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Topic: Granzyme

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Perforin

Cytotoxic T cell

T cell

Caspase

Apoptosis

Mitochondrion

Immunology

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	Mechanisms Responsible for Granzyme B-Independent Cytotoxicity -- Shresta et al. 89 (11): 4085 -- Blood
		Using granzyme B-deficient mice obtained by gene targeting, we previously demonstrated that granzyme B is required for the rapid induction of apoptotic target cell death by cytotoxic T lymphocytes (CTLs); however, CTLs are also equipped with additional effector mechanisms.
		Granzyme B and perforin mutations were identified by Southern blot analysis of mouse tail DNA, as described previously.
		CTLs to examine the contribution of granzyme B to the perforin/granzyme pathway (Fig 5).
	www.bloodjournal.org /cgi/content/full/89/11/4085 (4640 words)

	Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in ...
		Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis -- Ronday et al.
		The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).
		Expression of granzymes A and B in synovial tissue from patients with rheumatoid arthritis and osteoarthritis.
	rheumatology.oxfordjournals.org /cgi/content/full/40/1/55 (3362 words)

	A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death -- Trapani ...
		Association of granzyme B with the plasma membrane (m) and in the late endosomal compartment (l) are shown.
		Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.
		Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
	www.jcb.org /cgi/content/full/160/2/223 (6857 words)

	Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status: Implications for Initiation of Autoimmunity -- ... (Site not responding. Last check: 2007-11-06)
		The ability of granzyme B to cleave the purified nonautoantigens lactoferrin, apotransferrin, and thrombin was examined by incubating 20 µg of each substrate in the absence or presence of 30 nM granzyme B for 60 min at 37°C, followed by Coomassie blue staining of SDS-PAGE.
		Granzyme B–specific autoantigen fragments are generated after in vivo incubation of intact K562 cells with YT cell GC.
		Interestingly, the autoantigens susceptible to cleavage by granzyme
	www.jem.org /cgi/content/full/190/6/815 (7106 words)

	Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by ...
		The purification of human granzyme B from YT cells was performed as previously described (5, 23).
		Granzyme B is responsible for the cleavage and activation of Bid.
		Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. Biol.
	mcb.asm.org /cgi/content/full/20/11/3781 (7021 words)

	Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis -- Metkar et ...
		Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis -- Metkar et al.
		Extracellular granzymes A and B: detection of native species during CTL responses in vitro and in vivo.
		Granzyme B mimics apical caspases: description of a unified pathway for trans-activation of executioner caspases-3 and -7.
	www.jcb.org /cgi/content/full/160/6/875 (7041 words)

	Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B-mediated Caspase ...
		The granzyme B cleavage site of Bid (D75) is essential to overcome Bcl-2's block of granzyme B–mediated cell death, but the caspase-8 cleavage site (D59) is not.
		Bid is cleaved early in Jurkat cells exposed to granzyme B (GrB), irrespective of Bcl-2 overexpression.
		Release of cytochrome c from mitochondria in response to granzyme B is dependent on caspase activation.
	www.jem.org /cgi/content/full/192/10/1403 (7260 words)

	A Comparative Study of the Expression of Cytotoxic Proteins in Allergic Contact Dermatitis and Psoriasis : Spongiotic ...
		Perforin (a and g) and granzyme B (d and j) gene expression and immunoreactivity was barely detectable in normal skin.
		A marked enhancement of perforin (b and h) and granzyme B (e and k) expression was observed in the mononuclear cell infiltrate in contact dermatitis.
		Perforin (c and i) and granzyme B (f and l) expression was found in a few cells in psoriasis.
	ajp.amjpathol.org /cgi/content/full/158/3/803 (2807 words)

	Long-range disruption of gene expression by a selectable marker cassette -- Pham et al. 93 (23): 13090 -- Proceedings ...
		LAK cells, while granzyme H is expressed preferentially in NK and LAK cells (27).
		The granzyme A gene resides on chromosome 13 (31), and the granzyme
		Granzyme G and E panels were exposed for 72 h.
	www.pnas.org /cgi/content/full/93/23/13090 (5147 words)

	The genes for perforin, granzymes A-C and IFN-{gamma} are differentially expressed in single CD8+ T cells during ...
		The genes for perforin, granzymes A-C and IFN-{gamma} are differentially expressed in single CD8+ T cells during primary activation -- Kelso et al.
		The genes for perforin, granzymes A–C and IFN-
		Intraclonal heterogeneity in the expression of perforin, granzymes and IFN-
	intimm.oxfordjournals.org /cgi/content/full/14/6/605 (5244 words)

	Alcohol Consumption Decreases IL-2-Induced NF-{kappa}B Activity in Enriched NK Cells from C57BL/6 Mice -- Zhou and ...
		of EtOH consumption on mRNA of perforin, granzyme A, and granzyme
		A, and granzyme B expression in enriched murine splenic NK cells.
		Spitzer, J. H., and Meadows, G. Modulation of perforin, granzyme A, and granzyme B in murine natural killer (NK), IL-2 stimulated NK, and lymphokine-activated killer cells by alcohol consumption.
	toxsci.oxfordjournals.org /cgi/content/full/73/1/72 (5358 words)

	The 5' Flanking Region of the Human Granzyme H Gene Directs Expression to T/Natural Killer Cell Progenitors and ...
		Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural
		granzyme gene expression was identical to that for mouse LAK cells.
		Expression of human granzyme H is primarily restricted to LAK cells in humans, and this gene is located between granzyme B
	www.bloodjournal.org /cgi/content/full/93/3/963 (6252 words)

	Circadian Rhythms of Granzyme B, Perforin, IFN-{gamma}, and NK Cell Cytolytic Activity in the Spleen: Effects of ...
		Circadian Rhythms of Granzyme B, Perforin, IFN-{gamma}, and NK Cell Cytolytic Activity in the Spleen: Effects of Chronic Ethanol -- Arjona et al.
		Differential expression of granzyme A and granzyme B proteases and their secretion by fresh rat natural killer cells (NK) and lymphokine-activated killer cells with NK phenotype (LAK-NK).
		Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.
	www.jimmunol.org /cgi/content/full/172/5/2811 (4372 words)

	Perforin/granzyme-dependent and Independent Mechanisms are Both Important for the Development of Graft-versus-host ...
		Until recently, the expression of perforin and granzyme B had not been detected outside the lymphoid compartment (34, 35).
		Basal hematopoiesis in perforin and granzyme B-deficient mice.
		Cytotoxic T lymphocytes require perforin and granzyme B for the rapid induction of apoptosis in susceptible target cells (14).
	www.jci.org /cgi/content/full/100/4/904 (5959 words)

	Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role ... (Site not responding. Last check: 2007-11-06)
		Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction -- Hirst et al.
		Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction
		Granzyme B (graB) plays a pivotal role in cytotoxic lymphocyte
	molehr.oxfordjournals.org /cgi/content/abstract/7/12/1133 (558 words)

	Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B-mediated Caspase ...
		A triple-mutated allele of granzyme B incapable of inducing apoptosis
		A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death
		HSV and Glycoprotein J Inhibit Caspase Activation and Apoptosis Induced by Granzyme B or Fas
	www.jem.org /cgi/content/abstract/192/10/1403 (1940 words)

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