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Topic: HMG-CoA reductase

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Pfam 16.0 : HMG-CoA_red Although little sequence similarity is found between the transmembrane domains of HMG-CoA reductases from different species, the C-terminal catalytic domain is well conserved. HMG-CoA reductase is a membrane bound glycoprotein that remains in the endoplasmic reticulum after synthesis and glycosylation MEDLINE:3065625. Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 angstrom resolution. pfam.wustl.edu /cgi-bin/getdesc?name=HMG-CoA_red

HMG-CoA REDUCTASE FOUNDATION Engineering of Sulfolobus solfataricus HMG-CoA reductase to a form whose activity is regulated by phosphorylation and dephosphorylation. Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase. www.biochem.purdue.edu /~rodwell/pubs.htm

7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome -- Fitzky et al. 108 (6): 905 -- Journal of Clinical Investigation Because HMG CoA reductase activity is known to be proportional to HMGal activity in this system, these results demonstrate that 7DHC, but not cholesterol, causes excessive destruction of HMG CoA reductase enzyme protein. reductase protein present was determined with an Image Quant 7-sterol reductase gene and genotype-phenotype correlation in 84 patients with the Smith-Lemli-Opitz syndrome. www.jci.org /cgi/content/full/108/6/905

HMG CoA reductase inhibitors affect the fibrinolytic system of human vascular cells in vitro: a comparative study using different statins -- Wiesbauer et al. 135 (1): 284 -- British Journal of Pharmacology HMG CoA reductase inhibitors affect the fibrinolytic system of human vascular cells in vitro: a comparative study using different statins -- Wiesbauer et al. HMG CoA reductase inhibitors affect the fibrinolytic system of human vascular cells in vitro : a comparative study using different statins www.brjpharmacol.org /cgi/content/abstract/135/1/284

MedlinePlus Drug Information: HMG-CoA Reductase Inhibitors (Systemic) HMG-CoA reductase inhibitor --Atorvastatin; Cerivastatin #; Fluvastatin; Lovastatin; Pravastatin; Simvastatin Children— Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of HMG-CoA reductase inhibitors in children with use in other age groups. These medicines belong to the group of medicines called 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202284.html

Feedback and Hormonal Regulation of Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: The Concept of Cholesterol Buffering Capacity -- Ness and Chambers 224 (1): 8 -- Experimental Biology and Medicine Although much has been learned from studies of HMG-CoA reductase The responses of rats fed chow or an HMG-CoA reductase inhibitor, Attenuation of plasma low-density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low-density lipoprotein receptors. www.ebmonline.org /cgi/content/full/224/1/8

Cholesterol - Wikipedia, the free encyclopedia Amongst the genes transcribed are the LDL receptor and HMG-CoA reductase. Cholesterol is primarily synthesized from acetyl CoA through the HMG-CoA reductase pathway in many cells/tissues. The cleaved SREBP then migrates to the nucleus and acts as a transcription factor to bind to the "Sterol Regulatory Element" of a number of genes to stimulate their transcription. en.wikipedia.org /wiki/Cholesterol   (1712 words)

Zocor Side Effects - Zocor Drug Information - Dosage - Drug Interactions - Uses - Storage - Overdose - Precautions - Generic Simvastatin ZOCOR USES: Zocor is an enzyme blocker (HMG-CoA reductase inhibitor), also known as a "statin". It is used along with a proper diet to help lower cholesterol and fats (triglycerides) in the blood. health-medical.infomeds.biz /drug-information/Zocor.htm   (1712 words)

HMG CoA Reductase Inhibitors Consult with your CCT physician about taking HMG CoA Reductase Inhibitors if you are taking cyclosporin, gemfibrozil, niacin, erythromycin or any other prescription medication, particularly those prescribed for cholesterol/lipid lowering purposes. Elevations of liver enzyme blood tests that are significant, doctor will discontinue treatment Times and amounts vary by patient; consult your physician or pharmacist. www.cctheart.com /hmg.htm   (1712 words)

Pravachol Drug Description - Pravastatin - HealthScout These agents are com-petitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-CoA to mevalonate. PRAVACHOL ® (pravastatin sodium) is one of a new class of lipid-lowering compounds, the HMG-CoA reductase inhibitors, which reduce cholesterol biosynthesis. www.healthscout.com /rxdetail/1/63/1/main.html   (1712 words)

AstraZeneca letter to The Lancet in response to publication of a letter by Public Citizen about Crestor In response to the letter from Public Citizen (June 26, p 2189),1 rosuvastatin (Crestor) is a highly efficacious 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) with a safety profile comparable to those of other marketed statins. AstraZeneca’s ongoing review of post-marketed safety data as well as a recent review of data by health authorities worldwide, including the US Food and Drug Administration, supports this conclusion. AstraZeneca letter to The Lancet in response to publication of a letter by Public Citizen about Crestor www.medicalnewstoday.com /medicalnews.php?newsid=10018   (1712 words)

Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy -- DANESH and KANWAR 18 (7): 805 -- The FASEB Journal effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy -- DANESH and KANWAR 18 (7): 805 -- The FASEB Journal Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy www.fasebj.org /cgi/content/abstract/18/7/805   (1712 words)

What is an HMG-CoA reductase inhibitor? HMG-CoA reductase inhibitors are a group of prescription drugs used to lower cholesterol, a white waxy substance that can stick to the inside of blood vessels, resulting in clogged arteries, heart disease, and strokes. Wang, P.S. “HMG-CoA Reductase Inhibitors and the Risk of Hip Fractures in Elderly Patients,” Journal of the American Medical Association 283 (2000). These medicines work by slowing down the body’s ability to make cholesterol. www.drugstore.com /qxa1026_332828_sespider-what_is_an_hmg_coa_reductase_inhibitor.htm   (1712 words)

Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis at the Post-Transcriptional Level -- Peffley and Gayen 133 (1): 38 -- Journal of Nutrition Peffley, D. (1992) Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control. reductase mRNA and protein levels are elevated because feedback Labeled reductase was measured at various times by immunoprecipitation. www.nutrition.org /cgi/content/full/133/1/38   (1712 words)

Inflammation, Immunity, and HMG-CoA Reductase Inhibitors: Statins as Antiinflammatory Agents? -- Schönbeck and Libby 109 (21 Supplement 1): II-18 -- Circulation Implications of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mevalonate pathway in atherosclerosis. Inflammatory Pathways and Mediators Affected by HMG-CoA Reductase Inhibitors Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models. circ.ahajournals.org /cgi/content/full/109/21_suppl_1/II-18   (5077 words)

Dyslipidemia: HMG-CoA Reductase • The statins are metabolized by the CYP3A4 pathway. Since protease inhibitors inhibit this pathway, the resulting increased levels of statins may place patients at a greater risk for skeletal muscle toxicity. www.hivandhepatitis.com /recent/metabolic/dyslipidemias/1h.html   (218 words)

Feedback and Hormonal Regulation of Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: The Concept of Cholesterol Buffering Capacity -- Ness and Chambers 224 (1): 8 -- Experimental Biology and Medicine The responses of rats fed chow or an HMG-CoA reductase inhibitor, responsible for the in vitro degradation of the reductase with Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 3ß-hydroxy-lanost-8-en-32al, an intermediate in the conversion of lanosterol to cholesterol. www.ebmonline.org /cgi/content/full/224/1/8   (7533 words)

Coenzyme A It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. Acetyl-CoA (CoA with acetate highlighted) Coenzyme A ('''CoA''', CoASH, or HSCoA) is adapted from β-mercaptoethylamine, panthothenate and adenosine triphosphate and used in metabolism in areas such as fatty acid oxidization and the citric acid cycle. Furthermore, it contributes the acetyl group to acetylcholine; the addition of the acetyl group to choline a reaction that is catalysed by choline acetyltransferase. coenzyme-a.ask.dyndns.dk   (218 words)

HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats -- Usui et al. 18 (2): 265 -- Nephrology Dialysis Transplantation Keywords: diabetic nephropathy; HMG-CoA reductase inhibitor; ICAM-1; macrophage; NF- HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats -- Usui et al. HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats ndt.oupjournals.org /cgi/content/abstract/18/2/265   (218 words)

Texas Medicaid Vendor Drug Program, HMG-CoA Reductase Inhibitors If atorvastatin, cerivastatin, lovastatin or simvastatin are used in concurrently with nefazodone, conservative HMG-CoA reductase inhibitor doses are recommended in addition to close monitoring for skeletal muscle damage (e.g., muscle pain, weakness, elevated muscle enzymes). Rhabdomyolysis is a potentially life-threatening condition characterized by muscular necrosis, subsequent release of potassium and other ions into the plasma compartment, and severe myoglobulinuria which may precipitate oliguric renal failure. The ability of nefazodone to induce skeletal muscle damage is presumably dose related; therefore, the risk of combined therapy is probably higher in patients receiving large doses of either lovastatin or simvastatin. www.hhsc.state.tx.us /HCF/vdp/Criteria/hmg-coa.html   (218 words)

Effects of HMG-CoA Reductase Inhibitors on Endothelial Function: Role of Microdomains and Oxidative Stress -- Mason et al. 109 (21 Supplement 1): II-34 -- Circulation Effects of HMG-CoA Reductase Inhibitors on Endothelial Function: Role of Microdomains and Oxidative Stress -- Mason et al. Effects of HMG-CoA Reductase Inhibitors on Endothelial Function coenzyme A (HMG-CoA) reductase inhibitors (statins) are related www.circulationaha.org /cgi/content/abstract/109/21_suppl_1/II-34   (218 words)

HMG-CoA REDUCTASE FOUNDATION Our research activities center on the enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase, E.C., the rate-determining and key regulated enzyme of cholesterol biosynthesis in human subjects and of polyisoprenoid biosynthesis in eukaryotes in general. We study HMG-CoA reductases from different life forms. Our goal is to understand the mechanism of catalysis, the portions of the enzyme responsible for substrate binding, and structural changes that accompany the down-regulation of catalytic activity that follows phosphorylation of the regulatory serine. www.biochem.purdue.edu /~rodwell/resrch.htm   (218 words)

Texas Medicaid Vendor Drug Program, HMG-CoA Reductase Inhibitors Patients requiring concurrent therapy with certain HMG CoA reductase inhibitors and some macrolide antibiotics should be monitored regularly for muscular symptoms such as pain, tenderness, or weakness. Due to an unknown mechanism, gemfibrozil treatment used concomitantly with an HMG-CoA reductase inhibitor substantially increases the risk of myopathy and life-threatening rhabdomyolysis to 3-5%. Fluvastatin and pravastatin appear to be less likely to interact with nefazodone and may be reasonable alternatives in patients requiring both nefazodone and HMG-CoA reductase inhibitor therapy. www.hhsc.state.tx.us /HCF/vdp/Criteria/hmg-coa.html   (2201 words)

7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome -- Fitzky et al. 108 (6): 905 -- Journal of Clinical Investigation HMG-CoA reductase, LDL receptor, and sterol response element–binding reductase, HMG-CoA synthase, LDL receptor (LDLR), and squalene Northern blot analysis of (a) hepatic HMG-CoA reductase, HMG-CoA synthase, squalene synthase, LDLR, SREBP-1, and SREBP-2, and (b) RT-PCR–amplified brain HMG-CoA reductase and LDLR mRNA extracted from Dhcr7–/–, Dhcr7+/–, and Dhcr7+/+ newborn mice, demonstrating that expression of all of the genes is the same in the three genotypes. www.jci.org /cgi/content/full/108/6/905   (6696 words)

Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis at the Post-Transcriptional Level -- Peffley and Gayen 133 (1): 38 -- Journal of Nutrition Peffley, D. (1992) Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control. Cuthbert, J. & Lipsky, P. (1992) Differential regulation of the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, synthase, and LDL receptor genes. Brown, M. & Goldstein, J. (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. www.nutrition.org /cgi/content/full/133/1/38   (4699 words)

HMG-CoA_reductase_pathway The HMG-CoA reductase pathway, also known as MVA pathway or mevalonate-dependent (MAD) route, is an important cellular metabolic pathway present in virtually all organisms. A number of drugs targets the HMG-CoA reductase pathway: Regulation of this pathway is also achieved by controlling the rate of translation of the mRNA, degradation of reductase and phosphorylation. www.freecaviar.com /search.php?title=HMG-CoA_reductase_pathway   (355 words)

Articles - Statin Statins act by competitively inhibiting HMG-CoA reductase, an enzyme of the HMG-CoA reductase pathway, the body's metabolic pathway for the synthesis of cholesterol. This team reasoned that certain micro-organisms may produce inhibitors of the enzyme to defend themselves against other organisms, as mevalonate is a precursor of many substances required by organisms for the maintenance of their cell wall (ergosterol) or cytoskeleton (isoprenoids). Most physicians have now abandoned routine monitoring of liver enzymes and creatine kinase, although they still consider this prudent in those on high-dose statins or in those on statin/fibrate combinations, and mandatory in the case of muscle cramps or of deterioration in renal function. www.gaple.com /articles/Statin   (826 words)

Heart and Stroke Encyclopedia HMG CoA Reductase Inhibitor Drugs — see Cholesterol-Lowering Drugs HMO (Health Maintenance Organizations) — see Managed Health Care Plans HERS (Heart and Estrogen-progestin Replacement Study) — see Estrogen and Cardiovascular Diseases in Women www.americanheart.org /presenter.jhtml?identifier=10000056   (826 words)

HMG-COA REDUCTASE INHIBITORS You are allergic to any HMG-CoA reductase inhibitor. If person takes much larger amount than prescribed, call doctor, poison control center, or hospital emergency room for instructions. If you take immunosuppressive drugs, particularly following a heart transplant. www.nextmd.com /DRUGS/HMG-COA_REDUCTASE_INHIBITORS.asp   (826 words)

Arch Intern Med -- Abstract: An Overview of the Clinical Safety Profile of Atorvastatin (Lipitor), a New HMG-CoA Reductase Inhibitor, March 23, 1998, Black et al. 158 (6): 577 Arch Intern Med -- Abstract: An Overview of the Clinical Safety Profile of Atorvastatin (Lipitor), a New HMG-CoA Reductase Inhibitor, March 23, 1998, Black et al. An Overview of the Clinical Safety Profile of Atorvastatin (Lipitor), a New HMG-CoA Reductase Inhibitor A [HMG-CoA] reductase inhibitors) have been used for a decade archinte.ama-assn.org /cgi/content/abstract/158/6/577   (826 words)

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