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Topic: Hematological malignancies

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Aspergillus/Aspergillosis website 78 patients with hematological malignancies, 39 with inborn errors of metabolism, 3 with immunological deficiencies, and 2 patients with solid tumors. This assay has been evaluated with serum mainly from patients receiving treatment for hematological malignancies and although the specificity of the LA-test was high, substantial variation in sensitivity was observed (Table 1) (1,6-12). The LA-test was found positive in only 12% of serum samples from patients with hematological malignancies on the day the diagnosis of invasive pulmonary aspergillosis was made (20). www.aspergillus.man.ac.uk /secure/diagnosis/verweij.html   (1870 words)

Final Report, Leukemia, Lymphoma, and Myeloma, Progress Review Groups (PRGS), Office of Science Planning and Assessment (OSPA), National Cancer Institute (NCI Hematological malignancies are an especially diverse group of cancers because nearly every stage of development of blood cells gives rise to a distinct type of cancer. Hematological malignancies serve as a model system for the discovery and development of targeted therapies. These technologies are being separately applied to individual hematological cancers, but what is needed in the future is to study the same tumor specimens with all of these technologies in parallel and integrate the results to achieve a molecular portrait of each hematological cancer. prg.nci.nih.gov /llm/finalreport.html   (1870 words)

Hematological malignancy - Wikipedia, the free encyclopedia Hematological malignancies are the types of cancer that affect blood, bone marrow and lymph nodes. Although hematological malignancies are a form of cancer, they are generally treated by specialists in hematology, although in many hospitals oncology specialists also manage these diseases. This leads to a different approach in diagnosis and treatment of hematological malignancies. en.wikipedia.org /wiki/Hematological_malignancy   (404 words)

Cancer - Wikipedia, the free encyclopedia Hematological malignancies, such as leukemia and lymphoma, arise from blood and bone marrow. A cancer may be suspected for a variety of reasons, but the definitive diagnosis of most malignancies must be confirmed by microscopic examination of the cancerous cells by a pathologist. Prolonged exposure to radiation, particularly ultraviolet radiation from the sun, leads to melanoma and other skin malignancies. en.wikipedia.org /wiki/Cancer   (5818 words)

Professor Waldmann's Publications Clark, M., Bolt, S., Tunnacliffe, A. Waldmann, H. Use of bispecific monoclonal antibodies to treat hematological malignancies: a model system using CD3 transgenic mice. Dyer, M.J.S., Hale, G., Hayhoe, F.G.J. Waldmann, H. Effects of CAMPATH-1 Antibodies in vivo in Patients with Lymphoid Malignancies: Influence of Antibody Isotype. Hale G, Slavin S, Goldman JM, Mackinnon S, Giralt S, Waldmann H. Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning? users.path.ox.ac.uk /~scobbold/tig/hwcv.html   (10173 words)

Encyclopedia: Anemia Although hematological malignancies are a form of cancer, they are generally treated by specialists in hematology, although in many hospitals oncology specialists also manage these diseases. Leukemia (leukaemia in Commonwealth English) is a group of blood diseases characterized by malignancies (cancer) of the blood-forming tissues. Acute lymphocytic leukaemia (ALL), also known as acute lymphoblastic leukaemia is a cancer of the white blood cells, characterised by the overproduction and continuous multiplication of malignant and immature white blood cells (referred to as lymphoblasts) in the bone marrow. www.nationmaster.com /encyclopedia/Anemia   (4460 words)

Genes at Work - Lab Testing Chromosomal abnormalities in hematological malignancies are strongly correlated with tumor type and may play a role in earliest stages of tumor initiation. In the clinical setting, cytogenetic analysis has proven to be an invaluable tool in the diagnosis, prognosis, and management of hematologic malignancies. In some chronic hematologic disorders, longer incubation or short term stimulation with PHA or other mitogen may be required. www.umdnj.edu /genesatwork/labtesting/27_nonrandom.html   (568 words)

Title page for etd-0909104-145326 Conclusion: although our study is a primary result, study cases are varied, but it still provide important information that VEGF has an important role in hematological malignancies. The purposes of this study are to assay the VEGF activity and its correlation with disease prognosis in various hematological disorders; and to detect the VEGF autocrine activity of tumor cells in sequential culture without any stimulation in vitro. We will process further research of single and specific disease in the future to analyze the exact correlation of VEGF and hematological diseases. etd.lib.nsysu.edu.tw /ETD-db/ETD-search/view_etd?URN=etd-0909104-145326   (407 words)

Listeriosis in hematological malignancies: report of two cases. Listeriosis occurred in two patients with hematological malignancies, one with adult T-cell leukemia (ATL) (Case 1) and the other with chronic granulocytic leukemia (CGL) (Case 2). Listeriosis in hematological malignancies: report of two cases. In Case 1, listeriosis was the initial manifestation of ATL, while it occurred in Case 2 after prolonged treatment with an alkylating agent and splenic irradiation. www.aegis.com /aidsline/1989/sep/M8990458.html   (349 words)

Clinically Useful Information Provided by the Flow Cytometric Immunophenotyping of Hematological Malignancies: Current Status and Future Directions -- Orfao et al. 45 (10): 1708 -- Clinical Chemistry of hematological malignancies is not analyzed in depth. by the flow cytometric immunophenotyping of hematological malignancies, Leukaemias with megakaryoblastic involvement: clinical, hematological and immunological characteristics. www.clinchem.org /cgi/content/full/45/10/1708   (6845 words)

Medical Image Databases on the Internet The first installment of this fully searchable directory features more than 800 hematological slides depicting various blood disorders and malignancies. Note from Publisher: Any material found on our site may be downloaded or copied for the personal, noncommercial use of the visitors to our site, or for noncommercial (not-for-profit) educational purposes, provided that all copies bear any copyright, trademark, or other notice posted on the site that is applicable to the copied information. www.library.uthscsa.edu /internet/ImageDatabases.cfm   (6845 words)

Virginia Commonwealth University Health System, MCV Hospitals and Physicians: Services & Programs They work closely together, using the very latest methods for prevention, diagnosis, and treatment of a variety of hematological malignancies including leukemia, lymphoma, and multiple myeloma. By working together and pooling their expertise, Hematological Malignancy Clinic doctors are able to make the best decisions and give you the most comprehensive advice and information. Any additional tests will be scheduled and reviewed promptly and you will be contacted by one of the Hematological Malignancy specialists as soon as all of the results are available. www.vcuhealth.org /program-details.asp?programID=46   (6845 words)

Phase I Study of Oral Topotecan in Hematological Malignancies -- Beran et al. 9 (11): 4084 -- Clinical Cancer Research Beran M., Cortes J. E., O’Brien S., Thomas D. A., Onida F., Estey E. Phase I study of prolonged administration of oral topotecan in hematological malignancies. MTD in patients with myeloid hematological malignancies is approximately Hematological toxicity was noted in all 26 patients and with clincancerres.aacrjournals.org /cgi/content/full/9/11/4084   (6845 words)

Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies -- Ravandi et al. 9 (2): 535 -- Clinical Cancer Research Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies -- Ravandi et al. Scheijen B., Griffin J. Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease. truly realize the concept of targeted therapy in treating hematological clincancerres.aacrjournals.org /cgi/content/full/9/2/535   (6845 words)

Baseline and Early Treatment Factors are not Clinically Useful for Predicting Individual Response to Erythropoietin in Anemic Cancer Patients -- Littlewood et al. 8 (1): 99 -- The Oncologist Erythropoietin treatment for chronic anemia of selected hematological malignancies and solid tumours. Effects of epoetin alfa on hematological parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial. Beguin Y. A risk-benefit assessment of epoetin in the management of anemia associated with cancer. theoncologist.alphamedpress.org /cgi/content/full/8/1/99   (6845 words)

Physical performance, depression, immune status and fatigue in patients with hematological malignancies after treatment -- Dimeo et al. 15 (8): 1237 -- Annals of Oncology Physical performance, depression, immune status and fatigue in patients with hematological malignancies after treatment -- Dimeo et al. Physical performance, depression, immune status and fatigue in patients with hematological malignancies after treatment Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial. annonc.oupjournals.org /cgi/content/full/15/8/1237   (6845 words)

Mutations of the E2F4 gene in hematological malignancies having microsatellite instability -- Komatsu et al. 95 (4): 1509 -- Blood In this study, we analyzed 24 hematological malignancies having The present study has found for the first time that mutations within the important cell cycle gene E2F4 were present in hematological Department of Internal Medicine, Kochi Medical School, Nankoku, Japan; Department of Internal Medicine, Kagawa Prefectural Central Hospital, Takamatsu, Japan; School of Medicine, Nihon University, Tokyo, Japan; Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA; and the Institute of Human Genetics, University of Heidelberg, Heidelberg, FRG. www.bloodjournal.org /cgi/content/full/95/4/1509   (6845 words)

Clinically Useful Information Provided by the Flow Cytometric Immunophenotyping of Hematological Malignancies: Current Status and Future Directions -- Orfao et al. 45 (10): 1708 -- Clinical Chemistry Clinically Useful Information Provided by the Flow Cytometric Immunophenotyping of Hematological Malignancies: Current Status and Future Directions -- Orfao et al. Recent advances in flow cytometry: applications to the diagnosis of hematologic malignancy. U.S.-Canadian consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: medical indications. www.clinchem.org /cgi/content/full/45/10/1708   (6845 words)

Mechanisms of Glucocorticoid-mediated Apoptosis in Hematological Malignancies -- Greenstein et al. 8 (6): 1681 -- Clinical Cancer Research Mechanisms of Glucocorticoid-mediated Apoptosis in Hematological Malignancies -- Greenstein et al. is required for apoptosis, because hematological cell lines sensitivity of several hematological malignant cell lines is clincancerres.aacrjournals.org /cgi/content/full/8/6/1681   (6845 words)

The Epithelial Tumor Antigen MUC1 Is Expressed in Hematological Malignancies and Is Recognized by MUC1-specific Cytotoxic T-Lymphocytes -- Brossart et al. 61 (18): 6846 -- Cancer Research The Epithelial Tumor Antigen MUC1 Is Expressed in Hematological Malignancies and Is Recognized by MUC1-specific Cytotoxic T-Lymphocytes -- Brossart et al. Table 1 Expression of MUC-1 (BM-2) on primary malignant cells from patients with various hematological malignancies Jurcic J. G., Cathcart K., Pinilla-Ibarz J., Scheinberg D. Advances in immunotherapy of hematologic malignancies: cellular and humoral approaches. cancerres.aacrjournals.org /cgi/content/full/61/18/6846   (6845 words)

A Homozygous Germ-Line Mutation in the Human MSH2 Gene Predisposes to Hematological Malignancy and Multiple Cafe-au-Lait Spots -- Whiteside et al. 62 (2): 359 -- Cancer Research Ricciardone M. celik T., Cevher B., Ozdag H., Tuncer M., Gurgey A., Uzunalimoglu O., Cetinkaya H., Tanyeli A., Erken E., Ozturk M. Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type 1. A Homozygous Germ-Line Mutation in the Human MSH2 Gene Predisposes to Hematological Malignancy and Multiple Cafe-au-Lait Spots -- Whiteside et al. Robledo M., Martinez B., Arranz E., Trujillo M. J., Gonzalez Ageitos A., Rivas C., Benitez J. Genetic instability of microsatellites in hematological neoplasms. cancerres.aacrjournals.org /cgi/content/full/62/2/359   (6845 words)

Hematopoietic Cell Transplantation for Benign Hematological Disorders and Solid Tumors -- Storb et al. 2003 (1): 372 -- Hematology effects seen in patients given HCT for hematological malignancies Hematopoietic Cell Transplantation for Benign Hematological Disorders and Solid Tumors -- Storb et al. will update the status of HCT in the treatment of benign hematological www.asheducationbook.org /cgi/content/full/2003/1/372   (6845 words)

Molecular genetic biomarkers in hematological malignancies. Most hematopoietic malignancies are widely disseminated even in their "early" stages and often do not have a well-defined localized phase. Here, we outline the biological basis for the application of biomarkers for the early detection of hematological neoplasia. Accordingly, these clinical settings might prove to be good models for evaluating molecular cancer risk markers and the possible introduction of chemoprevention. www.aegis.com /aidsline/1997/jun/M9760506.html   (392 words)

Hematological Malignancies, University of Minnesota Cancer Center Hematologic malignancies are cancers of the body's blood-forming and immune systems---the bone marrow and lymphatic tissues. The hematological malignancy multidisciplinary program is actively engaged in both national and regional clinical trials for hematological malignant tumors. You may search the Cancer Center's clinical trial database to find a current list of trials for lymphoma, myeloma, and leukemia, or contact our program coordinators. www.cancer.umn.edu /page/clinical/hemato.html   (1990 words)

Multiple Myeloma Treatment - Multiple Myeloma symptoms. Multiple myeloma (MM) is one of several diseases that have been collectively termed "plasma cell dyscrasias" and accounts for 10% of all hematological malignancies. Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia. The immune system is composed of several types of cells that work together to fight off infection and other disease. clikngo.com /medical/HM008.HTM   (684 words)

Expression in Hematological Malignancies of a Glucocorticoid Receptor Splice Variant That Augments Glucocorticoid Receptor-mediated Effects in Transfected Cells -- de Lange et al. 61 (10): 3937 -- Cancer Research Genetic abnormalities of the GR are not a common cause of GC resistance in hematological malignancies. Expression in Hematological Malignancies of a Glucocorticoid Receptor Splice Variant That Augments Glucocorticoid Receptor-mediated Effects in Transfected Cells -- de Lange et al. The cause of GC resistance in hematological malignancies is cancerres.aacrjournals.org /cgi/content/full/61/10/3937   (4122 words)

UPCI 02-03 sci. rpt. hematological malignancies overview The Hematological Malignancies Program of the University of Pittsburgh Cancer Institute investigates the mechanisms involved with the onset and progress of blood disorders, and also studies novel methods by which these processes can be altered. Accordingly, much of the program's research is focused on the genetic and cellular origins of leukemia, lymphoma and myeloproliferative disorders, as well as the development of agents used in treating hematologic malignancies. The program intends their work to ultimately produce innovative and effective treatment methods for combating blood cancers. www.upci.upmc.edu /report/Clinical/hema   (143 words)

The Epithelial Tumor Antigen MUC1 Is Expressed in Hematological Malignancies and Is Recognized by MUC1-specific Cytotoxic T-Lymphocytes -- Brossart et al. 61 (18): 6846 -- Cancer Research The Epithelial Tumor Antigen MUC1 Is Expressed in Hematological Malignancies and Is Recognized by MUC1-specific Cytotoxic T-Lymphocytes -- Brossart et al. The Epithelial Tumor Antigen MUC1 Is Expressed in Hematological Malignancies and Is Recognized by MUC1-specific Cytotoxic T-Lymphocytes malignancies that could potentially be used for immunotherapeutic cancerres.aacrjournals.org /cgi/content/abstract/61/18/6846   (843 words)

Phase I Study of Oral Topotecan in Hematological Malignancies -- Beran et al. 9 (11): 4084 -- Clinical Cancer Research Phase I Study of Oral Topotecan in Hematological Malignancies -- Beran et al. (MTD) of oral topotecan in patients with hematological malignancies. Phase I Study of Oral Topotecan in Hematological Malignancies clincancerres.aacrjournals.org /cgi/content/abstract/9/11/4084   (355 words)

A NOVEL VACCINE FOR HEMATOLOGICAL MALIGNANCIES USING DENDRITIC CELLS Allogeneic stem cell transplantation has a significant contribution to the improved outcome of patients with hematological malignancies. Such specific anti-leukemic donor CTLs may be utilized to maximize the anti-tumor effects of DLI in patients relapsing after allogeneic transplantation. Nevertheless, a significant proportion of patients suffer from recurrence of the disease, which ultimately leads to death. www.celltherapy.org /Abstracts2004/Abstracts/080.htm   (244 words)

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