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Medmicro Chapter 30 Haemophilus influenzae colonizes healthy children and adults (although the rate of colonization is far greater for nontypable than for type b H influenzae) and is spread by direct contact, secretions, and/or aerosol. Haemophilus influenzae, the major pathogen, can be separated into encapsulated or typable strains, of which there are seven types (a through f including e') based on the antigenic structure of the capsular polysaccharide, and unencapsulated or nontypable strains. Haemophilus aegyptius, which causes conjunctivitis and Brazilian purpuric fever, and Haemophilus haemolyticus used to be separated on the basis of their ability to agglutinate or lyse red blood cells, but both are now included among the nontypable H influenzae strains. gsbs.utmb.edu /microbook/ch030.htm   (4620 words)

The sodA gene of Haemophilus ducreyi encodes a hydrogen peroxide-inhibitable superoxide dismutase. The sodA gene of Haemophilus ducreyi encodes a hydrogen peroxide-inhibitable superoxide dismutase. Haemophilus ducreyi is the etiologic agent of the sexually transmitted disease chancroid, an ulcerative condition implicated in increased HIV transmission. The sodA gene of Haemophilus ducreyi was isolated from a genomic plasmid library on the basis of its ability to rescue the hydrogen peroxide hypersensitivity of an Escherichia coli sodA sodB strain. www.aegis.com /aidsline/1998/jun/M9861754.html   (386 words)

Robert S. Munson, Jr.--OSU Department of Microbiology : Stephen T. Abedon Nontypeable Haemophilus influenzae is an important cause of otitis media in children, and a major cause of lower respiratory disease in children in the developing world. Haemophilus ducreyi is the causative agent of chancroid, a sexually transmitted disease. Cloning and characterization of the genes encoding the hemolysin of Haemophilus ducreyi. www.osumicrobiology.org /faculty/rmunson.htm   (309 words)

Faculty | Indiana University Department of Medicine A DltA mutant of Haemophilus ducreyi is partially attenuated in its ability to cause pustules in human volunteers. Evoolution of the cutaneous immune response to experimental Haemophilus ducreyi infection and its relevence to HIV-1 acqusition.J Immunology.2002;169:316-6323. Haemophilus ducreyi associates with phagocytes, collegen and fibrin and remains extracellular throughout experimental infection. medicine.iupui.edu /faculty/showme.asp?id=3035   (557 words)

ITREID Faculty - Patricia Totten:   (Site not responding. Last check: 2007-10-16) We have cloned and characterized a cytolysin (hemolysin) produced by Haemophilus ducreyi and propose that expression of this toxin is important in the pathogenesis of chancroid. Haemophilus ducreyi attaches to and invades cultured human foreskin epithelial cell in vitro. Molecular characterization of Haemophilus ducreyi strains from outbreaks in Jackson, MS and New Orleans, LA. J. Infect. depts.washington.edu /itreid/faculty/totten.html   (368 words)

Immunopathogenesis of Haemophilus ducreyi Infection (Chancroid) -- Spinola et al. 70 (4): 1667 -- Infection and Immunity Prevalence of, antibody response to, and immunity induced by Haemophilus ducreyi hemolysin. Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin. iai.asm.org /cgi/content/full/70/4/1667   (7180 words)

Expression of the cytolethal distending toxin in a geographically diverse collection of Haemophilus ducreyi clinical ...   (Site not responding. Last check: 2007-10-16) Cloning and characterisation of the genes encoding the haemolysin of Haemophilus ducreyi. Characterization of a Haemophilus ducreyi mutant deficient in the expression of the cytolethal distending toxin. Antigenic characterization of the oligosaccharide portion of the lipooligosaccharide of nontypable Haemophilus influenzae. sti.bmjjournals.com /cgi/content/full/79/4/294   (2351 words)

Chancroid Chancroid is a sexually transmitted disease caused by a bacterial infection that is characterized by painful sores on the genitals. Chancroid is an infection of the genitals that is caused by the bacterium Haemophilus ducreyi. Haemophilus ducreyi is spread from person to person by vaginal, anal, and oral sexual contact. www.healthatoz.com /healthatoz/Atoz/ency/chancroid.jsp   (1180 words)

Haemophilus ducreyi Is Susceptible to Protegrin -- Fortney et al. 42 (10): 2690 -- Antimicrobial Agents and Chemotherapy   (Site not responding. Last check: 2007-10-16) Haemophilus ducreyi Is Susceptible to Protegrin -- Fortney et al. Haemophilus ducreyi causes chancroid, a genital ulcer disease common in developing countries (10, 20). ducreyi forms tight intracellular junctions that cause the organisms to clump in vivo and in vitro (10). aac.asm.org /cgi/content/full/42/10/2690   (2280 words)

Morbidity and Mortality Weekly Report: Chancroid detected by polymerase chain reaction... @ HighBeam Research   (Site not responding. Last check: 2007-10-16) An examination of 81 patients with genital ulcers in Jackson, MS, between Oct 1994 and Feb 1995 revealed that 41 were infected with Haemophilus ducreyi, the organism responsible for chancroid. Chancroid is a sexually transmitted disease (STD) caused by infection with Haemophilus ducreyi and is characterized by genital ulceration. For 33 patients, DNA sequences from H. ducreyi only were identified; for seven, DNA sequences from H. ducreyi and one other organism were identified; and for one, DNA sequences from H. ducreyi and two other organisms were identified (Table 1, page 573). www.highbeam.com /library/doc0.asp?DOCID=1G1:17205361&refid=ip_encyclopedia_hf   (1315 words)

Gale Encyclopedia of Medicine: Chancroid Haemophilus ducreyi is spread from person to person by vaginal, anal, and oral sexual contact. For a clear-cut diagnosis of chancroid, Haemophilus ducreyi must be isolated from the ulcer. Haemophilus ducreyi takes from two to five days to grow in the laboratory. www.findarticles.com /p/articles/mi_g2601/is_0002/ai_2601000292   (1248 words)

Silvia Borrelli: Doktorsavhandling från Karolinska Institutet   (Site not responding. Last check: 2007-10-16) Among the Haemophilus species, H. influenzae and H. ducreyi are the most important in human medicine. The epitopes recognized by the MAbs were delineated and the feasibility of the MAbs, for the analysis of the epitope expression in Haemophilus spp. The MAb MAHI 3 bound to the LPS from all Haemophilus spp., and recognized the Hepa1-2Hepa1-3Hepa1-5Kdo tetrasaccharide including one of the phosphate groups in lipid A. The MAb DP8 bound to the LPS from all H.ducreyi strains and the proposed epitope is Hepa1-2(Glcb1-4)Hepa1-3Hepa1-5Kdo. diss.kib.ki.se /1996/91-628-2133-4   (671 words)

Haemophilus ducreyi A hemoglobin receptor is also known to be required for pathogenesis and, in fact, a vaccine composed of this hemoglobin binding protein (Hgb) has been shown to provide some protection from disease in a swine model of infection. H. ducreyi also produces a cytotoxin, the tripartite cytolethal distending toxin (CDT) that induces cell cycle arrest and apoptosis in eukaryotic cells. In this model wild type and mutant H. ducreyi are delivered to the skin of the upper arms of healthy adult volunteers by puncture wounds made by an allergy-testing device. medinfo.ufl.edu /year2/mmid/bms5300/bugs/haeducr.html   (441 words)

CiteULike: Chancroid and Haemophilus ducreyi.   (Site not responding. Last check: 2007-10-16) Haemophilus ducreyi is the causative agent of chancroid, one of the genital ulcerative diseases. ducreyi is the major cause of genital ulcer disease in Africa and Southeast Asia and is of increasing concern in the United States. @article{citeulike:738181, abstract = {Haemophilus ducreyi is the causative agent of chancroid, one of the genital ulcerative diseases. www.citeulike.org /user/abelmagalhaes/article/738181   (361 words)

The lipooligosaccharides of Haemophilus ducreyi are highly sialylated -- Melaugh et al. 178 (2): 564 -- The Journal of ... The lipooligosaccharides of Haemophilus ducreyi are highly sialylated -- Melaugh et al. Filiatrault, M. J., Munson, R. Jr., Campagnari, A. Genetic Analysis of a Pyocin-Resistant Lipooligosaccharide (LOS) Mutant of Haemophilus ducreyi: Restoration of Full-Length LOS Restores Pyocin Sensitivity. Cloning and Characterization of the Lipooligosaccharide Galactosyltransferase II Gene of Haemophilus ducreyi. jb.asm.org /cgi/content/abstract/178/2/564   (693 words)

Medical Dictionary: Haemophilus ducreyi - WrongDiagnosis.com Haemophilus ducreyi: Another name for Chancroid (or close medical condition association). Haemophilus ducreyi: Haemophilus ducreyi is listed as a type of (or associated with) the following medical conditions in our database: Sexually Transmitted Diseases, Male sexual conditions, Vagina conditions Haemophilus ducreyi (medical condition): Rare sexual disease causing genital ulcers and other symptoms. Haemophilus ducreyi: Chancroid ("shan-kroid") is an important bacterial infection caused by Haemophilus ducreyi, which is spread by sexual contact. www.wrongdiagnosis.com /medical/haemophilus_ducreyi.htm   (223 words)

Diagnostic tests for chancroid -- Lewis 76 (2): 137 -- Sexually Transmitted Infections   (Site not responding. Last check: 2007-10-16) Simplified PCR for detection of Haemophilus ducreyi and diagnosis of chancroid. Rapid detection of Haemophilus ducreyi in clinical and experimental infections using monoclonal antibody: a preliminary evaluation. DNA probes for the identification of Haemophilus ducreyi. sti.bmjjournals.com /cgi/content/full/76/2/137   (3472 words)

Margaret E. Bauer, PhD, Assistant Professor ducreyi is a pathogen of human skin and causes chancroid, a genital ulcer disease endemic in sub-Saharan Africa and Southeast Asia that facilitates the transmission of HIV. ducreyi infection, the organism survives extracellularly within pustules in a milieu of professional phagocytes where it is often surrounded by fibrin. ducreyi is also found in the dermis in vivo, where it localizes with collagen. www.iupui.edu /~micro/bauer.html   (484 words)

THE MOLECULAR BASIS OF HAEMOPHILUS DUCREYI PATHOGENESIS Abstract: DESCRIPTION (Adapted from the applicant's abstract): Haemophilus ducreyi, the etiologic agent of the genital ulcer disease chancroid, is an emerging bacterial pathogen in the United States. Regardless of its world-wide prevalence, and the fact that H. ducreyi infections significantly enhance heterosexual HIV transmission, this organism is arguably the least understood of the sexually transmitted pathogens. ducreyi survival and lesion development will be evaluated in the swine model of chancroid using both normal and neutropenic pigs. www.med.unc.edu /wrkunits/1dean/research/Kawula187.html   (432 words)

Ruth Lilly Medical Library Haemophilus ducreyi causes the sexually transmitted genital ulcer disease chancroid. In the human infection model, H. ducreyi is found in papules and pustules and colocalizes with neutrophils, macrophages, fibrin, and collagen. We hypothesized that H. ducreyi upregulates genes in response to binding to collagen and fibrinogen. www.medlib.iupui.edu /faculty/scs2002/P52002.html   (318 words)

Bacteria, fastidious gram negative bacilli Other Haemophilus species and the syndromes they cause include H parainfluenzae (pneumonia and endocarditis), H ducreyi (genital chancre), and H aegyptius (conjunctivitis or Brazilian purpuric fever).Haemophilus species are gram-negative coccobacilli similar in ultrastructural features to other pathogenic bacilli. Haemophilus ducreyi grows on Mueller-Hinton agar with 5 percent sheep blood in a CO2 enriched atmosphere." Haemophilus influenzae is a gram negative, fastidious coccobacillus requiring growth factors available in hemolyzed chocolate blood agar. www.buddycom.com /bacteria/gnr/gnrfastid.html   (1428 words)

Haemophilus Index.html   (Site not responding. Last check: 2007-10-16) In the BLAST comparisons presented here, each protein in the Haemophilus ducreyi proteome is used as a query against the entire Haemophilus influenzae proteome and vice versa to find similar proteins in the compared genome. Table of H. ducreyi proteins found in H. influenzae. View a map of orthologous proteins in the Haemophilus ducreyi and Haemophilus influenzae proteomes. hpv-web.lanl.gov /stdgen/bacteria/analysis/HDUC/Haemophilus_index.html   (448 words)

Anthony A We are currently characterizing this region and we are beginning studies designed to determine the function of this FHA homologue. Infection with H. ducreyi has been shown to be a cofactor in the heterosexual transmission of HIV. Haemophilus ducreyi Mutants Defective in Expression of a Heptosyltransferase III and a b1-4 Glucosyltransferase: Identification of LOS Glycoforms Containing Lactosamine Repeats”. www.smbs.buffalo.edu /wcmpi/faculty/campagnari.html   (1333 words)

Characterization of a transposon Tn916-generated mutant of Haemophilus ducreyi 35000 defective in lipooligosaccharide ... Characterization of a transposon Tn916-generated mutant of Haemophilus ducreyi 35000 defective in lipooligosaccharide biosynthesis -- Gibson et al. ducreyi in the pathogenesis of chancroid, Tn916 mutants of H. ducreyi 35000 Identification and Characterization of the N-Acetylglucosamine Glycosyltransferase Gene of Haemophilus ducreyi. jb.asm.org /cgi/content/abstract/179/16/5062   (1241 words)

Proteomics and Genomics - the application of separation science to systems biology The proteomes of several strains of this bacterium have been analyzed in an attempt to correlate the virulence of the strain with the protein content and the carbohydrate composition of the cell membranes. The disease is caused by the Gram-negative bacterium Haemophilus ducreyi that enters the victim via abrasions or small cuts and the symptoms occur within a week of exposure. In an effort to try and identify links between the virulence of the bacteria and the protein and LOS contents, researchers in the USA have compared eight different strains of the bacterium and their findings are reported in J. www.separationsnow.com /coi/cda/detail.cda?id=598&type=Feature&chId=6&page=1   (734 words)

Explore the Microscopic World of Health Science   (Site not responding. Last check: 2007-10-16) Haemophilus ducreyi is a major cause of human genital ulcer disease (chancroid) in developing countries (incidence being highest in African, Asian and Latin American nations). Until the 1980's, chancroid was believed to be of little medical importance in this country. Although treatment with antibiotics can cure the infection, strains resistant to ampicillin and penicillin are becoming more prevalent; strains even resistant to chloramphenicol are now being encountered. www.wadsworth.org /databank/haemoph.htm   (124 words)

Structural studies of the cell envelope lipopolysaccharides from Haemophilus ducreyi strains ITM 2665 and ITM 4747 -- ... Structural studies of the cell envelope lipopolysaccharides from Haemophilus ducreyi strains ITM 2665 and ITM 4747 -- Schweda et al. Structural studies of the cell envelope lipopolysaccharides from Haemophilus ducreyi strains ITM 2665 and ITM 4747 The lbgAB Gene Cluster of Haemophilus ducreyi Encodes a {beta}-1,4-Galactosyltransferase and an {alpha}-1,6-DD-Heptosyltransferase Involved in Lipooligosaccharide Biosynthesis www.jbc.org /cgi/content/abstract/269/16/12040   (545 words)

American Social Health Association - Learn about STDs/STIs It is caused by a bacteria called Haemophilus Ducreyi (or H. Ducreyi). Diagnosis is made by isolating the bacteria Hemophilus Ducreyi in a culture from a genital ulcer or sore. A gram stain to identify H. Ducreyi is possible but can be misleading because of other organisms found in most genital ulcers. www.ashastd.org /learn/learn_chancroid.cfm   (790 words)

Chancroid and Haemophilus ducreyi: an update. Haemophilus ducreyi is a fastidious gram-negative bacillus that causes the sexually transmitted infection chancroid. The diagnosis of chancroid based on the clinical appearance of the genital lesion or on the isolation of H. ducreyi on selective medium is relatively insensitive. Through the use of biochemical and molecular techniques, macromolecular components that may be important in virulence have been identified. www.aegis.com /aidsline/1996/jan/M9610546.html   (382 words)

HPA | Haemophilus species RSIL Respiratory and Systemic Infection Laboratory   (Site not responding. Last check: 2007-10-16) HRU offers a taxonomic identification service for strains of Haemophilus species isolated from cases of invasive disease. Use the Haemophilus Reference Unit request form and supply pure culture on chocolate agar slope. Specimen submissions regarded by the sending laboratory as urgent should be notified to HRU by telephone (020 8200 4400 ext 7330/7331) to ensure that the appropriate level of priority is accorded to these specimens immediately upon receipt. www.phls.co.uk /srmd/div_rsil/haemophilus_species.htm   (172 words)

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