

	granulosa cell tumors
		Granulosa cell tumors (1-2% of ovarian cancers) and Sertoli-Leydig cell tumors are the most common.
		Granulosa cell tumors are considered to be a low grade malignancy - although there is variability in the biologic activity of these tumors.
		Granulosa cell tumors, which are most common in postmenopausal women, may cause vaginal bleeding and an elevated level of the tumor marker inhibin in the blood.
	www.medhelp.org /forums/OvarianCancer/messages/264.html (344 words)

	EFFECTS OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 ON BOVINE OVARIAN GRANULOSA CELL PROLIFERATION AND ...
		Granulosa cells were obtained from small (1 to 5 mm) follicles collected from cattle and cultured for 4 d.
		Granulosa cells from small (1 to 5 mm) follicles were collected and cultured as previously described (Langhout et al., 1991).
		Granulosa cells were obtained from small follicles, cultured for 2 d in the presence of 10% fetal calf serum, and then treated in serum-free media with.25 g/ml of bovine serum albumin, 500 ng/ml of testosterone, IGF-I (0 or 10 ng/ml) and IGFBP-3 (0, 25 or 100 ng/ml) for an additional 2 d.
	www.ansi.okstate.edu /research/1999rr/51.htm (784 words)

	International Seminars in Surgical Oncology \| Full text \| Recurrence of granulosa cell tumour after thirty years with ...
		Granulosa cell tumours of the ovary are rare, comprising around 3% of ovarian tumours.
		Granulosa cell tumours are uncommon sex cord-stromal tumours of the ovary, and comprise approximately 3% of all ovarian malignancies [1].
		Inhibin is produced by granulosa cells, and should be absent in the oophorectomised, post-menopausal female [16].
	www.issoonline.com /content/1/1/4 (1583 words)

	granulosa cell tumor
		Dear juldan, Granulosa cell tumor accounts for only 2-3% of all ovarian tumors and may be either classified as a malignant or benign (non-cancerous).
		granulosa cell tumor has a tendency toward late relapse, reflecting their low-grade biology.
		granulosa cell tumor is a estrogen-secreting tumor, so it could cause even endometrial cancer.
	www.medhelp.org /perl6/OvarianCancer/messages/260a.html (1341 words)

	Gonadotropin and Steroid Control of Granulosa Cell Proliferation During the Periovulatory Interval in Rhesus Monkeys -- ...
		Alterations in the cell cycle characteristics of granulosa cells during the periovulatory period: evidence of ovarian and oviductal influences.
		Cell proliferation and vascular morphology in the marmoset corpus luteum.
		The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle.
	www.biolreprod.org /cgi/content/full/65/3/755 (5338 words)

	Autocrine Role of Transforming Growth Factor {beta}1 on Rat Granulosa Cell Proliferation -- Saragüeta et al. 66 ...
		Cells were cultured in presence of FSH (20 ng/ml) with addition of increasing concentration of activated and nonactivated conditioned medium from granulosa cells or TGFß1.
		Rat granulosa cells were cultured in presence of FSH (20 ng/ml), estradiol (100 ng/ml) or combination of both, with addition of 10% v/v conditioned medium or TGFß1.
		presumably by increasing cell adhesion to the substrate [33].
	www.biolreprod.org /cgi/content/full/66/6/1862 (4574 words)

	Adult Granulosa Cell Tumor of the Ovary
		The granulosa cell tumor of the ovary is classified as a sex-cord stromal tumor by pathologists.
		We report a testicular gonadal stromal tumor with granulosa cell differentiation in a 54-year-old white man. The tumor was discovered by an ultrasound evaluation for left hydrocele.
		Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors.
	www.thedoctorsdoctor.com /diseases/ovary_granulosacelltumor.htm (2377 words)

	GranulosaDifferentiation
		Among the endocrine, paracrine and autocrine factors that have been implicated in directly initiating steroidogenesis and/or enhancing gonadotropin (FSH and LH) receptor expression in granulosa cells from prehierarchal follicles are included FSH and the TGFbeta superfamily members, TGFbeta and activin.
		While the identity of the biologically relevant ligand(s) that promote MAPK signaling in granulosa cells has/have not been established, it has been determined that multiple Epidermal Growth Factor (EGF) family ligands are expressed within the avian ovary.
		A-F, Granulosa cells were processed for confocal microscopy and immunofluorescently labeled for endogenous Erk-p using FITC conjugated secondary antibodies (top row; A-C) and Erk2 (bottom row; D-F).
	www.nd.edu /~avianova/GranulosaDifferentiation.html (1401 words)

	Granulosa-Theca Cell Tumors
		Theca cell tumors (ie, thecomas) account for less than 1% of all ovarian tumors, and the mean age at diagnosis is 53 years.
		This hormone is produced exclusively by granulosa cells in postnatal females and both prenatally and postnatally by the Sertoli cells in the male testis.
		The term granulosa-theca cell tumor had been applied to all tumors in which both cell types were identified, regardless of the amounts present.
	www.indiandoctors.com /OBGYN/Malignancy/Malignancy_02.htm (4419 words)

	Effects of Insulin and Luteinizing Hormone on Ovarian Granulosa Cell Aromatase Activity in Cattle
		Estradiol is produced by bovine granulosa cells via the action of aromatase which is a granulosa-cell specific enzyme that converts androgens (e.g., testosterone) into estrogens (e.g., estradiol).
		To obtain optimal attachment, cells were maintained in the presence of 10% fetal calf serum for the first 48 h of culture (Langhout et al., 1991).
		After this time, granulosa cells were washed twice with 0.5 ml of serum-free medium and incubations continued in serum-free medium containing 500 ng/ml of testosterone (as an estrogen precursor for aromatase) with or without added hormones.
	www.ansi.okstate.edu /research/1998rr/42.html (952 words)

	Evidence for the Oligoclonal Origin of the Granulosa Cell Population of the Mature Human Follicle -- Van Deerlin et al. ...
		Evidence for the Oligoclonal Origin of the Granulosa Cell Population of the Mature Human Follicle -- Van Deerlin et al.
		The clonality of the granulosa cell population residing in individual mature
		cell population; 2) the granulosa cells of a given follicle are
	jcem.endojournals.org /cgi/content/abstract/82/9/3019 (367 words)

	GRANULOSA CELL TUMOR OF THE OVARY
		Microscopically, consist of granulosa cells (granulosa cell tumor), theca cells (thecoma) or various proportions of both cells.
		The granulosa cells are cuboidal to polygonal cells that are arranged in cords, sheets or strands.
		In the poorly-differentiated tumors, disorderly arranged epithelial cells are scattered in a sarcomatous stroma.
	www.bioscience.org /atlases/tumpath/freprod/ovary/9/micro.htm (298 words)

	FSH and TGF-{beta} Superfamily Members Regulate Granulosa Cell Connective Tissue Growth Factor Gene Expression in Vitro ...
		cells is up-regulated in vitro by TGFß1, growth/differentiation
		in granulosa cells of preantral and early antral follicles (6).
		knockout mice is the granulosa cell population in multilayered,
	endo.endojournals.org /cgi/content/full/143/9/3316 (5543 words)

	eMedicine - Granulosa-Theca Cell Tumors : Article Excerpt by: Chad M Michener, MD
		Germ cell tumors occur less frequently (20%), while sex cord—stromal tumors make up the smallest proportion, accounting for approximately 8% of all ovarian neoplasms.
		Granulosa-theca cell tumors, more commonly known as granulosa cell tumors (GCTs), belong to the sex cord—stromal group and include tumors made up of granulosa cells, theca cells, and fibroblasts in varying degrees and combinations.
		The second purports that sex cord and stromal cells of the mature ovary are derived from precursors found within the mesonephric and coelomic epithelium.
	www.emedicine.com /med/byname/granulosa-theca-cell-tumors.htm (656 words)

	All Granulosa Cell Cancer messages (Site not responding. Last check: 2007-11-03)
		My mother is getting ready to have surgery for granulosa cell cancer - ovarian cancer, she has already been thru 5 or 6 chemo treatments.
		Now the onco team says those treatments may have killed some of the cancer but that because granulosa is a "slow growing" cell, the cancer cells are able to lie dormant and unresponsive to chemo.
		I am involved with the Granulosa Cell Tumor Foundation (www.gctf.org), along with the New Zealand branch (www.gctf.org.nz), which are desperately trying to raise funds for research on this woefully under-researched cancer.
	www.cancercompass.com /message-board/message/all,2039,0.htm (1534 words)

	eMedicine - Granulosa-Theca Cell Tumors : Article by Chad M Michener, MD
		Lane AH, Lee MM, Fuller AF Jr: Diagnostic utility of Mullerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors.
		Lee WL, Yuan CC, Lai CR: Hemoperitoneum is an initial presentation of recurrent granulosa cell tumors of the ovary.
		Miller BE, Barron BA, Wan JY: Prognostic factors in adult granulosa cell tumor of the ovary.
	www.emedicine.com /med/topic928.htm (8805 words)

	Granulosa cell tumour - Wikipedia, the free encyclopedia
		Granulosa cell tumours (or granulosa-theca) are part of the sex cord-stromal tumour group of ovarian neoplasms.
		The peak age at which they occur is 50-55 years, but they may occur at any age.
		Call-Exner bodies (granulosa cells arranged haphazardly around a space containing eosinophilic fluid); and
	en.wikipedia.org /wiki/Granulosa_cell_tumor (168 words)

	Medical Dictionary: Granulosa cell tumor - WrongDiagnosis.com
		Granulosa cell tumor is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Granulosa cell tumor, or a subtype of Granulosa cell tumor, affects less than 200,000 people in the US population.
		Terms that may be interchangeable with Granulosa cell tumor:
	www.wrongdiagnosis.com /medical/granulosa_cell_tumor.htm (221 words)

	Basic Fibroblast Growth Factor Maintains Calcium Homeostasis and Granulosa Cell Viability by Stimulating Calcium Efflux ...
		granulosa cells were deprived of basic fibroblast growth factor.
		cells, as well as spontaneously immortalized granulosa cells, were
		Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro.
	endo.endojournals.org /cgi/content/abstract/142/10/4203 (551 words)

	Granulosa Cell Carcinoma
		I was told that this "granulosa cell carcinoma" was a low-grade cancer, that it was estimated mine was as large as a football before it ruptured, and that the consistency of this cancer was like moss, which crumbles into miniscule pieces when it ruptures.
		Now I was referred to a doctor who knew more about granulosa cell carcinoma.
		A study of the impact of the chemical Butadiene on granulosa cell cancer of ovary and other health problems.
	www.dacton.com /cancer.html (2036 words)

	Female Genital Pathology (Site not responding. Last check: 2007-11-03)
		This is a granulosa cell tumor of ovary with a variegated cut surface.
		These tumors are derived from the ovarian stroma and often have a component of thecoma.
		They are often hormonally active and can produce large amounts of estrogen such that the patient may initially present with bleeding from endometrial hyperplasia.
	www-medlib.med.utah.edu /WebPath/FEMHTML/FEM057.html (52 words)

	Granulosa Cell Tumor Of The Ovary Foundation - [gctf.org] (Site not responding. Last check: 2007-11-03)
		Granulosa Cell Tumor Of The Ovary Foundation - [gctf.org]
		We applaud the efforts of our volunteers and corporate sponsors who worked tirelessly this year towards this accomplishment!
		Granulosa Cell Tumor, Granulosa, Cell, Tumor, Cells, Tumors, Tumour, Tumours, Ovary, Ovarian, Ovaries, Foundation, Stromal Layer, Stroma, Survior, Cancer, Cancers, Research, Donate, How to, Help, Get Invloved
	www.gctf.org (94 words)

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