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| | FOCUS - February 22, 2002 - IMMUNOLOGY: Unexpected Immune System Pathway Linked to Rheumatoid Arthritis |
 | | In a report published in the Feb. 20 Immunity, researchers at Joslin Diabetes Center, in collaboration with four HMS labs, pinpoint a set of factors contributing to joint destruction in the mouse model. |
 | | Christophe Benoist and Diane Mathis, HMS professors of medicine who head the Section on Immunology and Immunogenetics at Joslin, working with HMS researchers Hong Ji, Koichiro Ohmura, Isao Matsumoto, Umar Mahmood, and David Lee, discovered that these accepted roles are not necessarily followed. |
 | | Using a mouse model for rheumatoid arthritis, they found that antibody-antigen complexes also could stimulate the alternative complement pathway, rather than the classic, and initiate the cascade to joint destruction. |
| focus.hms.harvard.edu /2002/Feb22_2002/immunology.html (1346 words) |
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