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Topic: Guanylate cyclase

Related Topics

Cyclic guanosine monophosphate

Cyclic adenosine monophosphate

Adenosine triphosphate

Impotence

	Marletta Lab - Soluble Guanylate Cyclase
		Stone, J.R. and Marletta, M.A. (1998) Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide.
		Zhao, Y., Schelvis, J.P.M., Babcock, G.T. and Marletta, M.A. (1998) Identification of histidine 105 in the beta-1 subunit of soluble guanylate cyclase as the heme proximal ligand.
		Stone, J.R. and Marletta, M.A. (1994) Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states.
	www.cchem.berkeley.edu /mmargrp/research/sgc/sgc.html (877 words)

	Review B (Site not responding. Last check: )
		Guanylate cyclase is the intracellular enzyme responsible for the synthesis of cGMP from GTP (GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2).
		Soluble guanylate cyclase is comprised of two subunits (a and b), with at least one heme prosthetic group loosely held in place with a histidine as the trans-axial ligand.
		Soluble guanylate cyclase isolated from the human placenta was found to exist primarily in the less active 6-coordinate heme configuration, whereas the more active enzyme isolated from the bovine lung, was found to be in the 5-coordinate heme configuration.
	home.earthlink.net /~whitelin3/review/revbsec.html (2967 words)

	Eurekah - Calcium-Dependent Activation of Guanylate Cyclase by S100b
		Calcium concentration in the dark-adapted retinal rod outer segment is in the 200 to 600 nM range, and the guanylate cyclase of rod outer segments is thought to be activated in response to a fall in calcium concentration triggered by light.
		We conclude from this study that rod outer segment guanylate cyclase, unlike any cyclase known so far, is capable of activation by two different types of calcium-binding proteins, one that activates in response to a decrease in calcium concentration, and the other, described here, which activates in response to an increase in calcium-concentration.
		Recoverin and the guanylate cyclase activating proteins (GCAPs) are calciumsensing proteins in retinal rod and cone cells that belong to the EF-hand superfamily and serve as important calcium...
	www.eurekah.com /chapter/85 (1621 words)

	Citebase - Protein kinase C regulates transcription of the human guanylate cyclase C gene (Site not responding. Last check: )
		Guanylate cyclase C is the receptor for the bacterial heatstable enterotoxins and guanylin family of peptides, and mediates its action by elevating intracellular cGMP levels.
		The reduction in guanylate cyclase C mRNA was inhibited when cells were treated with 4b-phorbol 12-myristate 13-acetate (PMA) in the presence of staurosporine, indicating that a primary phosphorylation event by protein kinase C triggered the reduction in RNA levels.
		Expression in T84 cells of a guanylate cyclase C promoter-luciferase reporter plasmid,containing 1973 bp of promoter sequence of the guanylate cyclase C gene, indicated that luciferase activity was reduced markedly on PMA treatment of cells, and the protein kinase C-responsive element was present in a 129-bp region of the promoter, containing a HNF4 binding element.
	citebase.eprints.org /cgi-bin/citations?id=oai:iiscePrints.OAI2:1939 (447 words)

	Characterization of rat testicular guanylate cyclase during development. (Site not responding. Last check: )
		The biochemical characteristics of rat testicular guanylate cyclase were investigated and the activity and subcellular distribution of the enzyme was determined during testicular development.
		Examination of the effects of metal ions, nucleotides, detergents and other in vitro activators on the activity of guanylate cyclase revealed that the testicular enzyme is similar in most respects to guanylate cyclase isolated from other mammalian tissues.
		guanylate cyclase activity and tissue cyclic GMP were highest during the early stages of development.
	www.arclab.org /medlineupdates/abstract_41593.html (216 words)

	Protein kinase C regulates transcription of the human guanylate cyclase C geneePrints@IISc - Open Access Archive of ...
		Guanylate cyclase C is the receptor for the bacterial heatstable enterotoxins and guanylin family of peptides, and mediates its action by elevating intracellular cGMP levels.
		The reduction in guanylate cyclase C mRNA was inhibited when cells were treated with 4b-phorbol 12-myristate 13-acetate (PMA) in the presence of staurosporine, indicating that a primary phosphorylation event by protein kinase C triggered the reduction in RNA levels.
		Expression in T84 cells of a guanylate cyclase C promoter-luciferase reporter plasmid,containing 1973 bp of promoter sequence of the guanylate cyclase C gene, indicated that luciferase activity was reduced markedly on PMA treatment of cells, and the protein kinase C-responsive element was present in a 129-bp region of the promoter, containing a HNF4 binding element.
	eprints.iisc.ernet.in /archive/00001939 (336 words)

	BLAST Search Results
		Guanyl cyclase beta-subunit at 100B, mRNA 102 3e-19 dbjAB025112.1AB025112 Xenopus laevis XGC-2 mRNA for guany...
		guanylate cyclase 99 4e-18 dbjAB000849.1AB000849 Oryzias latipes mRNA for soluble gu...
		guanylate cyclase 92 4e-16 embZ74734.1CPGCCMRNA C.porcellus mRNA for guanylyl cyclase C 92 4e-16 embX72801.1DMMGCR Drosophila melanogaster mRNA for guanyl...
	www.chickest.udel.edu /orthochick/c343.html (2157 words)

	Maturational Differences in Soluble Guanylate Cyclase Activity in Ovine Carotid and Cerebral Arteries -- WHITE et al. ... (Site not responding. Last check: )
		Ignarro LJ 1989 Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins.
		Wolin MS, Wood KS, Ignarro LJ 1982 Guanylate cyclase from bovine lung: a kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.
		Ignarro LJ 1992 Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism.
	www.pedresearch.org /cgi/content/full/47/3/369 (4389 words)

	Use of guanylate cyclase inhibitors in the treatment of shock - Patent 5298506
		The invention relates to the administration of guanylate cyclase inhibitors, such as methylene blue, for the treatment of septic shock, cardiogenic shock, hypovolemic shock, obstructive shock, neuropathic shock and hypotension caused by excessive doses of nitrovasodilators.
		The method of claim 1 wherein said guanylate cyclase inhibitor is selected from the group consisting of methylene blue, 6-anilino-5, 8-quinolinedione, N-methylhydroxylamine, hydroxylamine, ethacrynic acid and retinol.
		Finally, methylene blue inactivates guanylate cyclase, the enzyme responsible for raising cyclic GMP levels, which is critical, as the cGMP second messenger is central to the hypotensive effect of NO.
	www.freepatentsonline.com /5298506.html (2423 words)

	David L. Garbers's Publications (continued)
		Garbers, D.L., Chrisman, T.D. and Hardman, J.G. (1978) Guanylate cyclase: Purification of particulate and soluble forms of the enzyme and responses of the soluble form to cations and fatty acids. IN: Molecular Biology and Pharmacology of Cyclic Nucleotides (eds.
		Bentley, J.K. and Garbers, D.L. (1987) Stimulation of sea urchin spermatozoan guanylate cyclase in response to egg-associated peptides. Ann.
		Bentley, J.K., Khatra, A.S. and Garbers, D.L. (1988) Receptor-mediated activation of detergent-solubilized guanylate cyclase. Biol.
	www.utsouthwestern.edu /utsw/cda/dept14817/files/203226.html (5301 words)

	Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal ...
		Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies -- Payne et al.
		A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1.
		Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone dystrophy.
	jmg.bmjjournals.com /cgi/content/full/36/9/691 (1908 words)

	Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase -- Friebe and Koesling 93 (2): 96 -- Circulation Research
		inhibition of the membrane-bound guanylyl or adenylyl cyclases
		Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins: evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.
		subunit of soluble guanylate cyclase as the heme proximal ligand.
	circres.ahajournals.org /cgi/content/full/93/2/96 (4968 words)

	Pfam 19.0 : Guanylate_cyc (Site not responding. Last check: )
		Guanylate cyclase is found both in thesoluble and particulate fractions of eukaryotic cells.
		The soluble forms of guanylate cyclase arecytoplasmic heterodimers having alpha and beta subunits.
		In all characterized eukaryote guanylyl- and adenylyl cyclases, cyclic nucleotide synthesis is carried out by the conserved class III cyclase domain.
	pfam.wustl.edu /cgi-bin/getdesc?name=Guanylate_cyc (141 words)

	Web page title
		Partial sequences were obtained from the purified protein, which facilitated subsequent cloning and identification of photoreceptor guanylate cyclase-1.
		Margulis A, Sitaramayya A. Rate of deactivation of nitric oxide-stimulated soluble guanylate cyclase: influence of nitric oxide scavengers and calcium.
		Margulis A, Pozdnyakov N, Dang L, Sitaramayya A. Soluble guanylate cyclase and nitric oxide synthase in synaptosomal fractions of bovine retina.
	www2.oakland.edu /eri/faculty2.cfm?ID=1 (775 words)

	[No title]
		Guanylate cyclases (EC:4.6.1.2) catalyse the formation of cyclic GMP (cGMP) from GTP.
		Guanylate cyclase is found both in the soluble and particulate fractions of eukaryotic cells.
		The soluble forms of guanylate cyclase are cytoplasmic heterodimers having alpha and beta subunits.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR001054 (453 words)

	Calcium binding protein
		A key enzyme in photoreceptor cells is the membrane- bound guanylate cyclase that catalyzes the synthesis of the intracellular transmitter cyclic GMP.
		This activation pathway is localized in the photoreceptor-bipolar synapse and, therefore, does not interfere with the regulation of guanylate cyclase by GCAPs in the outer segment of the photoreceptor cell.
		The guanylate cyclase in photoreceptor cells is the first example of a membrane-bound guanylate cyclase that responds to opposite Ca signals by providing two distinct binding sites for two different Ca -sensors.
	www.fz-juelich.de /ibi/ibi-1/Calcium_binding_protein (221 words)

	Ca2+ sensor S100[beta]-modulated sites of membrane guanylate cyclase in thephotoreceptor-bipolar synapse
		Specific basal guanylate cyclase activity of ROS-GC1 and of the deletion mutants expressed in COS cells is given in the right-hand column [A].
		Margulis A, Pozdnyakov N, Dang L and Sitaramayya A (1998) Soluble guanylate cyclase and nitric oxide synthase in synaptosomal fractions of bovine retina.
		Nambi P, Aiyar NV and Sharma RK (1982) Adrenocorticotropin-dependent particulate guanylate cyclase in rat adrenal and adrenocortical carcinoma: comparison of its properties with soluble guanylate cyclase and its relationship with ACTH-induced steroidogenesis.
	www.nature.com /emboj/journal/v21/n11/full/7594475a.html (6739 words)

	Revew References (Site not responding. Last check: )
		Ahman I, Barnstable CJ 1993 Differential Laminar Expression of Particulate and Soluble Guanylate Cyclase Genes in Rat Retina.
		Garbers DL 1979 Purification of soluble guanylate cyclase from rat lung.
		Ignarro LJ 1989 Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins Semin Hematol 26:63-76.
	home.earthlink.net /~whitelin3/review/revdsec.html (2320 words)

	Localization of Soluble Guanylate Cyclase Activity in the Guinea Pig Cochlea Suggests Involvement in Regulation of ...
		Ahmad I, Barnstable CJ (1993) Differential laminar expression of particulate and soluble guanylate cyclase genes in rat retina.
		Furuta H, Mori N, Luo L, Ryan AF (1995) Detection of mRNA encoding guanylate cyclase A/atrial natriuretic peptide receptor in the rat cochlea by competitive polymerase chain reaction and in situ hybridization.
		Zubin P, Defagot C, Parlanti G (1995) Guanylate cyclase activity in the inner ear and auditory nerve of the rat.
	www.jhc.org /cgi/content/full/45/10/1401 (3743 words)

	Clustering and frequency of mutations in the retinal guanylate cyclase (GUCY2D) gene in patients with dominant cone-rod ...
		Clustering and frequency of mutations in the retinal guanylate cyclase (GUCY2D) gene in patients with dominant cone-rod dystrophies -- Payne et al.
		Guanylate cyclase (retGC-1) is a key enzyme in the recovery phase of phototransduction in both cone and rod photoreceptor
		Functional characterisation of missense mutations at codon 838 in retinal guanylate cyclase correlates with disease severity in patients with autosomal dominant cone-rod dystrophy.
	jmg.bmjjournals.com /cgi/content/full/38/9/611 (2704 words)

	BioMed Central \| Full text \| NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272
		Guanylate cyclases (GTP pyrophosphate-lyase [cyclizing]; EC 4.6.1.2) catalyze the biosynthesis of guanosine 3',5'-cyclic monophosphate (cGMP) from GTP.
		Stone JR, Marletta MA: Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide.
		Zhao Y, Schelvis JPM, Babcock GT, Marletta MA: Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand.
	www.biomedcentral.com /1471-2210/1/13 (6133 words)

	07.07.2004 - How worms' noses sense oxygen
		Marletta's students have painstakingly picked apart the guanylate cyclase protein, in particular the exact binding site for NO. It turns out to be a heme molecule nearly identical to the heme that binds oxygen in hemoglobin to carry it through the blood stream to muscle.
		In order to understand how guanylate cyclase is put together, Marletta and his students went in search of similar enzymes in the genomes of other organisms.
		By knocking out several genes coding for parts of the guanylate cyclase enzyme, they were able to show that this enzyme was acting as an oxygen detector, primarily steering worms away from too much oxygen.
	www.berkeley.edu /news/media/releases/2004/07/07_worms.shtml (1355 words)

	Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus -- ...
		Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus -- Deruelle et al.
		Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs.
		Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension
	ajplung.physiology.org /cgi/content/full/288/4/L727 (4153 words)

	Calcium-Modulated Rod Outer Segment Membrane Guanylate Cyclase Type 1 Transduction Machinery in the Testes -- Jankowska ...
		Membrane fraction of bovine testes was prepared and assayed for guanylate cyclase activity, as described in "Materials and Methods." (A) Response to Ca Membranes were incubated in the presence of indicated concentration of Ca Response to GCAP1 and GCAP2.
		Adrenocorticotropin-dependent particulate guanylate cyclase in rat adrenal and adrenocortical carcinoma: comparison of its properties with soluble guanylate cyclase and its relationship with ACTH-induced steroidogenesis.
		Coexistence of guanylate cyclase and atrial natriuretic factor receptor in a 180-kD protein.
	www.andrologyjournal.org /cgi/content/full/28/1/50 (4574 words)

	Increased Guanylate Cyclase Activity Is Associated with an Increase in Cyclic Guanosine 3',5'-monophosphate in Left ...
		Increased Guanylate Cyclase Activity Is Associated with an Increase in Cyclic Guanosine 3',5'-monophosphate in Left Ventricular Hypertrophy -- Sadoff et al.
		Soluble guanylate cyclase activity (25) was determined from a transmural sample obtained from the CFX region.
		Soluble guanylate cyclase activity was also determined in six control and six hypertrophic hearts.
	www.jci.org /cgi/content/full/98/3/838 (4778 words)

	Thiol oxidation inhibits nitric oxide-mediated pulmonary artery relaxation and guanylate cyclase stimulation -- Mingone ...
		Relaxation of BPA to adenylate cyclase activators isoproterenol (A, n = 4) and forskolin (B, n = 4) was not altered by the PPP inhibitor 6-AN.
		Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins.
		Activation of soluble guanylate cyclase from rat lung by incubation or by hydrogen peroxide.
	ajplung.physiology.org /cgi/content/full/290/3/L549 (5567 words)

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