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Topic: Guthrie test

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	Test
		The test is used to examine the significance of the associati...
		Guthrie test The Guthrie test is a series of heel of the baby, at or before 4 days of age.
		Ishihara colour test The Ishihara colour test is a test for 1917.
	www.brainyencyclopedia.com /topics/test.html (2856 words)

	Receiver operating characteristic plots to evaluate Guthrie, Wallac, and Isolab phenylalanine kit performance for ...
		of 0.30, 0.27, and 0.18 mmol/L for the Guthrie, Wallac, and
		0.27, and 0.18 mmol/L for the Guthrie, Wallac, and Isolab assays,
		and 0.18 mmol/L for the Guthrie, Wallac, and Isolab assays,
	www.clinchem.org /cgi/content/full/43/10/1838 (1988 words)

	The Museum of disABILITY History: Online Exhibits (Site not responding. Last check: 2007-09-12)
		Although this test was reliable in verifying PKU as a cause of mental retardation, it was not an effective tool in prevention because not enough phenylalanine may build up in the urine within the first few days after birth, so detection occurs too late to prevent damage.
		Guthrie’s test produced accurate results and was a pivotal point in newborn screening history, but his biggest contribution was the dried blood spot which made mass screening of all newborns possible.
		The "Guthrie Test," as it became known as, was ready to be implemented.
	www.people-inc.org /museum/exhibits_birth1.asp (881 words)

	Converted WP file 25790
		Guthrie argues that the State committed prosecutorial misconduct by seeking and obtaining an indictment with the felony offense of second degree sexual assault even though the parties were married at the time of the assault.
		Guthrie was excluded as a contributor to the mixture.
		Guthrie is contending that the State was informing the jury of something that was not introduced as evidence, the proper remedy was to object at trial during the State's closing argument and move for a curative instruction.
	www.state.wv.us /wvsca/DOCS/Spring99/25790.htm (8226 words)

	Guthrie
		Guthrie, Kentucky Guthrie is a city located in 2000 census, the city had a total population of 1,469.
		Guthrie Township, Minnesota Guthrie Township is a township located in 2000 census, the township had a total population o...
		Guthrie was first elected to the Tories on the Opposition benches.
	www.brainyencyclopedia.com /topics/guthrie.html (251 words)

	APPENDIX 5. THE HISTORY OF NEWBORN PHENYLKETONURIA SCREENING IN THE U.S.
		However, the ferric chloride urine test, then the only method available, was unreliable until the age of six to eight weeks, after the infant had been discharged from the hospital and possibly after he or she had already suffered some irreversible brain damage.
		Guthrie himself suggested that tests be run both on the blood collected in the hospital and on urine-impregnated filter papers, which the mother would mail back to the laboratory when the infant was 2 to 3 weeks old.
		This "expense of laboratory testing" was sometimes equated with the unit cost of the test rather than the cost of the program to identify one affected individual—perhaps because the latter would include the cost of retesting the large number of false positives that is involved in all screening for very rare conditions.
	biotech.law.lsu.edu /research/fed/tfgt/appendix5.htm (6266 words)

	Guthrie test - Wikipedia, the free encyclopedia
		The Guthrie test is a series of medical tests performed on newborns to detect several metabolic diseases.
		It is named after the U.S. bacteriologist Robert Guthrie, who first described it in 1963.
		The test is performed on blood samples taken from the heel of the baby, at or before 4 days of age.
	en.wikipedia.org /wiki/Guthrie_test (108 words)

	University of Miami School of Medicine - Glossary - Guthrie test
		The Guthrie test was the original impetus to newborn metabolic screening.
		After incubating the agar plate overnight, the diameter of the growth zone around the test disc is compared to that of a control disc of blood serum to which a known quantity of phe has been added.
		Guthrie went on to develop bacterial inhibition assays for other inherited disorders of metabolism, including maple syrup urine, galactosemia, maple syrup urine disease and homocystinuria.
	www.med.miami.edu /glossary/art.asp?articlekey=11390 (260 words)

	Full text
		Guthrie and Carey are studying chemical reactions that occur within concrete and cause the building material -- of which an estimated 260 million cubic yards were used in the United States last year -- to weather and decay.
		Guthrie and Carey are working with personnel in the New Mexico State Highway and Transportation Department to identify structures that may fall prey to alkali-silica reaction -- long before the cracks formed by expanding gel are apparent.
		Unlike other testing techniques (uranyl acetate, a radioactive material, is now used to detect ASR in concrete), Guthrie's and Carey's test reduces chances of false positives, is easily used and disposed of in the field, is nontoxic and doesn't require any special viewing apparatus.
	www.lanl.gov /orgs/pa/News/021997.html (2129 words)

	Parenting and Child Health - Health Topics - Neonatal screening test
		The test can tell if a baby has one of many rare but serious health problems before any harm is done and even before there are signs that there is a health problem.
		If the baby goes home from hospital before the test is done, it may be done by the home visiting midwife, or the parents may be asked to bring the baby back to the hospital for the test.
		In South Australia the results of the blood tests are sent back to the birth centre (or to the doctor if the baby was born at home) within a week, checked, and if they were normal, placed in the baby's case notes.
	www.cyh.com /HealthTopics/HealthTopicDetails.aspx?p=114&np=304&id=1466 (1524 words)

	Report of the NIH Consensus Development Conference on Phenylketonuria (PKU): Screening and Management: Chapter II (Site not responding. Last check: 2007-09-12)
		The Guthrie test has been found to have high sensitivity, however, the test is semi-quantitative and difficult to automate.
		The test seems to be as reliable as the Guthrie BIA and may be slightly more sensitive (Jew et al, 1994).
		Testing is performed on a small amount of blood obtained on a filter paper collection device, air dried, and submitted to a newborn screening laboratory.
	www.nichd.nih.gov /publications/pubs/pku/sub30.htm (5226 words)

	[No title]
		Infants who are tested in the first 24 hours of age should receive a repeat screening test by 2 weeks of age.
		All parents should be adequately informed regarding the indications for testing and the interpretation of PKU test results, including the probabilities of false-positive and false-negative findings.
		Guthrie R, Susi A. A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants.
	odphp.osophs.dhhs.gov /pubs/guidecps/text/CH44.TXT (1577 words)

	eumom.com - Medical Info
		The tests vary from hospital to hospital, but will probably include a test for thyroid function and a test for phenylketonuria (Guthrie test).
		The Guthrie test is used to check your baby's blood for an inherited illness called phenylketonuria (PKU).
		Other rare conditions may also be tested for on the Guthrie card, including cystic fibrosis, hypothyroidism (underactive thyroid gland) and galactosaemia.
	www.eumom.com /uk/medinfo/print.asp?id=further_checks (489 words)

	Full text
		The test that Guthrie and Carey have developed not only shows when the reaction is occurring, but has given them insight into how it occurs.
		To aid in early detection of alkali-silica reaction, Guthrie and Carey have developed a simple, environmentally benign test that will identify ASR in concrete: a set of chemicals that can be poured on concrete core samples in the field.
		Unlike other testing techniques (uranyl acetate, a radioactive material, is now used to detect ASR in concrete), the Guthrie and Carey's test reduces chances of false positives, is easily used and disposed of in the field, is non-toxic and doesn't require any special viewing apparatus.
	www.lanl.gov /orgs/pa/News/021997text.html (2242 words)

	EP Healthcare - Newborn Screening Special Report: PART ONE - Testing for Disorders at Birth (Site not responding. Last check: 2007-09-12)
		The National Association for Retarded Children, the Children’s Bureau, and the Kennedy Foundation were among the organizations that pushed for widespread adoption of the Guthrie test for PKU, which is now mandated by all 50 states and the District of Columbia.
		Guthrie’s work in the field of mental retardation led him to develop tests for galactosemia, maple syrup urine disease (MSUD), and homocystinuria.
		The Guthrie test, based on a blood spot on filter paper from a heelstick (a method of obtaining blood samples from newborns by pricking the heel) and bacterial assays (tests), required a separate test for each disorder although the same blood spot could be used.
	www.eparent.com /healthcare/birthDisorders.htm (1879 words)

	babyworld - your baby - your newborn - checking your new baby - other tests (Site not responding. Last check: 2007-09-12)
		This is a blood test that is done routinely towards the end of your baby’s first week.
		Your midwife will take a drop of blood from the baby’s heel by pricking it, which will be tested for a rare genetic condition called phenylketonuria.
		In some cases, especially if your baby is small or premature, you may be advised to have his blood sugar level tested in his first couple of days to make sure that he doesn’t have hypoglycaemia (low blood sugar), which can cause various problems, some of them serious.
	www.babyworld.co.uk /information/baby/newborn/checking/other_tests.asp (198 words)

	Screening Technologies: Types and Effectiveness (Site not responding. Last check: 2007-09-12)
		A collaboration between Guthrie and MacCready, a physician who directed the diagnostic laboratories of the Massachusetts Department of Public Health, resulted in the application of Guthrie’s test to spots of blood routinely collected from the heel of newborn infants at nursery discharge and dried on filter paper.
		In California, the screening test is performed in eight medical center laboratories under contract to the State, and Pennsylvania contracts its screening to Neo Gen Screening, Inc., of Pittsburgh, a large private newborn screening laboratory (Chace, Naylor, 1999).
		Guthrie’s bacterial assay remains the most frequently used PKU screening test in the United States (Dougherty, Levy, 1999).
	www.nichd.nih.gov /publications/pubs/pku/sub11.htm (1264 words)

	HDC - Health and Disability Commissioner -
		The consumer advised that she did not know that a blood sample for PKU and Guthrie Test analysis had been taken, and that she had not given her consent for this sample to be obtained.
		The samples are retained after the original testing so that if there are any errors in the screening process and the child develops one of these deficiencies, the samples are available for re-testing so that future threshold screening levels can be adjusted.
		The Director advised that it is the responsibility of the LMCs to inform the mother about Guthrie Testing, to obtain her consent for the blood collection, and ensure that the samples have been collected.
	www.hdc.org.nz /page.php?&page=publications&publication=96 (963 words)

	MSUD Volume 17 #1 (Site not responding. Last check: 2007-09-12)
		MacCready learned about the screening test from Dr. Guthrie, was convinced that it would indeed prevent mental retardation in PKU, brought the test to Massachusetts, and asked doctors throughout the state to obtain heel stick blood specimens from newborn babies.
		Guthrie flew to the state of Oregon when Monte’s second Guthrie test was confirmed positive.
		Guthrie’s dedication to preventing mental retardation was instrumental in saving the life and health of our son in 1965 and many others with MSUD since.
	www.msud-support.org /web17_1.htm (4707 words)

	The Callahan Racing Page: News
		But the test is even more important for drivers Jim Guthrie and Jason Leffler, because they face a learning curve with the track and their teams.
		Veteran Guthrie will drive for Cobb Racing for the first time at the test, and rookie Leffler will serve as a test driver for Treadway Racing at Atlanta.
		Guthrie, 36, joined Cobb Racing in late May after the Indianapolis 500 but was unable to drive due to injuries suffered in a crash at Indy.
	www.theautochannel.com /callahan/news/98070203.html (636 words)

	Congenital hypothyroidism
		The heel prick or Guthrie, test, where a small amount of blood is collected from your baby's foot a few days after birth, checks for thyroid function among other rare conditions.
		The heel prick or Guthrie test (where a small drop of blood is taken for testing) is usually performed by the midwife in the first 24 to 72 hours after birth.
		Screening tests can sometimes be confusing, and infantile hypothyroidism can still develop even when the test is normal.
	www.ivillage.co.uk /print/0,,181890,00.html (882 words)

	Inborn errors of metabolism: Organic Acidemia Association (Site not responding. Last check: 2007-09-12)
		The original Guthrie test for PKU relied on a microbe that cannot grow unless there is excess phenylalanine in the blood spot.
		This test has been used for diagnosis of sick patients and testing their relatives for the past decade.
		The results of the new testing programs should include faster and more accurate diagnosis of organic acidemias and related disorders, so that infants will be identified before catastrophic illness has begun, or else earlier in the illness so that better treatment can be started sooner.
	www.oaanews.org /article.asp?article=74 (949 words)

	Testing ASP.NET 2.0 and Visual Web Developer (Site not responding. Last check: 2007-09-12)
		Our test team is staffed by engineers who own writing test plans, developing automated tests, and building the test infrastructure required to run and analyze them.
		Test plans are the first step, and happen as early as possible in the product cycle.
		Note that some of the test cases have a number associated with them (look at the first AutoFormat one) – this indicates that this test case was missed during the original review of the document (meaning a test hole) and has been added in response to bugs being opened (110263 is the bug number).
	weblogs.asp.net /scottgu/archive/2004/10/28/249458.aspx (4255 words)

	EP Healthcare - Managed Care and Children With Illnesses or Disabilities (Site not responding. Last check: 2007-09-12)
		In 1961, Dr. Robert Guthrie of the University of Buffalo developed a test to identify PKU in newborns.
		Guthrie’s test requires several drops of a baby’s blood, retrieved at birth and placed on a small filter paper.
		Guthrie realized that this test was an effective screen that could prevent mental retardation in children with PKU, and urged public health officials and professional medical associations to assure that all babies be screened at birth for PKU.
	www.eparent.com /healthcare/unbs.htm (3131 words)

	Guthrie Test - Definition (Site not responding. Last check: 2007-09-12)
		Definition: The Guthrie test is a blood test that all newborns receive.
		The blood is tested for several diseases, the most important being PKU (polyketonurea).
		Without this test, children with PKU would receive irreparable brain damage before the disease was detected.
	parenting.allinfoabout.com /glossary/guthrie.html (76 words)

	[No title]
		For instance, the accuracy of DNA testing when the evidence had been degraded by having been buried underground for 2 years is simply not something that the scientist doing research projects in the laboratory had to worry about.
		I can't just assert that the test is valid based on my expertise and experience dealing with children with these problems; I have to provide data on the error rates of the screening test.
		The application of the CF testing for the general population was not recommended, because it was felt that the risk outweighed the potential benefit for the general population.
	www.ncjrs.org /txtfiles1/nij/179630.txt (19809 words)

	Phenylketonuria (Site not responding. Last check: 2007-09-12)
		The primary diagnostic test for PKU is the measurement of phenylalanine levels in a drop of blood taken from the heel of a newborn baby's foot.
		In this test, PKU is confirmed by the appearance of bacteria growing around high concentrations of phenylalanine in the blood spot.
		If the initial PKU test produces a positive result, then follow-up tests are performed to confirm the diagnosis and to determine if the elevated phenylalanine levels may be caused by some medical condition other than PKU.
	www.healthatoz.com /healthatoz/Atoz/ency/phenylketonuria.jsp (3090 words)

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