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Topic: Haematopoiesis

	HAEMATOPOIESIS
		Haematopoiesis is the process by which primitive stem cells proliferate and differentiate to produce mature blood cells.
		It is driven by highly co-ordinated patterns of gene expression under the influence of growth factors and hormones.
		We have set up a DNA bank for samples from patients with leukaemia and are currently examining the clinical correlates of MRD, as measured by RQ-PCR, in a number of different forms of leukaemia.
	www.leukaemia-ni.org /Haematopoiesis.htm (822 words)

	thelittlelibrary: Haematopoiesis
		Haematopoiesis is the formation of blood cellular components.
		All of the cellular components of the blood are derived from haematopoietic stem cells.
		While most haematopoiesis in adults occurs in the marrow of the long bones such as the femurs, it also occurs in spongy bone.
	thelittlelibrary.blogspot.com /2006/10/haematopoiesis.html (224 words)

	Haematopoiesis
		This process occurs in myeloid tissue, which is found in the bone marrow and lymphatic tissue, such as lymph nodes or the spleen.
		While most haematopoiesis in adults occurs in the bone marrow of the femurs (also the ribs and sternum), the liver, thymus, and spleen may resume their haematopoietic function if necessary (called extramedullary haematopoiesis).
		In some vertebrates, haematopoiesis can occur wherever there is a loose stroma of connective tissue and slow blood supply, such as the gut, spleen, kidney or ovaries.
	www.dejavu.org /cgi-bin/get.cgi?ver=93&url=http%3A%2F%2Farticles.gourt.com%2F%3Farticle%3Dhematopoiesis%26type%3Den (208 words)

	PhD - The Institute of Human Genetics - University of Newcastle
		The Role of WT1 in haematopoiesis and leukaemia.
		WT1 targeted leukaemia therapies are being explored although the role of WT1 in normal haematopoiesis and leukaemia is not known.
		Molecular and cellular techniques will be employed to dissect the function of WT1 in haematopoiesis and leukaemia in order to identify the underlying molecular mechanisms by which WT1 is involved in leukaemia.
	www.ncl.ac.uk /ihg/postgrad/phd/studentship/miles (176 words)

	Focus on stem cells
		And depending on the source, they have the potential to form one, many or all cell types of an organism.
		Stem cell research has a history of more than 20 years, and has made some outstanding contributions to our understanding of haematopoiesis and mouse embryology.
		But the field has been transformed in the past few years by successes achieved in culturing human embryonic stem cells, the building blocks for every tissue we comprise, and in manipulating their differentiation in vitro.
	www.nature.com /nature/stemcells (514 words)

	CHLORPROPHAM
		Microscopic examination of the spleen revealed increased haematopoiesis and haemosiderosis, slight to moderate congestion, and follicular atrophy in all animals at the two higher doses.
		Microscopic examination showed increased severity of haematopoiesis, quantitatively increased haemosiderosis in the spleen, and increased severity of bone-marrow cellularity at the highest dose.
		Microscopy showed increased haematopoiesis and pigmentation in the liver, increased haematopoiesis, haemosiderosis, and congestion in the spleen, and increased cellularity in the bone marrow at doses from 300 mg/kg bw per day and more.
	www.inchem.org /documents/jmpr/jmpmono/v00pr02.htm (5562 words)

	Extra-medullary haematopoiesis in β-thalassaemia Habibzadeh F, Yadollahie M, Haghshenas M - J Postgrad Med
		The patient was diagnosed to have extra-medullary haematopoiesis (EMH) that was treated with low-dose radiation therapy.
		Patients with thalassaemia intermedia are not usually treated with regular transfusion therapy as the medullary and EMH are able to maintain haemoglobin concentration above a reasonable level, in contrast to individuals with thalassemia major whose life is dependent upon regular transfusion therapy.
		Consequently, subjects with thalassemia intermedia demonstrate severe grade of manifestations referable to medullary and extra-medullary haematopoiesis such as haemolytic facies and severe hepato-splenomegaly.
	www.jpgmonline.com /article.asp?issn=0022-3859;year=2005;volume=51;issue=1;spage=45;epage=46;aulast=Habibzadeh (869 words)

	Final Diagnosis -- Case 283 (Site not responding. Last check: )
		Theories concerning the pathogenesis of this lesion include the hematopoietic capacity of the dura (in the fetus), primitive rests, embolization of hematopoietic stem cells to the dura, and extrusion of vertebral bone marrow consequent to bony erosions or fractures.
		Spinal cord compression due to extramedullary haematopoiesis in homozygous thalsassemia.
		Heffez DS, Sawaya R, Udvarhelyi, Mann R. Spinal extramedullary haematopoiesis with cord compression in a patient with refractory sideroblastic anaemia.
	path.upmc.edu /cases/case283/dx.html (298 words)

	Novartis
		They provide a valuable focus on immunology as a key area for medical progress, and are intended to further remarkable recent advances in understanding which have made it possible to treat or even cure conditions that have long been seen as an inescapable part of the human condition.
		Outstanding achievements in the understanding of immunology and major immunological discoveries that lead to therapeutic applications in such fields as transplantation, haematopoiesis, cancer immunology, immunity to infectious diseases, rheumatology, dermatology and asthma.
		Innovative immunological research in these areas has amply demonstrated its immense potential, leading to significant advances.
	www.novartisimmunologyprizes.org (291 words)

	Medcyclopaedia - Thalassaemia
		There is splenomegaly and because of the extramedullary haematopoiesis and abnormal marrow there are secondary bony changes with prominent parietal and frontal bones.
		Secondary effects may be demonstrated in the heart in which there is cardiomegaly, plus or minus pericardial effusion or pericarditis; CNS
		In severe cases, paraspinal soft tissue masses reflect the extramedullary haematopoiesis.
	www.medcyclopaedia.com /library/topics/volume_vii/t/thalassaemia.aspx (406 words)

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