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Topic: Guanidine

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	Guanidine - Wikipedia, the free encyclopedia
		Guanidine is a crystalline compound of strong alkalinity formed by the oxidation of guanine.
		Empirically, guanidine hydrochloride is known to denature proteins with a linear relationship between concentration and free energy of unfolding.
		In the presence of a catalyst, a mole of free-base guanidine combines with 2 moles of water to form 3 moles of ammonia and 1 mole of carbon dioxide.
	en.wikipedia.org /wiki/Guanidine (267 words)

	GUANIDINE NITRATE
		The aqueous mixture of (Note 10) is similar to some aqueous mixtures used in sizable quantities for rock blasting; a confined mixture of this sort is especially hazardous.
		A 10 per cent excess of ammonium nitrate is used because the biguanide mononitrate which is formed as an intermediate is strongly basic and tends to attack the unreacted ammonium nitrate, as is evidenced by the liberation of ammonia during the heating.
		The excess of ammonium nitrate can be easily separated from the guanidine nitrate by the crystallization from water, and it does not interfere with the conversion of guanidine nitrate into nitroguanidine by the action of strong sulfuric acid.
	www.orgsyn.org /orgsyn/orgsyn/prepContent.asp?prep=CV1P0302 (899 words)

	The picornavirus replication inhibitors HBB and guanidine in the echovirus-9 system: the significance of viral protein ...
		NTPase activity was not altered in the presence of HBB or guanidine.
		ATPase activity of 2C proteins of E9 wild-type and the mutants in the presence of HBB or guanidine (Gua).
		A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerisation.
	vir.sgmjournals.org /cgi/content/full/81/4/895 (2851 words)

	Pharmaceutical guanidine preparations and methods of using same - Patent 3976787
		A guanidine compound, prepared by either of the foregoing procedures, or by other suitable procedures, may be converted to its acid addition salt, e.g., hydrochloride by the addition of the appropriate acid to the guanidine compound.
		Representative of the salts embodied in the preparations of this invention are: phenyl guanidine nitrate; 3'-hydroxyphenyl guanidine hydrochloride; 2'-methylphenyl guanidine nitrate; and 3',4'-dichlorophenyl guanidine hydrochloride.
		The guanidine compound is dispersed in a cream vehicle consisting of a water-miscible base of stearic acid, propylene glycol, sorbitol monostearate and mono-oleate, polyoxyethylene sorbitan monostearate with citric acid and methyl and propyl parabens as preservatives.
	www.freepatentsonline.com /3976787.html (3142 words)

	(WO/2000/009115) GRP RECEPTOR LIGANDS (Site not responding. Last check: 2007-10-20)
		Example 4 (+/-)-N-cyano-N'- 2- (3-cyclopentyloxy-4-methoxyphenyl)-4-phenylbut-3-ynyl-N"- (benzyl) guanidine 4 (a) (+/-)-N-cyano-N'- 2- (3-cyclopentyloxy-4-methoxyphenyl)-4-phenylbut-3-ynyl- N'-(t-butoxycarbonyl)-N"-(benzyl)(t-butoxycarbonyl)-N"-(benzyl) guanidine A mixture of the compound from Example 2 (b) (0.05 g, 0.09 mmol) and benzyl amine (0.01 g, 0.09 mmol) was stirred in DMF (0.2 mL) for 4 days.
		Example 68 (+/-)-N-cyano-N'- 2- (3-hydroxy-4-methoxyphenyl)-4-phenylbut-3-ynyl guanidine To a solution of (+/-)-N-cyano-N'- 2- (3-cyclopentyloxy-4-methoxyphenyl)- 4-phenylbut-3-ynyl guanidine (3.6 g 8.94 mmol) in methylene chloride (160 mL) was cooled to-78 °C and borontribromide (4.5 g 17.9 mmol) was added slowlly and the resulting mixture was stirred for 15 min.
		Example 69 (+/-)-N-cyano-N'- 2- (3-decyloxy-4-methoxyphenyl)-4-phenylbut-3-ynyl guanidine To a solution of (+/-)-N-cyano-N'- 2- (3-hydroxy-4-methoxyphenyl)-4- phenylbut-3-ynyl guanidine (70 mg 0.21 mmol) in dimethylformamide (50 mL) was added 1-iododecane (62 mg 0.23 mmol) and potassium carbonate (32 mg 0.23 mmol), respectively, and the resulting mixture was stirred at 25 °C for 18 h.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/09115.000224&ELEMENT_SET=DECL (7592 words)

	Untitled
		Comparison of the chromatograms at 0M guanidine HCl with those at the sample guanidine HCl concentrations reveal that the scFv is aggregating as it moves through the chromatography column.
		At low guanidine HCl concentrations active conformations are detected in the 0M guanidine HCl chromatograms but not in the traces obtained at the guanidine HCl concentration of the sample, indicating that the final folding steps to the active conformation occurred during the chromatography run at 0M (Figure 2).
		As the guanidine concentration is reduced, a gradual shift in the primary monomer peak to a smaller volume conformation is observed in the 0M guanidine HCl runs.
	www.che.udel.edu /research_groups/robinson/scfvresearch.html (1560 words)

	Agricultural and horticultural guanidine-type fungicide and process for production thereof - Patent 4659739
		The acid addition salt is produced by reacting a fungicidal guanidine compound or its acid addition salt with an acid having an oleophilic group with at least 9 carbon atoms in total or its salt.
		Generally, the strong phytotoxicity of many fungicidal guanidine compounds to useful plants has precluded their practical application as agricultural and horticultural fungicides or limited the range of their application as such despite their significant efficacy as an active ingredient of such fungicides.
		The active ingredient of the fungicide of this invention may also be produced by subjecting the acid addition salt of the guanidine compound to ion exchange by an ion exchange resin, and reacting the resulting free base of the guanidine compound with the aforesaid acid having an oleophilic group with at least 9 carbon atoms.
	www.freepatentsonline.com /4659739.html (4089 words)

	Jetex.org: Motors - Fuel (Site not responding. Last check: 2007-10-20)
		Guanidine itself is crystalline, deliquescent, and strongly caustic, taking up CO2 from the air.
		This is a substance found in guano and closely related to uric acid; it is interesting to note that the saltpeter [KNO3 and NaNO3] deposits of history were also associated with guano deposits, often within caves.
		Guanidine nitrate can be synthesized from dicyandiamide by the action of aqua regia (a process patented in 1909).
	jetex.org /motors/propellants.html (504 words)

	Jetex.org: Archive - Patent 644,073 (Site not responding. Last check: 2007-10-20)
		It is known that guanidine nitrate undergoes an exothermic gas evolving decomposition when it is strongly heated, but under atmospheric pressure conditions the reaction does not sustain itself if a portion only of a quantity of the compound is heated from atmospheric temperature to the temperature at which decomposition begins, unless external heating is maintained.
		When charges made up from guanidine nitrate and a polynitro-phenol or polynitroso-phenol are consumed under atmospheric pressure conditions or at comparatively low super-atmospheric working pressures e.g.
		The gas generating charges obtained in accordance with the invention are suitable for a variety of purposes and are free from many of the disadvantages attendant on the use of hypophosphites or gelatinised nitrocellulose as sensitisers, e.g.
	jetex.org /archive/patents/patent-ici-644,073.html (3754 words)

	Mutations in the 2C Region of Poliovirus Responsible for Altered Sensitivity to Benzimidazole Derivatives -- Shimizu et ... (Site not responding. Last check: 2007-10-20)
		The structures of MRL-1237, HBB, enviroxime, and guanidine hydrochloride are presented in Fig.
		The effect of 2C mutations on drug susceptibility was examined with MRL-1237 and guanidine hydrochloride by plaque-reduction assay.
		The minor determinants responsible for guanidine phenotypes are indicated by small arrows (72).
	jvi.asm.org /cgi/content/full/74/9/4146 (5322 words)

	Guanidine Hydrochloride Products
		The company is now a GMP manufacturer of guanidine hydrochloride, providing high-quality products with the documentation required for biopharmaceutical production.
		The complete line of guanidine hydrochloride is now available in Flowmor packaging for free-flowing dispensing.
		Guanidine hydrochloride is available in 12 kg or 50 kg poly drums.
	www.bioresearchonline.com /content/productshowcase/product.asp?docid={5A177976-8937-11D3-9A68-00A0C9C83AFB}&VNETCOOKIE=NO (101 words)

	Functional Characterization of Organic Cation Drug Transport in the Pigmented Rabbit Conjunctiva -- Ueda et al. 41 (3): ...
		Total mucosal-to-serosal guanidine fluxes in the pigmented rabbit conjunctiva as a function of guanidine concentration.
		C]guanidine and 0.02 to 10 mM unlabeled guanidine.
		guanidine transport in the conjunctiva was significantly inhibited
	www.iovs.org /cgi/content/full/41/3/870 (3486 words)

	8 M Guanidine•HCl Solution and Guanidine·HCl
		However, because the degradation products of guanidine and urea include ammonia, which contains a primary amine that will compete for reaction to the support, urea and guanidine solutions must be prepared with high quality reagents immediately before use.
		In addition to increasing solubility of hydrophobic molecules, guanidine is a general protein denaturant, unfolding proteins and altering their three-dimensional structure.
		Before any large-scale use of guanidine, it is best to test a small sample and determine whether the denaturing effects will adversely affect the intended use of the protein.
	www.piercenet.com /Products/Browse.cfm?fldID=02040301&Format=Print (265 words)

	Selective Substrates for Non-Neuronal Monoamine Transporters -- Gründemann et al. 56 (1): 1 -- Molecular ...
		) was determined in the presence and absence of histamine (a) or guanidine (b).
		Eisenhofer G, McCarty R, Pacak K, Russ H and Schömig E (1996) Disprocynium24, a novel inhibitor of the extraneuronal monoamine transporter, has potent effects on the inactivation of circulating noradrenaline and adrenaline in conscious rat.
		Miyamoto Y, Ganapathy V and Leibach FH (1988) Transport of guanidine in rabbit intestinal brush-border membrane vesicles.
	molpharm.aspetjournals.org /cgi/content/full/56/1/1 (5829 words)

	Chemical Rescue by Guanidine Derivatives of an Arginine-Substituted Site-Directed Mutant of Escherichia coli Ornithine ... (Site not responding. Last check: 2007-10-20)
		The best rescue agent is guanidine hydrochloride, which enhances the rate of the mutant 2000-fold.
		The kinetic mechanism of the mutant is random in the presence or absence of guanidine, in contrast to the sequential ordered mechanism of the wild-type enzyme.
		Thus, chemical rescue of R57G by guanidine hydrochloride restores many but not all wild-type properties to the mutant enzyme.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/1996/35/i50/abs/bi961311i.html (289 words)

	Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck -- Olszewski et al. 101 ...
		Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck -- Olszewski et al.
		Guanidine alkaloids of the batzelladine family, which were isolated
		Guanidines 14, 17, and 22 were the most potent inhibitors of
	www.pnas.org /cgi/content/full/101/39/14079 (3335 words)

	Molecular Research Center RNA & DNA isolation reagents for RT-PCR, PCR, microarrays with blood samples
		A sample of blood is lysed in TRI REAGENT BD and the lysate is separated into the aqueous and organic phases by the bromochloropropane or chloroform addition and centrifugation.
		Decant the phenol-ethanol supernatant and disperse the protein pellet in 0.5 ml of 0.3 M guanidine hydrochloride in 95% ethanol + 2.5 % glycerol (V:V).
		In general, protein pellets suspended in 0.3 M guanidine hydrochloride/ethanol/glycerol wash solution or in ethanol/glycerol wash solution can be stored for at least one month at 4 C or one year -20 C. Individual proteins may display different sensitivity to long-term storage and optimal storage conditions should be established for sensitive and labile proteins.
	www.mrcgene.com /tribd.htm (3912 words)

	Kinetics of Actin Unfolding Induced by Guanidine Hydrochloride (Site not responding. Last check: 2007-10-20)
		Kinetics of Actin Unfolding Induced by Guanidine Hydrochloride
		We have shown that the transition from native to inactivated actin induced by guanidine hydrochloride (GdnHCl) passes through essential unfolding of the protein.
		This means that inactivated actin should be considered as the off-pathway species rather than an intermediate conformation between native and completely unfolded states of actin, as has been assumed earlier.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2002/41/i03/abs/bi015548c.html (232 words)

	Guanidine Carbonate,Guanidine Nitrate,Guanidine Hydrochloride,Guanidine Carbonate Manufacturers,Guanidine Nitrate ...
		Guanidine Carbonate,Guanidine Nitrate,Guanidine Hydrochloride,Guanidine Carbonate Manufacturers,Guanidine Nitrate Suppliers,Guanidine Hydrochloride Exporter
		Guanidine Nitrate is both an explosive compound and a precursor to other explosives similar to this one.
		Guanidine, also called carbamidine, is a strongly alkaline, water-soluble compound, NHC(NH2)2 formed by the oxidation of guanine.
	www.indiamart.com /sborganicsltd (277 words)

	Intracellular location and translocation of silent and active poliovirus replication complexes -- Egger and Bienz 86 ...
		Kinetics and location of viral synthetic activities in PV-infected cells in the absence of guanidine (–gua) or after guanidine release (gua 2–4 h) where guanidine was added to the cells at 2 h p.i.
		(b) After guanidine removal, the location of PV protein 2B (i–iii), negative-strand RNA (iv–vi) or positive-strand RNA (vii–ix) was determined by IF and strand-specific FISH at 0·5 (i, iv, vii), 1·0 (ii, v, viii) and 1·5 (iii, vi, ix) h after release from the block.
		Paul, A. V., Rieder, E., Kim, D. W., van Boom, J. and Wimmer, E. Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg.
	vir.sgmjournals.org /cgi/content/full/86/3/707 (6154 words)

	THE REACTION OF GUANIDINE WITH TRIHALOMETHYLCARBINOLS (Site not responding. Last check: 2007-10-20)
		Trihalomethylcarbinols have been shown to react with a variety of nucleophiles such as cyanamide and thiourea to produce heterocyclic rings.
		In the current investigation the reaction of these carbinols with guanidine is investigated.
		Once reaction conditions are optimized the reaction with a variety of trihalomethylcarbinols will be investigated to determine the scope of the reaction.
	www.usip.edu /research/scholarlyday/abstractDetail.asp?id=169 (81 words)

	Chem 544 Exam 2 Answers (Site not responding. Last check: 2007-10-20)
		In guanidine, solvent cages are not present, so nonpolar side chains are soluble.
		Negative delta-G means toluene is more soluble in guanidine than water.
		In 6 M guanidine, proteins are random coils and all side chains are fully exposed, so they absorb the same as free amino acids.
	www.csulb.edu /~cohlberg/544/examanswers.html (422 words)

	chem327pset5 (Site not responding. Last check: 2007-10-20)
		Of particular interest to protein analysis is the potential effect of the protein denaturant Guanidine Hydrochloride.
		You are provided with stock solutions of N-Acetyl Tryptophan and N-Acetyl Tyrosine at a concentration of 1mg/mL in 20mM Phosphate Buffer at pH 7.0 together with 20mM Phosphate Buffer, pH 7.0 and a Guanidine Hydrochloride solution at 8M in 20mM Phosphate buffer, with the pH adjusted to 7.0.
		From this information and the data that you are provided with calculate an absorption spectrum, in 8M Guanidine hydrochloride, for Glutamate Dehydrogenase assuming that only tyrosine and tryptophan contribute to its absorption properties.
	www.richmond.edu /~jbell2/chem327pset5.html (508 words)

	Combinatorial libraries of bicyclic guanidine derivatives and compounds therein (US6359144)
		The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds.
		The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.
		Esser et al., "Cyclic guanidines: V. Synthesis of Novel Benzodiazepines and related systems by intramolecular electrophilic aromatic substitution." Synthesis 77-82 (1994).
	www.delphion.com /details?&pn=US06359144__ (386 words)

	Guanidine derivatives restore activity to carboxypeptidase lacking arginine-127 -- PHILLIPS et al. 1 (4): 517 -- ...
		Guanidine derivatives restore activity to carboxypeptidase lacking arginine-127 -- PHILLIPS et al.
		Guanidine derivatives restore activity to carboxypeptidase lacking arginine-127
		guanidine binds in the cavity vacated by Arg-127 specifically and in a
	www.proteinscience.org /cgi/content/abstract/1/4/517 (317 words)

	Distinct Interaction of Human and Guinea Pig Histamine H2-Receptor with Guanidine-Type Agonists -- Kelley et al. 60 ...
		In contrast, the potencies and efficacies of guanidines
		In contrast, the efficacies of the guanidines 5 to 13
		with guanidines and 2) to study the importance of the suggested
	molpharm.aspetjournals.org /cgi/content/full/60/6/1210 (5399 words)

	GUANIDINE HYDROCHLORIDE
		Synonyms: Aminomethanamidine; guanidine monohydrochloride; guanidine chloride; iminourea hydrochloride; carbamidine hydrochloride
		Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride.
		Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste facility.
	www.jtbaker.com /msds/englishhtml/g8370.htm (806 words)

	Black Hair Media Hair Forum: relaxer ph (Site not responding. Last check: 2007-10-20)
		The most damaging chemicals tend to be calcium hydroxide and guanidine carbonate and sodium hydroxide.
		Most "no-lye" relaxers are based on the calcium hydroxide and guanidine carbonate chemicals.
		Ammonium bisulfite and ammonium thioglycolate are the least damaging of the chemicals and are normally used as texturizers because they do not get the hair as straight.
	forum.blackhairmedia.com /forum_posts.asp?TID=1264 (1622 words)

	Dodecyl guanidine hydrochloride Use
		Dodecyl guanidine hydrochloride - Pesticide use statistics for 2003
		Top 50 Crops and Sites for for Dodecyl guanidine hydrochloride use in California in 2003
		Regional Use for Dodecyl guanidine hydrochloride on All Sites in 2003
	www.pesticideinfo.org /Detail_ChemUse.jsp?Rec_Id=PC33274 (927 words)

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