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Topic: HCM

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Hypertrophic cardiomyopathy

Aortic insufficiency

Aortic stenosis

Left ventricular hypertrophy

Sudden cardiac death

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Myocardial infarction

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	cats and heart disease
		HCM, or Hypertrophic Cardiomyopathy, is a heart disorder in which the left wall of the heart grows and thickens.
		Symptoms of HCM are most frequently seen in young and middle-aged male cats, usually before the age of 5-6, but have been recorded in cats as young as 8 months and as old as 16.
		The symptoms of HCM vary greatly, from cats that are seemingly unaffected, to cats that die suddenly.
	home.online.no /~colmar/hcm_eng.html (1103 words)

	HCMA :: Hypertrophic Cardiomyopathy Association \| HCM Overview \| What is Hypertrophic Cardiomyopathy (HCM)?
		HCM is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease causing mutations in the genes encoding proteins of the cardiac sacomere have been reported.
		While HCM has typically been recognized by its structure ie., hypertrophy, the electrical function of the heart are also adversely affected.
		The most characteristic feature of HCM is a hypertrophied left ventricle (asymmetric thickening of the wall usually most prominently involving the ventricular septum) without abnormal enlargement of the ventricular cavities.
	www.4hcm.org /WCMS/index.php?overview (552 words)

	Hypertrophic Cardiomyopathy Center - Background Data
		Because HCM is a genetic disease, the clinical manifestations are varied and range from asymptomatic to congestive heart failure symptoms, stroke and even sudden cardiac death.
		In fact, HCM is the most common cause of sudden cardiac death in the young (including trained athletes) while also being responsible for cardiovascular disability (heart failure and stroke-related complications) at any age.
		HCM is a disease primarily of an abnormal enlargement of heart muscle (cardiac hypertrophy).
	www.nemc.org /medicine/card/hcm_background_data.htm (545 words)

	Hypertrophic Cardiomyopathy (HCM)
		Fundamentally, HCM is a genetic disease with autosomal dominant inheritance occurring in at least one in 1,000 to one in 500 of the general population.
		For example, midcavity HCM is frequently a result of mutations in the essential or regulatory light chain (or the Leu908Val mutation of beta-myosin, in the domain that binds light chains).
		In HCM as in many other genetic diseases, the basic hurdle is that any of a large number of different mutations in a large number of different genes may be causative.
	www.rjmatthewsmd.com /Definitions/hypertrophic_cardiomyopathy.htm (6083 words)

	eMedicine - Cardiomyopathy, Hypertrophic : Article by Michael E Zevitz, MD
		Obstructive HCM is due to midsystolic obstruction to flow through the LV outflow tract as a result of a Bernoulli effect–induced systolic anterior mitral valve movement toward the septum.
		The molecular basis for HCM is defects in several of the genes encoding for the sarcomeric proteins, such as myosin heavy chain, actin, tropomyosin, and titin.
		The hallmark of HCM associated with a pressure gradient is the abnormal systolic motion of the anterior leaflet of the mitral valve (ie, systolic anterior motion) and, in rare cases, the systolic motion of the posterior leaflet.
	www.emedicine.com /med/topic290.htm (6691 words)

	Feline Hypertrophic Cardiomyopathy
		The proposed pathophysiologyy of HCM is summarized in
		That mitral regurgitation is very common in cats with HCM is clear, and this hemodynamic abnormality seems to be especially common when the ventricular septum is hypertrophied either symmetrically or asymmetrically.
		When HCM is associated with aortic thrombosis, severe mitral regurgitation, atrial fibrillation, or biventricular heart failure with pleural effusion or chylothorax, the prognosis is guarded to poor.
	maxshouse.com /hypertrophic_cardiomyopathy.htm (4880 words)

	hypertrophic cardiomyopathy
		HCM may also cause thickening in other parts of the heart muscle, such as the bottom of the heart called the apex, right ventricle, or throughout the entire left ventricle.
		HCM may be inherited, caused by an abnormality in the gene that codes the characteristics for the heart muscle.
		Because the cause of HCM varies, it is frequently difficult to identify a high-risk population.
	www.clevelandclinic.org /heartcenter/pub/guide/disease/hcm (1864 words)

	PawPeds
		Since the 1970's it is known that HCM is the common cause for heart failure, thrombus and sudden death in cats.
		HCM is characterized by an abnormal thickness of the heartmuscle, mainly at the height of the left side of the heart.
		HCM is not a congenital defect, but a disease that develops very slowly.
	www.pawpeds.com /healthprogrammes/hcm.html (508 words)

	Minneapolis Heart Institute (Site not responding. Last check: 2007-10-12)
		The magnitude of this particular problem among all HCM patients has probably been exaggerated over the years due to the disproportionate number of reports from institutions in which there was the preferential referral of high-risk patients.
		Therefore, an important aspiration of the HCM evaluation is to identify which patients, among all those with this condition appear to be at particularly high risk.
		The latter disease feature applies to an important ten percent of all HCM patients in whom the maximum thickness of the left ventricular wall is 3.0 centimeters or more, and who may therefore be at increased risk based solely on their particular heart structure.
	www.mplsheart.com /pages/complications_hcm.asp (1294 words)

	eMedicine - Cardiomyopathy, Hypertrophic : Article by Charles Berul, MD (Site not responding. Last check: 2007-10-12)
		HCM has a complex set of symptoms and potentially devastating consequences for both patients and their families.
		Thus, familial HCM is a genetically heterogenous disease because it is caused by defects at multiple genetic loci.
		Paramount to any therapy for an individual with HCM is reduction in the risk of sudden death (by early identification of the disorder), effective medical care, and implantation of either a pacemaker or an automatic cardioverter defibrillator.
	www.emedicine.com /ped/topic1102.htm (6188 words)

	IBM HCD and HCM Newsletter 24
		If you use HCM for your configuration definitions without documenting your physical environment, then migrating from a non-2084 processor type/model to a 2084 processor type/model is a straightforward task.
		If you have documented your physical environment with HCM, then skip this section and go to the next one that deals with migration scenarios where the physical configuration definitions are also considered.
		Use HCM again, and log on to the host again (this type of import step cannot be performed in HCM stand-alone mode).
	www-03.ibm.com /servers/eserver/zseries/zos/hcm/hcmhtmls/newsletter24.html (2813 words)

	Hypertrophic Cardiomyopathy (HCM): Adult Onset Genetic Disease Program at The University Hospital, Newark, NJ
		HCM scrambles the cells of the heart muscles, which can interrupt the heart’s electrical impulses and cause arrhythmia.
		The test is done in two panels, one for the five most common mutations, the second for another three genes; together, the panels have a 55 percent to 70 percent detection rate.
		Because HCM is an autosomal dominant disorder, it is important for all first degree relatives of an HCM patient to be tested for the gene mutation.
	www.theuniversityhospital.com /adultgenetics/hcm.htm (320 words)

	Medical Treatment of Hypertrophic Cardiomyopathy
		Subsequently, the agents available for the medical treatment of HCM are discussed along with a practical strategy for rapid medical reduction of outflow gradients.
		Patients with HCM have diastolic dysfunction due to hypertrophy and myocardial fibrosis.
		Though increased LV diastolic pressures are often present in HCM, exercise limitation has been shown to correlate with an inability to increase cardiac output with exercise (4).
	www.hcmny.org /hcmprog/Hyper_Cardio.html (1025 words)

	::HCM Consulting US, LLC.::
		HCM is a management and business consulting group founded in 1996.
		At HCM, we feel that in the era of broadband connections, secure VPNs and VOIP there is little need for the high costs associated with multiple data lines, computers servers sitting in a room locally when twenty four hour coverage and efficiency can be achieved through the use of global partners and relationships.
		HCM Consulting US has consistently reached out and collaborated with partners in Russia, Poland, Czech Republic, China, and now India long before it was fashionable to do so.
	www.hcmconsultingus.com (123 words)

	HCM Immigration Solutions, L.L.C.
		HCM Immigration Solutions, L.L.C. As former Virginia SESA/SWA Alien Labor Certification Specialists and Prevailing Wage Specialists, HCM Solutions is perfectly qualified to assist attorneys with the new PERM program and any other Labor Certification needs.
		Members of HCM Solutions have many years of experience with the old Permanent ALC program and were involved in the development of the new PERM regulations.
		HCM knows that getting results is important and has received numerous approved labor certifications under the PERM program.
	hcmsolutions.net (332 words)

	morris
		Here's an HCM maturity model intended to help HR leaders increase success rates their HCM strategy as they move from basic knowledge enablement to reaping the benefits of fully integrated HCM.
		While the order of precedence for deploying HCM technology may be debatable, there are fundamental principals that organizations must follow to help ensure the success of their HCM programs.
		With a fully integrated HCM environment, HR and training leaders can finally have a solution that fulfills the true promise of HCM: The ability to quickly and accurately disseminate company goals to employees through the use of cost-effective training, and thereby making a significant contribution to organizational success by improving workforce performance.
	www.learningcircuits.org /2006/May/morris.htm (2138 words)

	Brigham and Women's Hospital, Boston: Hypertrophic Cardiomyopathy (HCM) Clinic at the Cardiovascular Genetics Center
		Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by unexplained left ventricular hypertrophy (increased muscle thickness), myocyte disarray (disorganized cardiac cells) and fibrosis (see Figure A, below).
		Genetic studies have defined HCM as a disease of the sarcomere, with more than 250 mutations identified in 10 different components of the contractile apparatus of the heart.
		Although most individuals with HCM do well with appropriate treatment, this condition can be associated with an increased risk for progressive heart failure and sudden death.
	www.brighamandwomens.org /cvcenter/Services/genetics/HCM.asp (261 words)

	HCM Hitachi Cable Manchester Manufacturers of Copper Premise Wire, Fiber Optic, Electronics Round Cable and Electrical ...
		HCM is a standards and technology based manufacturing company.
		HCM is ISO 9001 registered and is a showcase example of a fully-automated cable maunfacturing plant.
		HCM is world renowned for our highly skilled manufacturing engineers and knowledgeable sales staff.
	www.hcm.hitachi.com /corporate.htm (318 words)

	Feline Hypertrophic Cardiomyopathy (HCM) Studies
		HCM causes the heart muscle to increase in thickness resulting in improper filling of the chambers of the heart with blood.
		If this is accomplished, theoretically HCM in certain breeds could be eliminated within a few generations by educating breeders on responsible practices.
		In addition to the drug research, Dr. Alwood is exploring the use of new tests for monitoring cats with HCM and determining their risk of developing blood clots.
	www.peteducation.com /article.cfm?cls=0&cat=2013&articleid=3083 (454 words)

	VetGo Cardiology
		DCM, Hypertrophic cardiomyopathy (HCM), hemangiosarcoma and pericardial effusion, bacterial endocarditis
		The definitive diagnostic test for feline HCM is echocardiography with the demonstration of thickening of the interventricular septum and/or left ventricular free wall with normal to reduced left ventricular chamber size and normal to enhanced contractility.
		Non-obstructive HCM is a variant that does not involve obstruction of the LVOT. In this form, the left ventricular wall (LVFW) and IVS may be symmetrically thickened or there may be only focal thickening of the walls of the left ventricle involving only the IVS, LVFW or apex of the LV.
	www.vetgo.com /cardio/concepts/concsect.php?conceptkey=101 (9162 words)

	Hypertrophic Cardiomyopathy: Pet Health Topics from the College of Veterinary Medicine, Washington State University
		HCM is a disease that causes thickening of the heart muscle resulting in poor relaxing and filling ability.
		The cause of HCM is unknown, although certain breeds of cats appear to be predisposed.
		Blood pressure measurement and, in cats over five years of age, a blood thyroid hormone test should be done to exclude these secondary causes when cardiac hypertrophy (thickening) is diagnosed.
	www.vetmed.wsu.edu /cliented/hcm.asp (806 words)

	Where to read Steve
		Kittleson explains that HCM is a thickening of the left chamber of the heart, causing the heart to over-work.
		Since HCM often isn’t found until cats are young adults or older, breeding out genetic carriers is challenging if not downright impossible.
		While there are drugs currently used to hopefully control HCM (in the cats who are lucky enough to be diagnosed), the reviews on their effectiveness are mixed at best.
	www.petworldradio.net /mainecoonscolumn.html (903 words)

	What is HCM? (Site not responding. Last check: 2007-10-12)
		The diagnosis of HCM is usually made with echocardiography, a cardiac ultrasound examination.
		For example, it is sometimes difficult to differentiate HCM from the athlete's heart syndrome, a mild thickening of the heart due to exercise conditioning.
		In HCM patients, it is thought that the walls of the heart thicken because of a genetic abnormality of the heart muscle.
	hcmny.org /whatis/index.html (324 words)

	USNews.com: Health: HCM: Treatment overview
		For instance, many HCM patients have chest pain and shortness of breath--a common symptom of coronary artery disease that is treated with nitroglycerin.
		If a person with HCM were to take nitroglycerin, the symptoms would worsen and the nitroglycerin could even cause a catastrophic deterioration in the person's condition.
		Individualized treatment plans should be developed by cardiologists with an expertise in HCM and be based upon the condition of the heart and the severity of symptoms, as well as the overall health and preferences of the patient.
	www.usnews.com /usnews/health/heart/hcm/hcm.treat.htm (262 words)

	HCM Education
		HCM's newest ministry, the Superior Institute of Translation and Interpretation, opened in the year 2000.
		HCM conducts a leadership training program at least once a year for its pastors, teachers and church workers.
		Through the years, HCM churches and schools have raised up new Christian leaders who now work as teachers, nurses, pastors and administrators.
	www.haitianchristianmission.org /education.html (270 words)

	PawPeds
		HCM wird charakterisiert durch eine anomale Verdickung des Herzmuskels.
		Katzen mit HCM können Flüssigkeit ansammeln in den oder um die Lungen herum was zu erschwerter Atmung führen kann.
		HCM ist kein angeborener Defekt sondern eine Krankheit die sich sehr langsam entwickelt.
	www.pawpeds.com /healthprogrammes/hcm_de.html (472 words)

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