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| | Roles of BRCA2 in Repairing DNA Damage by Homologous Recombination (Site not responding. Last check: 2007-11-02) |
 | | The Rad51 protein is a central player, which with the help of other proteins, possibly BRCA2, promotes the key reaction required for HRR. |
 | | Thus, when the BRCA2's functions become impaired, the HRR mechanism may become defective. |
 | | Using protein biochemistry approaches, including a novel baculovirus co-expression strategy, enzyme activity assays, protein pull-down experiments, and gel filtration chromatography, we propose to demonstrate the functions of BRCA2 in controlling the actions of Rad51, and the formation of a stable HRR complex involving BRCA2 and Rad51. |
| www.ucop.edu /srphome/bcrp/symposium/2002/abstracts/a/a_27.html (409 words) |
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