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Topic: Heat shock protein


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In the News (Tue 23 Jul 19)

  
  ScienceDaily: Heat shock protein   (Site not responding. Last check: 2007-11-05)
Heat shock proteins (HSP) are a group of proteins the expression of which is increased when the cells are exposed to elevated temperatures.
Heat shock protein -- Heat shock proteins (HSP) are a group of proteins the expression of which is increased when the cells are exposed to elevated...
Protein folding -- Protein folding is the process by which a protein structure assumes its functional shape or conformation.
www.sciencedaily.com /encyclopedia/Heat_shock_protein   (1384 words)

  
  Heat shock protein -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-11-05)
Consequently, the heat shock proteins are also referred to as stress proteins and their upregulation is sometimes described more generally as part of the stress response.
Heat shock proteins are molecular (One who accompanies and supervises a young woman or gatherings of young people) chaperones for protein molecules.
Some physicians are conducting research on using heat shock proteins in the treatment of (Type genus of the family Cancridae) cancer.
www.absoluteastronomy.com /encyclopedia/h/he/heat_shock_protein.htm   (630 words)

  
 Heat shock proteins: basics   (Site not responding. Last check: 2007-11-05)
Heat shock proteins (HSPs), also called stress proteins, are a group of proteins that are present in all cells in all life forms.
Heat shock proteins are also believed to play a role in the presentation of pieces of proteins (or peptides) on the cell surface to help the immune system recognize diseased cells.
Heat shock proteins trigger immune response through activities that occur both inside the cell (intracellular) and outside the cell (extracellular).
www.antigenics.com /products/tech/hsp   (829 words)

  
 Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.
Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.
To identify proteins that may act as protectors from CAV, a global proteomic approach was used comparing cardiac biopsies from 12 patients taken within the first 2 weeks after transplant and those taken after 9 years from the same patient.
A particular protein spot was found in 4/6 biopsies from patients without CAV, but absent from 5/6 biopsies from those with CAV (P=0.24); however, quantitative analysis of spot intensity showed a significant difference (0.061+/-0.05 versus 0.003+/-0.01, P=0.04).
hearttransplant.researchtoday.net /archive/1/7/146.htm   (380 words)

  
 Morimoto Publications   (Site not responding. Last check: 2007-11-05)
Role of the heat shock response and molecular chaperones in oncogenesis and cell death.
Mathew A, Mathur SK, Morimoto RI Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin- proteasome pathway Mol Cell Biol:18(9):5091-8, 1998.
Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures.
www.biochem.northwestern.edu /ibis/morimoto/morimoto_publications.html   (2574 words)

  
 Heat-shock protein - Open Encyclopedia   (Site not responding. Last check: 2007-11-05)
Heat-shock proteins (otherwise known as HSPs or stress proteins) are created when cells are exposed to elevated temperatures, or to other kinds of environmental stress, such as ethanol, ultraviolet light, trace metals, or oxygen deprivation.
These activities are part of a cell's own repair system, called the "cellular stress response" or the "heat-shock response." The function of heat-shock proteins is similar in virtually all living organisms, from bacteria to humans.
Heat-shock proteins are of potential interest to cancer researchers, based on research that has shown that animals may respond to cancer "vaccinations." Tumor cells were "attenuated" (or weakened) and injected in small quantities into a rodent, causing the rodent to become immune to future full-fledged tumor-cell injections.
open-encyclopedia.com /Heatshock_protein   (311 words)

  
 Heat Shock Antigen Cancer Vaccine
ITL's heat shock antigen vaccine (HSAV) is an investigational personalized vaccine designed to treat the immune systems of people with cancer while minimizing side effects.
The HSAV is made from individual patients' tumors and heat shock proteins produced by the patients' own white blood cells.
Using a proprietary process, heat shock proteins from the white blood cells are purified and combined with purified antigens from the tumor.
www.immunemedicine.com /heat-shock-protein-therapy.asp   (349 words)

  
 Polymorphism and intracellular self/not-self discrimination
Thus, polymorphism of intracellular proteins should be of adaptive value serving to amplify and individualise the immune response to intracellular pathogens.
A viral protein (A) can be considered in the same way as a mutant oncogene, so that host proteins B, C and D would be recruited into the antigenic repertoire of the infected cell.
Furthermore, the recruitment of only one host protein should suffice to trigger an antiviral response in that host, while, because of polymorphism, the same protein might not be recruited in a subsequent host (which might present peptides from another polymorphic protein).
post.queensu.ca /~forsdyke/theorimm2.htm   (5288 words)

  
 heat capacity on Encyclopedia.com
or thermal capacity, ratio of the change in heat energy of a unit mass of a substance to the change in temperature of the substance; like its melting point or boiling point, the heat capacity is a characteristic of a substance.
The measurement of heat and heat capacity is called calorimetry.
In the metric system, heat capacity is often expressed in units of calories per gram per degree Celsius (cal/g-°C); in the English system, British thermal units per pound per degree Fahrenheit (Btu/lb-°F) are often used.
www.encyclopedia.com /html/h1/heatcapa.asp   (399 words)

  
 [No title]
A family of heat shock proteins, the hsp70 proteins have an average molecular weight of 70 kDa [1, 2, 3].
Some evidence suggests that the constitutive members have a role in the disassembly of clathrin cages [4], and may also participate in the post-translational transmembrane targetting of proteins to cellular organelles.
Flaherty K.M. McKay D.B. Kabsch W. Holmes K.C. Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.
www.ebi.ac.uk /interpro/IEntry?ac=IPR001023   (593 words)

  
 Sloan-Kettering - Heat-Shock Protein 90
Heat-shock protein 90 (HSP90) is a cellular chaperone protein required for the activation of several eukaryotic protein kinases, including the cyclin-dependent kinase CDK4.
Geldanamycin, an inhibitor of the protein-refolding activity of Hsp90, has been shown to have antiproliferative and antitumor activities.
Geldanamycin (in yellow) binds HSP90 (in cyan, interacting side chains in red) in a well-defined deep pocket lined by residues conserved across different species expressing HSP90.
www.mskcc.org /mskcc/html/10853.cfm   (84 words)

  
 Longevity: Essential Concepts -Taking the LONG View
This was generalized into a theory that some aging is caused when sugar chemically combines with proteins and other bodily chemicals.
Breaker medication to remove glycosylated (sugar-damaged) proteins and to restore elasticity to the organs, especially the heart.
A chain of three CoQ10 molecules marks a protein as "old" and allows cellular digestive enzymes to attach to it and cleave it.
longevity.essential-facts.com   (3551 words)

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