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Topic: HBX

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	Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of ...
		Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins.The HBx protein is a small polypeptide encoded by mammalian hepadnaviruses that is essential for viral infectivity and is thought to play a role in development of hepatocellular carcinoma during chronic hepatitis B virus infection.
		In addition, HBx mediates a striking reduction in cytoplasmic p105 NF-kappaB1 inhibitor and p50 protein levels and release of RelA protein that was sequestered by the p105 inhibitor, concomitant with nuclear accumulation of NF-kappaB complexes.
		HBx mediated only a slight reduction in the cytoplasmic levels of NF-kappaB2 p100 protein, an additional precursor inhibitor of NF-kappaB, which is thought to be less efficiently processed or less responsive to release of NF-kappaB.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/587395.html (338 words)

	BioCarta - Charting Pathways of Life
		The fourth reading frame has been called the X gene and produces HBx protein that is essential for viral replication in liver cells and acts broadly to activate a variety of transcription factors.
		HBx does not appear to interact directly with Ras or protein kinases but does appear to activate the calcium activate protein kinase Pyk2.
		A dominant negative form of Pyk2 blocks HBx activity and the involvement of calcium in HBx activation of Pyk2 is indicated by the action of several molecular probes that alter cytosolic calcium signaling.
	www.biocarta.com /pathfiles/h_HBxPathway.asp (439 words)

	HBX - Complimentary Services (Site not responding. Last check: 2007-11-04)
		HBX acts as a common supplier to the three liner divisions.
		HBX Nigeria operates and maintains the largest fleet of plant, equipment, trucks and trailers in the Hull Blyth Group.
		HBX have recently obtained the necessary authority from the NPA (Nigerian Port Authority) to open a bonded container terminal.
	www.ed-ng.com /nigeria/port/index.html (211 words)

	Intracellular localization of the hepatitis B virus HBx protein -- Henkler et al. 82 (4): 871 -- Journal of General ...
		of HBx are predominantly compartmentalized in the nuclei in
		Compartmentalization of HBx was observed in the cytoplasm of
		HBx was detected in transiently transfected cells predominantly (A) or substantially (B) in the nuclei, when its overall expression levels were low (A, B; nucleoli are indicated by arrowheads).
	vir.sgmjournals.org /cgi/content/full/82/4/871 (5080 words)

	Role of NF-{kappa}B and Myc Proteins in Apoptosis Induced by Hepatitis B Virus HBx Protein -- Su et al. 75 (1): 215 -- ...
		HBx is largely a cytoplasmic protein (25, 27, 49, 92) that moderately activates transcription and is essential for
		Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases.
		Hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.
	jvi.asm.org /cgi/content/full/75/1/215 (6244 words)

	Detection of the Hepatitis B Virus X Protein (HBx) Antigen and Anti-HBx Antibodies in Cases of Human Hepatocellular ...
		a polypeptide, HBx, that is implicated in HBV-mediated HCC (4,
		Western blotting of HBx protein in cell lysates of 20 HCC tumor tissues with a monoclonal antibody (MAb 8419).
		HBx gene of hepatitis B virus induces liver cancer in transgenic mice.
	jcm.asm.org /cgi/content/full/41/12/5598 (3734 words)

	Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx ... (Site not responding. Last check: 2007-11-04)
		Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein -- Hafner et al.
		Articles by Hafner, A. Articles by Hildt, E. Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein
		motif (TLM), cell-permeable HBx fusion proteins were generated.
	emboreports.npgjournals.com /cgi/content/abstract/4/8/767 (168 words)

	WebSideStory Launches HBX Stream: APIs for Digital Marketing Products and Services (Site not responding. Last check: 2007-11-04)
		The HBX Stream services (http://www.websidestory.com/stream/) are available to all providers of online marketing technology, including e-mail service providers, search engine marketing firms, affiliate marketing companies, and CRM vendors.
		The HBX Stream platform consists of two components: partner support, including joint marketing and sales commitments and access to a suite of APIs that will enable partners to integrate their data, products, and services with WebSideStory's HBX Web analytics technology.
		HBX is a trademark and WebSideStory is a registered trademark of WebSideStory.
	www.forrelease.com /D20041021/lath005.P1.10192004062323.17306.html (781 words)

	Features And Articles - Wachovia Improves Online Marketing ROI with HBX
		With assets of $418 billion, Wachovia (http://www.wachovia.com) is one of the largest providers of financial services to retail, brokerage and corporate customers throughout the East Coast and the nation.
		HBX is an award-winning, on-demand analysis and reporting service that delivers real-time information about online visitor and customer behavior.
		More than 550 enterprises use HBX to improve the performance of their online business initiatives in e-commerce, entertainment, publishing, financial services, travel and more.
	www.webanalyticsasia.com /news/ROI.htm (303 words)

	Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal ... (Site not responding. Last check: 2007-11-04)
		The recruitment of c-FLIP to DISC is blocked by the interaction with HBx and, consequently, caspase-8 and caspase-3 are hyperactivated by death signals even below the threshold concentration that renders the cells susceptible to apoptosis.
		The HBx (subtype ayw)-expressing vector (pEG-HBx) was subcloned
		Benn,J., Su,F., Doria,M. and Schneider,R.J. (1996) Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-jun N-terminal mitogen-activated protein kinases.
	embojournal.npgjournals.com /cgi/content/full/22/9/2104 (6946 words)

	Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx ... (Site not responding. Last check: 2007-11-04)
		HBx with this peptide is suitable for assessing this question.
		Benn, J., Su, F., Doria, M. and Schneider, R.J. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases.
		Su, F. and Schneider, R.J. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha.
	emboreports.npgjournals.com /cgi/content/full/4/8/767 (3801 words)

	Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase ...
		Five micrograms of the HBx expression plasmid was cotransfected with an equal amount of the luciferase construct (p21P), in which transcription is driven by a full-length form of the p21 promoter, into either HepG2 cells (A and C) or Hep3B cells (B and D).
		The levels of p21, p53, HBx and actin in the HBx-transfected HepG2 (A) and Hep3B (C) cells were determined by western blotting and indicated in (B) and (D), respectively.
		Benn,J., Su,F., Doria,M. and Schneider,R.J. (1996) Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases.
	nar.oupjournals.org /cgi/content/full/32/7/2202 (5847 words)

	Detection of the Hepatitis B Virus X Protein (HBx) Antigen and Anti-HBx Antibodies in Cases of Human Hepatocellular ...
		Detection of the Hepatitis B Virus X Protein (HBx) Antigen and Anti-HBx Antibodies in Cases of Human Hepatocellular Carcinoma -- Hwang et al.
		Detection of the Hepatitis B Virus X Protein (HBx) Antigen and Anti-HBx Antibodies in Cases of Human Hepatocellular Carcinoma
		Western blotting of HBx protein in liver extracts from 20 HCC
	jcm.asm.org /cgi/content/abstract/41/12/5598 (300 words)

	Mitotic Aberration Coupled With Centrosome Amplification Is Induced by Hepatitis B Virus X Oncoprotein via the ...
		Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication.
		The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis.
		Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis.
	mcr.aacrjournals.org /cgi/content/full/2/3/159 (6059 words)

	Expression of fas ligand in human hepatoma cell lines: role of hepatitis-B virus X (HBX) in induction of Fas ligand.
		For further analysis of the role of HBx in the induction of FasL, PLC/PRF/5 cells were transfected transiently with the HBV genome, or HBx, or the frameshift mutant of HBx.
		In PLC/PRF/5 cells transfected with the HBV genome or HBx but not in cells transfected with the frameshift mutant of HBx, FasL expression was detected.
		Our data suggest that HBx plays a role in the induction of FasL in hepatoma cells and in the escape from immune surveillance.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/1926960.html (208 words)

	Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative ...
		Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis -- Tralhao et al.
		Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis
		The role of the hepatitis B virus X protein (HBx) in the pathogenesis of hepatitis B virus (HBV) infection remains unclear.
	www.pnas.org /cgi/content/abstract/99/10/6991 (348 words)

	WebSideStory Debuts Active Dashboard with Launch of HBX 3.0 On-Demand Web Analytics
		HBX 3.0 is the cornerstone of the WebSideStory Active Marketing Suite™, a collection of integrated, on-demand digital marketing applications that includes web analytics, site search, web content management and keyword bid management.
		HBX Active Dashboard adds to WebSideStory’s extensive list of alternative reporting capabilities, including HBX Report Builder, a plug-in for Microsoft Excel and considered one of the most advanced reporting tools in the industry; and Active Viewing, a browser plug-in that overlays key metrics right on top of a web page.
		HBX 3.0 was developed with feedback from one of the largest enterprise customer bases in the industry.
	www.websidestory.com /news-events/press-releases/view-release.html?id=294 (836 words)

	Tumor Eradication by Hepatitis B Virus X Antigen-Specific CD8+ T Cells in Xenografted Nude Mice -- Chun et al. 170 (3): ...
		(HBx) protein may be one of these factors (3, 4).
		The peptides, HBx 15–23, HBx 52–60, HBx 92–100, and HBx 115–123, respectively, were added at 10 µg/ml during the first week of stimulation.
		Determination of the binding affinity of synthetic peptides derived from the HBx protein to HLA-A2.1 molecules.
	www.jimmunol.org /cgi/content/full/170/3/1183 (4873 words)

	Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative ...
		HBx exhibits a predominantly cytoplasmic localization (partly associated with the proteasome and mitochondria) although, at
		HBx is expressed in a small proportion of liver cells in patients
		The aim of the study was to assess the effect of HBx expression on liver cell proliferation in vivo in the context of liver
	www.pnas.org /cgi/content/full/99/10/6991 (5259 words)

	Caspase-dependent Alterations of Ca2+ Signaling in the Induction of Apoptosis by Hepatitis B Virus X Protein -- Chami ...
		A, counting of apoptotic bodies (shown as percentage) in HepG2 (left panel) and HeLa cells (right panel) transfected with GFP alone (Control) or cotransfected with GFP and HBx (HBx) was determined at 36 and 48 h post-transfection in HepG2 and at 44 and 52 h post-transfection in HeLa.
		B, Western blot analyses of cytochrome c release (Cyt.c) in nontransfected HeLa cells (Control) or transiently transfected with HBx (HBx) was determined at 36 h and 48 h post-transfection in cytosolic fraction and at 48 h post-transfection in mitochondrial fraction and quantified versus
		that the overexpression of HBx in hepatic (HepG2) and nonhepatic
	www.jbc.org /cgi/content/full/278/34/31745 (6113 words)

	pdaPhoneHome.com Archive - HBX won't launch expansion card apps
		I just installed version 3.0 of HBX and the new version of the hack.
		I noticed in the update description it said that one of the things addressed was to enable the launching of apps from an expansion card.
		I was able to assign my third button to a game on my SD card and it started it just fine.
	pdaphonehome.com /forums/showthread/t-23864.html (221 words)

	Adversitement \| HBX \| Web Analytics en website analyse oplossingen (Site not responding. Last check: 2007-11-04)
		HBX versie 3.0 met Active Dashboard en Bid Management integratie.
		HBX is door Network Computing in een uitgebreide review gekozen tot beste all-around product.
		HBX is een perfecte on-demand tool die informatie verzamelt over het gedrag van de bezoekers van uw websites.
	www.hbxondemand.de (161 words)

	Flaw in Gmail, fixed in a flash
		Two hackers working for The HBX Networks UNIX Community Group identified a flaw in Google’s mailing service 'Gmail' and published the their findings of the glitch on their site to make Google and Gmail users aware of it.
		Whatever the reason of the failure may be, one thing is clear that although the Gmail service is still in its Beta stage there are lot of people who are relying on the service had their privacy is now compromised.
		The HBX Networks UNIX Community Group is known for their Free Anonymous UNIX Hacking Shells and is now slowly expanding to other areas.
	www.earthtimes.org /articles/show/1218.html (599 words)

	Human protein: O43504 - Hepatitis B virus X interacting protein (HBX-interacting protein) (HBV X interacting protein). ...
		This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx).
		The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.
		suppression of caspase activation by the birc5/hbxip complex is increased in the presence of hbx.
	harvester.embl.de /harvester/O435/O43504.htm (921 words)

	N2VR - Rohn HBX-48 Tower Install
		This pic shows the difference in height between the shed tower and the HBX.
		If you have limited space and want a tower, definately look into the Rohn HBX option.
		The shed tower was moved to the roof of the house for 6m/10m/VHF/UHF use.
	www.qsl.net /n2vr/hbx48_tower.htm (786 words)

	Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERKs and PI-3K/AKT ...
		Hepatitis B virus (HBV) X protein (HBx) has been shown to be essential for the development of hepatocellular carcinoma (HCC).
		Recently, we have found that HBx causes the progression of liver cancer through down-expression of PTEN, known as a tumor suppressor gene (1).
		These results clearly suggest that the HBx contributed to the transcriptional regulation of MMP-9 through the ERKs and PI-3K-AKT/PKB pathway, and increased an invasive potential of cells.
	www.fasebj.org /cgi/content/abstract/03-1429fjev1 (509 words)

	Web Analytics and Website Statistics By WebSideStory
		Online visitor activity and web site statistics captured by HBX Analytics enables marketers to measure online conversions and to act on how Internet users respond to web site design and web site content changes, online marketing campaigns, e-commerce offerings and customer support site effectiveness.
		HBX Analytics actually ties clickstream behavior with various web site conversion activities to unveil key visitor patterns and trends.
		Learn how site search is helping businesses optimize their web sites to increase online sales and conversions with this free report.
	www.hitbox.com (487 words)

	X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo -- ...
		Kim, C.M., Koike, K., Saito, I., Miyamura, T., and Jay, G. HBx gene of hepatitis B virus K induces liver cancer in transgenic mice.
		Doria, M., Klein, N., Lucito, R., and Schneider, R.J. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.
		Truant, R., Antunovic, J., Greenblatt, J., Prives, C., and Cromlish, J.A. Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation.
	www.jci.org /cgi/content/full/108/10/1523 (4526 words)

	Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase ...
		X protein (HBx), the effects of HBx on the important cellular
		HBx variants with Ser-101 instead of Pro-101 stabilized p53
		the effect of HBx on p21 expression seems to be determined by
	nar.oupjournals.org /cgi/content/abstract/32/7/2202 (254 words)

	Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis -- Elmore et al. 94 ...
		We have reported previously that the hepatitis B virus oncoprotein, HBx, can bind to the C terminus of p53 and inhibit several
		HBx (from residues 111 to 154) being critical for this interaction.
		Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein
	www.pnas.org /cgi/content/abstract/94/26/14707 (1346 words)

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