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Topic: Harmaline

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	Ayahuasca, Yage and Harmaline
		Harmaline is about twice as toxic as harmine in most lab animals; the half-lethal dose (half the animals die) of harmine in dogs and mice is about 200 mg./kg.
		When Naranjo gave harmaline and harmine in psychotherapeutic situations to city dwellers (people who had never been in the jungle), he observed that much of the imagery that was aroused had to do with snakes, panthers, jaguars and other large felines.
		Harmaline and harmine are both crystalline, the first appearing as yellow and the second as green hydrochloride salts.
	diseyes.lycaeum.org /fresh/encycay.htm- (7534 words)

	Erowid Online Texts : TiHKAL #13 HARMALINE
		In a capillary tube, harmaline melted at 256°C and harmadine at 257 °C.
		This is of course pharmacological nonsense in that harmaline is a pure chemical substance, whereas the seeds of the P.
		By this time the visual latency characteristic of harmaline was pronounced (when rotating the head or gazing quickly in a different direction, the prior images exit the visual field in a multiple wave fashion in a direction opposite to the motion).
	www.erowid.org /library/books_online/tihkal/tihkal13.shtml (5108 words)

	British Journal of Pharmacology - Modulation of voltage-gated channel currents by harmaline and harmane
		Harmaline and harmane (Sigma, Taufkirchen, Germany) were freshly dissolved in the respective bath solution (Table 1) at a concentration of 1 mM.
		Figure 1 illustrates the action of harmaline (a, c, e) and harmane (b, d, f) on voltage-activated calcium (a, b), sodium (c, d) and potassium channel currents (e, f) under control conditions and after a steady state of the effect had been reached.
		While harmaline reduced the current by 25% (at lower voltages) to 45% (at more depolarised voltages) (Figure 4e), the effect of harmane increased from 50% at lower to 75% at higher depolarisations (Figure 4f).
	www.nature.com /bjp/journal/v144/n1/full/0706024a.html (4195 words)

	abstract book
		Harmaline probes act as non-toxic vital stains or markers for intracellular pools of serotonin, and enable direct visualization of the cellular interactions through fluorescence microscopy and flow cytometry.
		Since tricyclic antidepressants and other classes of psychoactive drugs function through affecting serotonin neurotransmitter systems interactions, the harmaline probe would be a highly valuable tool in developing and assessing the effectiveness of novel drugs.
		Furthermore, since many disease states involve the serotonin system, the harmaline probe would also be useful in the research on the neuro-pharmacology of disease.
	www.uth.tmc.edu /otm/tech/pharm/serotonin.htm (209 words)

	[No title]
		The separation of harmaline from harmine is based on the fact that when a warm aqueous solution of the hydrochlorides is alkalinized with ammonia, harmaline is liberated only after the decomposition of harmine hydrochloride is complete.
		The appearance of harmaline is readly detected under the microscope since it consists of plates while harmine forms long needles.
		The addition of ammonia, therefore, is stopped as soon as crystals of harmaline are detected, the harmine is filtered off and the harmaline recovered from the filtrate by the addition of ammonia, The bases are then further purified by recrystallization of their hydrochlorides.
	diseyes.lycaeum.org /dmt/harmpmp.txt (1774 words)

	[No title] (Site not responding. Last check: 2007-11-03)
		Harmaline and harmine are both crystalline powders, the fromer being a yellow hydrochloride salt while the latter appears green.
		This suggests that harmaline, which differs only in the position of the methoxy group, may derive it’s activity from the mimicry of a metabolite that is normally involved in the control of states of consciousness.
		Studies have been done where harmaline and harmine were given in psychotherapeutic situations to city dwellers (those who have never been to the jungle).
	sulcus.berkeley.edu /mcb/165_001/papers/manuscripts/_632.html (2915 words)

	Abstract 8 (Site not responding. Last check: 2007-11-03)
		Harmaline (ß-carboline alkaloid)-induced tremor is considered a relevant animal model of postural or essential tremor.
		The scoring system is as follows: 0 - no tremor, 1 - discontinuous and slight tremor during movements (intentional tremor), 2 - discontinuous slight or severe tremor during both rest and movements, 3 - severe and continuous, generalized tremor during both rest and movements.
		Administration of harmaline 10 mg/kg SC induced tremors that became more intense with time, and reached their peak score 25-30 minutes later (mean score±SEM at 30 minutes 2.83±0.17).
	brain99.pet.rh.dk /scientific/abstracts/000101.html (411 words)

	A change in the pattern of activity affects the developmental regression of the Purkinje cell polyinnervation by ...
		The ratio between the amplitudes of the larger and the smaller climbing fiber-evoked EPSC increases in parallel with the decline of the polyinnervation factor, indicating a gradual enlargement of the synaptic contribution of the winning climbing fiber synapse at the expense of the losing one.
		Harmaline treatment had no later effects on the climbing fiber EPSC kinetics and I/V relation in Purkinje cells (P15-36).
		In the same period, after harmaline treatment, parallel fiber-Purkinje cell electrophysiology was unaffected.
	www.arclab.org /medlineupdates/abstract_14568018.html (368 words)

	The Ibogaine Dossier
		The indole alkaloids ibogaine and harmaline are beta-carboline derivatives that cause both hallucinations and tremor.
		Reports that ibogaine may have potent anti-addictive properties have led to initiatives that it be tested for the treatment of opiate and cocaine addiction.
		We conclude that both ibogaine and harmaline have selective neurotoxic effects which lead to degeneration of Purkinje cells in the cerebellar vermis.
	www.ibogaine.desk.nl /abstract/41.html (273 words)

	the Lycaeum - Harmaline (Site not responding. Last check: 2007-11-03)
		As psilocybin is solar and THC is lunar; harmaline is Saturnian in nature.
		I happen to have a pathologically high tolerance to many drugs, and harmaline is one of them.
		Bear in mind that harmaline can be very disruptive to sleep in general, especially high doses.
	www.lycaeum.org /drugs.old/trip.report.old/harmaline/harm15.shtml (359 words)

	Ayahuasca, Yage and Harmaline (Site not responding. Last check: 2007-11-03)
		Harmaline and other harmala alkaloids, principle psychoactive substances in the "magical" beverage yagé, appear throughout the plant world.
		This compound is more abundant in the pineal glands of highly advanced yogis, according to some reports, which has led to speculation that its presence may impart power to the "third eye" in mid-forehead, where the pineal gland lies.
		Harmaline, when taken orally by itself, takes a comparatively long time to prompt psychological effects, often about two hours.
	www.biopark.org /peru/Ayaharmaline.html (7558 words)

	Ayahuasca (Site not responding. Last check: 2007-11-03)
		Normally DMT is not active when taken orally - it has to be smoked (and there are several other snuffs and smoking mixtures in jungle sorcery that do contain only DMT).
		But it's been found that harmaline prevents the breakdown of DMT by the digestive system and allows it to enter the bloodstream when one drinks Ayahuasca.
		In Europe and the Middle East, there are also plants which contain harmaline and DMT: Syrian Rue and the Giant River Reed.
	www.deoxy.org /ayadef2.htm (447 words)

	WASHED
		I was on no medication or vitamin supplements, had gone through a regular day with no fasting or excessive meals at the end of a week during which I'd not ingested anything psychoactive.
		Fifty minutes after taking these, there was an onset of barely detectable fuzziness, not in my visual field but in my tactile field: specifically, the boundary between my body and the world around it were blurring, the sensation can be described as either absorbing the world into myself or the world absorbing me.
		It seems worth noting that Harmaline has a softening and expanding effect on LSD, and possibly others (that I haven't tried mixing it with yet).
	www.geocities.com /dxmaddicted/aya.html (979 words)

	Tryptamine Carriers FAQ (Site not responding. Last check: 2007-11-03)
		Recreational drug users around the world are using mainly harmine and harmaline despite the lack of scientific studies on their effects on humans.
		The usual 'North American ayahuasca' consists of Peganum harmala seeds and Desmanthus illinoensis roots, and in Australian 'acaciahuasca' leaves of Acacia complanata are combined with material from DMT-containing acacias (the effectivity of this mixture hasn't been confirmed).
		Harmine and harmaline are hallucinogenic on their own with doses starting from around 300 mg (Naranjo 1967), but often cause physical side-effects such as nausea and tremors in this dose range.
	userpages.umbc.edu /~jfreed1/lsdrecords/trypfaq.htm (3574 words)

	Enter the DMT Room (Site not responding. Last check: 2007-11-03)
		The DMT source was Acacia phlebophylla, the harmaline source Peganum harmala.
		This article describes the visuals seen during 3 seperate DMT sessions using ayahuasca and harmaline.
		To date, with the exception of marijuana and nitrous oxide, DMT is the only true psychedelic I have tried.
	deoxy.org /h_dmtrom.htm (2185 words)

	Ibogaine: Fantasy and Reality, The Healing Journey, Claudio Naranjo (Site not responding. Last check: 2007-11-03)
		As to physical effects, neither ibogaine nor the harmala alkaloids cause dilation of the pupils or a rise in blood pressure, is the case with the LSD-like hallucinogens or the amphetamine derivatives MDA and MMDA.
		In view of the high incidence of these symptoms, it is advisable to administer the drug when the patient has an empty stomach, and not to use more than 4 mg.
		Both ibogaine and harmaline may elicit mythical, dreamlike sequences that are contemplated with little emotional involvement, the outcome of such sessions being no different from what we might expect from exposure to a film of similar content.
	www.ibogaine.org /naranjo.html (16277 words)

	[No title] (Site not responding. Last check: 2007-11-03)
		HR> I tried this substance, assuming it was 1/3 harmaline and had nausea.
		operty of harmaline and harmine hydrochloric salt that are not soluble in=
		that harmaline and harmine are being destroyed under these conditions).
	www.puzzlepiece.org /ibogaine/121397b.html (710 words)

	Quantitation of N,N-Dimethyltryptamine and Harmala Alkaloids in ... (Site not responding. Last check: 2007-11-03)
		Harmine, harmaline, tetrahydroharmine (THH), and N,N-dimethyltryptamine (DMT) were quantitated in plasma from 15 healthy male volunteers after the ingestion of ayahuasca, a beverage that has been used for religious purposes in Brazil since pre-Columbian times.
		A growing awareness of the interest in this ancient shamanistic practice in modern urban cultures and the widespread popular dissemination of the inebriant effects and type and sources of the plant admixtures used to prepare the beverage have provided additional impetus for this study.
		Linearity was observed for harmine, harmaline, and THH within these respective ranges.
	www.jatox.com /abstracts/1996/oct/492-mash.htm (374 words)

	The Olivocerebellar Projection Mediates Ibogaine-Induced Degeneration of Purkinje Cells: A Model of Indirect, ...
		ibogaine was indistinguishable from that induced by harmaline.
		Baude A, Nusser Z, Roberts JD, Mulvihill E, McIlhinney RA, Somogyi P (1993) The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction.
		Crepel F, Dhanjal SS, Sears TA (1982) Effect of glutamate, aspartate and related derivatives on cerebellar Purkinje cell dendrites in the rat: an in vitro study.
	www.jneurosci.org /cgi/content/full/17/22/8828 (8174 words)

	harmaline - OneLook Dictionary Search
		Harmaline : Online Plain Text English Dictionary [home, info]
		harmaline : Stedman's Online Medical Dictionary, 27th Edition [home, info]
		harmaline : Dorland's Illustrated Medical Dictionary [home, info]
	www.onelook.com /?w=harmaline (125 words)

	APStracts 4:0215H, 1997. (Site not responding. Last check: 2007-11-03)
		The purpose of the present study was to examine mechanisms of activity-dependent changes of cerebral blood flow (CBF) in rat cerebellar cortex by laser-Doppler flowmetry, using two synaptic inputs that excite different regions of the same target cell, and with different synaptic strength.
		The apical part of Purkinje cells was activated by electrical stimulation of parallel fibers, while the cell soma and the proximal part of the dendritic tree was activated by climbing fibers using harmaline i.p.
		The results suggest that CBF increases elicited by activation of Purkinje cells are partially mediated by the NO-cGMP system independent of the input function, but that adenosine contributes as well when climbing fibers are activated.
	www.uth.tmc.edu /apstracts/1997/heart/May/215h.html (321 words)

	MAPS: Harmaline Neurotoxicity? (Site not responding. Last check: 2007-11-03)
		Mark Molliver of the Dept of Neuroscience and Neurology at John Hopkins University(Baltimore) has asserted that harmaline is neurotoxic for Purkinje cells in the cerebellum.
		There would appear to be no concern for people using traditional Ayahuasca given that the amount of harmaline in it is quite small.
		But those using analogues involving Syrian Rue are exposed to significantly higher amounts of harmaline.
	www.maps.org /pipermail/maps_forum/2001-July/003650.html (163 words)

	Attenuation of activity-induced increases in cerebellar blood flow by lesion of the inferior olive -- Zhang et al. 285 ...
		Effect of harmaline administration on mean arterial pressure (A) and cerebellar blood flow (BF crb
		in mice in which the response to harmaline was studied (Fig.
		Jones N, Le Marec N, Stelz T, and Caston J. Effect of administration of 3-acetylpyridine followed by niacinamide injection on survival, extent of the inferior olivary complex lesion, and response to harmaline in the young rat.
	ajpheart.physiology.org /cgi/content/full/285/3/H1177 (2553 words)

	[No title]
		Reversible MAOIs, such as moclobemide, which is used as an antidepressant, and the beta- carbolines harmine and harmaline, are effective for much shorter time, maybe up to 24 hours.
		Harmine and harmaline are hallucinogenic on their own with doses starting from around 300 mg (Naranjo 1967).
		Family: Myristicaceae Genus: Virola Species: calophylla calophylloidea rufula sebifera theiodora The bark resin of these trees is used to prepare hallucinogenic snuffs in northwestern Brazil by boiling, drying and pulverizing it.
	paranoia.lycaeum.org /psychedelics/tryptamines/FAQ-Tryptamines (3521 words)

	Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and ...
		Interestingly, harmine and harmaline, and, to a lesser
		harmaline, 1.0 ng/ml for THH, and 0.3 ng/ml for harmol and harmalol.
		Plasma concentration-time curves (n = 15) for three of the four main alkaloids present in ayahuasca (DMT, harmaline, and THH) and the O-demethylated analogs of harmine (harmol) and harmaline (harmalol).
	jpet.aspetjournals.org /cgi/content/full/306/1/73 (5500 words)

	PakMediNet - View Abstract
		In number of studies the effects of diazepam, on harmaline and other beta carboline containing compounds-induced tremors were investigated.
		The present study was undertaken to examine the effect of diazepam on pretreated animals with harmaline and its synthesized phenacyl and coumarine analogues.
		Diazepam successfully inhibited the tremor and convulsions and attenuated the other behavioural response produced by Harmaline and its derivatives.
	www.pakmedinet.com /view.php?id=4573 (221 words)

	[No title] (Site not responding. Last check: 2007-11-03)
		harmala is a rich source of both harmaline and of
		Subject's cocaine use was interrupted for a period of four months.
		750 mg of harmaline base in a split dose of 500 mg followed by 250 mg
	www.puzzlepiece.org /ibogaine/120997c.html (939 words)

	Avant Labs -> Bulk passiflora
		I understand the active ingredient in passiflora is harmaline, and that the passiflora has a very low concentration of it.
		There are companies that sell harmaline and harmala.
		Some are research chemical companies and others are Shamanic in nature.
	forum.avantlabs.com /topic12809.html (255 words)

	Attenuation of activity-induced increases in cerebellar blood flow in mice lacking neuronal nitric oxide synthase -- ...
		Effect of harmaline (20 mg/kg ip) on mean arterial pressure (A) and on BF crb
		Methods for assessment of the effect of harmaline on
		harmaline (20 mg/kg) was injected intraperitoneally, and the
	ajpheart.physiology.org /cgi/content/full/285/1/H298 (3510 words)

	Rhythmicity without Synchrony in the Electrically Uncoupled Inferior Olive -- Long et al. 22 (24): 10898 -- Journal of ...
		Many neurons in the CNS generate rhythmic, synchronized activity, using mechanisms that are poorly understood.
		B, Power spectra from force measurements in control (thick) and harmaline (thin) states; harmaline tremor is evident as a sharp, strong peak at ~14 Hz.
		C, Similar force measurements in a representative KO mouse before and after harmaline (same scale as in A).
	www.jneurosci.org /cgi/content/full/22/24/10898 (5720 words)

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