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Topic: HLA-B27

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Prevalence of HLA-B27.. B27 are seen in a 30% of mexican population that affexted by this spondiloarthropathy. B27 and those that are not related to it has been observed where the antigen B27 is considered as a prognosis factor. B27 in idiopathic uveitis is less (26.6%) than in patients with spondiloarthropathies and uveitis. www.imbiomed.com.mx /HG/Hgv61n2/english/Zhg82-01.html   (383 words)

MedlinePlus Medical Encyclopedia: HLA-B27 antigen For example, HLA-B27 is found in 80 - 90% of people with ankylosing spondylitis and Reiter's syndrome. HLA antigens are the major histocompatibility antigens for tissue recognition. The human leukocyte antigens (HLAs) are proteins present on the surface of all body cells that contain a nucleus, and are in especially high concentrations in white blood cells (leukocytes). www.nlm.nih.gov /medlineplus/ency/article/003551.htm   (742 words)

HLA-B27 - Wikipedia, the free encyclopedia HLA B27 in health and disease: a double-edged sword? Human Leukocyte Antigen B*27 (subtypes B*2701-2724) is a class I surface antigen encoded by the B locus in the MHC on chromosome 6. It presents microbial antigens to T-cells and is strongly associated with certain immunity diseases (SpA spondyloarthropathies). en.wikipedia.org /wiki/HLA-B27   (157 words)

Reactive arthritis and HLA-B27 - mechanisms - antigen processing - Chlamydia Unlike their normal (wild type) counterparts, HLA-B27-transgenic rats are tolerant of B27 immunization using either B27(+) splenocytes [as source of T and B lymphocytes] or B27-expressing plasmid DNA. Popov et al., 2002 explored this question using HLA-B27 transgenic rats expressing human B27 antigen. Chlamydial-induced up-regulation of HLA class 1 antigen expression in synovial fibroblasts appears to be primarily caused by the induction of IFN-beta [Rodel et al., 2002]. chlamydiae.com /restricted/docs/infections/arthritis_pathogenesis.asp   (2976 words)

HLA B27 HLA B27, a class I product of the human major histocompatibility complex, is strongly associated with ankylosing spondylitis (AS) and reactive arthritis (ReA): 70% of patients with ReA and 90% with AS posses the B27 gene compared with 7% of the general population. The research of my group is focused on the role of HLA B27 in these disorders. It is likely that the unpaired cysteine residue at position 67 (Cys67) of the B27 heavy chain could form a disulfide bond with homocysteine, causing a conformational change in B27, thereby triggering autoimmune CTL responses. homepages.which.net /~ks.burrell/nassdb/hlab27.htm   (253 words)

HLA-B27 associated uveitis The HLA-B27 patients were also more likely than the idiopathic patients to require systemic therapy for the ocular condition, and this was even more so in patients with systemic disease associated with the B27 positive uveitis. Unlike the classic uveitis associated with the B27 gene, uveitis in IBD may occur in both eyes simultaneously and is subacute or chronic in up to 50% of cases of Crohn’s associated uveitis. The inflammation associated with the B27 gene has traditionally been viewed as easy to control, but as mentioned above, and discussed in the section on complications and prognosis, recurrences may be more frequent than in idiopathic recurrent uveitis and the complication rate is higher. www.uveitis.org /WebEyeMD_htmbank/md_hlab27.htm   (2081 words)

The Pathogenetic Role of HLA-B27 HLA-B27 derived peptides may themselves elicit an immune response if there is loss of immune tolerance. B*2706 is a common subtype among B27 positive individuals in Southeast Asia, while B*2709 is primarily observed in the Italian island of Sardinia. However, CD4+ T cells that interacted with B27, an MHC class I molecule, could be isolated from three B27 positive patients with ankylosing spondylitis, thus breaking the conventional rules of MHC restriction (Boyle et al. www.rheuma21st.com /archives/report_050225_hlab27.html   (1664 words)

iritis.com: HLA B27 HLA's are what the body's immune system uses to keep track of "self" and "non-self". If you have B27 it means you have a statistically higher chance of developing the symptoms of other B27-associated diseases. In the United States, 6-8% of the Caucasian population is B27 positive. www.iritis.co.uk /b27.htm   (323 words)

AFCG Clinical Standards: HLA-B27 For HLA B27 typing, a putative positive result requires confirmation if the primary antibody is known to cross-react with other antigens. The development of monoclonal antibodies to HLA antigens has rendered flow cytometry a proficient alternative procedure. Problems may arise, however, when antibody cross-reactivity occurs between different HLA antigens. jcsmr.anu.edu.au /facslab/AFCG/Standards/hla-b27.html   (1730 words)

HLA-B27 Misfolding Is Associated with Aberrant Intermolecular Disulfide Bond Formation (Dimerization) in the Endoplasmic Reticulum -- Dangoria et al. 277 (26): 23459 -- Journal of Biological Chemistry A, HLA class I complexes were immunoprecipitated with W6/32 from B lymphoblastoid cell lines (B-LCL: HF and BL) expressing HLA-B27 as well as other alleles, and from C1R transfected with different HLA alleles, separated by SDS-PAGE under nonreducing conditions, and HC visualized by immunoblotting with 3B10.7. HLA class I complexes were immunoprecipitated with W6/32 or HC10, separated by SDS-PAGE under nonreducing conditions, and visualized by immunoblotting with 3B10.7. C, folding of each B27 B pocket mutant was analyzed as described in B, and the time required to reach 75% folded W6/32 reactive HC is compared. www.jbc.org /cgi/content/full/277/26/23459   (7244 words)

HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27? -- Ringrose 58 (10): 598 -- Annals of the Rheumatic Diseases Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. to the modification of HLA antigens that is recognised by Hom-CTL. are tolerant to the B27 and bacterial crossreactive epitopes, ard.bmjjournals.com /cgi/content/full/58/10/598   (7635 words)

HLA-B27 Approximately 85% of patients with ankylosing spondylitis and Reiter's syndrome will have the HLA-B27 antigen present on the leukocytes. Human leukocyte antigens, or HLA antigens, are present on the surface of all nucleated cells. Some HLA antigens have been identified to be correlated with the presence of certain autoimmune diseases. www.medhelp.org /glossary/new/gls_2284.htm   (125 words)

eMedicine - HLA-B27 Syndromes : Article by A Luisa Di Lorenzo, MBBCh The HLA system is genetically encoded in humans by the major histocompatibility complex (MHC), which is found on chromosome 6, and plays a determining role in immunity and in self-recognition in virtually all cells and tissues, with the exception of erythrocytes. An HLA disease association is defined as a statistically increased frequency of the HLA haplotype in individuals with the disease compared to the frequency in individuals without the disease. In ophthalmology, HLA associations are strongest in diseases of the uvea. www.emedicine.com /OPH/topic721.htm   (4156 words)

Kimball Genetics - HLA-B27 DNA TEST This group of disorders is associated with human leukocyte antigen (HLA) B27 suggesting a possible autoimmune etiology. www.kimballgenetics.com /tests-hlab27.html   (288 words)

HLA-B27 - Information and Side Effects To determine whether you have human leukocyte antigen B27 (HLA-B27) on the surface of your cells. This test is sometimes ordered to help assess the likelihood that you have an autoimmune disorder that is associated with the presence of HLA-B27. Consult a physician regarding the applicability of any information found on GoldBamboo.com to your symptoms or medical condition. goldbamboo.com /topic-t4276.html   (130 words)

HLA-B27-Associated Cardiac Disease -- Bergfeldt 127 (81): 621 -- Annals of Internal Medicine A follow-up study of the impact of HLA B27 and associated rheumatic disorders. Bergfeldt L. Disturbances of the Cardiac Conduction System in HLA-B27 Associated Disease. HLA and Disease: Predisposition to Disease and Clinical Implications. www.annals.org /cgi/content/full/127/8_Part_1/621   (4694 words)

Medcyclopaedia - Hla-b27 antigen Among the conditions in which HLA-B27 antigen may play a causative role are ankylosing spondylitis, psoriatic arthritis, Reiters syndrome, Crohns disease and ulcerative colitis. a histocompatibility antigen of the HLA group that is found in many diseases with musculoskeletal manifestations. medcyclopaedia.com /library/topics/volume_iii_1/h/HLA_B27_ANTIGEN.aspx   (112 words)

Cytotoxic T-Cell-Mediated Response against Yersinia pseudotuberculosis in HLA-B27 Transgenic Rat -- Falgarone et al. 67 (8): 3773 -- Infection and Immunity Susceptibility of inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of expression of B27. offspring for the B27 transgene and for the absence of RT1 Structural and genetic analyses of HLA class I molecules using monoclonal xenoantibodies. iai.asm.org /cgi/content/full/67/8/3773   (4421 words)

health.iafrica.com doc online ask the doctor musculoskeletal Hla b27 The HLA B27 antigen is closely associated with the inflammatory disorder, ankylosing spondylitis. My son has recently been found to have the HLA B27 antigen. Since your son has the peripheral joint involvement which is one of the characteristics of this disease, he probably has early signs of the illness. health.iafrica.com /doconline/qa/musculoskeletal/hlab27.htm   (422 words)

Animal Models - HLA-B27 Transgenic Rats Features: The HLA-B27 transgenic rat, expressing HLA-B27 and human ß2m, exhibits a phenotype similar to humans suffering B27 related rheumatic disorders such as reactive arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease. This rat model is useful for research and pharmacological studies of spontaneous systemic inflammation, arthritis, inflammatory bowel disease and skin diseases including psoriasis and alopecia. www.taconic.com /anmodels/HLAB27.htm   (305 words)

HLA-B27 Expression Does Not Modulate Intracellular Chlamydia trachomatis Infection of Cell Lines -- Young et al. 69 (11): 6670 -- Infection and Immunity Spontaneous inflammatory disease in HLA-B27 transgenic mice is independent of MHC class II molecules: a direct role for B27 heavy chains and not B27-derived peptides. HLA B27 expression modulates gram-negative bacterial invasion into transfected L cells. Invasion and persistence of Salmonella in human fibroblasts positive or negative for endogenous HLA B27. iai.asm.org /cgi/content/full/69/11/6670   (3253 words)

Ankylosing spondylitis - Genetics Home Reference The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria). HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA-B gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign invaders. 0-ghr.nlm.nih.gov.portia.nesl.edu /condition=ankylosingspondylitis/sho...   (828 words)

HLA-B27: Test Sample Human leukocyte antigen B27 (HLA-B27) is found in about 5-10% of the U.S. population. While not as unique as a fingerprint, the presence or absence of each antigen creates a distinctive HLA combination for each person. (This is important when someone needs a bone marrow or organ transplant, as the donor’s HLA antigens must be matched up with the recipient’s.) www.labtestsonline.org /understanding/analytes/hla_b27/sample.html   (224 words)

HLA-B27 phenotyping with flow cytometry: further improvement by multiple monoclonal antibodies -- Hoffmann and Janssen 43 (10): 1975 -- Clinical Chemistry HLA class I phenotypes, discrete patterns emerged of non-B27 Therefore, the main clinical use of the HLA-B27 antigen is to and practical assay of soluble B27 antigens in serum is not www.clinchem.org /cgi/content/full/43/10/1975   (3054 words)

The Solvent-Inaccessible Cys67 Residue of HLA-B27 Contributes to T Cell Recognition of HLA-B27/Peptide Complexes -- Appel et al. 173 (11): 6564 -- The Journal of Immunology Immunogenetic study of a new HLA allele, B*2723. Nature of polymorphism in HLA-A, -B, and -C molecules. on this HLA association, it has been postulated to be a T cell-driven www.jimmunol.org /cgi/content/full/173/11/6564   (5330 words)

Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series Energy Citations Database (ECD) Document #5563011 - Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. www.osti.gov /energycitations/product.biblio.jsp?osti_id=5563011   (124 words)

HLA-B27 typing in the categorisation of uveitis in a HLA-B27 rich population -- Huhtinen and Karma 84 (4): 413 -- British Journal of Ophthalmology Vinje O, Dale K, Møller P. Radiographic changes, HLA B27 and back pain in patients with psoriasis or acute anterior uveitis. manifestation from the idiopathic B27 positive ones, although The remaining 11 did not differ in clinical bjo.bmjjournals.com /cgi/content/full/84/4/413   (2384 words)

Citebase - Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis Kim, SK; Devine, L; Angevine, M; DeMars, R; Kavathas, PB (2000) "Direct detection and magnetic isolation of Chlamydia trachomatis major outer membrane protein-specific CD8+ CTLs with HLA class I tetramers" J Immunol 165 7285-7992 citebase.eprints.org /cgi-bin/citations?id=oai:biomedcentral.com:ar1221   (1437 words)

HLA-B27: The Test If it is present, then the HLA-B27 antigen (protein structure) exists on the surface of the body’s white blood cells and nucleated cells. If a patient has HLA-B27 and has symptoms such as: chronic pain, inflammation, and/ or degenerative changes to his bones (as seen on X-ray), then it supports a diagnosis of AS, Reiter’s syndrome, or another autoimmune disorder that is associated with the presence of HLA-B27. Under these circumstances HLA-B27 is not diagnostic but adds additional information, increasing or decreasing the likelihood that the patient has ankylosing spondylitis. www.labtestsonline.org /understanding/analytes/hla_b27/test.html   (628 words)

Introduction - Continuing Medical Education: Spondyloarthropathies. The HLA B27 antigen is a so-called class 1 major histocompatibility complex product whose gene is located on the short arm of the sixth chromosome. Below is the relative percentages of HLA B27 in patients with these diseases. At least one family study suggests that up to 25% of HLA B27 positive relatives of patients with ankylosing spondylitis may have signs and symptoms of inflammatory back pain but do not meet full criteria for ankylosing spondylitis. www.orthop.washington.edu /uw/tabID__3376/ItemID__130/mid__10313/Articles/Default.aspx   (351 words)

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