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Topic: Hemochromatosis

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	Hemochromatosis - Genetics Home Reference
		Hemochromatosis is classified by type depending on the age of onset and other factors such as genetic cause and mode of inheritance.
		Mutations in the HAMP, HFE, HFE2, SLC40A1, and TFR2 genes cause hemochromatosis.
		Type 1 hemochromatosis is caused by mutations in the HFE gene, and type 2 hemochromatosis is caused by mutations in either the HFE2 or HAMP gene.
	ghr.nlm.nih.gov /condition=hemochromatosis (908 words)

	What is Hemochromatosis? - American Diabetes Association
		Hereditary hemochromatosis is the most common of several "iron overload" diseases, which are characterized by an excess accumulation of iron in the body.
		In the case of hemochromatosis, a single gene mutation causes extra iron to be absorbed from food in the intestine, and the body lacks an efficient means of excreting the excess iron it takes in.
		In the case of hemochromatosis, it is believed that a single individual in Europe, 60 to 70 generations ago, was the sole origin of most of the hemochromatosis seen in the world today.
	www.diabetes.org /type-1-diabetes/hemochromatosis.jsp (1271 words)

	Hemochromatosis-Blood Diseases & Disorders
		Hemochromatosis is a genetic disease, often most prevalent among people of northern European descent.
		Once parents have had a child with hemochromatosis, there is a one in four, or 25 percent, chance with each future pregnancy for another child to be born with hemochromatosis.
		Hemochromatosis is usually discovered during a medical examination through a routine blood test.
	www.umm.edu /blood/hemachro.htm (461 words)

	Hemochromatosis
		Hemochromatosis, the most common form of iron overload disease, is an inherited disorder that causes the body to absorb and store too much iron.
		Juvenile hemochromatosis and neonatal hemochromatosis are two forms of the disease that are not caused by an HFE defect.
		Hemochromatosis is usually treated by a specialist in liver disorders and digestive disorders (gastroenterologist).
	www.drvergilio.com /hemochromatosis.htm (1431 words)

	Hemochromatosis \| AHealthyMe.com
		Hemochromatosis is an inherited blood disorder that causes the body to retain excessive amounts of iron.
		Hemochromatosis is also known as iron overload, bronze diabetes, hereditary hemochromatosis and familial hemochromatosis.
		Hemochromatosis is so common, however, that families are seen in which both parents are affected, or one parent is affected and the other parent is a carrier.
	www.ahealthyme.com /article/gale/100084675 (1716 words)

	Hemochromatosis (Site not responding. Last check: 2007-10-19)
		Hemochromatosis is the #1 genetic killer in the U.S., affecting nearly two million Americans, yet most victims are unaware that they have it.
		Hemochromatosis is an inherited disorder of the small intestine that causes a person to absorb too much iron from their food.
		The Hemochromatosis Foundation is a nonprofit organization that has worked for nearly twenty years to improve the lives of people with hemochromatosis.
	members.aol.com /ThreePeb/hemochromatosis.html (246 words)

	Hemochromatosis for Health Care Pros: Course Summary \| CDC (Site not responding. Last check: 2007-10-19)
		The disease, hemochromatosis, a disorder of iron metabolism, occurs as a result of excess iron accumulation in tissues and organs.
		Hemochromatosis is a disease that occurs as a result of significant iron overload.
		Encouraging hemochromatosis patients to urge family members to have biochemical tests for iron overload, (fasting transferring saturation and serum ferritin), is an important disease prevention opportunity.
	origin.cdc.gov /hemochromatosis/training/course_summary (1186 words)

	Hemochromatosis (Site not responding. Last check: 2007-10-19)
		Juvenile hemochromatosis leads to severe iron overload and liver and heart disease in adolescents and young adults between the ages of 15 and 30.
		Hemochromatosis is considered rare and doctors may not think to test for it.
		Hemochromatosis is usually treated by a specialist in liver disorders called a hepatologist, a specialist in digestive disorders called a gastroenterologist, or a specialist in blood disorders called a hematologist.
	digestive.niddk.nih.gov /ddiseases/pubs/hemochromatosis/index.htm (1996 words)

	Hemochromatosis
		Hemochromatosis is a condition in which the body accumulates excess amounts of iron.
		The gene for hemochromatosis, HFE, was identified in 1996.
		Research priorities aimed at future prevention and control of hemochromatosis include (1) determining the proportion of people with hemochromatosis who will become symptomatic and (2) evaluating the risks, benefits, and effectiveness of different methods of case detection and follow-up.
	healthlink.mcw.edu /article/974757337.html (1085 words)

	What Is Hemochromatosis? (Site not responding. Last check: 2007-10-19)
		Although few people have ever heard of hemochromatosis, it is estimated to affect 1.5 million Americans, and probably accounts for 15 percent of the cases of adult-onset diabetes.
		Hemochromatosis is a disorder that causes the body to absorb more iron than it needs.
		The most common cause of hemochromatosis is genetic: hereditary hemochromatosis is a form of this disease that can run in families.
	www.dnadirect.com /resource/conditions/hfe/GH_Hemo_What_Is.jsp (390 words)

	Hemochromatosis
		Hemochromatosis, also called iron overload, can result from several medical conditions, the most common of which is an inherited disorder of iron metabolism that occurs primarily in Caucasians, termed hereditary hemochromatosis or HH.
		Approximately 1 in 10 Caucasians have one abnormal (or mutated) copy of the gene associated with hereditary hemochromatosis and are referred to as carriers.
		Laboratory testing for hereditary hemochromatosis begins with two blood tests: transferrin saturation and serum ferritin, which are measures of the body's iron metabolism and iron stores.
	www.labtestsonline.org /understanding/conditions/hemochrom.html (402 words)

	eMedicine - Hemochromatosis : Article by Sandor Joffe, MD
		In primary hemochromatosis, the liver is the main organ for abnormal iron deposition, consisting of ferritin and hemosiderin.
		Cardiomyopathy and diabetes are uncommon causes of death in patients with hemochromatosis; however, patients with hemochromatosis and diabetes have a worse prognosis than other patients with hemochromatosis.
		Patients with early hemochromatosis (noncirrhotic) frequently have insulin resistance, while patients with cirrhosis and hemochromatosis often have type 1 diabetes mellitus.
	www.emedicine.com /radio/topic323.htm (2797 words)

	Liver Facts - Hemochromatosis
		Hemochromatosis is a metabolic disorder that results in excess deposits of iron in the liver, pancreas, and other iron-storing organs.
		Hemochromatosis is uncommon and rarely occurs before middle age.
		That hemochromatosis frequently escapes early detection is very troubling, particularly in light of the simplicity of its treatment, which is periodic phlebotomy or blood-letting to get rid of excess iron stores.
	www.liverfacts.com /ms/ency/743/main.html (616 words)

	Hemochromatosis Gene Test (HFE)
		Hereditary hemochromatosis is a disorder that is passed from a parent to a child (inherited) that causes too much iron to build up in the blood.
		Hemochromatosis gene (HFE) testing is a blood test that is used to evaluate a person's risk for developing hereditary hemochromatosis.
		Hemochromatosis gene testing can provide information about whether you have hereditary hemochromatosis and whether you are a carrier of the disease.
	my.webmd.com /hw/health_guide_atoz/tv7864.asp (940 words)

	Effects of Hemochromatosis
		In contrast, with hereditary hemochromatosis the iron is placed directly onto transferrin and from there moves to the tissues.
		The distinguishing feature between transfusional iron overload and hereditary hemochromatosis is the presence of large deposits of iron in the reticuloendothelial cells with the former.
		Decades of iron deposition in articular cartilage in hereditary hemochromatosis is the presumed cause of this condition.
	sickle.bwh.harvard.edu /hemochromatosis.html (3159 words)

	Hemochromatosis (Site not responding. Last check: 2007-10-19)
		Primary hemochromatosis is an autosomal disorder characterized by an accumulation of iron in parenchymal tissues including the liver.
		The Genotype of HFE, The Hemochromatosis Gene, Affects The Age of Onset of Sporadic Alzheimer 's Disease - by J.Tagliabue, M.Sampietro, L.Caputo, G.annoni, C.Vergani.
		Hemochromatosis 11 M - abnormal accumulation of iron in the liver.
	www.genomelink.org /hemochromatosis (1246 words)

	Hemochromatosis (Site not responding. Last check: 2007-10-19)
		Hemochromatosis is a disorder in which the body absorbs too much iron from food.
		Hemochromatosis is a hereditary disease and is sometimes called hereditary hemochromatosis, or HHC.
		Hemochromatosis is treated by drawing blood to remove excess iron from the body and keep it from building up in organs.
	www.niddk.nih.gov /health/hematol/pubs/hemoch/hemoc.htm (317 words)

	Hemochromatosis Gene
		A mutation at cysteine 282 is a common cause of hereditary hemochromatosis.
		Firgure 2: Most common HFE mutation that causes HH The most common mutation responsible for hereditary hemochromatosis is the substitution of tyrosine for cysteine at the 282nd amino acid position in the protein sequence (C282Y mutation).
		The cysteine residue at this position is part of a disulfide bond that forms a loop in the alpha-3 domain of the HFE protein.
	ornl.gov /sci/techresources/Human_Genome/posters/chromosome/hfe.shtml (903 words)

	Untitled Document
		A: Hemochromatosis (pronounced: He-mo-chro-ma-toe-sis) is a genetic condition of abnormal iron metabolism that permits absorption of too much iron from an ordinary diet.
		A: Frequency (incidence in the general population) of the abnormal gene is: 1 in 100-200 people has hemochromatosis (double gene mutation known as a homozygote) and 1 in 8-10 people is a carrier of hemochromatosis (single gene mutation known as a heterozygote or "het" for short).
		Hereditary hemochromatosis is one of the few genetic diseases which has a prevention plan so that all organ damage and premature death can be completely prevented.
	www.americanhs.org /faq.htm (2864 words)

	Gale Encyclopedia of Medicine: Hemochromatosis
		Hemochromatosis causes excess iron storage in several organs of the body including the liver, pancreas, endocrine glands, heart, skin, and intestinal lining.
		Hereditary hemochromatosis is passed by an autosomal recessive trait on the genes.
		Relatives, especially siblings, of patients with hemochromatosis should be tested for genes that indicate predisposition to the disease.
	www.findarticles.com /p/articles/mi_g2601/is_0006/ai_2601000645 (1089 words)

	Hemochromatosis: Online Reference For Health Concerns
		Because hemochromatosis patients have chronic high iron levels, they are at risk for a host of free-radical-generated diseases, including cancer and heart disease.
		One problem that hemochromatosis patients must face is that the potent antioxidant vitamin C, when taken in the presence of iron-containing foods, can increase the absorption of iron from the digestive tract into the bloodstream.
		Desferal (deferoxamine) is the preferred agent for iron chelation in cases of secondary iron overload from transfusion-dependent anemias or as an adjunct in acute iron intoxication.
	www.lef.org /protocols/prtcl-056.shtml (2140 words)

	Haemochromatosis - Wikipedia, the free encyclopedia
		Haemochromatosis, also spelled hemochromatosis, is a hereditary disease characterized by improper processing by the body of dietary iron which causes iron to accumulate in a number of body tissues, eventually causing organ dysfunction.
		In hemochromatosis, the cell is constantly fooled into thinking there is iron depletion.
		As a consequence, it overexpresses the necessary channel proteins, this leading to a massive, and unnecesary iron absorption.
	en.wikipedia.org /wiki/Hemochromatosis (1196 words)

	Hemochromatosis for Health Care Pros: Home \| CDC (Site not responding. Last check: 2007-10-19)
		Hemochromatosis: What every clinician and health care professional needs to know is an online training course for primary care providers describing the pathophysiology, epidemiology, diagnosis, treatment, and management of patients with adult onset hemochromatosis.
		If you are looking for basic information about hemochromatosis and hereditary hemochromatosis, visit the CDC Web site Iron Overload and Hemochromatosis for information designed to help patients and their families maintain healthy lifestyles.
		Hemochromatosis experts at the Centers for Disease Control and Prevention and medical experts throughout the United States developed this course to promote early detection and early intervention of adult onset hemochromatosis.
	www.cdc.gov /hemochromatosis/training (407 words)

	Hemochromatosis - Canada's Most Common Genetic Disorder - Canadian Hemochromatosis Society [canadian hemochromatosis ...
		The Canadian Hemochromatosis Society was established to create awareness about this little-known, but common disorder so that early diagnosis would become the rule rather than the exception and needless suffering and premature death from undiagnosed hemochromatosis would become a thing of the past.
		The Canadian Hemochromatosis Society is dedicated to building awareness of hemochromatosis and its early screening, diagnosis and treatment.
		The Canadian Hemochromatosis Society is currently seeking for someone to assist our Office Manager in our national office located in Richmond.
	www.cdnhemochromatosis.ca (554 words)

	CNN - Hemochromatosis: If you don't know what it is, you should - July 26, 1999
		If you have any of the following conditions, you should be screened for hemochromatosis: an enlarged liver, cirrhosis or cancer of the liver, arthritis, diabetes or heart irregularities.
		Hemochromatosis is a frequently asymptomatic disorder in which the body absorbs too much iron from food.
		And ironically, it is possible to have both hemochromatosis and anemia, as there are different forms of anemia, according to the American Liver Foundation.
	www.cnn.com /HEALTH/9907/26/hemochromatosis (599 words)

	Hemochromatosis
		Hill Country Aviaries, L.L.C. One of the biggest challenges of keeping and maintaining a large softbill collection or just a single pet is the problem of the iron storage disease known as hemochromatosis.
		Hemochromatosis is probably the leading cause of death of mynas and toucans in captivity, and collections of birds-of-paradise have been decimated by this malady.
		The same therapy used in humans, where hemochromatosis also occurs, does not seem to work in birds, probably because the causes are different.
	www.mynahbird.com /articles/ironstorage/ironstorage.html (1027 words)

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