| | Defective clotting factor clears arteries (Site not responding. Last check: 2007-10-26) |
 | | For decades, scientists assumed that factor XII (or Hageman factor) was not important for clotting, as both humans and mice that lack this protein do not develop bleeding disorders. |
 | | Although clot formation was initiated at the sight of injury in the factor XII-deficient mice, the clots detached from the blood vessel wall before they could grow large enough to impede blood flow. |
 | | Consistent with these findings, studies in humans have shown that elevated levels of factor XII in the blood have been associated with increased coronary artery disease and lower levels with protection. |
| www.eurekalert.org /pub_releases/2005-07/joem-dcf070605.php (247 words) |