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Topic: Hairy cell leukemia

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	Dr. Koop - Hairy Cell Leukemia- Health Encyclopedia and Reference
		Hairy cell leukemia is a disease in which cancer (malignant) cells are found in the blood and bone marrow.
		When hairy cell leukemia develops, the leukemia cells may collect in the spleen and the spleen swells.
		There also may be too few normal white blood cells in the blood because the leukemia cells invade the bone marrow, and the marrow cannot produce enough normal white blood cells.
	www.drkoop.com /encyclopedia/93/11/Hairy_Cell_Leukemia.html (573 words)

	National Cancer Institute - Hairy Cell Leukemia Treatment (Site not responding. Last check: 2007-11-05)
		Hairy cell leukemia is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).
		Hairy cell leukemia is a cancer of the blood and bone marrow.
		The cause of hairy cell leukemia is unknown.
	www.cancer.gov /cancerinfo/pdq/treatment/hairy-cell-leukemia/patient (877 words)

	Gale Encyclopedia of Medicine: Hairy cell leukemia
		Hairy cell leukemia is a disease in which the cells that are present in the blood and bone marrow turn abnormal or cancerous.
		There are three types of cells found in the blood: red blood cells that carry oxygen to all the parts of the body; the white blood cells which are responsible for fighting infection and protecting the body from diseases; and platelets which help in the clotting of blood.
		The cause of hairy cell leukemia is not known.
	www.findarticles.com /p/articles/mi_g2601/is_0006/ai_2601000615 (895 words)

	The Leukemia & Lymphoma Society : Disease Information - Hairy Cell Leukemia
		The hairy cells accumulate in the bone marrow and spleen and to a lesser extent in lymph nodes.
		Hairy cell leukemia may be difficult to diagnose early because its symptoms are vague and resemble those of other illnesses.
		Occasionally, the hairy cells are numerous in the blood, resulting in an increase in the white cell counts.
	www.leukemia-lymphoma.org /all_page?item_id=8507 (925 words)

	Hairy Cell Leukemia
		HCL comprised 2% of all leukemias diagnosed in Los Angeles County during the study period.
		Derivation of multiple isotypes from individual cells was demonstrated by analyzing transcripts in single sorted cells from one patient, with evidence for coexistence of isotype variants in 10 of 10 cells.
		To determine the degree of bone marrow infiltration with hairy cells which is compatible with long-term hematological remission in patients treated with splenectomy, we have investigated 7 patients surviving in hematological remission 61 to 255 months (median 184 months) after splenectomy.
	www.thedoctorsdoctor.com /diseases/leukemia_hairycell.htm (7571 words)

	Hairy Cell Leukemia
		Because hairy cell leukemia is a blood related disease, most hairy cell leukemia symptoms show up when the disease has progressed enough to alter a person's blood.
		The swollen spleen symptom of hairy cell leukemia is a result of tumors.
		The hairy cell leukemia symptom of increased infections usually results from a low white blood cell count.
	www.cancercenter.com /hairy-cell-leukemia.htm (336 words)

	Hairy cell leukemia
		Untreated hairy cell leukemia is characterized by splenomegaly, varying degrees of leukopenia (occasionally leukocytosis) and/or pancytopenia, and bone marrow infiltration by an atypical cell with prominent cytoplasmic projections ("hairy cells").
		Cheson BD, Sorensen JM, Vena DA, et al.: Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine via the Group C protocol mechanism of the National Cancer Institute: a report of 979 patients.
		Splenectomy will partially or completely normalize the peripheral blood in the vast majority of patients with hairy cell leukemia.[13] There is usually little or no change in the bone marrow after splenectomy, and virtually all patients have progressive disease within 12 to 18 months.
	www.meds.com /pdq/hairycell_pro.html (1614 words)

	Leukemia, Hairy Cell
		Hairy cell leukemia is a rare type of blood cancer characterized by the presence of abnormal mononuclear blood cells called "hairy cells," and by a deficiency of other blood cell elements (pancytopenia), including an abnormal decrease of certain white blood cells (neutrophils [neutropenia]) and certain red blood cells (platelets [thrombocytopenia]).
		Hairy cell leukemia accounts for one to two percent of all cases of adult leukemia.
		Leukemias are the generalized cancerous (neoplastic) disorders of the blood forming tissues, such as bone marrow.
	hw.healthdialog.com /kbase/nord/nord269.htm (1058 words)

	Hairy Cell Leukemia
		The hairy cell leukemia is newly diagnosed and has not been treated except to relieve symptoms such as weight loss and infections.
		Hairy (leukemia) cells are found in the blood and bone marrow.
		If the patient's blood cell counts are not too low and there are no symptoms, treatment may not be needed and the patient is carefully watched for changes in his or her condition.
	www.meb.uni-bonn.de /cancer.gov/CDR0000258013.html (2232 words)

	MedlinePlus Medical Encyclopedia: Hairy cell leukemia
		Hairy cell leukemia is a cancer of lymphocytes (B cells) that leads to low blood counts.
		Hairy cell leukemia (HCL) is an uncommon cancer of the blood.
		Newer treatments using chemotherapy have greatly improved the survival of patients with hairy cell leukemia.
	www.nlm.nih.gov /medlineplus/ency/article/000592.htm (545 words)

	Hairy cell leukemia
		Hairy cell leukemia is a rare, slow-growing cancer of the blood in which your bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection.
		As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced.
		Hairy cell leukemia is sometimes found in families with a history of this and other blood cancers.
	www.cnn.com /HEALTH/library/DS/00673.html (1883 words)

	eMedicine - Hairy Cell Leukemia : Article by Emmanuel C Besa, MD
		HCL is observed mostly in males, with a male-to-female ratio of 5:1.
		The typical hairy cells are named because of their characteristic cytoplasmic projections, which appear as fine (hairlike) microvilli when seen by light microscopy, phase-contrast, and electron microscopy.
		HCL cells can be identified immunophenotypically in 92% of cases, even when the cells represent less than 1% of circulating lymphocytes.
	www.emedicine.com /med/topic937.htm (2400 words)

	Leukemia Hairy Cell
		-- Hairy cell leukemia is a disease in which cancer (malignant) cells are found in the blood and bone marrow.
		The chance of recovery (prognosis) depends on how many cancer cells are in the blood and bone marrow, and the patient's age and general health.
		There are treatments for all patients with hairy cell leukemia that is causing symptoms.
	www.medhelp.org /lib/cancernet/201651.htm (1711 words)

	Hematology Hairy cell leukemia (Site not responding. Last check: 2007-11-05)
		Hairy cell leukemia, or leukemic reticuloendotheliosis, is a rare malignant disorder.
		Hairy cells are characterized by their fine, irregular pseudopods and immature nuclear features.
		Bone marrow aspiration is often unsuccessful because of complete infiltration by hairy cells, resulting in a dispersed spongy web of cells in an increased meshwork of reticulin fiber.
	www.wadsworth.org /chemheme/heme/microscope/hairycellleukemia.htm (69 words)

	Hairy Cell Leukemia (Site not responding. Last check: 2007-11-05)
		Hairy cell leukemia is an uncommon malignant disorder of small B-lymphocytes that gets its name from the presence of cytoplasmic projections in these cells.
		The peripheral blood usually contains a small number of hairy cells, but it is uncommon to have a "leukemic picture".
		Hairy cells proliferate in the red pulp of the spleen, and so splenomegaly is common.
	www.mcl.tulane.edu /classware/pathology/Krause/Leukemias/HCL.html (162 words)

	Hairy cell leukemia definition - Medical Dictionary definitions of popular medical terms
		Hairy cell leukemia: A form of chronic leukemia in which malignant B-lymphocytes (a type of white blood cell) are seen in the bone marrow, spleen, and peripheral blood and when viewed under the microscope, these cells appear to be covered with tiny hair-like projections.
		The characteristic features of the disease include marked enlargement of the spleen (splenomegaly), low blood cell counts (pancytopenia), a relatively small number of circulating tumor cells with a hairy appearance, and infiltration of the spleen, liver, and bone marrow by the leukemic hairy cells.
		Annexin A1 (ANXA1) is a gene that is unregulated in hairy cell leukemia.
	www.medterms.com /script/main/art.asp?articlekey=33213 (424 words)

	Leukemia Hairy Cell
		-- Untreated -- Untreated hairy cell leukemia is characterized by splenomegaly, varying degrees of leukopenia (occasionally leukocytosis) and/or pancytopenia, and bone marrow infiltration by an atypical cell with prominent cytoplasmic projections ("hairy cells").
		For patients with advanced hairy cell leukemia treated with cladribine (2-chlorodeoxyadenosine, 2-CdA), pentostatin, or interferon alfa, the survival rate appears to be greater than 85% at 5 years after the initiation of any one of these therapies.[1,2] References: 1.
		Splenectomy will partially or completely normalize the peripheral blood in the vast majority of patients with hairy cell leukemia.[16] There is usually little or no change in the bone marrow after splenectomy, and virtually all patients have progressive disease within 12 to 18 months.
	www.medhelp.org /lib/cancernet/101651.htm (1878 words)

	Hairy Cell Leukemia
		This disease is due to overproduction of mature lymphoid cells.
		It is, however, associated with a peculiar shape of the lymphoid cells that look like they have hair.
		Some patients with HCL may develop an immune mediated low platelet count, which is due to destruction of platelets and not due to stage 4 disease.
	www.tirgan.com /hairylk.htm (287 words)

	Hairy Cell Leukemia
		Untreated hairy cell leukemia is characterized by splenomegaly, varying degrees of leukopenia (occasionally leukocytosis) and/or pancytopenia, and bone marrow infiltration by an atypical cell with prominent cytoplasmic projections (i.e., hairy cells).
		For patients with advanced hairy cell leukemia treated with cladribine (2-chlorodeoxyadenosine, 2-CdA), pentostatin, or interferon alfa, the survival rate appears to be >85% at 5 years after the initiation of any one of these therapies.
		With the use of cladribine, an increased risk of second malignancies is possible among patients with hairy cell leukemia (observed to expected ratio of about 1.8 in several series after 6 years).
	www.meb.uni-bonn.de /cancer.gov/CDR0000062926.html (2452 words)

	Hairy cell leukemia
		Splenectomy will partially or completely normalize the peripheral blood in the vast majority of patients with hairy cell leukemia.[5] There is usually little or no change in the bone marrow after splenectomy, and virtually all patients have progressive disease within 12-18 months.
		interferon alfa-2b in patients with hairy cell leukemia.
		Splenectomy will partially or completely normalize the peripheral blood in the vast majority of patients with hairy cell leukemia.[8] There is usually little or no change in the bone marrow after splenectomy, and virtually all patients have progressive disease within 12-18 months.
	www.uoc.muni.cz /guidelines/19krev/HAIRYLEU.htm (1373 words)

	Hairy Cell Leukemia (Site not responding. Last check: 2007-11-05)
		Hairy cell leukemia (HCL) is characterized by a reduction in all types of blood cells: white blood cells, red blood cells, and platelets.
		Characteristic hairy cells are seen in the peripheral blood and bone marrow.
		HCL cells have fine projections from their surface that creates an impression of the cells appearing "hairy." Liver and spleen enlargement is common.
	www.introna.com /introna/indications/leukemia (413 words)

	What Is HCL?
		Hairy Cell Leukemia is a chronic (slow progressing) lymphocytic leukemia (CLL) that was first reported at Ohio State University in 1958.
		HCL develops in the bone marrow as does the blood.
		In this rather stagnant area of blood flow, HCL tumors will gather which will trap and destroy normal blood cells.
	www.hairycellleukemia.org /hcl.htm (208 words)

	Hairy Cell Leukemia (Site not responding. Last check: 2007-11-05)
		A bacterial poison fused to the antibody is then carried into the interior of the cancer cells and kills them.
		The blood and bone marrow cancer, named for the hairy look of the cells under a microscope, accounts for about two percent of all leukemia cases.
		Many hairy cell cases are easily controlled, but the disease can sometimes be fatal.
	www.grg.org /HairyCell.htm (495 words)

	Hairy cell leukemia
		For patients with advanced hairy cell leukemia treated with cladribine (2-chlorodeoxyadenosine, 2-CdA), pentostatin, or interferon alfa, the survival rate appears to be greater than 85% at 5 years after the initiation of any one of these therapies.[1,2]
		the vast majority of patients with hairy cell leukemia.[16] There is usually little or no change in the bone marrow after splenectomy, and virtually all patients have progressive disease within 12 to 18 months.
		Saven A, Burian C, Adusumalli J, et al.: Filgrastim for cladribine-induced neutropenic fever in patients with hairy cell leukemia.
	cancerweb.ncl.ac.uk /cancernet/101651.html (1855 words)

	Hairy cell leukemia (Site not responding. Last check: 2007-11-05)
		This slide illustrates the peripheral blood from a patient with leukemia reticuloendotheliosis (hairy cell leukemia).
		The most distinguishing characteristic of the "hairy cell" is the hair-like cytoplasmic projections: The nuclear chromatin pattern may be confused with that either of a monocyte or a lymphocyte.
		Staining these cells with acid phosphatase (with and without tartrate inhibition) may aid the diagnosis.
	www.academic.marist.edu /~jzmz/topics/lymphocytic_leukemia/lympholeukemia27.html (97 words)

	ACOR Leukemia Links: Resources for HCL
		Mark is an HCL survivor and has collected quite a bit of information on HCL, including stories of other survivors.
		Hairy Cell Leukemia (HCL) a booklet from the Leukemia and Lymphoma Society of America which aims to provide information about CML to patients and their families.
		Hairy Cell Leukemia by Emmanuel C Besa, MD and Ulrich Woermann, MD, from the eMedicine World Medicine Library.
	www.acor.org /leukemia/hcl.html (241 words)

	What Is Hairy Cell Leukemia
		There is no staging system for hairy cell leukemia.
		Splenectomy (surgery to remove the spleen) has been done or systemic therapy (treatment that uses substances that travel through the bloodstream, reaching and affecting cells all over the body) has been given, but the leukemia is getting worse.
		The leukemia has been treated but no longer responds to the treatment.
	cancer.uchc.edu /patients_families/treatment_types/leukemia/hairycell.html (952 words)

	Hairy Cell Leukaemia - Genetics
		p53 gene deletion and trisomy 12 in hairy cell leukemia and its variant.
		Trisomy 12 in chronic lymphocytic leukemia and hairy cell leukemia: a cytogenetic and interphase cytogenetic study.
		Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates.
	www.cancerindex.org /geneweb/X1209.htm (171 words)

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