
	Where results make sense

Topic: Haplotype

Related Topics

Race

Mitanni

Caucasian race

Sanskrit

Slavs

Aryan

Aryan race

Indian subcontinent

Indra

India

Iranians

In the News (Sat 26 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Evolution - A-Z - Haplotype
		A haplotype is the set of genes at more than one locus which is inherited by an individual from one of its parents.
		While the theory of population genetics for a single locus is concerned with gene frequencies; the analogous variable in two locus population genetics is haplotype frequency.
		The frequency of a haplotype in a population can be counted as the number of gametes bearing a particular combination of genes.
	www.blackwellpublishing.com /ridley/a-z/Haplotype.asp (180 words)

	genome.gov \| Haplotype Map Development Report
		Demographic and social factors: Haplotype and allele frequencies are also affected by population history factors such as population size, bottlenecks or expansions of population size, founder effects, isolation of a population or admixture between populations, and patterns of mate choice.
		To the extent that populations differ in their haplotype structure, it may be useful to study different populations during different stages of the process of finding disease genes.
		Although the haplotype map would not have any individual medical information, another risk to the groups that participate could arise from later studies that use the haplotype map to find genes contributing to diseases; the participating groups could become more intensely studied, leading to the perception that their members are at high risk for diseases.
	www.genome.gov /10001665 (4248 words)

	Haplotype blocks
		Identification of haplotype blocks is a way of examining the extent of LD in the genome, which generally provides useful information for the planning of association studies.
		Often haplotype blocks are discussed alongside haplotype tagging; however "tagging" SNPs are aimed at characterizing (candidate) genes/avoiding redundancies in genotyping, this issue is not particularly related to LD block DEFINITION.
		A second approach to defining haplotype blocks is described by Greenspan and Geiger (2003).
	www.meb.ki.se /genestat/tl/genass_ldmap/measuring_ld/estimation_haplo/haplotype_blocks.htm (520 words)

	HaploBlock - SNP Haplotype Block Software - Haplotyping SNPs - Linkage Disequilibrium Mapping
		HaploBlock is suitable for high density haplotype or genotype SNP marker data and is based on a statistical model which takes account of recombination hotspots, bottlenecks, genetic drift and mutations and has a Markov Chain at its core.
		Haplotype resolution by the Clark algorithm or Local EM.
		HAPLOTYPER and PL-EM divide-and-conquer methods for haplotype resolution.
	bioinfo.cs.technion.ac.il /haploblock (352 words)

	Haplotype Database Search
		The data can also be viewed as a new track on the UCSC Human Genome Browser.
		To view haplotype data for a specific region:
		The haplotype data is also available in plain-text tabular form.
	genome.perlegen.com /haplotype (119 words)

	dbSNP:Haplotype
		Welcome to the development area for haplotype specifications in dbSNP.
		These specifications are a prototype based on available haplotype data for the human HLA gene region where traditional serological alleles have been defined at the molecular (SNP) level.
		We welcome your suggestions and feedback as we work with the genome centers, academic institutions and our international partners in developing a uniform standard for the description of haplotype data.
	www.ncbi.nlm.nih.gov /SNP/HapMap (85 words)

	HelixTree \| Haplotype Trend Regression
		Under the hypothesis of no haplotype effects and under the assumption of Hardy-Weinberg equilibrium, the haplotype trend regression is closely related to the previously suggested likelihood ratio test (LRT) for the binary phenotype, described in Xie and Ott, (1993), Fallin and Schork, (2000) and Zhao et al., (2000).
		Using a novel haplotype trend regression methodology, it is possible to associate disease or drug response with haplotype frequencies of individuals.
		Haplotype trend regression takes a series of marker genotypes, computes haplotype probabilities for each observation using the composite haplotype method (CHM), and forms a linear regression on the response using the haplotype probabilities as the regression matrix as in seen in Figure 1.
	www.goldenhelix.com /haplotype_trend_regression.html (490 words)

	ScienceDaily: Scientists Build Case For "Haplotype" Map Of Human Genome, Find New Gene For Crohn's Disease
		Haplotypes are ancestral segments of chromosomes that contain many single letter genetic variations inherited together as a set or a block, and they can be used to decipher the genetic differences that make some people more susceptible to disease than others.
		Identifying haplotypes became an important concept when scientists began to realize that single nucleotide polymorphisms (SNPs)the single letter DNA differences between individuals that comprise most genetic variation and thus underlie disease susceptibilitytravel together in blocks that are quite large.
		If the architecture of the blocks and the existing haplotypes are mapped, for instance, then a researcher studying a particular disease will be able to pick a few SNPs from every block in the genome and study this set in his patients.
	www.sciencedaily.com /releases/2001/10/011004065851.htm (1317 words)

	CiteULike: Haplotype variation in structure and expression of a gene cluster associated with a quantitative trait locus ... (Site not responding. Last check: )
		CiteULike: Haplotype variation in structure and expression of a gene cluster associated with a quantitative trait locus for improved yield in rice
		Haplotype variation in structure and expression of a gene cluster associated with a quantitative trait locus for improved yield in rice
		More importantly, the genes themselves also differed between two haplotypes: Only 92% identity was observed for one allele, and another allele was found to have completely lost its allelic counterpart in Guichao2.
	www.citeulike.org /user/bsmagic/article/777007 (607 words)

	Haplotype - Psychology Wiki - a Wikia wiki
		A haplotype, a contraction of the phrase "haploid genotype", is the genetic constitution of an individual chromosome.
		A genotype is distinct from a haplotype because an individual's genotype may not uniquely define that individual's haplotype.
		Haplotype diversity refers to the uniqueness of a particular haplotype in a given population.
	psychology.wikia.com /wiki/Haplotype (626 words)

	Whitehead Institute - Center to Build Haplotype Map
		Called a "haplotype map," this effort is expected to make it easier, faster, and perhaps cheaper to find genes that predispose us to common diseases such as diabetes and cancer.
		Haplotypes are ancestral segments of chromosomes that have been inherited together as a unit with little genetic shuffling across the generations.
		Moreover, the boundaries of these blocks and the haplotypes observed were found to be remarkably similar across populations from three continents, supporting the idea that a single ancestral population of small size gave rise to the current human population.
	www.wi.mit.edu /news/archives/2002/el_1029.html (1162 words)

	A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation ...
		This haplotype block was split into eight WI blocks, and the red and blue colors label the corresponding WI blocks in which C57BL/6J and 129S1/SvImJ were projected to have different or the same alleles in the WI study.
		The WI haplotype map was extracted from the file (http://www.broad.mit.edu/personal/claire/strainsnplist_all.xls), and the melded haplotype blocks in our study were enclosed in rectangles; those that are labeled with a gray line (i.e., a, c, e, g, h, and i) represent a split of melded haplotype blocks into multiple WI blocks.
		Of the 110 haplotypes in the laboratory inbred strains, 91 (84%)
	www.genome.org /cgi/content/full/15/2/241 (5386 words)

	BioMed Central \| Abstract \| Paraoxonase gene polymorphisms and haplotype analysis in a stroke population
		Paraoxonase gene polymorphisms and haplotype analysis in a stroke population
		Haplotype frequencies for the six loci (PON2-148, PON2-311, PON3-3, PON3-1, PON1-55 and PON1-192) were estimated.
		The 112211 (1 = frequent allele, 2 = rare allele) haplotype arrangement was commoner in cases than controls (p = 0.015), and the 111121 haplotype was commoner in controls (p = 0.006).
	www.biomedcentral.com /1471-2350/7/28/abstract (317 words)

	Sweep - Broad
		Primarily, it uses the Long Range Haplotype (LRH) test to look for alleles of high frequency with long-range linkage disequilibrium (LD), which suggest the haplotype rapidly rose to high frequency before recombination could break down associations with nearby markers (Nature 419(6909): 832-7).
		Haplotypes closer to the ancestral are at the top of the figure.
		The area of the squares is proportional to the frequency of the haplotype.
	www.broad.mit.edu /mpg/sweep (421 words)

	The Individualist: Haplotype (Site not responding. Last check: )
		As a result, the haplotypes seen outside Africa tend to be subsets of the haplotypes inside Africa.
		In addition, haplotypes in non-African populations tend to be longer than in African populations, because populations in Africa have been larger through much of our history and recombination has had more time there to break up haplotypes.
		As a result, a given haplotype can occur at different frequencies in different populations, especially when those populations are widely separated and unlikely to exchange much DNA through mating.
	www.dadamo.com /wiki/wiki.pl/Haplotype (1168 words)

	NIH Guide: LARGE-SCALE GENOTYPING FOR THE HAPLOTYPE MAP OF THE HUMAN GENOME
		The haplotype map is expected to be a key resource for finding genes affecting health, disease, and response to drugs and environmental factors, and for beginning to understand the pattern of human genetic variation.
		These data provide strong support for the idea that a human haplotype map built with samples from populations of African, Asian, and European ancestry would apply to most populations in the world, although further testing of this conclusion is needed.
		NHGRI is currently consulting with a number of advisors, including haplotype producers and users as well as the National Advisory Council for Human Genome Research, to develop policies that will ensure the timely public release of genotype and haplotype-related data produced under this initiative.
	grants.nih.gov /grants/guide/rfa-files/RFA-HG-02-005.html (6294 words)

	PAH : Phenylalanine Hydroxylase Locus Knowledgebase web site
		The apparent shortage of PAH haplotypes is explained by linkage disequilibrium across the 100 kb region of the extended haplotype.
		Codominant segregation of polymorphic PAH haplotypes, in association with the known mutant genotype, when the latter has been ascertained from a propositus, is compatible with carrier detection and prenatal diagnosis, without recourse to mutation analysis itself.
		Polymorphic haplotypes at the PAH locus can be used to study human evolution and the histories of human populations without reliance on disease-causing alleles.
	www.pahdb.mcgill.ca /?Topic=Information&Section=Haplotype&Page=0 (436 words)

	Triangulation Method for Deducing the Ancestral Haplotype in Y-DNA Surname Projects
		Unless there is an exact match at all alleles at all DYS markers in the haplotypes of the two different direct male lines of descendants, at least three haplotypes are required to triangulate and deduce the ancestral allele for each marker.
		Note: The Ancestral Haplotype cannot always be precisely deduced due to insufficient data for a particular surname project, i.e., not having enough independent direct male line descendant branches with surviving males to test.
		Triangulation can also be used for maternal lines of descent, i.e., determining the mitochondrial DNA Ancestral Haplotype of a female ancestor by triangulating with the haplotype data from direct maternal line descendants of two or more daughters of the common female ancestor.
	www.kerchner.com /deducedancestralhaplotype.htm (622 words)

	Optimal Haplotype Structure for Linkage Disequilibrium-Based Fine Mapping of Quantitative Trait Loci Using Identity by ...
		Interestingly, the LSMD for a 4-marker haplotype decreased
		The LSMD for the one-locus haplotype was significantly worse
		With a haplotype size of 1, the true QTL position was at position 5.
	www.genetics.org /cgi/content/full/172/3/1955 (5860 words)

	Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes ...
		Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes mellitus -- Kanková et al.
		Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes mellitus
		Haplotypes are ordered according to decreasing haplotype frequency in the DM + DN group, those with frequencies <1% in all three groups were pooled together as ‘others’.
	ndt.oxfordjournals.org /cgi/content/full/20/6/1093 (4652 words)

	Citations: The structure of haplotype blocks in the human genome - Gabriel, Scha, Nguyen, Moore, Roy, Blumenstiel, ...
		The sequence of alleles in contiguous SNP positions along a chromosomal region is called a haplotype.
		A major recent discovery is that haplotypes tend to be preserved along relatively long genomic stretches, with recombination occurring primarily in narrow regions called hot spots
		The regions between two neighboring hot spots are called blocks, and the number of distinct haplotypes within each block that are observed in a population is very limited: typically, some 70 90 of the haplotypes within a block belong to very few (2 5) common haplotypes [16] The remaining....
	citeseer.ist.psu.edu /context/2134746/0 (1031 words)

	Variant IRAK-1 Haplotype Is Associated With Increased Nuclear Factor- [Kappa]B Activation and Worse Outcomes in Sepsis ...
		This information on haplotype block structure can be used to identify the subset of SNPs that represent, or tag, each haplotype (haplotype tagging SNPs; htSNPs), thereby permitting determination of one SNP (532 L[arrow right]S) to define the IRAK-1 haplotypes.
		The population was in Hardy-Weinberg equilibrium for all haplotypes.
		Patients with pneumonia and the IRAK-1 variant haplotype also had a higher risk of being on the ventilator for longer periods of time, suggesting that pulmonary infection may interact with this genetic trait as a contributory risk factor for poor outcome in ALL Preexistent comorbidities, sex, and age were not independently associated with mortality.
	www.redorbit.com /news/health/551223/variant_irak1_haplotype_is_associated_with_increased_nuclear_factor_kappab/index.html?source=r_health (5481 words)

	The Effect of Haplotype-Block Definitions on Inference of Haplotype-Block Structure and htSNPs Selection -- Ding et al. ...
		Hoehe, M. Haplotypes and the systematic analysis of genetic variation in genes and genomes.
		Haplotype tagging for the identification of common diseases genes.
		Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation.
	mbe.oxfordjournals.org /cgi/content/full/22/1/148 (4165 words)

	Gene Expression: The Haplotype Map
		The haplotype project “wants to make sure it has a range of population groups” so that its results are widely applicable.
		For example, he says, if the patterns of the haplotype blocks in the populations are sufficiently different, it could be a key clue to understanding genetic factors underlying disease risks.
		But using its preliminary haplotype map, and working with several large pharmaceutical partners, Perlegen is conducting a series of tests to compare the genomes of individuals to their drug reactions.
	www.gnxp.com /MT2/archives/000789.html (6762 words)

	Haplotype frequency poser (Site not responding. Last check: )
		We know that the various loci are linked, so it would not be valid to estimate the population frequency of a haplotype by assuming the "multiplication rule" – most haplotypes figure to be more common than the product of the frequencies of the alleles at each locus.
		If I guess that every haplotype has a frequency of about 1/100, then I am guessing that almost all the men in the population are one of these 100 types.
		I think it is reasonable to guess that any particular haplotype is at least as rare as 1/5000 (and the sky's the limit).
	www.dna-view.com /haplofreq.htm (289 words)

Try your search on: Qwika (all wikis)