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	Two novel assays for the detection of haemin-binding properties of antimalarials evaluated with compounds isolated ...
		the inhibition of the reaction(s) of GSH with haemin;
		on the reversal of the inhibition by haemin of the dopachrome
		the reversal of haemin inhibition of MIF dopachrome
	jac.oxfordjournals.org /cgi/content/full/50/1/25 (4705 words)

	Inter Research » DAO » v48 » n2 » p109-115
		Proteinase K treatment of whole cells markedly reduced the binding of haemin, indicating that protein receptors located at the cell surface are involved in the binding.
		This was confirmed by the observation that isolated total as well as outer membrane proteins from all the strains, regardless of the iron levels of the media, were able to bind haemin, with the outer membranes showing the strongest binding.
		Haemin binding by membrane protein extracts was not affected by heat treatment but was almost completely abolished by Proteinase K treatment, suggesting the presence of thermostable protein receptors for haemin.
	www.int-res.com /abstracts/dao/v48/n2/p109-115 (362 words)

	[No title] (Site not responding. Last check: 2007-10-10)
		In the cases of artemether, dihydroartemisinin, and arteether, haemin (ferriprotoporphyrin IX) significantly increased the dose-related inhibition of neurite outgrowth from differentiating NB2a cells and significantly increased the dose-dependent inhibition of MTT metabolism.
		Haemin did not enhance the neurotoxicity of desoxyarteether, a structural analogue of arteether with an ether linkage in the place of the endoperoxide bridge.
		It is suggested that haemin may catalyse the transformation of these derivatives via an interaction with the endoperoxide bridge of the artemisinin derivative to produce free radicals or electrophilic intermediates that are toxic to neuronal cells.
	www.elsevier.com /cdweb/journals/00062952/articles/53/1/S000629529600591.abstract.en (204 words)

	Haemin enhancement of glucose transport in human lymphocytes: stimulation of protein tyrosine phosphatase and ...
		Haemin enhancement of glucose transport in human lymphocytes: stimulation of protein tyrosine phosphatase and activation of p56lck tyrosine kinase.
		Haemin enhancement of glucose transport in human lymphocytes: stimulation of protein tyrosine phosphatase and activation of p56lck tyrosine kinase.At high doses, tyrphostins inhibited the effect of haemin.
		Haemin also activated the tyrosine kinase p56lck, which is negatively controlled by phosphorylation of Tyr-505 at the C-terminus, and increased protein tyrosine phosphorylation in these cells.
	www.ihop-net.org /UniPub/iHOP/gp/87594.html (280 words)

	Haemin - Wikipedia, the free encyclopedia
		If this article can be modified to be more than a dictionary entry, please do so and remove this message.
		Haemin: a red-brown to blue-fl crystalline salt C34 H32 N4 O4 Fe Cl derived from oxidized heme but usually obtained in a characteristic crystalline form from hemoglobin by treatment with hot glacial acetic acid containing sodium chloride; ferriprotoporphyrin chloride -- called also protohemin.
		This page was last modified 00:58, 17 November 2005.
	en.wikipedia.org /wiki/Haemin (130 words)

	[No title] (Site not responding. Last check: 2007-10-10)
		The aim of investigating the dynamics of the haemin - hydrogen peroxide - sulfite reaction is to explore, if an under which conditions this reaction system is capable of showing nonlinear dynamical behaviour.
		The haemin - hydrogen peroxide - sulfite system is the third reaction system which contains a metalloporphyrin as the active centre of the enzyme (or model enzyme), and that is capable of displaying nonlinear dynamical behaviour.
		During the haemin - hydrogen peroxide - sulfite reaction the haemin acts as catalyst in the oxidation of sulfite to sulfate by hydrogen peroxide.
	iep463.nat.uni-magdeburg.de /w3mh/haemin-e.html (518 words)

	Nobel Prize in Chemistry 1930 - Presentation Speech
		Elementary analysis showed that the haemin molecule contains a large number of carbon atoms (the data fluctuated between 32 and 34) and an almost equal number of hydrogen atoms, and also 4 oxygen atoms, 4 nitrogen atoms, 1 iron atom, and 1 chlorine atom.
		Further, it was discovered that the pigment in the pinions of certain birds is the copper salt of a porphyrin, whereas the pigment which forms the dark spots on the eggs of a large number of wild birds, the so-called ooporphyrin, has been found to be blood pigment without iron.
		Almost, we are tempted to say that life is pigment, because oxygen transport, by means of blood pigment, to the various tissues of the bodies of animals and humans, and carbon dioxide assimilation in plants, due to chlorophyll, constitute two of the most fundamental processes of organic life.
	www.nobelprize.org /chemistry/laureates/1930/press.html (1077 words)

	[No title]
		To complement the site-directed mutagenesis approach, histidine and cysteine modifying reagents were used to assess the importance of the histidine and cysteine residues in C612KAC615H616 segment.
		Even with 500 nM haemin, the fractional inhibition was much smaller and the inhibition time course was slower after MTSEA treatment (Supplementary Fig.
		These results suggest that the inhibitory effect of haemin is likely to involve cysteine and histidine and support the mutagenesis results that the C612KAC615H616 segment is an important determinant of the haem sensitivity.
	www.nature.com /nature/journal/v425/n6957/extref/nature02003-s2.doc (493 words)

	Nobel Prize in Chemistry 1930 - Presentation Speech (Site not responding. Last check: 2007-10-10)
		Elementary analysis showed that the haemin molecule contains a large number of carbon atoms (the data fluctuated between 32 and 34) and an almost equal number of hydrogen atoms, and also 4 oxygen atoms, 4 nitrogen atoms, 1 iron atom, and 1 chlorine atom.
		Further, it was discovered that the pigment in the pinions of certain birds is the copper salt of a porphyrin, whereas the pigment which forms the dark spots on the eggs of a large number of wild birds, the so-called ooporphyrin, has been found to be blood pigment without iron.
		Almost, we are tempted to say that life is pigment, because oxygen transport, by means of blood pigment, to the various tissues of the bodies of animals and humans, and carbon dioxide assimilation in plants, due to chlorophyll, constitute two of the most fundamental processes of organic life.
	nobelprize.org /chemistry/laureates/1930/press.html (1080 words)

	Abstract: Vibrio hemin and hemoglobin iron utilization (Site not responding. Last check: 2007-10-10)
		Henderson, D.P. and Payne, S.M. Cloning and characterization of the Vibrio cholerae genes encoding the utilization of iron from haemin and haemoglobin.
		Escherichia coli 1017 transformed with pHUT1 failed to utilize haemin as an iron source; a second plasmid containing a different cloned fragment of V. cholerae DNA (pHUT3) was required in addition to pHUT1 to reconstitute the system in E. coli.
		An E. coli hemA mutant that cannot synthesize porphyrins was transformed with the recombinant plasmids to determine whether the plasmids encoded the ability to transport the porphyrin as well as the iron.
	www.sbs.utexas.edu /paynelab/Abstracts/abstract9.htm (242 words)

	Modified haem - Patent 4822877
		The invention further provides a chemically modified haem which is superior to naturally occurring haemin enzymes in terms of stability, especially with respect to the effect of temperature, whereby it can be used in reactions at higher temperatures or can be stored at ambient temperature for a prolonged period without any loss of activity.
		The modified haemin obtained in Example 1 was dissolved in water (0.305 mg/ml) and 0.25 ml of the solution was added to a mixture comprised of 0.1M phosphate buffer solution (ph 7.0, 1 ml), 11.5 mM phenol (1.3 ml), 10 mM 4-aminoantipyrine (0.25 ml) and 6 mM hydrogen peroxide (0.2 ml).
		Therefore, the peroxidase activity of the modified haemin was determined as 0.213 U/ml (0.698 U/mg).
	www.freepatentsonline.com /4822877.html (1605 words)

	Method of obtaining haemin from slaughter blood
		The development concerns a method of obtaining haemin.
		In оrder to separate haemin from the globin component, slaughter blood is subjected to an acid treatment at a pH of between 1.2 and 3 and a temperаture of between 45 and 80.degree.
		C., the haemin next being sepаrаted from globin.
	www.patentalert.com /docs/000/z00006489.shtml (75 words)

	haemin's progress on live in New York City on 43 Things
		haemin's progress on live in New York City on 43 Things
		haemin has written 1 entry about this goal
		haemin has gotten 0 cheers on this goal.
	www.43things.com /people/progress/haemin/302396 (228 words)

	Reference.com/Web Search/haemin
		Haemin uptake and use as an iron source by Candida albicans: role...
		Several of the antimalarial compounds that bind haemin are isoquinolines, a class
		Haemin enhancement of glucose transport in human lymphocytes: stimulation of...
	www.reference.com /search?db=web&q=haemin (242 words)

	Read about Haemin at WorldVillage Encyclopedia. Research Haemin and learn about Haemin here! (Site not responding. Last check: 2007-10-10)
		Look for Haemin in Wiktionary, our sister dictionary project.
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	encyclopedia.worldvillage.com /s/b/Haemin (125 words)

	A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptor
		In mammalian cells, haemin is degraded to carbon monoxide and bilirubin by the enzyme haeme oxygenase
		Thus, iron apparently cannot be liberated from haemin and instead is sequestered in infected red cells as haemozoin, the characteristic pigment associated with malarial infection
		If iron bound to transferrin is the source of ferric ions for malaria parasites within mature erythrocytes, then the parasite must synthesize its own transferrin receptor and localize it on the surface of the infected cell, because the receptors for transferrin are lost during erythrocyte maturation
	www.nature.com /cgi-taf/DynaPage.taf?file=/nature/journal/v324/n6095/abs/324388a0.html (482 words)

	[No title] (Site not responding. Last check: 2007-10-10)
		GSH-mediated haemin degradation in the presence of ascorbic acid in phosphate-buffered saline and in erythrocyte ghosts was determined by recording absorbance at 365 and 399nm, respectively.
		The oxidation of ascorbic acid in the presence of haemin was stimulated by GSH, suggesting that ascorbic acid can alter the mechanism of H
		These results suggest that enhancement of GSH-mediated haemin degradation by ascorbic acid may be due to an increase in the production of H
	www.elsevier.com /cdweb/journals/00062952/articles/64/4/S000629520201214.abstract.en (131 words)

	IngentaConnect Corynebacterium diphtheriae genes required for acquisition of iro... (Site not responding. Last check: 2007-10-10)
		Corynebacterium diphtheriae and Corynebacterium ulcerans use haemin and haemoglobin as essential sources of iron during growth in iron-depleted medium.
		HmuT binds in vitro to haemin- and haemoglobin-agarose, suggesting that it is capable of binding both haemin and haemoglobin and may function as the haemin receptor in C.
		This study reports the first genetic characterization of a transport system that is involved in the utilization of haemin and haemoglobin as iron sources by a Gram-positive bacterium.
	www.ingentaconnect.com /content/bsc/mole/2000/00000036/00000001/art00007 (301 words)

	Erythroid gene expression is differentially regulated by erythropoietin, haemin and delta-aminolaevulinic acid in UT-7 ...
		Erythroid gene expression is differentially regulated by erythropoietin, haemin and delta-aminolaevulinic acid in UT-7 cells.
		Erythroid gene expression is differentially regulated by erythropoietin, haemin and delta-aminolaevulinic acid in UT-7 cells.Conversely, SCL expression was up-regulated by Epo and further increased by haemin and delta-ALA.
		We have compared the effects of Epo and the chemical inducers, delta-aminolaevulinic acid (delta-ALA) and haemin on the differentiation capacity of UT-7 cells.
	www.ihop-net.org /UniPub/iHOP/gp/1868296.html (239 words)

	Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt ...
		A: effect of haemin and haemoglobin; B: effect of inhibitors in a high-haemin context; C: in a low-haemin context
		A: effect of haemin and haemoglobin diets; B: effect of antioxidant; high calcium and olive oil diet on a haemin context; C: effect of calcium and olive oil on control diet
		Haemin was used to explore the effect of haem from red meat
	carcin.oxfordjournals.org /cgi/content/full/24/10/1683 (5394 words)

	Effect of haemin limitation on the cytochrome complement and glucose metabolism of non-typable Haemophilus influenzae ...
		Effect of haemin limitation on the cytochrome complement and glucose metabolism of non-typable Haemophilus influenzae -- O'Reilly et al.
		Effect of haemin limitation on the cytochrome complement and glucose metabolism of non-typable Haemophilus influenzae
		presence of excess haemin (10 micrograms/ml), the haemin-limited organisms
	jmm.sgmjournals.org /cgi/content/abstract/37/2/133 (230 words)

	Products of Red Blood Cell Degradation Inhibit Responsiveness of the Erythropoietin Oxygen Sensor (Site not responding. Last check: 2007-10-10)
		Since more red blood cells are decomposed under this condition, the effects of exogenous haemin and of lysed or heat-damaged red blood cells on activation of the erythropoietin gene have been studied in mice rendered hypoxic.
		Total RNA was extracted from the kidney and the liver and subjected to northern blot analysis with a probe containing part of the murine erythropoietin gene.
		Erythropoietin gene activation was suppressed by haemin and increased red blood cell haemolysis.
	www.lf2.cuni.cz /physiolres/1996/issue5/iss5cl5.htm (222 words)

	Pfam 18.0 : HemS (Site not responding. Last check: 2007-10-10)
		The Yersinia enterocolitica O:8 periplasmic binding-protein- dependent transport system consisted of four proteins: the periplasmic haemin-binding protein HemT, the haemin permease protein HemU, the ATP-binding hydrophilic protein HemV and the haemin-degrading protein HemS (this family).
		The Yersinia enterocolitica O:8 periplasmic binding protein-dependent transport system consisted of four proteins: the periplasmic haemin-binding protein HemT, the haemin permease protein HemU, the ATP-binding hydrophilic protein HemV and the haemin-degrading protein HemS (this family).
		Transport of haemin across the cytoplasmic membrane through a haemin-specific periplasmic binding-protein-dependent transport system in Yersinia enterocolitica.
	pfam.wustl.edu /cgi-bin/getdesc?name=HemS (87 words)

	Molecular cloning, partial purification, and characterization of a haemin-binding lipoprotein from Haemophilus ... (Site not responding. Last check: 2007-10-10)
		Molecular cloning, partial purification, and characterization of a haemin-binding lipoprotein from Haemophilus influenzae type b.E. coli RR1(pHM2) adsorbed haemin in liquid suspensions as well as from solid media.
		Affinity chromatography on haemin-agarose was utilized to purify the haemin- binding protein from both E. coli RR1(pHM2) and Hib DL42(pHM1002) to near homogeneity.
		Expression of haemin-binding activity by clones correlated with the expression of a protein with an apparent molecular weight of 51,000 (51K) that was also recognized by anti-Hib strain DL42 serum in immunoblots.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/33359.html (249 words)

	Meat and cancer: haemoglobin and haemin in a low calcium diet promote colorectal carcinogenesis at the aberrant crypt ...
		Meat and cancer: haemoglobin and haemin in a low calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats -- Pierre et al., 10.1093/carcin/bgg130 -- Carcinogenesis
		Meat and cancer: haemoglobin and haemin in a low calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats
		Haemin (0.25, 0.5 and 1.5 µmol/g) or haemoglobin (1.5 and
	carcin.oxfordjournals.org /cgi/content/short/bgg130v1 (493 words)

	THE USE OF ANTIMALARIAL DRUGS
		Biochemical studies suggest that its antimalarial effect involves lysosomal trapping of the drug in the intra-erythrocytic parasite, followed by binding to toxic haemin that is produced in the course of haemoglobin digestion.
		This binding prevents the polymerization of haemin to non-toxic malaria pigment.
		A total of 16 clinical trials with more than 3 000 patients, including 600 children under 5 years of age, have been carried out in Europe, South-East Asia and Africa.
	mosquito.who.int /cmc_upload/0/000/014/923/am2_1-13.htm (589 words)

	HmsT, a protein essential for expression of the haemin storage (Hms(+)) phenotype of Yersinia pestis -- Jones et al. ... (Site not responding. Last check: 2007-10-10)
		HmsT, a protein essential for expression of the haemin storage (Hms(+)) phenotype of Yersinia pestis -- Jones et al.
		HmsT, a protein essential for expression of the haemin storage (Hms(+)) phenotype of Yersinia pestis
		The haemin storage (Hms) phenotype of Yersinia pestis has been shown to be
	intl-mic.sgmjournals.org /cgi/content/abstract/145/8/2117 (433 words)

	Haemin promotes rapid neurite outgrowth in cultured mouse neuroblastoma cells
		Haemin promotes rapid neurite outgrowth in cultured mouse neuroblastoma cells
		Therefore, the availability of a rapidly acting agonist effective in the presence of the normal complement of serum would be a useful tool.
		We report here that haemin can rapidly and reversibly induce neurite outgrowth in cultured mouse neuroblastoma cells and suggest that haemin may have a wider role in cells than previously thought.
	www.nature.com /nature/journal/v274/n5669/abs/274372a0.html (415 words)

	Friendster - Haemin
		haemin is also an extremely ambitious person who will be successful in all that she does.
		Anyways Haemin is a kind and loving friend.
		She's the type of friend that will always bring a smile to your face.
	www.friendster.com /1123173 (293 words)

	Catalogo Articoli (Site not responding. Last check: 2007-10-10)
		The effect of environmental haemin on the physiology and biochemistry of Prevotella intermedia R78 grown in batch culture was assessed.
		In addition, cell morphology was predominantly cocco-bacillary when cultured in high haemin environments, while bacillary forms were prevalent in low haemin conditions (< 2.5 mu mol l(-1)).
		Cells harvested from low haemin environments produced greater numbers of extracellular vesicles and greater amounts of peptidolytic activity, haemagglutinating potential and haemin binding activity when compared with cells harvested from high haemin conditions.
	serials.cib.unibo.it /cgi-ser/start/it/spogli/df-s.tcl?prog_art=1885968&language=ITALIANO&view=articoli (223 words)

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