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Topic: Haematopoietic stem cell

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	SCDb: The Stem Cell Database
		Stem cell fate decisions are regulated by the complex interplay of cell-autonomous and non-cell-autonomous (instructive) mechanisms.
		These regulatory mechanisms are assembled, at least in part, from molecular components expressed preferentially in stem cells and in stem cell supportive microenvironments.
		HSC are the best characterized stem cells in the mammal, and have been widely utilized in clinical settings.
	stemcell.princeton.edu (197 words)

	The list of diseases treated with haematopoietic cells transplantation
		Despite the complications that the haematopoietic stem cells transplantation therapy currently bring, it is already used today in the treatment of more than fifty different terminal diseases, while the spectrum of these diseases is still enlarging (see the table).
		In such case the haematopoietic stem cells must be from the umbilical cord blood of siblings, and eventually from another source.
		Haematopoietic stem cell transplant therapy is limited by the fact that the matching source of haematopoietic stem cells can only be found for a percentage of patients.
	www.cordbloodcenter.com /en/01_oc_li.htm (700 words)

	5. Hematopoietic Stem Cells [Stem Cell Information]
		A single tagged cell could produce all lineages for as many as seven weeks, and 30 purified cells were sufficient to rescue mice and fully repopulate the bone marrow without extra doses of backup cells to rescue the mice [49].
		Connection to the interstices of bone marrow is important to both the engraftment of transplanted cells and to the maintenance of stem cells as a self-renewing population.
		Once stem cells and their progeny can be multiplied in culture, gene therapists and blood experts could combine their talents to grow limitless quantities of "universal donor" stem cells, as well as progenitors and specific types of red and white blood cells.
	stemcells.nih.gov /info/scireport/chapter5.asp (9778 words)

	Hinduja Hospital:P.D.Hinduja National Hospital & Medical Research Centre
		In addition, the development of recombinant haematopoietic growth factors and improved understanding of biology of circulating stem cells have permitted the use of peripheral blood stem cell transplantation.
		All haematopoietic elements are derived from a single pluripotent stem cell capable of both self-renewal and differentiation.
		It was initially thought that only bone marrow contained haematopoietic stem cells (HSCs), but the development of effective stem cell phenotypic and functional assays established the presence of even the most primitive progenitors in adult peripheral blood and interestingly in significant quantity in cord blood as well.
	www.hindujahospital.com /stem.html (398 words)

	CRDG
		The pluripotent stem cell holds enormous therapeutic potentials and the research theme of Stem Cells and Regenerative Medicine is therefore a priority area of development for the Centre.
		Stem cells form the basic building progenitors for all types of cells, which constitute the many different tissues in the body.
		Embryonic stem cells are able to grow into each of the more than 200 cell types in the body as long as they are specified to do so.
	www.hku.hk /crdg/themes/stem_cell.htm (687 words)

	Quiescence of CD34-negative haematopoietic stem cells is mediated by downregulation of Cyclin B and no stat activation.
		The CD34-negative, adherent growing, fibroblast-like canine haematopoietic stem cell line D064 was recently identified as the earliest progenitor population in the bone marrow.
		Quiescence is mediated by the accumulation of the cyclin-dependent kinase inhibitor p27(kip-1)and in parallel, by the downregulation of Cyclin B, leading to an accumulation of quiescent cells in the G(0)/G(1)-phase of the cell cycle.
		Stem cell factor (SCF), the ligand for the tyrosine kinase receptor c-kit, usually induces differentiation of the CD34-negative stem cells into CD34-positive haematopoietic precursors.
	www.uni-hohenheim.de /i3v/00068900/22550041.htm (264 words)

	Irishhealth.com - Online Medical Dictionary (Site not responding. Last check: 2007-10-26)
		The transference of stem cells from one animal or human to another (allogeneic), or within the same individual (autologous).
		The source for the stem cells may be the bone marrow or peripheral blood.
		Stem cell transplantation has been used as an alternative to autologous bone marrow transplantation in the treatment of a variety of neoplasms.
	www.irishhealth.com /dictionary.html?query=haematopoietic+stem+cell+transplantation (77 words)

	Stem Cell Sciences: Senior Executives & Management
		The goal of his laboratory is to characterise the cellular and molecular mechanisms governing the formation, self-renewal and differentiation of pluripotent and tissue-restricted stem cells.
		Prior to joining SCS, Dr Bello was a senior scientist with BresaGen's Cell Cycle group and then the Human Stem Cell Studies Group Leader where he initiated projects investigating transcription factors known to be essential in maintaining ES cell "stemness" and their differentiation into embryoid bodies.
		Dr Mee’s major scientific focus is in the self renewal of embryonic stem cells as a means of understanding the pluripotent state with the hope of harnessing this understanding for therapeutic benefit.
	www.stemcellsciences.com /About/Profile/Management (1585 words)

	CCIA - Stem Cell Biology Program (Site not responding. Last check: 2007-10-26)
		Cell lifespan and division in haematopoietic stem cells
		The aims of the Stem Cell Biology Program are to delineate the processes by which normal cells evolve into cancer and leukaemia cells, to develop new methods for manipulating haematopoietic stem cell proliferation and to apply these studies to the development of novel gene therapy approaches to the treatment of cancer and leukaemia.
		The regulation of haematopoietic stem cell division is also critical to the success of stem cell transplantation, used for treatment of cancer and leukaemia.
	www.ccia.org.au /page.php?id=77 (132 words)

	Reference.com/Encyclopedia/Haematopoiesis
		All of the cellular components of the blood are derived from haematopoietic stem cells.
		As a stem cell matures it undergoes changes in gene expression (the levels of genes change) that limit the cell types that it can become and move it closer to a specific cell type.
		This process is usually presented as a dendrogram or decision tree starting with a stem cell at the single starting point and branches for the major lineages that branch into intermediate semi-differentiated cell types and eventually to fully differentiated cells.
	www.reference.com /browse/wiki/Haematopoiesis (466 words)

	Adult Stem Cell Successes - Life Issues Institute
		Intercellular signals that control the proliferation, differentiation and survival of stem cells are being identified and include a diverse array of growth factors, cytokines and cell adhesion molecules.
		The remarkable plasticity of stem cells suggests that endogenous or transplanted stem cells can be 'tweaked' in ways that will allow them to replace lost or dysfunctional cell populations in diseases ranging from neurodegenerative and hematopoietic disorders to diabetes and cardiovascular disease.
		According to the authors, however, “HSCs of early embryonic origin, including those derived from differentiated embryonic stem cells, are inefficient in engrafting adult recipients upon transplantation.” The researchers have now shown that adding the same growth gene, Lhx2, to adult bone marrow stem cells allows unlimited growth of the cells.
	www.lifeissues.org /cloningstemcell/adultstemsuccess.htm (8156 words)

	MedWorm: Stem Cell Therapy
		We studied the responses of these cells to stab wound injury in rats and in two transgenic mouse models in which Y/GFP is driven either by Sox2 (a neural stem cell marker) or by T[alpha]-1 (which marks newly born neurons).
		Recent studies have shown that neural stem cells (NSCs) are present in the subventricular zone (SVZ) lining the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) in adult mouse, rat, nonhuman primate, and human brain.
		Further experiments defining the optimal cell dose, time point and route of application and particularly strategies to improve the homing of transplanted cells towards the CNS region of interest are warranted to define the therapeutic potential of mesodermal stem cells for the treatment of ALS.
	www.medworm.com /rss/medicalfeeds/therapies/Stem-Cell-Therapy.xml (7478 words)

	UK Stem Cell Bank
		The Bank was established to provide stocks of human stem cell lines that have been established in the laboratory and are grown in tissue culture.
		This is distinct from the harvesting of haematopoietic stem cells from bone marrow, peripheral blood and umbilical cord blood for transplantation which undergoes minimal manipulation to provide the cells necessary to treat a range of haematological malignancies and other disorders.
		The harvesting of umbilical cord blood, bone marrow and peripheral blood stem cells is undertaken in the UK by a number of organisations, both within and outside the National Health Service.
	www.ukstemcellbank.org.uk /cord.html (187 words)

	Haematopoietic Stem Cells: Evidence for Competing Proliferative Demands
		A HAEMATOPOIETIC stem cell must be able both to replicate itself and to differentiate into a formed blood element.
		The presence of a pool of multipotent, functionally important, common stem cells for the various haematopoietic formed elements has not as yet been established.
		We are interested in whether this class of cells is functionally important, and specifically whether demand for one blood element limits the ability of the animal to produce other cell types.
	www.nature.com /nature/journal/v216/n5110/abs/216065a0.html (375 words)

	Stem cell databank launched
		Stem cells, which can be extracted from embryos a few days old, children and even adults, are capable of growing into any of the 300 different kinds of cell in the human body.
		Isolated from the blood or bone marrow, haematopoietic stem cells are able to form blood and immune cells.
		Haematopoietic stem cell transplants are now routinely used to treat patients with cancer and other disorders of the blood and immune systems.
	www.chinadaily.com.cn /english/doc/2005-09/19/content_478903.htm (375 words)

	Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe -- Barkholt et al. 17 (7): ...
		Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe -- Barkholt et al.
		Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe
		haematopoietic stem cell transplantation (HSCT) for renal cell
	annonc.oxfordjournals.org /cgi/content/abstract/17/7/1134 (412 words)

	:: CRYOLIFE :: Cell Therapy Technologies Centre Ltd (Site not responding. Last check: 2007-10-26)
		Researchers collect the stem cell from their arm, culturing in the laboratory for six weeks, and then utilize the three-dimensional ultrasonic instrument to inject stem cell in the urethra wall and sphincter, which enters them, improve a patient and control the ability to urinate.
		Additional, umbilical cord blood stem cells trigger little immune response in the recipient as embryonic stem cells have a tendency to form tumors when it is injected into animals or humans.
		Now, research is carried out to collect the haematopoietic stem cell from the father or the mother, and then cooperate with medication, bring the new hope to the patient.
	www.cryolife.com.hk /eng/news_stem.htm (1488 words)

	[Megachemotherapy followed by autologous haematopoietic stem cell rescue in children with high risk CNS tumours]
		the Lublin bone marrow transplantation unit experience in megachemotherapy followed by autologus haematopoietic stem cell transplantation in children with high-risk CNS tumours is described.
		Stem cell apheresis from peripheral blood was performed during chemotherapy after surgery.
		megachemotherapy followed by stem cell rescue is a safe and feasible procedure in children with malignant brain tumours and may improve results of the treatment in high-risk patients, but these results should be con firmed in larger series of patients.
	www.galenicom.com /medline/article/16719156/mt:Teratoma (310 words)

	Tuberculosis in Pakistan: Are We losing the battle? (Site not responding. Last check: 2007-10-26)
		Haematopoietic stem cell transplantation remains the treatment of choice for a variety of benign and malignant blood disorders.1 In this modality Haematopoietic stem cell transplantation is the intravenous infusion of haematopoietic stem and progenitor cells to re-establish marrow function in patients with damaged or defective marrow.
		Also the number of candidate stem cells in the harvest (CD34+ CD38-, Thy -1+) is higher compared to BM harvest.2,8 This results in faster, durable and complete engraftment which is translated into reduced morbidity, mortality and hospital stay costs.
		The number of colony forming cells in CB (26,000/ml) is as great or greater than BM or SC harvest and these cells have higher self-renewal capacity.14 T-cells in cord bood are much less allo-reactive therefore th incidence and severity of acute GvHD (Grade 2-4) is much less.
	jpma.org.pk /JPMA/9sep03/edit.html (1054 words)

	BSP :: Current Stem Cell Research & Therapy Home Page
		The concept behind reprogramming differentiated cells to a stem cell state is to enable the switching of development towards the required cell lineage that is capable of correcting the underlying cellular dysfunction.
		Stem cells have been isolated at all stages of development from the early developing embryo to the post-reproductive adult organism.
		Stem cells turning into hepatocytes by transdifferentiation introduce new functioning liver cells into a diseased organ, which can support intrinsic liver regeneration or bridge the time gap until a definitive treatment is available.
	www.bentham.org /cscrt/contabs/cscrt1-3.htm (3338 words)

	Finite lifespans of T cell clones derived from CD34+ human haematopoietic stem cells in vitro. (Site not responding. Last check: 2007-10-26)
		It was, therefore, impossible to assess the contribution of differences in in vivo age to the subsequent differences between clones in in vitro aging.
		In this way it is possible to perform "longitudinal" studies on T cells derived de novo in vitro.
		We show here that T cell clones derived under these circumstances also manifest variable finite life expectancies, for which the only uncontrolled (nonstochastic) effects of aging must already have occurred at the stem cell level.
	www.arclab.org /medlineupdates/abstract_10197729.html (244 words)

	Stem Cell Research
		While stem cell transplants have been used for decades for certain types of cancer, it is only recently that researchers have used these techniques, specifically hematopoietic stem cell transplantation (HSCT), to try to stop the onslaught of multiple sclerosis in patients with severe, progressive MS.
		Doctors in Milan, Italy, are using neural stem cells to create glial cells (the cells that produce myelin), to treat mice with an MS-like disease.
		While Dr. Kraft and his group work to refine their procedure to use a person’s own stem cells to stop their MS, and other researchers begin to follow the path that will hopefully use stem cells to repair the damage caused by MS, the race to develop stem cell treatments continues to build momentum.
	www.msakc.org /Articles/StemCellResearch.htm (1235 words)

	People's Daily Online -- Stem cell databank launched
		Stem cells, which can be extracted from embryos a few days old, children and even adults, are capable of growing into any of the 300 different kinds of cell in the human body.
		Isolated from the blood or bone marrow, haematopoietic stem cells are able to form blood and immune cells.
		Haematopoietic stem cell transplants are now routinely used to treat patients with cancer and other disorders of the blood and immune systems.
	english.peopledaily.com.cn /200509/19/eng20050919_209387.html (384 words)

	Eurekah - High-Dose Chemotherapy with Haematopoietic Stem Cell Transplantation in Primary Systemic Vasculitis, Behcet's ...
		Allogeneic Hematopoietic Stem Cell Transplantation for Autoimmune Diseases
		Autologous Hematopoietic Stem Cell Transplantation for Crohn’s Disease
		Autologous Hematopoietic Stem CellTransplantation for Idiopathic Inflammatory Myositis
	www.eurekah.com /chapter/2492 (2371 words)

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