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Topic: Hematopoietic

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  Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse.   (Site not responding. Last check: 2007-09-11)
Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse.
This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation.
These data indicate that 1) ERalpha is not necessary for regulating male mouse normal hematopoietic progenitor cell proportions, but is involved in B cell regulation; and 2) ERalpha in hematopoietic elements is predominantly responsible for mediating E2-induced hematopoietic and B cell changes.
www.arclab.org /medlineupdates/abstract_10875230.html   (259 words)

 5. Hematopoietic Stem Cells [Stem Cell Information]
Hematopoietic stem cell transplants are now routinely used to treat patients with cancers and other disorders of the blood and immune systems.
A hematopoietic stem cell is a cell isolated from the blood or bone marrow that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood, and can undergo programmed cell death, called apoptosis—a process by which cells that are detrimental or unneeded self-destruct.
As sketchy as data may be on the hematopoietic powers of human ES and EG cells, blood experts are intrigued by their clinical potential and their potential to answer basic questions on renewal and differentiation of HSCs [19].
stemcells.nih.gov /info/scireport/chapter5.asp   (9750 words)

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Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells.
Hematopoietic and immune recovery after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation in a pediatric population.
Hematopoietic progenitor cells derived from embryonic stem cells: analysis of gene expression.
www.hair-loss-stop.com /ref-stem-cell/stem-cell-refs.html   (10160 words)

 Telomeres in hematopoietic stem cells.
Hematopoietic stem cells have an impressive regenerative potential, strikingly illustrated in transplantation experiments using limited number of cells.
In mice, serial transplantation experiments suggest that individual hematopoietic cells are capable of extensive self-renewal and that any possible limitations in the replicative potential of individual hematopoietic stem cells are not affecting normal blood cell formation.
Telomere length measurements appear useful to distinguish between depletion and exhaustion of hematopoietic stem cells as a cause of marrow failure.
www.arclab.org /medlineupdates/abstract_12799281.html   (265 words)

 Cytokine Regulation During Embryonic Hematopoiesis   (Site not responding. Last check: 2007-09-11)
hematopoietic cells is associated with the ventral floor of the aorta.
hematopoietic cell population in fetal liver and bone marrow, is mainly concentrated within the ventral stromal region underlying the hematopoietic clusters.
In the hematopoietic system, clues as to the factors that regulate HSC generation and development during embryogenesis are beginning to emerge and the use of new technologies, such as gene chip expression analysis, will increase our understanding of how pluripotency and self-renewal are maintained in these fascinating cells.
www.rndsystems.com /asp/g_sitebuilder.asp?bodyId=467   (3253 words)

 Recent Publications   (Site not responding. Last check: 2007-09-11)
An expansion phase precedes terminal erythroid differentiation of hematopoietic progenitor cells from cord blood in vitro and is associated with up-regulation of cyclin E and CDK2.
CCR7 and CXCR3 ligand SLC/Exodus 2/6 Ckine induces chemotaxis of hematopoietic progenitor cells: Differential activity of ligands of CCR7, CXCR3, or CXCR4 in chemotaxis/actin polymerization vs. suppression of progenitor proliferation.
Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GROb.
www.iupui.edu /~woc/Recent_Publications/recent_publications.html   (9897 words)

 Modeling pO2 Distributions in the Bone Marrow Hematopoietic Compartment. I. Krogh's Model -- Chow et al. 81 (2): 675 -- ...
Hematopoietic cells are closely packed in the marrow with the interstitial space filled with extracellular matrix.
Lichtman, M. The relationship of stromal cells to hematopoietic cells in marrow.
Weiss, L. The hematopoietic microenvironment of the bone marrow: an ultrastructural study of the stroma in rats.
www.biophysj.org /cgi/content/full/81/2/675   (3730 words)

It is of particular importance to characterize cellular and molecular mechanisms that lead to the capacity of adult stem cells with hematopoietic potential to express other potentials and precursor cells of adult non-hematopoietic tissues to express hematopoietic potential.
However, studies which focus on stem cell expansion or differentiation within a given tissue (e.g., hematopoietic stem cell expansion with cytokines, signals required for differentiation of neurons from neuronal stem cells) are not responsive.
Studies which focus on stem cell expansion or differentiation within a given tissue (e.g., hematopoietic stem cell expansion with cytokines, signals required for differentiation of neurons from neuronal stem cells) are not responsive to this RFA.
grants.nih.gov /grants/guide/rfa-files/RFA-HL-01-007.html   (3897 words)

 Hematopoietic stem cells Transplantation. - Medicine - What's Been Published
Hematopoietic stem cell transplantation [electronic resource] / edited by Anthony D. Ho, Rainer Haas, Richard E. Champlin.
Hematopoietic cell transplantation / edited by E. Donnall Thomas, Karl G. Blume, Stepehn J. Forman.
Hematopoietic stem cell transplantation / edited by Anthony D. Ho, Rainer Haas, Richard E. Champlin.
www.pitbossannie.com /rps-r-hematopoietic-stem-cells-transplantation.html   (321 words)

 Pathology and Microbiology
Although G-CSF has significant hematopoietic stimulating ability, recent data suggest that G-CSF drives the recovering immune system to a T helper 2 (TH2) type of response, which may be counterproductive for preventing disease relapse.
Cytokines such as IL-12 and FLT/3L are being used in combination with G-CSF to mobilize hematopoietic stem cells and immune cells, to reconstitute both the hematopoietic and immune systems of high dose therapy recipients and to exhibit anti-tumor activity in vivo.
We are examining the potential of hematopoietic stem cells to differentiate into brain, liver and lung cells as well as characterizing stem cell populations from these tissues.
www.unmc.edu /Pathology/facultypages/jacksonbio.htm   (613 words)

 : The AMEDEO Literature Guide
Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established.
Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo.
YOON D, Watowich SS Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway.
www.amedeo.com /medicine/stc/exph.htm   (3453 words)

 BioMed Central | Full text | Fanconi anemia genes are highly expressed in primitive CD34+hematopoietic cells
Since the hematopoietic defect in Fanconi anemia is thought to reside in the stem cell compartment [17], we sought to determine the expression profile of FA genes in murine hematopoietic stem and progenitor cells.
Taken together, these results suggest that Fanc genes are differently regulated in hematopoietic stem cells and suggest that each FA proteins may act separately from the FA complex during hematopoiesis similarly to what has been suggested for MMC sensitivity and cytokine signaling [26-29].
Our results showing increased Fanca and Fancc expression in primitive hematopoietic stem cells and reduced levels in differentiated BM cells are consistent with previous studies showing Fanca and Fancc expression in cells of mesenchymal origin that give rise to hematopoietic tissues during mouse development [30].
www.biomedcentral.com /1471-2326/3/1   (4077 words)

 FTC Staff Advisory Opinion - Foundation for the Accredititation of Hematopoietic Cell Therapy
According to your letter, hematopoietic progenitor cell therapy refers generally to the infusion into a patient of blood-forming stem cells for the treatment of leukemia, certain other kinds of cancers, and some non-cancerous blood disorders.
FAHCT states that its accreditation program is intended to address concerns about the safety and quality of hematopoietic progenitor cell therapy that have arisen as the science and technology of this therapy have developed and the number of facilities performing stem cell transplants has increased.
Providing information about the quality and services of hematopoietic progenitor cell transplant services providers is potentially beneficial to consumers, and the standards do not appear, on their face, unduly to restrict competition among accredited entities in ways not reasonably related to FAHCT's legitimate purposes in establishing the standards.
www.ftc.gov /bc/adops/fahctlet.htm   (2388 words)

 Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal ...   (Site not responding. Last check: 2007-09-11)
Proliferation, differentiation, and self-renewal of hematopoietic bone marrow cells are strictly regulated and complex processes.
Influence of hematopoietic organ stroma (hematopoietic inductive microenvironments) on stem cell differentiation.
Cotinine (a metabolite of nicotine) suppresses the growth of hematopoietic progenitor cells at the concentration range equivalent to its serum levels in smokers.
www.bloodjournal.org /cgi/content/full/98/2/303   (5705 words)

 Hematopoietic Progenitor Cells Derived from Embryonic Stem Cells: Analysis of Gene Expression -- Lu et al. 20 (5): 428 ...
Hematopoietic Progenitor Cells Derived from Embryonic Stem Cells: Analysis of Gene Expression -- Lu et al.
Hematopoietic colony-forming cells derived from human embryonic stem cells.
Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors.
stemcells.alphamedpress.org /cgi/content/full/20/5/428   (3734 words)

 StemCell :: products & services :: Proficiency Testing & Training   (Site not responding. Last check: 2007-09-11)
The availability of reproducible and quantitative in vitro assays for various hematopoietic progenitor cells has been a powerful tool for investigating both normal and abnormal hematopoiesis.
In order to achieve a highly reproducible environment, conditions such as temperature, humidity, incubation time, cell processing and plating concentration must be optimized for consistent analysis of colony growth and morphology.
Identification and quantification of these hematopoietic progenitor cells are major issues for standardizing colony assays.
www.stemcell.com /product_catalog/pttraining.asp?pm=1   (251 words)

 Stem Cell Transplantation (Cord Blood Transplants) -- Chao et al. 2004 (1): 354 -- Hematology
Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling.
Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors.
Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.
www.asheducationbook.org /cgi/content/full/2004/1/354   (8951 words)

 Variant Forms of alpha -Fetoprotein Transcripts Expressed in Human Hematopoietic Progenitors. IMPLICATIONS FOR THEIR ...
Hematopoietic stem cells have been identified as multipotent cells that give rise to all adult hematopoietic lineages.
the hematopoietic lineage is derived from the mesodermal germ
At present, apart from the hematopoietic organs, the brain is the only tissue where vAFP expression is observed.
www.jbc.org /cgi/content/full/277/31/27629   (4947 words)

 Optimizing hematopoietic stem cell engraftment: a novel role for thrombopoietin -- Verfaillie 110 (3): 303 -- Journal ...
Hematopoietic stem cells (HSC) and progenitors are commonly
Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor.
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells.
www.jci.org /cgi/content/full/110/3/303   (1433 words)

 Modeling pO2 Distributions in the Bone Marrow Hematopoietic Compartment. II. Modified Kroghian Models -- Chow et al. 81 ...
Hematopoietic cells of various lineages are organized in distinct cellular architectures in the bone marrow hematopoietic
In the multilayer model the extravascular hematopoietic tissue is divided into separate cell layers surrounding a sinus (Fig.
The influence of oxygen tension on the long-term growth in vitro of hematopoietic progenitor cells from human cord blood.
www.biophysj.org /cgi/content/full/81/2/685   (3665 words)

 The power of stem cells reconsidered? -- Lemischka 96 (25): 14193 -- Proceedings of the National Academy of Sciences   (Site not responding. Last check: 2007-09-11)
Hematopoietic activity in the cultured cell population was measured
source of hematopoietic stem cell activity (22, 23).
It is quite clear that the cultured cell population possesses striking hematopoietic activity; however, the biological significance
www.pnas.org /cgi/content/full/96/25/14193   (2769 words)

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